ライフサイエンスコーパス: synthetic route

1 ation of the natural product and to plan the synthetic route.

2 over 30 analogues using a novel solid-phase synthetic route.

3 -like morphologies were obtained through the synthetic route.

4 uces additional steps and obstacles into the synthetic route.

5 ually interpenetrating rings, via an unusual synthetic route.

6 kbone, giving a straightforward and low-cost synthetic route.

7 ared using a highly efficient and convergent synthetic route.

8 ized in 40-47% overall yield along four-step synthetic routes.

9 onditions than the conventional hydrothermal synthetic routes.

10 s, a complete set of step reactions in their synthetic routes.

11 hat have never before been accessed by fully synthetic routes.

12 re difficult to achieve through conventional synthetic routes.

13 groups not otherwise accessible with current synthetic routes.

14 ompositions that are inaccessible via direct synthetic routes.

15 explore and select more efficient syntheses/synthetic routes.

16 /macromolecules tailored through appropriate synthetic routes.

17 action times in comparison with conventional synthetic routes.

18 vestigations, which have led to new valuable synthetic routes.

19 vironmental friendliness low cost and simple synthetic routes.

20 de clues for developing new and controllable synthetic routes.

21 azardous and costly chemicals or any complex synthetic routes.

22 SPP), into a network displays tentative (bio)synthetic routes.

23 icinal chemistry programs to self-optimizing synthetic routes.

24 ives and are a preferred choice over de novo synthetic routes.

25 njunction with the versatile access to their synthetic routes.

26 een held back by the scarcity of appropriate synthetic routes.

27 Three synthetic routes aimed at achieving the stereoselective

28 A newly developed synthetic route allowed synthesizing the biologically mo

29 The synthetic route allows additional functionalities to be

30 nd 8 metals (for which a number of versatile synthetic routes already exist) to provide access to com

31 The nine-step synthetic route also features a novel desymmetrizing ena

32 oth bioactive small molecules and associated synthetic routes, analogous to the evolution of biosynth

33 ns a critical challenge in drug development, synthetic route and chemical process design, extraction

34 This agent was prepared by a concise synthetic route and formulated for dynamic nuclear polar

35 Our study not only provides a bottom-up synthetic route and mechanistic understanding of nanohel

36 ause of the limitation of a high-temperature synthetic route and the limited understanding of high-en

37 Also presented are some interesting synthetic routes and procedures that can be used toward

38 s has been underexplored, due to the lengthy synthetic routes and the lack of structure-activity rela

39 ance of the raw materials, the simplicity of synthetic routes, and processing versatility make MHPs i

40 was prepared through two different stepwise synthetic routes, and the complicated chemical structure

41 Blatter's radicals are limited, however, and synthetic routes are complex.

42 Especially simple synthetic routes are disclosed that provide access to dy

43 spects for the industrial amenability of new synthetic routes are exemplified through case studies.

44 Synthetic routes are proposed through generalization of

45 Some newly developed synthetic routes are selected and discussed in detail.

46 ne (TPE) small molecule prepared by a facile synthetic route as a superior dopant-free HTL for lead-f

47 ties they can exhibit and the growing set of synthetic routes available to produce them.

48 Cu2O NPs were prepared by means of a novel synthetic route based on flame spray pyrolysis.

49 ha-position has gathered much attention as a synthetic route because of the wide biological importanc

50 y semisynthetic and to a lesser degree fully synthetic routes, but economic factors have led to a sub

51 -state compounds inaccessible by traditional synthetic routes, but there has been little development

52 s) were prepared following a straightforward synthetic route by cross-linking arylamine-based ligands

53 Using the same synthetic route, called Urea-Glass-Route, but in absence

54 The synthetic route can access >400 mg in a single batch, em

55 licated posttranslational modifications, the synthetic route can be considered challenging.

56 This divergent synthetic route can be exploited to prepare dibenzylbuta

57 e report how a metal organic framework (MOF) synthetic route can be optimized using an in situ monito

58 The synthetic route comprises three steps: site-specific (ed

59 s, and hemostats, their design requirements, synthetic routes, determination of properties, and the t

60 The synthetic routes developed here should prove to be usefu

61 We describe new synthetic routes developed toward a range of substituted

62 es valuable oxygenated structures for use in synthetic route development.

63 smonic NPs are promising candidates for such synthetic routes due to the strong rotatory power of hig

64 Our synthetic route effectively overcomes this limitation th

65 bis-tosyl-cystamine was integrated into the synthetic route, eliminating the use and isolation of vo

66 The ease and scalability of the synthetic route employed and the quality of the interfac

67 The concise synthetic route features a cascade process involving a 6

68 This synthetic route features a palladium-catalyzed alkoxycar

69 Our synthetic route features a stereospecific solid-state ph

70 The synthetic route features iodine-catalyzed tandem isomeri

71 Here we describe a facile, tandem synthetic route for indolo[3,2-c]quinolinones, a class o

72 An efficient synthetic route for ipomoeassin F and its tiglate-modifi

73 A novel synthetic route for preparation of proxyphylline enantio

74 We have developed a modular practical synthetic route for preparation of turn-ON fluorophore-t

75 A new, four-step synthetic route for substituted 2,3-benzodiazepines 1, s

76 that the transformation can be an effective synthetic route for the annulation of benzene rings to v

77 A convenient synthetic route for the construction of functionalized 2

78 An analogue-oriented synthetic route for the formulation of furazan-functiona

79 is protocol not only provides an alternative synthetic route for the preparation of diverse alpha-ami

80 An efficient and mild synthetic route for the preparation of functionalized bi

81 a kinetically tuned dimensional augmentation synthetic route for the preparation of highly crystallin

82 rspective, this protocol offers an efficient synthetic route for the preparation of pharmaceutical dr

83 this article, a facile two-step and one-pot synthetic route for the preparation of substituted aryl

84 Furthermore, this study provides a synthetic route for the synthesis of 1,20S(OH)2D3 using

85 Disclosed herein is an efficient synthetic route for the synthesis of functionalized 2-be

86 In this work, we developed a concise synthetic route for the synthesis of polysubstituted nap

87 address this issue, we have developed a new synthetic route for the synthesis of site-specifically p

88 pure oxides and thus enable a more targeted synthetic route for their preparation.

89 order to develop an efficient and versatile synthetic route for this molecule, a modular strategy is

90 In many cases, the synthetic routes for both synthetic intermediates and mo

91 on framework and exploration of two distinct synthetic routes for forging the flavanoid C-ring by red

92 Engineering and evaluation of synthetic routes for generating valuable compounds requi

93 Synthetic routes for heteroatom-containing polycyclic ar

94 and amorphous MOFs, as well as providing new synthetic routes for MOF preparation.

95 In this work, we have developed synthetic routes for novel trifluorinated glucopyranose

96 In this paper, we describe synthetic routes for preparing a novel switchable BNC-ba

97 y well explored owing to a lack of available synthetic routes for preparing them.

98 iates, and the development of more selective synthetic routes for quinone derivatives.

99 We have explored the synthetic routes for regioselective formation of 2-pyrid

100 tegic advances to develop various sequential synthetic routes for the multiarylation of heteroarenes.

101 is paper, we developed facile and high-yield synthetic routes for the preparation of 2-sulfonyl inden

102 A straightforward, scalable synthetic route gives access to the gold(I) complex of a

103 A robust synthetic route has been developed for preparing optical

104 the Gq subfamily of G proteins; however, no synthetic route has been reported previously for these c

105 terest of mechanochemistry as an ecofriendly synthetic route has inspired original methodologies to p

106 ained from zinc acetate/cycteine/oxalic acid synthetic route has the highest sensitivity of 64.29 muA

107 Two complementary rational synthetic routes have been developed in order to synthes

108 The different synthetic routes have been grouped according to the way

109 New convenient wet-chemistry synthetic routes have made it possible to explore cataly

110 groups to the polymer backbone, alternative synthetic routes have to be developed.

111 This new synthetic route, having a Blaise reaction, iron-catalyze

112 ey ( references) of the most promising novel synthetic routes, i.e., electrochemical, microwave, mech

113 Key steps in the synthetic route include kinetic protonation of an enolat

114 Key elements of the synthetic route include the use of an isopropenyl group

115 Key features of the synthetic routes include trifluoroacetic acid-mediated f

116 The synthetic route includes a Pd-catalyzed monoallylation s

117 The synthetic route includes an original Ti(II)-mediated hyd

118 ists of a one-pot straightforward three-step synthetic route, including (i) CuBr(2)-mediated alpha-br

119 H2CBD cannot be converted by any reasonable synthetic route into THC, and thus has the potential to

120 This synthetic route involves four steps of deprotection, imi

121 The synthetic route involves the coupling of 4-substituted a

122 e nanoparticles (MNPs) through a single-step synthetic route involving the simultaneous nanoparticle

123 are synthesized by a simple, easily scalable synthetic route involving thermal treatment of Co(2+) -e

124 In contrast to traditional synthetic routes involving solution chemistry and ionic

125 The synthetic route is based on the oxidative condensation o

126 The synthetic route is highly efficient (13 steps), featurin

127 The synthetic route is highly stereoselective, featuring (1)

128 This synthetic route is in competition with a reaction previo

129 A facile synthetic route is presented that produces a porous Ga-I

130 The synthetic route is rapid, efficient and possible on the

131 The synthetic route is robust, with 94 mg of racemic materia

132 lid/gas and single-crystal to single-crystal synthetic routes is reported for the synthesis and chara

133 The process development of a new synthetic route leading to an efficient and robust synth

134 The synthetic route leading to the trinuclear clusters invol

135 this purpose, such as inexpensive, scalable synthetic routes, low-toxicity and tuneable surface chem

136 The same synthetic route may be applied to (S)-carvone to afford

137 hodology has been applied toward an improved synthetic route of uncialamycin and its analogs.

138 This synthetic route opens a new avenue for an expeditious as

139 This synthetic route opens a path for exploring superconducti

140 s methods, all previously published fentanyl synthetic routes or hybrid versions thereof, were studie

141 The synthetic routes presented here could, in principle, be

142 The synthetic route proceeds in 7 steps with 47% overall yie

143 The synthetic route proposed was chosen to facilitate both t

144 This synthetic route provides practical access to 2-alkyl-2H-

145 We have established a concise synthetic route relying on a key base-promoted epimeriza

146 lbicans for these early de novo analogs, the synthetic route reported here permits more comprehensive

147 The successful execution of this synthetic route resulted in the total synthesis of all t

148 2-phenylacetaldehyde oxime, a reagent in the synthetic route, reveal existence of strong intramolecul

149 enabling high-throughput experimentation for synthetic route scouting to identify conditions for prep

150 s between particles, often influenced by the synthetic route taken to form them, lead to difficulties

151 We report here a synthetic route that allowed us to characterize and unam

152 d-solution nanotubes synthesized by a facile synthetic route that contain 56 % less iridium than IrO(

153 mimic nature's biopolymers, but a practical synthetic route that enables absolute control over polym

154 compounds of importance to life by multistep synthetic routes that do not resemble biochemistry.

155 ave the potential to streamline and simplify synthetic routes, they are currently limited by a narrow

156 cribe the development of an enantioselective synthetic route to (+)-pleuromutilin (1), (+)-12-epi-mut

157 the course of this study, a highly efficient synthetic route to (+/-)-yezo'otogirin C has been establ

158 We have developed a short, general synthetic route to 1,3,6-trisubstituted azulenes.

159 A simple and efficient synthetic route to 2,3,4,5-tetrahydrobenzoxazepines and

160 A new synthetic route to 3-(heteroaryl) tetrahydropyrazolo[3,4

161 talyst was found to be an efficient one-step synthetic route to 5-iodo-4-ethynyltriazoles.

162 A new synthetic route to a 3'-fluoro-3'-deoxytetrose adenine p

163 This study demonstrates an improved synthetic route to a highly valuable natural product, fa

164 Here we developed a synthetic route to a library of compositionally defined,

165 xfoliation of the layers, providing a facile synthetic route to a new class of 2D chalcogenide materi

166 l-Crafts cyclization constitute an efficient synthetic route to access enantioenriched substituted 2,

167 A synthetic route to access phevalin and similar pyrazinon

168 Here, we report optimization of a synthetic route to access triazole-containing DBOs and b

169 rategy targeted designed analogues along the synthetic route to address particular biological questio

170 Herein, we report a practical two-step synthetic route to alpha-arylpyrrolidines through Suzuki

171 nzaldehyde was investigated as a streamlined synthetic route to an N-confused porphyrin bearing penta

172 A straightforward synthetic route to arylazoindazoles via nucleophilic aro

173 To test this hypothesis, we devised a synthetic route to assemble oligosaccharides with natura

174 ver, for these applications to be realized a synthetic route to bulk C3B must be developed.

175 A synthetic route to cis-2-methyl-4-oxo-6-alkylpiperidines

176 We have developed a modular synthetic route to combretastatin analogs based on a pyr

177 ticle products, may provide an important new synthetic route to control final metal nanoparticle comp

178 We developed a straightforward synthetic route to convert nucleophilic thiols into elec

179 s this cyclization reaction attractive for a synthetic route to cyclohexadiene derivatives from alkyn

180 by inter- or intramolecular ways provides a synthetic route to derivatives of styrene, stilbene, cha

181 We describe an efficient synthetic route to differentially protected diester, 1-(

182 A versatile synthetic route to distannyl-substituted polyarenes was

183 provides with an atom-economical and general synthetic route to generate aryl-(hetero)aryl ketones us

184 To achieve this, we devise a synthetic route to halogenated sulfonated carbofluoresce

185 A highly enantioselective synthetic route to hexahydropyrrolo[2,3-b]indoles via Le

186 This work highlights metal flux as a synthetic route to high quality single crystals of novel

187 A mild one-pot stereospecific synthetic route to highly functionalized imidazolidines

188 simple and efficient one-pot three-component synthetic route to highly substituted and functionalizab

189 Additionally, a practical and flexible synthetic route to KA and analogs remains to be develope

190 Herein, we report a modular synthetic route to linear and branched homoallylic amine

191 Here we present a practical, fully synthetic route to macrolide antibiotics by the converge

192 cleophilic radiofluorination is an efficient synthetic route to many positron-emission tomography (PE

193 Besides these studies, we developed a synthetic route to mixed dianilides as starting material

194 To this end, we have developed a facile synthetic route to nanoporous polymer monoliths based on

195 A facile synthetic route to NiPt(3)@NiS heteronanostructures is r

196 A new synthetic route to nonracemic tetrahydropyrrolo[2,3-b]in

197 In this work, we propose a simple synthetic route to obtain different vlasouliolides in go

198 The first synthetic route to obtain salt-free intrinsic plutonium

199 of aromatic molecules could provide a viable synthetic route to ordered carbon nanomaterials, but des

200 A palladium-catalyzed multicomponent synthetic route to polysubstituted pyrroles from aryl io

201 This convenient synthetic route to porous polymer monoliths has the pote

202 Herein we describe a flexible and convergent synthetic route to prepare advanced precolibactins and d

203 To demonstrate the utility of this synthetic route to prepare catalytically active TMC NPs,

204 A new and general synthetic route to prepare dibenzosultams is here report

205 m and progenitor cells; the development of a synthetic route to provide laboratory access to the natu

206 A synthetic route to racemic helicenes via a vinylacetylen

207 ith dienes provide a mild and chemoselective synthetic route to seven-membered carbocycles.

208 In the present study, a facile synthetic route to the 2,3-dideoxy 1-O-glucosides of imp

209 ing an efficient and economically affordable synthetic route to the amides in excellent yields.

210 A novel synthetic route to the chemoselectively protected N,S-di

211 A convergent synthetic route to the fungal metabolites cladosins B an

212 Development of a synthetic route to the oxaphenalenone (OP) natural produ

213 An efficient synthetic route to the resveratrol oligomers quadrangula

214 A convergent synthetic route to the sesterterpenoid framework of the

215 calization and simultaneously simplifies the synthetic route to the voltage sensors.

216 g in a concise, unified, and stereoselective synthetic route to these complex targets in only 10 step

217 of the parasite's life cycle, but a lengthy synthetic route to these compounds may affect the feasib

218 , structural analogs and provide a practical synthetic route to these important bioactive agents.

219 A synthetic route to these inhibitors was subsequently dev

220 However, a scalable synthetic route to these molecules has long been hindere

221 -benzoylethylpyridinium-4-oximate, the novel synthetic route to this engaging target class of compoun

222 ing from d-glucose, we developed a divergent synthetic route to three derivatives of 3,5-diamino-3,5-

223 odel studies demonstrating a stereoselective synthetic route to tricyclic analogues of the bis(piperi

224 Herein, we present a synthetic route to tune the color of In(2)O(3) to pitch

225 ude olefins and alkynes; this provides a new synthetic route to valuable amino-substituted phosphiran

226 effective design strategy with an efficient synthetic route to xanthene-based far-red to near-infrar

227 The first synthetic route to yndiamides, a novel class of double a

228 We cover the synthetic routes to AdoMet analogues, their stability in

229 However, the lack of synthetic routes to all but the simplest molecular knots

230 Direct synthetic routes to amidines are desired, as they are wi

231 In this paper, parallel synthetic routes to benzothiadiazole derivatives, inspir

232 multiscale biological assembly inspires new synthetic routes to complex materials.

233 Furthermore, we suggest synthetic routes to control surface terminations based o

234 ormance as heterogeneous catalysts; however, synthetic routes to control the spatial distribution of

235 lopment of renewable monomers, the versatile synthetic routes to convert these monomers to polyesters

236 mical fragments and two experimentally known synthetic routes to design in silico a large database of

237 in selecting an amide bioisostere (the why), synthetic routes to each (the how), and success stories

238 We developed efficient synthetic routes to explore a wide variety of substituti

239 s review, we first summarize the established synthetic routes to grow high quality nanocrystals of se

240 Importantly, the mild synthetic routes to halide perovskites and the templatin

241 The development of synthetic routes to hierarchically organized porous mate

242 s highlight the importance of developing new synthetic routes to high quality oxynitrides.

243 xidation of alkene feedstocks could simplify synthetic routes to many important molecules and solve a

244 We describe efficient synthetic routes to murrayamine A (mukoenine C), O-methy

245 ed systems and for the design of appropriate synthetic routes to new macrocyclic compounds.

246 o study its role in more detail, we designed synthetic routes to novel analogues of ADPR and 2'-deoxy

247 n this Perspective, we summarize the diverse synthetic routes to obtain spirocyclic systems.

248 The main synthetic routes to soft, hard, and hybrid soft/hard Jan

249 We focus on the development of new synthetic routes to stable and isolable radicals contain

250 Previous synthetic routes to the 1,3,2-benzodiazaborole core have

251 New synthetic routes to the 1-amino-2,5-diarylpyrrolidines w

252 Two synthetic routes to the chiral azinylferrocenes (CAFs) 5

253 ified functional group reactivity molded our synthetic routes to the hasubanan and acutumine alkaloid

254 Synthetic routes to these compounds allowed for the prep

255 nic semiconductors; despite their potential, synthetic routes to thionated NDIs are generally lengthy

256 and high-yielding (for macrocyclic species) synthetic routes to two novel alkynyl-conjugated multipl

257 Novel synthetic routes to various hydantoin structures, the ad

258 Successful development of synthetic routes to various triynes and the subsequent c

259 In this paper, a new synthetic route toward 6-hydroxysphingosine and alpha-hy

260 A facile synthetic route toward either 3- or 5-fluoroalkyl-substi

261 A straightforward synthetic route toward indole-fused heteroacenes was dev

262 This work not only opens up a new synthetic route toward mixed-linker MOFs, but also provi

263 A convergent synthetic route toward orthogonally protected alphaGlcN(

264 We present a simple and generalizable synthetic route toward phase-pure, monodisperse transiti

265 ides one of the first examples of a scalable synthetic route toward sequence-defined thermosets that

266 vaccine adjuvant, we undertook to develop a synthetic route toward single-glycoform GM-CSF.

267 ndole formed the basis of a first-generation synthetic route toward the alkaloid bisindigotin.

268 To this end, we first designed a convergent synthetic route toward the diminutive analogue (+)-C(8)-

269 A new synthetic route toward the synthesis of benzo[b]phosphol

270 A flexible and efficient synthetic route toward these alkaloids would allow for i

271 is work describes a set of new and efficient synthetic routes toward 3-acyl-substituted chromones ran

272 ecent years with their ability to streamline synthetic routes toward complex molecules.

273 concepts have emerged enabling unprecedented synthetic routes toward molecules of this kind.

274 es, and furthermore, elaborate on convenient synthetic routes toward preparing borides.

275 Herein, we report a synthetic route towards carbon-aerogel scaffolds decorat

276 embranes and, in some cases, the only viable synthetic route towards certain membranes.

277 This represents a viable synthetic route towards pharmaceutically important fragm

278 ein, we report a concise and stereodivergent synthetic route towards some novel carbasugar SGLT2 inhi

279 Reported herein is a short and convergent synthetic route towards some small-molecule SGLT2 inhibi

280 A new general synthetic route towards three key Maillard flavour compo

281 During the course of the development of the synthetic route, two novel coupling reactions were devel

282 Reported herein is a new synthetic route utilizing the isoacyl peptide approach t

283 The efficiency of the synthetic route was demonstrated by preparing a collecti

284 ng in seven steps from dihydrofarnesal, this synthetic route was designed to circumvent macrocyclizat

285 The new synthetic route was effective for the total synthesis of

286 In this work, an efficient synthetic route was employed to construct extended benzo

287 The developed synthetic route was used to prepare 90 mg of (-)-bactobo

288 e of polycrystalline films, depending on the synthetic route, we demonstrate the presence of both dee

289 Through this versatile synthetic route, we obtain large single crystals of 34 d

290 Taking advantage of a modular synthetic route, we systematically "mutated" the configu

291 This synthetic route, well-suited to SAR, represents a genera

292 Synthetic routes were developed based on N-acylpyridiniu

293 Two alternative synthetic routes were devised for preparation of the req

294 Specifically, two synthetic routes were employed to grow Co/Mn metal-organ

295 and SAR interpretation, robust and flexible synthetic routes were established.

296 -membered ring lactam intermediates in these synthetic routes were sensitive to elimination side reac

297 A concise synthetic route with the potential to access DMOA-derive

298 ry and the capability of different colloidal synthetic routes with regard to controlling the shape, s

299 Representative synthetic routes within each class are discussed in deta

300 Exploration of multiple synthetic routes yielded an approach that has permitted