ライフサイエンスコーパス: synthetically

1 rdless of whether they arise geologically or synthetically.

2 atterned biosilica that cannot be replicated synthetically.

3 as long been proposed but was never realized synthetically.

4 n oligomers produced either enzymatically or synthetically.

5 is more stable and therefore more accessible synthetically.

6 The findings establish a series of synthetically accessible electrophilic scaffolds tunable

7 The CB[8]-based supramolecular networks are synthetically accessible in large scale and exhibit outs

8 verse and mechanically robust nanotubes from synthetically accessible macrocycles.

9 nique; the reaction is irreversible and uses synthetically accessible reagents.

10 Our arylazopyrazole ureas and sulfones offer synthetically accessible scaffolds that can be expanded

11 cates and interlocked molecules that are not synthetically accessible through the use of other common

12 aminocyclohex-2-enes, compounds that are not synthetically accessible using existing dearomatization

13 sely substituted cyclopentane structures not synthetically accessible using other catalytic methods.

14 efficient and rapid discovery of novel, yet synthetically accessible, bioactive chemotypes.

15 TePhe is synthetically accessible, nontoxic, stable under biologi

16 Several of these improved ligands are synthetically accessible, with rigid piperidine or quinu

17 ) ), a species that has only recently become synthetically accessible.

18 hannels(1,2), both of which are essential to synthetically achieve proton transport performance compa

19 een used as catalyst for the construction of synthetically and biologically important [4 + 2] cycload

20 ophosphonates could be easily transformed to synthetically and biologically useful quaternary alpha-a

21 single step direct access of a wide range of synthetically appealing ortho-substituted biarylamides i

22 Ring1B/RNF2 further induced these genes and synthetically arrested cell proliferation.

23 The reaction has led to the formation of synthetically as well as biologically important 3,4-disu

24 d fluorescent dye, Cy7, and doxorubicin were synthetically attached to polyfluorinated aryl azide to

25 The inability to synthetically attain the diversity enabled by these modi

26 derivatives of 1-aminonaphthalene as simple, synthetically available, and nicely preorganized models

27 Switch sequencing, which combines capture of synthetically capped 5' mRNA fragments with template-swi

28 ple and also represent a facile entry to the synthetically challenging 1,2,3-substituted pyrroles.

29 gold-promoted glycosylations to install the synthetically challenging alpha- and beta-glycoside moie

30 ynthesis of numerous family members of these synthetically challenging and hitherto inaccessible mari

31 Because of both their synthetically challenging and stereochemically complex s

32 rovides direct and ortho-selective access to synthetically challenging anilines, and addresses long-s

33 c chemists due primarily to the historically synthetically challenging C(8)-C(12) all-anti stereopent

34 5-c]pyridine P2X7 antagonists that contain a synthetically challenging chiral center.

35 ids constitute a structurally intriguing and synthetically challenging class of marine natural produc

36 eparing a series of structurally diverse and synthetically challenging congeners including 1.

37 ion sequence enabled the construction of the synthetically challenging dioxatricyclic framework.

38 es were constructed and elaborated to access synthetically challenging glycans of biological relevanc

39 alkyl couplings, provides a general entry to synthetically challenging high Fsp(3)-containing drug-li

40 In addition, synthetically challenging intermediates, such as the cor

41 The architecturally symmetrical and synthetically challenging marine natural products lomaiv

42 Carbohydrates are synthetically challenging molecules with vital biologica

43 facilitate the chemical and semisynthesis of synthetically challenging proteins from multiple fragmen

44 could effectively catalyze the formation of synthetically challenging spiro/glycoquinazolinones unde

45 , a task which addresses construction of the synthetically challenging spirocyclic tetrahydrofuran mo

46 (1) analogues, achieved by removal of three synthetically challenging structural units, as well as b

47 ent counter anions, including those that are synthetically challenging to install.

48 ly, providing a supramolecular solution to a synthetically challenging transformation.

49 ource that leads to structurally complex and synthetically challenging tri- and tetrasubstituted alke

50 provide access to complex products that are synthetically challenging using traditional hot-injectio

51 o species for late transition metals remains synthetically challenging, notably, a number of high-val

52 ternary stereocenters render these alkaloids synthetically challenging.

53 to control multiple stereogenic axes remain synthetically challenging.

54 ver, the introduction of an azetidine can be synthetically challenging.

55 pha to a fully substituted carbon center, is synthetically challenging.

56 nd Snd3 (for SRP-independent targeting), can synthetically compensate for the loss of both the SRP an

57 be significantly enhanced through the use of synthetically conjugated cationic cell penetrating pepti

58 efficiency of charge separation needs to be synthetically considered.

59 the duration of its competence events than a synthetically constructed analog that performs the same

60 e control of a single naturally occurring or synthetically constructed biological oscillator.

61 if, cross-antagonism with autoregulation, by synthetically constructing this network in yeast.

62 Here, we demonstrate the synthetically controlled encapsulation of first-row tran

63 Their location is synthetically controlled to be either unconfined at term

64 copolymers, provide an interface that can be synthetically controlled to better investigate this rela

65 Synthetically coupling 14-3-3 to K19 through a unique fu

66 t this hypothesis, the C3-hydroxyl group was synthetically deleted, and the resulting derivative, C3d

67 Inasmuch as the neurohormone melatonin is synthetically derived from serotonin (5-HT), a close int

68 an overview of the current biologically and synthetically derived glycan-binding scaffolds that incl

69 rs to provide a new platform for functional, synthetically derived polydeoxyribonucleotide-analogue m

70 s used as the basis for similar functions in synthetically derived small molecules and materials.

71 Herein, we report synthetically derived, structurally more complex vinblas

72 hese results lays in that they indicate that synthetically-derived microstructured substrate material

73 Directed knockdown of matR expression via synthetically designed ribozymes altered the processing

74 hich we monitored Psi levels at thousands of synthetically designed sequence variants comprising eith

75 y which guest confinement within MOFs can be synthetically designed.

76 ocol is further demonstrated via a number of synthetically diverse product transformations.

77 tum are in a slow-growing, metabolically and synthetically downregulated state.

78 ndergo a McMurry coupling to form previously synthetically elusive cycloheptanone-fused indoles.

79 icted to be the precursor needed to access a synthetically elusive family of 2-D metal boride (MBene)

80 taset, with the exception of MOFs containing synthetically elusive V(2+) open metal sites.

81 unctionalization but have until now remained synthetically elusive.

82 calculations while simultaneously leveraging synthetically enabled chemistry and structure-based drug

83 t materials, however, where conflicts can be synthetically encoded in the molecular structure, stagin

84 heir expansion, including the development of synthetically encoded polynucleotide mimics.

85 After synthetically encoding lysine-acetylation at natural mod

86 Synthetically engineered biological components ("BioBric

87 mote growth or even full transformation into synthetically engineered DLBCL models.

88 Synthetically engineered genetic circuits can perform a

89 e, we describe the development of mosquitoes synthetically engineered to impede vector competence to

90 tations in hesx1, cct5 and gdf6a, which give synthetically enhanced eye specification or growth pheno

91 These findings ultimately contribute a synthetically facile approach toward highly emissive TAD

92 It is envisioned that libraries of synthetically facile composites will be broadly deployed

93 We define synthetically feasible pathways to 65,520 distinct multi

94 ries of new zeolite structures that would be synthetically feasible.

95 This method is synthetically general, with five different 2D COFs prepa

96 Using family genomes from HapMap and synthetically generated datasets, we show that having on

97 to assess the eco-hydrological dynamics in a synthetically generated landscape and three representati

98 orm super resolution in image space by using synthetically generated low-resolution data.

99 functionalized with hundreds to thousands of synthetically generated phage display peptides exhibit v

100 Analysis of synthetically generated scored networks shows that robus

101 These synthetically glycosylated antigens also expanded functi

102 yridines treated with aluminum chloride into synthetically hard-to-reach benzo[c][1,7]naphthyridinone

103 rward and often stereoselective formation of synthetically highly versatile metalloid-substituted alk

104 ated the application of UCs as catalysts for synthetically important alkylation reactions under phase

105 ld) could be achieved with the generation of synthetically important beta-aryl ketone intermediates i

106 he primary acetamide can be manipulated into synthetically important derivatives such as nitriles and

107 and secondary aliphatic alcohols, affording synthetically important ethers.

108 he selective construction of medicinally and synthetically important indole-based unsymmetrical triar

109 cope, allowing even the most challenging and synthetically important methylations to be accomplished

110 mproved, lower temperature versions of these synthetically important processes.

111 efficient methodology of the preparation of synthetically important tetrahydrofuran derivatives with

112 The products were synthetically important, and a couple of them were subje

113 y that sex ratio distortion can be generated synthetically in the main human malaria vector Anopheles

114 The prodrug monomers are synthetically incorporated into homopolymer or block des

115 tive stress either introduced by TNFalpha or synthetically incorporated into precise locations focuse

116 Here, we show that synthetically inducing a burst in the production of phyt

117 ation of arenes has been developed utilizing synthetically inert unactivated acyclic internal olefins

118 phagy/mitophagy genes ATG8, ATG18, and ATG32 synthetically interact with CL synthase mutant crd1Delta

119 ificantly improved the enantioselectivity of synthetically interesting building blocks.

120 o broaden the scope of the transformation in synthetically interesting directions.

121 hieves average precision up to 0.99 for both synthetically introduced and naturally occurring modific

122 Two genes are synthetically lethal (SL) when defects in both are letha

123 els, supporting clinical development of this synthetically lethal combination as a therapy for HK1(-)

124 infancy; however, technologies to understand synthetically lethal dependencies and track cancer evolu

125 We found that autophagy ablation was synthetically lethal during Lkb1-deficient lung tumorige

126 oad-coverage applications such as extracting synthetically lethal genes from the cancer literature.

127 ilitating for instance the identification of synthetically lethal genes from the literature.

128 ous recombination exemplifies the utility of synthetically lethal genetic interactions in the treatme

129 al studies show that arginine deprivation is synthetically lethal in argininosuccinate synthetase 1 (

130 h for additional targets whose inhibition is synthetically lethal in BRCA2-deficient backgrounds, we

131 hibitor, we investigated ATR inhibition as a synthetically lethal strategy to target CLL cells with T

132 manner, we determined that PTEN and ATM were synthetically lethal when jointly inhibited.

133 ertion sequencing screen to identify mutants synthetically lethal with a defect in the division prote

134 Deficiency in its homolog ARID1B is synthetically lethal with ARID1A mutation.

135 Depletion of RAD52 is synthetically lethal with defects in tumor suppressors B

136 Moreover, DeltagpsB mutations are synthetically lethal with Deltapbp1a, but not Deltapbp2a

137 red for LPS O-polysaccharide biosynthesis is synthetically lethal with eipA deletion.

138 Aldh3a2 inhibition was synthetically lethal with glutathione peroxidase-4 (GPX4

139 s that drugs decreasing LptD assembly may be synthetically lethal with inhibitors of the Dsb pathway,

140 bility (CSM3, CTF4, YKE2, DCC1, and GIM4) as synthetically lethal with ISC1 The second group, to whic

141 The results indicated that crd1Delta is synthetically lethal with mutants in pyruvate dehydrogen

142 Pol epsilon proofreading deficiency) and is synthetically lethal with pol2-M644G (encoding altered P

143 gle therapeutic agent has been identified as synthetically lethal with SMARCA4/BRG1 loss.

144 in lipopolysaccharide assembly, lptD4213, is synthetically lethal with the deletion of dsbB as well a

145 y in the anti-inflammatory IL10 receptor was synthetically lethal with the Mcm4(Chaos3) helicase muta

146 was to identify chemical compounds that are synthetically lethal with VHL deficiency in CC-RCC.

147 e stressed UPR seen intrappc11mutants and is synthetically lethal withtrappc11mutation.

148 found that rdi1Delta bem2Delta mutants were synthetically lethal, suggesting that they also act in p

149 By using synthetically methylated DNA, we were able to train a hi

150 uester polyadenine-containing nucleotides to synthetically mimic RNA granules.

151 l modes associated with these coherences, we synthetically modified an iron(II) chromophore to interf

152 Numerous natural nucleosides and their synthetically modified analogues have been reported to h

153 S/MS by producing and analyzing a library of synthetically modified histone peptides mixed in equal m

154 s of unmodified and posttranscriptionally or synthetically modified RNA.

155 Here, we synthetically modified several moieties of the KCNQ2-5 c

156 omprising the so-called A/B ring system, was synthetically modified to provide antibacterially active

157 Proteins synthetically modified with a simple aromatic boronate m

158 Instead of synthetically modifying the internal surface structure o

159 We synthetically modulate the spin density distribution in

160 ucture by a C-C single bond, in place of the synthetically more demanding enol ester double bond foun

161 Their design was based on a synthetically more efficient benzyl adaption of a potent

162 tutorial review is limited to the simplest, synthetically most accessible self-assembling minidendro

163 icles within the bulk of oxides is, however, synthetically much more challenging and therefore less e

164 Here we synthetically optimize the retrotransposon Ty1 to enable

165 ules-remain enormously challenging to access synthetically owing to poor aqueous solubility of one or

166 and (Ph4P)2[VO(C9H6S8)2] (4), we are able to synthetically place a spin-laden propyl moiety at well-d

167 characterized the fragmentation pattern of a synthetically prepared dityrosine cross-linked dimer of

168 om plausibly prebiotic dry-down reactions or synthetically prepared in pure form, can engage in direc

169 plete data, since it persists in error-free, synthetically produced datasets and does not necessarily

170 s) interactions with its client proteins use synthetically produced heparin mimetics with defined str

171 Developing a synthetically produced stabilized virus-like particle (s

172 ndamental advantages of viruses, compared to synthetically programmed materials, include the highly p

173 On the basis of these findings, we synthetically re-derived an infectious full-length SHC01

174 se results show that iPOLYMER can be used to synthetically reconstitute the nucleation of biologicall

175 We used tiled CRISPR activation (CRISPRa) to synthetically recruit a transcriptional activator to sit

176 Nonnative cues for synthetically regulating kinases are thus much sought af

177 roducts being suitable precursors to prepare synthetically relevant chiral nonfunctionalized alcohols

178 athesis polymerization (ROMP) catalyst under synthetically relevant conditions (e.g. unmodified indus

179 zero order in alkenoic acid substrate under synthetically relevant conditions.

180 ically active metal halide Lewis acids under synthetically relevant conditions.

181 the redefinition of a flow module to a more synthetically relevant one based on the overall induced

182 ngaging a wide range of energy demanding and synthetically relevant organic substrates including aryl

183 Synthetically relevant polycyclic building blocks featur

184 all with conventional halenium donors under synthetically relevant reaction conditions.

185 ound the two rings in good to high yields at synthetically relevant scales (1.5 g L(-1) day(-1) ).

186 ty through transient enamine formation, this synthetically relevant transformation is easy to perform

187 ocycloaddition chemistry with an emphasis on synthetically relevant, regio-, and stereoselective reac

188 which a hydrogen bond in the NBD peptide is synthetically replaced by a non-labile bond, shows an ab

189 mediate hosts of human disease outbreaks, we synthetically resurrected a recombinant virus (rSADS-CoV

190 we report the development of a scalable and synthetically robust building block based on norbornadie

191 dentify an allele of the GTPase obgE that is synthetically sick in the absence of Mla; providing anot

192 This strategy is both conceptually and synthetically simple and offers a new approach to the de

193 In this study, we report the production of synthetically stabilized PV VLPs in plants.

194 Finally, we provide examples of synthetically sulphated natural polysaccharides and sulp

195 Accordingly, synthetically tethering hnRNPK to Xist RNA lacking XR-PI

196 rom cannabis plants but can also be prepared synthetically, the topic of this review.

197 Peptide antibiotics are an abundant and synthetically tractable source of molecular diversity, b

198 ular hydrogen evolution catalysts (HECs) are synthetically tunable and often exhibit high activity, b

199 These results show the ability to synthetically tune the size of the Pt islands to control

200 al) and, thereby, emission properties can be synthetically tuned by either withholding or including t

201 ereotype, and provide dendrimers that can be synthetically tuned to be used in applications such as s

202 ve proposition because it allows chemists to synthetically tweak various kinetic and thermodynamic fa

203 ne primary products can be protected to form synthetically ubiquitous pinacol boronate esters or used

204 Herein, we demonstrate that synthetically unexplored but readily accessible benzothi

205 Synthetically useful (E)-alkenyl-CF3 building blocks and

206 opening coupled with SO2 extrusion provided synthetically useful 1,2-diamines.

207 to aldehyde substrates, providing a range of synthetically useful 1,3-dicarbonyl products in excellen

208 talyst from decomposition while preserving a synthetically useful 13 mus excited state and produces s

209 ightforward approach to pharmaceutically and synthetically useful 2-aminobenzoxazole and 4-aminoquina

210 echanochemical method for the preparation of synthetically useful 2-arylindoles is developed using Pd

211 A convenient method for the preparation of synthetically useful 3-iodoindene derivatives has been d

212 emote hydrocarbofunctionalization of several synthetically useful alkene-containing substrate classes

213 This skeletal remodeling process accesses synthetically useful allyl cation intermediates that con

214 s, isatins, and imines to deliver a range of synthetically useful allylic alcohols and amines in high

215 s method offers a direct approach to produce synthetically useful alpha-carbonyl-alpha'-amide sulfoxo

216 Synthetically useful aminodioximes are prepared via a no

217 This transformation also can be scaled up to synthetically useful amounts, affording >250 mg of produ

218 d conditions, and tolerates a broad range of synthetically useful aromatic functionality.

219 s the reactivity repertoire of biocatalytic, synthetically useful asymmetric transformations by the m

220 anipulated in a variety of ways to result in synthetically useful bond constructions.

221 oceeds without air-free techniques to access synthetically useful borylated thiophenes, benzothiophen

222 e highly diverse one-step transformations to synthetically useful building blocks, such as flavones,

223 of relatively inert C-H bonds with the more synthetically useful C-OH group.

224 Friedel-Crafts acylation reaction to produce synthetically useful carboxylic acid derivatives.

225 des, allowing for high-yielding formation of synthetically useful chiral [3.1.0]-bicyclic aziridines

226 Additionally, they represent synthetically useful chiral building blocks in organic s

227 thodology is applied to (i) the reduction of synthetically useful classes of phosphine oxides, (ii) t

228 In particular, many are synthetically useful either as oxidants (e.g., Cp(2)Fe(+

229 not readily achieved when more reactive and synthetically useful electron-deficient quinones are use

230 We describe the synthetically useful enantioselective addition of Br-CX3

231 up tolerance, and operational simplicity are synthetically useful features.

232 The derivatives of 7-amino indole are synthetically useful for accessing a variety of natural

233 in good to excellent yields bearing diverse synthetically useful functional groups of different elec

234 f hindered terminal alkenes to various other synthetically useful functional groups, resulting in for

235 cific ring contractions, providing access to synthetically useful hydroxymethyl cyclopropanes.

236 t as versatile building blocks for accessing synthetically useful intermediates and biologically acti

237 ed by transforming the products into various synthetically useful intermediates.

238 n two distinct carbonyl compounds to provide synthetically useful intermediates.

239 ns to maximize the product distribution to a synthetically useful level of the allylation product ove

240 ly with a wide range of substrates providing synthetically useful N-nitroso N-alkyl nitroanilines in

241 everal important common pathways involved in synthetically useful organic reactions catalyzed by phot

242 enantioselective catalysts, able to promote synthetically useful organic reactions with high levels

243 few methods that allow their conversion into synthetically useful partially saturated derivatives and

244 ition state for the remote C-H activation, a synthetically useful phenyl nitrile functional group cou

245 modynamic preference of an olefin, providing synthetically useful quantities of a kinetically favored

246 ion reactions, the direct use of alcohols as synthetically useful radical sources is less known.

247 nds (C-H) is important in the development of synthetically useful reactions, owing to the proximity-i

248 for creating tailored biocatalysts for many synthetically useful reactions.

249 The synthetically useful resolution of a mixture of branched

250 ation of centrosymmetric meso derivatives on synthetically useful scales.

251 ge of heteroaryl and aryl systems as well as synthetically useful secondary and tertiary amide, urea,

252 resolution of select trans-epoxides to give synthetically useful selectivity factors of 17-23 for be

253 The synthetically useful selectivity observed with cobalt wa

254 )R(5)SiH, R(4), R(5) = H or R(3)) to produce synthetically useful silylphosphines (R(1)R(2)P-SiR(3)R(

255 N-sulfamoylaziridines have proved to be more synthetically useful synthons that afford crystalline po

256 idyl radicals, which are involved in various synthetically useful transformations, including olefin a

257 was developed in order to obtain products in synthetically useful yield and enantioselectivity.

258 Various cyclobutanones were obtained in synthetically useful yields from substrates with minimal

259 e desired arylated products were obtained in synthetically useful yields using electronically and str

260 g materials, chemoselective cascade process, synthetically useful yields, and green conditions by uti

261 The method shows broad scope, proceeds in synthetically useful yields, and provides a rare means t

262 h nitrones to give isoxazolidine products in synthetically useful yields.

263 cally enriched chiral gamma-amino ketones in synthetically useful yields.

264 imple, noncyclic tertiary alkyl amines under synthetically useful, mild conditions through a biologic

265 rnative radical processes, thereby providing synthetically useful, temperature-controlled reaction ou

266 is important as that will make the reaction synthetically useful.

267 product could be further oxidized to yield a synthetically valuable 1,2-diketo building block.

268 action provides direct and general access to synthetically valuable 1,3-bromohydrin building blocks f

269 on migration in diboronate complexes to form synthetically valuable 1,n-bisborylalkanes is reported.

270 atom-, step-, and energy-economic access to synthetically valuable 1-azadienes.

271 ven elusive, thereby limiting access to many synthetically valuable aldehydes.

272 Organoboranes are some of the most synthetically valuable and widely used intermediates in

273 thods and increases the accessibility of the synthetically valuable aryl halide compounds.

274 conversion of readily available amines into synthetically valuable aziridines in high enantiomeric r

275 iants of sperm whale myoglobin catalyze this synthetically valuable C-C bond-forming transformation w

276 hyde olefination and extends the spectrum of synthetically valuable chemical transformations accessib

277 alkyl malonates has been presented to afford synthetically valuable dihydrobenzoindoles and isoindoli

278 r the first time to allylic ethers, yielding synthetically valuable enantioenriched (up to 97% ee) en

279 the development of new breakthroughs in the synthetically valuable field of diazo chemistry.

280 aliphatic aldehydes can be transformed into synthetically valuable homoallylic alcohols with high le

281 to vicinal primary diamines as well as other synthetically valuable nitrogen-containing building bloc

282 d a chlorogermylene compound, leading to the synthetically valuable phosphaketenide (PCO(-)) ligand a

283 ation of readily available silyl ethers into synthetically valuable silyl enols.

284 an intermediates provide efficient access to synthetically valuable substituted alpha-benzyloxyvinyl

285 ate) with high yield and (Z)-selectivity for synthetically valuable vinylboronate esters is described

286 Synthetically versatile 3,3-disubstituted fluorooxindole

287 These synthetically versatile bicyclic isoxazolidines allowed

288 The quantitative formation of synthetically versatile bromolactones occurs in the pres

289 ducts that contain a quaternary carbon and a synthetically versatile carbon-boron bond with control o

290 Cyclobutanones are synthetically versatile compounds that often require ext

291 kanes as the alkylating agents, and delivers synthetically versatile five-membered carbocycles contai

292 The imine partner bears the synthetically versatile N-Cbz group, avoiding the use of

293 pplicability of this methodology for forming synthetically versatile organo-boronate esters and boron

294 , this method is demonstrated to provide the synthetically versatile photosensitizer [Ir(ppy)2(dtbbpy

295 The synthetically versatile pinacol boronic ester group (Bpi

296 llow for the formation of a diverse range of synthetically versatile products from simple precursors.

297 nd the feedstock gas carbon monoxide to form synthetically versatile value-added amide products.

298 Synthetically versatile, multifunctional 3-hydroxyindoli

299 lylation of few products is shown to furnish synthetically viable enantioenriched 2-oxindoles with C-

300 Among them, azobenzenes are synthetically well accessible and show excellent fatigue