ライフサイエンスコーパス: synthetic pathway

1 ing the strict specificity of the fatty acid synthetic pathway.

2 itical regulatory contribution to the serine synthetic pathway.

3 form of a stable prehapten through a 5 step synthetic pathway.

4 b product precolibactin 886 via a biomimetic synthetic pathway.

5 was synthesized through an efficient 13-step synthetic pathway.

6 ynthesis in a highly convergent and flexible synthetic pathway.

7 n recycling purine groups from the polyamine synthetic pathway.

8 complished through exploitation of a related synthetic pathway.

9 talyses the first, rate-limiting step in the synthetic pathway.

10 synthase, a pivotal enzyme in the early GSL synthetic pathway.

11 way with the cholesterol catabolic bile acid synthetic pathway.

12 onvergence of PPARalpha with the cholesterol synthetic pathway.

13 s the first committed step of the fatty acid synthetic pathway.

14 ve or negative regulators of the siderophore synthetic pathway.

15 3z, sidearm buildup was also employed in the synthetic pathway.

16 stimulation of a normal but under-utilized, synthetic pathway.

17 ated S-adenosylmethionine from the polyamine synthetic pathway.

18 e host for purines since they lack a de novo synthetic pathway.

19 through the branches of this essential lipid synthetic pathway.

20 xcitons (25-28%, biased), independent of the synthetic pathway.

21 (UDP-GlcA) to UDP-xylose in the proteoglycan synthetic pathway.

22 ere primarily concentrated in the amino acid synthetic pathway.

23 were previously inaccessible along the same synthetic pathway.

24 cid elongases and/or desaturases in the PUFA synthetic pathway.

25 ta and reference texts are available on this synthetic pathway.

26 oxo-3,4-dehydroxyneomajucin (ODNM) along the synthetic pathway.

27 ures of intermediates and a stereocontrolled synthetic pathway.

28 to determine the site of action in the PGD2 synthetic pathway.

29 ase (NMNAT) is a conserved enzyme in the NAD synthetic pathway.

30 for transforming TCP based on an immobilized synthetic pathway.

31 lic antimalarial agent that derived from the synthetic pathway.

32 o manno epimerization at a late stage of the synthetic pathway.

33 ylase (TH), a rate-limiting enzyme in the CA synthetic pathway.

34 aphthyridinediones were prepared via a novel synthetic pathway.

35 otein oxygenases involved in natural product synthetic pathways.

36 of BH4 salvage/reduction versus de novo BH4 synthetic pathways.

37 o seven urea linkages were made by iterative synthetic pathways.

38 novel analogues were prepared by two general synthetic pathways.

39 se phosphate shunt, and lipogenic and sterol synthetic pathways.

40 nt antibiotics that act to inhibit bacterial synthetic pathways.

41 potentially indicating similarities in their synthetic pathways.

42 cts in two key genes in different methionine synthetic pathways.

43 edirect precursor molecules into alternative synthetic pathways.

44 hips between the degradation, recycling, and synthetic pathways.

45 nd aerobic conditions, albeit with different synthetic pathways.

46 NMR spectroscopy, and additional independent synthetic pathways.

47 those compounds obtained through each of the synthetic pathways.

48 to either the P1 or P1' residue required new synthetic pathways.

49 mbinant microorganisms containing artificial synthetic pathways.

50 ts role in early steps of both wax and cutin synthetic pathways.

51 elds varying from 32 to 64% according to two synthetic pathways: (1) using a titanium-reductive amina

52 Fatty acid synthetic pathway activity and the magnitude of DNA synt

53 etylglucosamine, a product of the hexosamine synthetic pathway, acts as a substrate at an early stage

54 This synthetic pathway allowed for the creation of hydrogel m

55 The lipid synthetic pathway also provides precursors for protein m

56 ldehydes and ketones represents an important synthetic pathway, although the selective formation of C

57 tolerance to salinity and hypoxia makes its synthetic pathway an interesting target for metabolic en

58 This review concentrates on the phospholipid synthetic pathway and discusses recent data on the synth

59 e incorporation of a protein switch into the synthetic pathway and encapsulation of the bacteria with

60 of genes in the leaf involved in the sucrose synthetic pathway and photosynthesis, such as Calvin cyc

61 The highly convergent nature of our synthetic pathway and the flexibility of the modular syn

62 ifran analogs prepared using newly developed synthetic pathways and evaluated as agonists for GPR109a

63 lytical scientist as well as inspiration for synthetic pathways and innovative research into next-gen

64 plications is limited by complex, multi-step synthetic pathways and polymerization reactions that rel

65 limiting enzyme in the mammalian NAD(+) main synthetic pathway) and extracellular NAMPT (eNAMPT, a cy

66 tured HOK express enzymes of the epinephrine synthetic pathway, and generate epinephrine.

67 the rate-limiting enzyme in the de novo BH4 synthetic pathway, and human single-nucleotide polymorph

68 lecular tools for several key enzymes in the synthetic pathway are becoming available.

69 hase and other components of the ganglioside synthetic pathway are crucial host factors that are requ

70 ions that patients with disorders in the PyN synthetic pathway are not overtly immunodeficient milita

71 The described synthetic pathways are based on a highly anti-diastereos

72 The two synthetic pathways are connected by prostaglandin E2 (PG

73 Simple and effective synthetic pathways are described to prepare compounds R(

74 ring offers an alternative approach in which synthetic pathways are engineered into user-friendly hos

75 These synthetic pathways are frequently upregulated in cancer

76 Herein, two distinct synthetic pathways are rationalized to install nitride l

77 Biotin synthetic pathways are readily separated into two stages

78 The synthetic pathways are sensitive to metal radius.

79 ive metabolism to accommodate the demands of synthetic pathways, as these pathways will alter the hom

80 ere enriched in specific metabolic and lipid synthetic pathways, as well as the draper/Megf10 and Mer

81 In this regard, synthetic pathways based on thiolase enzymes to catalyze

82 Cell-free synthetic pathway biotransformation (SyPaB) is the imple

83 NAD levels are maintained by multiple synthetic pathways but which ones are important in bone

84 mparable complexity, which are united in the synthetic pathway by conjugate addition of a nucleophili

85 amide generation is derived from the de novo synthetic pathway by coordinate activation of SPT and ce

86 creasing vesicular glutamate, access to this synthetic pathway by exogenously applied glutamine to ne

87 s requirement provided the currently complex synthetic pathway can be simplified.

88 In theory, hybrid polyketide synthetic pathways can be constructed through the ration

89 Furthermore, the synthetic pathways can be used to construct pancratistat

90 tic species and dramatically limited de novo synthetic pathway capabilities but include either restri

91 eir target enzymes at different steps in the synthetic pathway, causing the accumulation of various i

92 izes and the regulation of the two bile acid synthetic pathways (classic, via cholesterol 7alpha-hydr

93 As a whole, de novo fermentation and synthetic pathway construction for these molecules remai

94 However, synthetic pathway construction in cyanobacteria is still

95 eered 13 strains of Yarrowia lipolytica with synthetic pathways converting glycolytic NADH into the l

96 proach would circumvent the need for complex synthetic pathways currently used to introduce functiona

97 An intermediate in the synthetic pathway, Delta(23,24)-dehydroascomycin, was li

98 Astrocyte synthetic pathways, dependent on glutathione, are involv

99 trates the efficacy of ensemble modeling for synthetic pathway design.

100 However, there does not exist a synthetic pathway either from monomers or via the functi

101 that could afford both the precursors of the synthetic pathways eventually leading to RNA and to the

102 lidated experimentally by designing a 3-step synthetic pathway for a challenging small molecule, demo

103 nuatum, a member of the genus that lacks the synthetic pathway for beta-Ala betaine.

104 Herein a fundamentally different synthetic pathway for bioalcohol production at 70 degree

105 id excipients and open a novel and effective synthetic pathway for derivation of phenyl alcohols.

106 ndocytic signals, we were able to generate a synthetic pathway for efficient transport of a reporter

107 In one example, we divided the synthetic pathway for the acetylated diol paclitaxel pre

108 This method provides an efficient synthetic pathway for the combinatorial synthesis of con

109 ene-based molecular receptors is a important synthetic pathway for the elaboration of more sophistica

110 axial MTB gates in this work suggest a novel synthetic pathway for the integration of two-dimensional

111 A one-step synthetic pathway for the preparation of fully conjugate

112 Towards this aim we express a synthetic pathway for the production of the rhizopine sc

113 Because the synthetic pathways for both molecules are complex, in ad

114 nd q-1D vdW crystals, the lack of accessible synthetic pathways for growing well-defined nanostructur

115 After optimizing synthetic pathways for iE-VP-linked dimer phosphoramidit

116 interest in the design and execution of new synthetic pathways for indenoisoquinoline production.

117 Establishing efficient synthetic pathways for microbial production of biochemic

118 molecular generation approaches, we generate synthetic pathways for molecules to ensure that designs

119 Engineering synthetic pathways for production of alpha-methyl acids

120 It notably describes the most important synthetic pathways for R-Co(III), the influence of the l

121 ind nucleation as a key parameter to predict synthetic pathways for shape-controlled nanocrystals.

122 Several synthetic pathways for the production of liquid biofuels

123 The approach opens versatile synthetic pathways for the production of valuable phenol

124 hallenging functional groups and opens novel synthetic pathways for the utilization of renewable carb

125 Current synthetic pathways for uranyl peroxide materials introdu

126 nature of the involved chemistries sets the synthetic pathway free from any functional group protect

127 We uncovered a placental 5-HT synthetic pathway from a maternal tryptophan precursor i

128 alization in cellular organelles can isolate synthetic pathways from competing pathways, and provide

129 an efficient method for building large-scale synthetic pathways from standardized, reusable component

130 ssion of the first enzyme in the glutathione synthetic pathway [glutamate cysteine ligase (GCL)] were

131 key regulatory enzyme in the de novo purine synthetic pathway, glutamine PRPP amidotransferase (also

132 sing the possibility that loss of the purine synthetic pathway had rendered 10-CHO-THF dispensable in

133 H biosynthesis and provide evidence that the synthetic pathway has similarities to that established f

134 hain acyl-ACPs, the intermediates of the UFA synthetic pathway have been followed in vivo for the fir

135 The synthetic pathways have been developed to prepare 7-, 8-

136 l-network algorithms that can plan multistep synthetic pathways have revolutionized this field(1,3-7)

137 Classical synthetic pathways, i.e., anionic polymerization, coordi

138 We now identify a novel retinoid synthetic pathway in differentiating F9 cells that resul

139 ion of an exogenous stepwise O-glycosylation synthetic pathway in E. coli In addition, we have determ

140 ion of an exogenous stepwise O-glycosylation synthetic pathway in E. coli.

141 investigated the keratinocyte catecholamine synthetic pathway in response to acute trauma.

142 lighted the role of the polyphosphoinositide synthetic pathways in activated cells.

143 e sensing repertoire and the assembly of new synthetic pathways in engineered cells for innovative dr

144 t of new tools and approaches to engineering synthetic pathways in microbial hosts for chemical produ

145 , suggesting a different regulation of these synthetic pathways in the adrenal cortex inner zone duri

146 notyped for functional variants on vitamin D synthetic pathway including GC (rs4588, rs7041, rs22020,

147 triplet) states offer a myriad of attractive synthetic pathways, including cycloadditions, selective

148 ithin the de novo fatty acid and cholesterol synthetic pathways, including sterol regulatory element

149 oxylase (ODC), a key enzyme of the polyamine synthetic pathway, increased cellular aggregates and inc

150 tures and a mouse model and showed that this synthetic pathway increases free fatty acid beta-oxidati

151 tamine (polyQ) proteins promote the spermine synthetic pathway, increasing polyQ-aggregation and cell

152 The reconstructed synthetic pathways indicate that small radicals and form

153 Here, a simple synthetic pathway integrates gold quantum dots within a

154 ethionine metabolism-related and glutathione synthetic pathway intermediates, including S-adenosylmet

155 of the use of these reactions to devise new synthetic pathways, investigate reaction mechanisms, and

156 The alternative synthetic pathway involves an initiator containing a mal

157 This synthetic pathway involves the use of a Crimmins titaniu

158 A key step in the synthetic pathways involves the one-carbon ring expansio

159 A two-step synthetic pathway involving decyanation chemistry for th

160 Key to the success of this synthetic pathway is a Pd-catalyzed C(sp(3))-H arylation

161 ide formation from IMP in the de novo purine synthetic pathway is carried out by two isoforms of the

162 Furthermore, the impact of the synthetic pathway is investigated and a qualitative desc

163 However, the mycobacterial biotin synthetic pathway is not fully understood.

164 The taurine synthetic pathway is proposed to be incomplete in astroc

165 This large synthetic pathway is shared by virtually all salmonellae

166 The synthetic pathway is suitable for preparation and biolog

167 The type II fatty acid synthetic pathway is the principal route for the product

168 le, atom-economical, and efficient (= short) synthetic pathways is of high interest in organic chemis

169 ase (TPH), the first enzyme in the melatonin synthetic pathway, is expressed rhythmically under the c

170 ding suppression of the intermediates in the synthetic pathway leading to expression of the T cell co

171 hology, as exemplified by a proof-of-concept synthetic pathway leading to vesicle fission.

172 The synthetic pathway leads to platinum nanoparticles of app

173 With recent advances in the design of synthetic pathways, lignocellulosic biomass can be regar

174 +)-lucidumone is described through a 13-step synthetic pathway (longest linear sequence).

175 B12 in living forms, we suggest that the B12 synthetic pathway may have evolved to allow anaerobic fe

176 exogenous fatty acids into particular lipid synthetic pathways may contribute to the sensitivity/res

177 Activity of the fatty acid synthetic pathway measured by labeling of six surgical s

178 Although the unsaturated fatty acid (UFA) synthetic pathway of Escherichia coli is the prototype o

179 The anaerobic unsaturated fatty acid synthetic pathway of Escherichia coli requires two speci

180 protein (ACP)) synthase I/II (FabF/B) in the synthetic pathway of fatty acids.

181 While studying the bile acid synthetic pathway of hamsters, we discovered an NADP+-de

182 e candidate substance that emanates from the synthetic pathway of melanin that plays a key role in re

183 This paper aims to elucidate whether the synthetic pathway of Melatonin in Saccharomyces and non-

184 The synthetic pathway of morphine in the opium poppy has bee

185 The synthetic pathway of the cluster 2 could indicate the na

186 ression, suggesting that the thyroid hormone synthetic pathway of the mouse could be dissociated into

187 In particular, we present a plausible synthetic pathway of the tetramers and their further com

188 anscript levels of the genes involved in the synthetic pathways of antimicrobial metabolites camalexi

189 ers an important foundation for decoding the synthetic pathways of bioactive compounds in medicinal p

190 ided by experimental research, into the main synthetic pathways of prebiotic chemistry, suggesting ho

191 ic mesolimbic activity, and (2) in controls, synthetic pathways of this neurocircuitry maintain suffi

192 The glycan synthetic pathways of this pathogen are of great interes

193 his article explores the connections between synthetic pathway, PAF defectivity, and microporosity.

194 is illustrated with several case studies: a synthetic pathway problem of signaling regulation, a two

195 One synthetic pathway produced valine at a sufficient level

196 expression of enzymes in the alternative BA synthetic pathway, production of hepatic chenodeoxycholi

197 nes coding for ribosomal, mitochondrial, and synthetic pathway proteins.

198 erimental methods testedincluded the use of "synthetic pathways" (random sets of genes) to estimate p

199 merization, plant metabolic engineering, and synthetic pathway reconstruction were demonstrated for v

200 have highlighted the relevance of the serine synthetic pathway (SSP), which consists of three success

201 limitations, here we develop an alternative synthetic pathway termed the isoprenoid alcohol (IPA) pa

202 The synthetic pathways tested improved photosynthetic quantu

203 This work benefits from a synthetic pathway that allows for the facile preparation

204 ia coli BioC protein as the initiator of the synthetic pathway that forms the pimeloyl moiety of biot

205 OX-2) is a cellular enzyme in the eicosanoid synthetic pathway that mediates the synthesis of prostag

206 anscriptome of a mutant lacking a putrescine synthetic pathway that was required for surface motility

207 The next frontier is to create synthetic pathways that adapt to changing environments.

208 vides the experimentalist with complimentary synthetic pathways that afford either the pyrimidin-7-on

209 Synthetic pathways that are able to systematically produ

210 hotochemistry of TiO(2) and suggests general synthetic pathways that are the result of the ability to

211 This review focuses on those synthetic pathways that build up a polymer chain from et

212 sively investigated, together with plausible synthetic pathways that might have led, abiotically, to

213 lism into energy production rather than into synthetic pathways that require hexosamines.

214 Synthetic pathways that yield polyaromatic AEPs include

215 matic specificity within the N-linked glycan synthetic pathway, the sequencing results of GlycoSeq we

216 latelets and defects in the arachidonic acid synthetic pathway, thereby suppressing serotonin release

217 steps in the classic and alternate bile acid synthetic pathways, thereby reducing the hepatic bile ac

218 addressed and manipulated through molecular synthetic pathways, they are chemically similar to molec

219 highlighting its ability to simplify complex synthetic pathways through entirely different bond disco

220 he substrate for the next enzyme in the dTTP synthetic pathway, thymidylate synthase.

221 The synthetic pathway to 2 was optimized from seven to five

222 A synthetic pathway to a functionalized tetrahydro[5]phena

223 Finding a synthetic pathway to artificial analogs of nacre and bon

224 Here we report a new and simple synthetic pathway to form ordered, hollow carbon nitride

225 We redesigned the DAP synthetic pathway to generate L,L-NSDAP and other L,L-NS

226 This work suggests a simple synthetic pathway to high surface-area, low-density nano

227 ical pentafluorosulfanylation simplifies the synthetic pathway to modify complex and bioactive molecu

228 of xenobiotics and in a recently constructed synthetic pathway to produce D-glucaric acid, a "top val

229 lic Zr/Co complex provides a new cooperative synthetic pathway to promote multielectron redox process

230 and our approach provides a straightforward synthetic pathway to such compounds.

231 Unfortunately, no general synthetic pathway to such derivatives exists.

232 A new synthetic pathway to the 4,5-diarylphenanthrenes 8 havin

233 The synthetic pathway to the metal-organic framework compoun

234 mical and oxidative permutations, a unifying synthetic pathway to this broad family of natural produc

235 Here, we describe the first de novo synthetic pathway to this exceptionally rare C5-nor stem

236 Herein, we report a general synthetic pathway to various shapes of three-dimensional

237 Synthetic pathways to (salcy)CoX (salcy = N,N'-bis(3,5-d

238 Investigations of potential synthetic pathways to 1 initially utilized as starting m

239 New synthetic pathways to 11H-benzo[b]fluoren-11-ols, 1H-cyc

240 In this report, we present synthetic pathways to a variety of SF5CF2-substituted co

241 aminomethanol changes our perception of the synthetic pathways to amino acids and the unexpected kin

242 eagents for polyarsenic entities open up new synthetic pathways to avoid the direct generation of yel

243 new applications and to propose alternative synthetic pathways to be built easily, at each step and

244 Synthetic pathways to complex meroterpenes derived from

245 s of glycosidic linkage as defined by glycan synthetic pathways to eliminate improbable glycan struct

246 the structure of the helical pores indicate synthetic pathways to helical pores with bioinspired fun

247 Here, we report novel synthetic pathways to introduce Psi and chi angle constr

248 ew insights for the design of more effective synthetic pathways to minimise structural defects in con

249 Here, we show that targeting synthetic pathways to peroxisomes can increase the produ

250 New synthetic pathways to the 5H-pyrido[3',4':4,5]pyrrolo[2,

251 tic properties and reveals a straightforward synthetic pathway toward novel energetic 1,2,4-triazole

252 A simple and unpredicted synthetic pathway toward racemic and scalemic tetrahydro

253 The synthetic pathways used for the syntheses of dicarba-clo

254 future from an evolving forward analysis of synthetic pathways, used in diversity-oriented synthesis

255 0 g) and can be predictably implemented into synthetic pathways using experimentally or computational

256 n of microsomal and peroxisomal glycerolipid synthetic pathways, using D-[3-(3)H, U-(14)C]glucose as

257 The synthetic pathway was unique in that the major product,

258 The synthetic pathway was via Wittig-Horner coupling of the

259 Flux through the synthetic pathways was maximized by inhibiting glycolate

260 n to enhance muscle regeneration and protein synthetic pathways, we asked whether high levels of musc

261 Using multiple synthetic pathways, we probed diverse substitutions of t

262 ing for promiscuous aldehyde dehydrogenases, synthetic pathways were constructed to produce both C5 a

263 rity of genes involved in fructan and starch synthetic pathways were positively correlated with sucro

264 This synthetic pathway, which avoids intermediate purificatio

265 ovo DNA synthesis approach for engineering a synthetic pathway with microchip-synthesized oligonucleo

266 ween specific BA molecular species and their synthetic pathways with diabetes is unclear.