ライフサイエンスコーパス: systemic

1 Nc hypoactivity that can also be reversed by systemic 5-HT2C receptor antagonism.

2 abnormal immune cells may be the drivers of systemic abnormalities such as autoimmune disease.

3 A prior pilot study demonstrated the systemic absorption of 4 sunscreen active ingredients; a

4 ditional studies are needed to determine the systemic absorption of additional active ingredients and

5 in the neurological symptoms that accompany systemic acid/base imbalances.

6 which is restricted by NPR1, an activator of systemic acquired resistance.

7 In this study, we investigated the role of systemic ADMA overburden in cerebromicrovascular patholo

8 Moreover, systemic administration of acetazolamide immediately aft

9 We found that systemic administration of acetazolamide, a CA inhibitor

10 Systemic administration of an in vivo imaging probe inco

11 We have shown that systemic administration of Bacille Calmette-Guerin (BCG)

12 ction in vitro We show that local as well as systemic administration of BK1.3 potently blocks inflamm

13 OIHP was induced in vivo by systemic administration of fentanyl and confirmed by pro

14 Using an animal model of CIPS, we found that systemic administration of FK506 in male and female mice

15 tral CA1 pyramidal cells 24 h after a single systemic administration of L-655,708 revealed a signific

16 ivity and tolerability profiles of effective systemic administration of MSA-2.

17 evable using engineered MSCs, strategies for systemic administration require further modeling.

18 The percentage of participants with local or systemic adverse events was similar in the two groups.

19 Systemic adverse events were more common after the secon

20 sponse in sRCCs, although a proven effective systemic agent remains elusive.

21 Single-cell mRNA sequencing revealed that systemic Akt1 deletion maintains the pro-metastatic clus

22 im to identify the allergens responsible for systemic allergic reactions following ingestion of pizza

23 duce changes in the gut microbiome can alter systemic alloimmunity in mice, in part through the produ

24 other common age-related comorbidity, senile systemic amyloidosis, a nongenetic disease associated wi

25 deficiency in mice leads to enhanced passive systemic anaphylaxis, reflected by increased drop in bod

26 Aridification led to systemic and abrupt changes in multiple ecosystem attrib

27 Here, we demonstrate systemic and direct effects of Fibroblast growth factor

28 quadrantic involvement, despite combination systemic and intravitreal antiviral therapy; however, no

29 Reported systemic and local events were mild and transient.

30 ering oxygen to overcome the effects of both systemic and local hypoxia that occurs as a result of tr

31 ts physiological homeostasis and alters both systemic and local microenvironments that impact stem ce

32 Specifically, superior sustained systemic and mucosal HIV Gag-specific poly-functional/cy

33 ata were collected on baseline demographics, systemic and ocular comorbidities, ocular surgical histo

34 Participants underwent standardized systemic and ocular examinations and interviewer-adminis

35 , HeV and NiV infections present as a severe systemic and often fatal neurologic and/or respiratory d

36 iven the role of statins in the reduction of systemic and pancreatic intraluminal inflammation, we hy

37 In vivo neutrophil depletion altered the systemic and peritoneal immune microenvironment of mice

38 luated i.m., aerosol (Aer), and simultaneous systemic and respiratory immunization (SIM) by both rout

39 ry distress syndrome is associated with both systemic and respiratory severity of illness and is also

40 Interestingly, a systemic anti-Bst2 blocking antibody approach attenuated

41 vascular function and its relationship with systemic anti-oxidative defence capacity in normal indiv

42 The combination of IT CMP-001 with systemic anti-PD-1 enhanced antitumor responses in both

43 We present a CPG for systemic antibacterial prophylaxis administration in ped

44 robiotic group had a mean of 12.9 cumulative systemic antibiotic administration days (95% CI, 0 to 18

45 , controlled pilot trial, a post-debridement systemic antibiotic therapy course for DFO of 3-weeks ga

46 d influenza vaccine induces both mucosal and systemic antibodies and systemic T-cell responses.

47 RR of death comparing patients with recent systemic anticancer therapy to no treatment was 1.17 (95

48 Systemic application of NS8593, a known TRPM7 inhibitor,

49 Systemic arginine restriction improves outcome in multip

50 vealed a limited therapeutic time window and systemic aspects of the disease.

51 Systemic associations were found in 6 of 62 patients (9.

52 our in the search for effective treatment of systemic autoimmune diseases.

53 e that regulates humoral immunity and limits systemic autoimmunity.

54 t and adoption of a systems-based concept of systemic autoinflammatory diseases is anticipated to hav

55 Here we demonstrate that systemic autophagy inhibition induces the premature acqu

56 However, tools to track the systemic behaviour and dynamics of leukocytes non-invasi

57 How exercise is able to promote such systemic benefits has remained somewhat of a mystery but

58 Compared with almost all other systemic cancer treatment options, RPT has shown efficac

59 del of cocaine relapse, we evaluated whether systemic CB1R antagonism (AM251; 3 mg/kg, i.p.) during m

60 horts differed significantly in preoperative systemic chemotherapy exposure, node-positive primary st

61 Importantly, aberrant systemic circulation of bile acids can greatly disrupt m

62 ravel through this capillary plexus, reenter systemic circulation, and seed in the brain.

63 rophils engaged in diapedesis to reenter the systemic circulation.

64 GS mRNA expression (P = 2.1 x 10-3), and MTX systemic clearance (P = 4.4 x 10-2) explained 42% of the

65 ition of the TMEM173-GSDMD-F3 pathway blocks systemic coagulation and improves animal survival in thr

66 Systemic comorbidities that increased the risk of EE in

67 iginous skin and is associated with numerous systemic comorbidities.

68 Consistently increased systemic complement activation was observed in the major

69 Consistent with reduced systemic contamination, the median IgG measured in OriCo

70 J vs C57Bl/6 tendons that were isolated from systemic contributions via organ culture, highlighted th

71 Systemic corticosteroid use to manage uncontrolled asthm

72 ement regarding remission, and (4) no use of systemic corticosteroids.

73 er immunization, requiring a short course of systemic corticosteroids; in 4 cases, this occurred with

74 Cyclophosphamide, systemic cytarabine, and central nervous system radiothe

75 Depletion of HIRA elicits systemic death of ALT cancer cells that is mitigated by

76 dine/decitabine (100/35 mg) produced similar systemic decitabine exposure, DNA demethylation, and saf

77 4 mutants were compromised in both local and systemic defences.

78 together, our results show that MSC-mediated systemic delivery of oncolytic viruses is a promising st

79 The analysis shows AVNFH to be a multi-systemic disease and provides molecular signatures that

80 d FAZ topography in patients with retinal or systemic disease could negatively impact the accuracy an

81 fect of nonsurgical periodontal treatment on systemic disease outcomes.

82 nitourinary malignancy, and greater risks of systemic disease.

83 DR, DMO and RVO, indicating need to control systemic diseases such as diabetes, hypertension, and dy

84 It normally causes localized or disseminated systemic diseases, particularly skin infections and arth

85 stress in the respiratory tract facilitates systemic dissemination and ultimately death of infected

86 ng method we provide direct evidence for the systemic dissemination of rTEM neutrophils, and showed t

87 acytic differentiation on recall and undergo systemic dissemination.

88 A single, systemic dose of methotrexate, a DNA-synthesis (S phase)

89 Moreover, we find that lifespan-extending systemic down-regulation of insulin signaling results in

90 mental stimulus to skin results in local and systemic effects is an area of active research.

91 peritoneal cavity and lung, consistent with systemic effects of HpBARI.

92 n the circulation to prevent the deleterious systemic effects of Il-18.

93 be potential intervention targets to prevent systemic effects of periodontal disease if further studi

94 metabolism in order to reveal its local and systemic effects on host health and aging.

95 peripheral injection of alpha-syn has acute systemic effects on the central nervous system such that

96 cell-mediated cytotoxic immune response with systemic effects.

97 Marked systemic elevation in C5a activity was demonstrated in p

98 pared with warfarin for prevention of stroke/systemic embolism in patients with atrial fibrillation.

99 Systemic EP2 antagonism prevented monocyte brain infiltr

100 Further, while systemic estrogen synthesis blockade suppressed juvenile

101 rticipant-reported local reactions (LRs) and systemic events (SEs), adverse events (AEs), serious AEs

102 Local reactions and systemic events were dose-dependent, generally mild to m

103 Primary end points: mean decitabine systemic exposure (geometric least-squares mean [LSM]) o

104 dditional active ingredients and how quickly systemic exposure exceeds 0.5 ng/mL as recommended by th

105 roaches to promote tumor retention and limit systemic exposure of potent intratumoral therapies.

106 those tested particles exhibited significant systemic exposure.

107 Strategies for reperfusion therapy include systemic fibrinolysis, surgical pulmonary embolectomy, a

108 there are limited data regarding nephrogenic systemic fibrosis (NSF) risk, but there are few if any u

109 ine peak O(2) consumption and pulmonary flow/systemic flow ratio.

110 Systemic free thiols are amenable to nutritional or ther

111 pulation can experience discrete episodes of systemic genomic instability, when the entire genome bec

112 isplayed no changes in energy expenditure or systemic glucose handling.

113 e in the regulation of energy metabolism and systemic glucose homeostasis.

114 amic Jnk signaling, insulin sensitivity, and systemic glucose tolerance was consistent with functiona

115 stigate oral health and its interaction with systemic health conditions.

116 for multiple reasons, including its link to systemic health.

117 vival upon prolonged fasting and maintaining systemic homeostasis under metabolic stress.

118 s demonstrate that MI induces alterations in systemic homeostasis, triggering cross-disease communica

119 s (SA) skin infection substantially improved systemic host defense against secondary SA infections in

120 r dosing of ChAd-SARS-CoV-2-S induces robust systemic humoral and cell-mediated immune responses and

121 cine-only group developed strong mucosal and systemic humoral and cellular immunity but did not exhib

122 both acute respiratory distress syndrome and systemic hypercoagulability.

123 flow in response to flicker stimulation and systemic hyperoxia in mice using a laser speckle flowgra

124 flow in response to flicker stimulation and systemic hyperoxia may be useful indexes for noninvasive

125 ry minute for 20 min during and after 10 min systemic hyperoxia; and on day 3, electroretinography (E

126 ars, P = 0.002) and were more likely to have systemic hypertension (17.7% vs. 33.8%, P < 0.001), tumo

127 d at all ages, including before the onset of systemic hypertension.

128 erative hemodialysis may have contributed to systemic hypotension.

129 e correlation between tonsillar TFH-cell and systemic IgG induction after LAIV.

130 wrist actigraphy, severity of neurologic and systemic illness by Glasgow Coma Scale and Sequential Or

131 When severe, COVID-19 is a systemic illness characterized by hyperinflammation, cyt

132 Prior studies suggest that PTSD may be a systemic illness, affecting not just the brain, but the

133 of the complex interplay between tumoral and systemic immune response has been provided through tissu

134 -FDG PET/CT in the monitoring of tumoral and systemic immune response.

135 iota in regulating not only mucosal but also systemic immune responses has led to investigations into

136 ates with both the intestinal mucosa and the systemic immune system, given that these networks have a

137 specific manner without suppressing local or systemic immunity against infectious agents or cancer.

138 o evidence for a severe, clinically relevant systemic immunodeficiency.

139 In the absence of systemic immunosuppression, diabetic recipients containi

140 and considerable burden to the host prior to systemic impact that extends beyond the oral compartment

141 Candida albicans can cause systemic infection in immunocompromised individuals that

142 more vascular disease in a zebrafish larvae systemic infection model over 72 h compared to those inj

143 produce clinical manifestations ranging from systemic infection typhoid to invasive nontyphoidal Salm

144 otic tolerance in the spleen during a murine systemic infection.

145 SARS-CoV-2 (COVID-19) is a systemic infection.

146 We find that systemic infections with a variety of pathogens trigger

147 as assessed on a patient-reported scale) and systemic inflammation (as shown by an elevated C-reactiv

148 d significantly ameliorates their underlying systemic inflammation and autoimmunity.

149 inflammatory diseases, which cause low-grade systemic inflammation and contribute to several common c

150 ratio (MLR) are respectively associated with systemic inflammation and immune suppression and have be

151 P) is a biomarker used clinically to measure systemic inflammation and is reproducibly increased in a

152 t mice were protected from developing severe systemic inflammation and multi-organ injury following t

153 al peripheral proinflammatory insult-induced systemic inflammation and normalized compromised blood-b

154 In addition to decreasing systemic inflammation and providing glycemic control wit

155 content in blood, thereby helping to reduce systemic inflammation and reverse insulin resistance.

156 Systemic inflammation may influence trajectories of depr

157 distress syndrome (stage 3) associated with systemic inflammation often termed a "cytokine storm." B

158 impact of age on the overall changes in the systemic inflammation profiles in subpopulation of TB pa

159 ection in vivo is characterized by extensive systemic inflammation that can exacerbate infection by p

160 They showed systemic inflammation with high levels of serum proinfla

161 toms during the course of a fever, a sign of systemic inflammation(1,2).

162 nt role of IL-1beta in controlling local and systemic inflammation, its overall regulation is still n

163 ely progressing brain dysfunction induced by systemic inflammation.

164 y virus (HIV) and is associated with reduced systemic inflammation.

165 s, which may spread to produce more advanced systemic inflammation.

166 We found higher levels of systemic inflammatory biomarkers among PLHIV who were vi

167 nfection from other, noninfectious causes of systemic inflammatory illness.

168 ry calprotectin levels, that correlated with systemic inflammatory markers.

169 and skeletal muscle radiodensity (SMD), the systemic inflammatory response as measured by the modifi

170 The systemic inflammatory response syndrome (SIRS) frequentl

171 nfection, surgery, and variceal bleeding; R: systemic inflammatory response syndrome (SIRS), spontane

172 e were highly resistant to endotoxin-induced systemic inflammatory response syndrome symptomatology a

173 rtality were 39% greater in patients who met systemic inflammatory response syndrome-first compared w

174 ia, and viral detection and had more intense systemic inflammatory response than those carrying non-P

175 ions are associated with a significant acute systemic inflammatory response.

176 infection as well as tumour growth and other systemic inflammatory responses originating deeply in so

177 ted by anemia and thrombocytopenia following systemic injection, side effects that might be eliminate

178 was treated with maribarir, intravitreal and systemic injections of foscarnet, and anti-Cytomegalovir

179 his study was to characterize the effects of systemic injections of the CB1r agonist (CP55940) on the

180 ode of action addressed by SPT, a well-known systemic insecticide for sucking pest control.

181 pose tissue (AT) inflammation contributes to systemic insulin resistance.

182 , age, injury (high-sensitivity troponin T), systemic involvement, and electrical abnormalities (righ

183 oid cells and is an important focal point in systemic iron regulation.

184 Our findings demonstrate that systemic K(ATP) channel inhibition reduces V O(2) max an

185 n this article, we report that NOX2 controls systemic L. monocytogenes spread through modulation of t

186 meters reflecting decreased tissue damage at systemic level and improved renal function in conditione

187 on of murine TNBC tumors in vivo and reduced systemic levels of pro-inflammatory cytokines.

188 icted trade-offs, it remains unclear whether systemic lifespan-extending interventions could ameliora

189 absorption were unchanged in ppHF dams, but systemic lipoprotein lipase (LPL) activity was increased

190 roposed causative agents in neuropsychiatric systemic lupus erythematosus (NPSLE).

191 Patients with systemic lupus erythematosus (SLE) display a complex blo

192 Systemic lupus erythematosus (SLE) is a multisystem, chr

193 Systemic Lupus Erythematosus (SLE) is the prototype of a

194 Cutaneous inflammation is recurrent in systemic lupus erythematosus (SLE), yet mechanisms that

195 gan manifestations of the autoimmune disease systemic lupus erythematosus (SLE).

196 n several autoimmune diseases, in particular systemic lupus erythematosus (SLE).

197 stant malaria, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).

198 observed within the kidneys of patients with systemic lupus erythematosus and lupus nephritis (LN).

199 ection, psoriasis, rheumatoid arthritis, and systemic lupus erythematosus predispose to atherosclerot

200 Systemic lupus erythematosus was excluded from all patie

201 a target of autoantibodies in patients with systemic lupus erythematosus.

202 e previously shown that TBX1 is required for systemic lymphatic vessel development in prenatal mice a

203 t juvenile csf1r-deficient zebrafish exhibit systemic macrophage depletion.

204 of malignancy because of known pre-existing systemic malignancy or the presence of an atypical orbit

205 Advanced systemic mastocytosis (advSM) is characterized by presen

206 Systemic mastocytosis (SM) has greatly benefited from th

207 the work-up for clonal MC disorders such as systemic mastocytosis and monoclonal MC activation syndr

208 cantly reduces lifespan and causes local and systemic metabolic pathology.

209 cycling reveal additional roles for ATMs in systemic metabolism.

210 risk for recurrence, extraocular spread, and systemic metastases.

211 nt lineage emerges that initiates and drives systemic metastasis, where polyclonal seeding between si

212 9 (21%) were alive and 34 (79%) had died of systemic metastasis.

213 is treated with scaling and root planing and systemic metronidazole and amoxicillin.

214 1.39 +/- 0.27 s-1; P = .003), and heightened systemic monocyte activation.

215 current view of nitrate transport, local and systemic nitrate sensing/signaling, and the regulatory n

216 suppressed juvenile song production, neither systemic nor unilateral E2 synthesis inhibition in NCM d

217 No patients exhibited any systemic or local allergic reactions or complications af

218 Importantly, either systemic or neutrophil-specific Akt1 deletion is suffici

219 -bronchial sources, which may be either from systemic or pulmonary arteries or cardio-pulmonary fistu

220 uated the effect of periodontal treatment on systemic outcomes.

221 time, minute ventilation, cardiac output and systemic oxygen delivery did not differ between protocol

222 Systemic pathway activation, however, may be detrimental

223 on but show exacerbated HSC activation under systemic poly(I:C)-induced inflammation.

224 combining mucosal priming immunizations and systemic protein boosting.

225 e of specific glucuronidase could yield free systemic quercetin in human body.

226 A systemic reaction (SR) occurred in 28 out of 33 (84.8%)

227 ) of 49 in the 70 years and older group, and systemic reactions in 42 (86%) participants in the 18-55

228 iated with a lower incidence and severity of systemic reactions than BNT162b1, particularly in older

229 exercise, were other relevant cofactors for systemic reactions.

230 e after previous treatment with one to three systemic regimens (with at least one anti-CD20 therapy),

231 ailability of new treatment options, initial systemic regimens for solid tumors are dominated by a se

232 n lungs a supportive, physiologic milieu and systemic regulation that resulted in functional and hist

233 how these signals convey specificity to the systemic response, and how are they integrated under con

234 tentially triggering its own stress-specific systemic response, highlighting a new fundamental questi

235 reated and contralateral tumors suggesting a systemic response.

236 und against H3N2 and B viruses, whereas only systemic responses were observed against A/H1N1.

237 and clinical studies have demonstrated that systemic restriction of serum l-Met, either via partial

238 Despite these high systemic ROS levels, stomatal aperture size returns to c

239 In addition, they highlight a key role for systemic ROS signals in coordinating the response of dif

240 or function-positive bNAb via the airway and systemic routes showed increased effectiveness.

241 C3H/HeN mice were vaccinated by mucosal and systemic routes with C. trachomatis serovar D (UW-3/Cx)

242 the traditional skin score in patients with systemic sclerosis and may additionally aid in the monit

243 in a sample of human patients diagnosed with systemic sclerosis and to an experiment that examined mu

244 sults revealed three signals associated with systemic sclerosis in Han Chinese and suggested the impo

245 se and suggested the importance of LRP2BP in systemic sclerosis pathogenesis.

246 Systemic sepsis is a known risk factor for bronchopulmon

247 ons, as well as provide a proposed model for systemic signal integration, focusing on the ROS wave.

248 Systemic signaling in plants is orchestrated by a comple

249 rated by a complex network of interconnected systemic signals and cell types.

250 control amongst symplastic continuity, age, systemic signals and local regulators during internode m

251 plants capable of integrating two different systemic signals simultaneously generated during conditi

252 ) are a group of disorders involving severe, systemic, small-vessel vasculitis and are characterized

253 oader defects of the motor unit, arguing for systemic SMN repletion.

254 of infection can limit or completely prevent systemic spread of GAS infection, suggesting that hepcid

255 In this study, we found that systemic steroid use in ARTI is common with a great geog

256 The use of systemic steroids does not seem to worsen long-term outc

257 diagnoses but influenza predicted receiving systemic steroids.

258 returns to control size within 3 h, and the systemic stomatal response can be retriggered within 6 h

259 into asymptomatic carriage, respiratory and systemic strains with distinct genomic signatures.

260 nflammation that causes neuronal cell death, systemic stress, and lethal immunodepression.

261 However, SadP adhesin from systemic subtype P(N) strains also binds to globotetraos

262 um graminicola but instead displayed induced systemic susceptibility.

263 nted with delayed seroma (69.2%) and without systemic symptoms (86.5%).

264 syndrome/drug reaction with eosinophilia and systemic symptoms (DiHS/DRESS) is a potentially fatal mu

265 Detailed demographic profiles, systemic symptoms, comorbidities, and ocular manifestati

266 is of scleral nodules even in the absence of systemic symptoms.

267 th the priming and effector phases, provokes systemic T cell responses against dominant and subdomina

268 Tonsillar and systemic T-cell responses differed between influenza str

269 ces both mucosal and systemic antibodies and systemic T-cell responses.

270 Systemic therapies and radiotherapy boost did not increa

271 C), and predictive biomarkers of response to systemic therapies are lacking.

272 n the context of treatment with contemporary systemic therapies such as immunotherapies and targeted

273 Notwithstanding, the use of systemic therapy alone can result in a castrate-resistan

274 nd/or metastatic disease, no known effective systemic therapy exists.

275 ndations updating the 2017 ASCO guideline on systemic therapy for patients with stage IV non-small-ce

276 Targeted systemic therapy may be used to treat advanced or metast

277 s poor overall survival (OS) and no approved systemic therapy options.

278 on, which despite clinical improvement under systemic therapy was only partially reverted, and which

279 s; range, 30-88 years; 11 had received prior systemic therapy).

280 s substantially higher risk of glaucoma than systemic therapy, a difference not entirely explained by

281 rative treatment sequencing, and response to systemic therapy, to safely guide patients through this

282 ider the expected outcomes (e.g., ocular vs. systemic) to ensure that the selected measurement is sen

283 eatment by improving efficacy while reducing systemic toxicities.

284 ed but not to an amount that would cause any systemic toxicity if taken at the recommended dosages.

285 o-delivery of Dox and Val via ISFI can avoid systemic toxicity issues seen with clinical Pgp inhibito

286 The intercellular and systemic trafficking of small interfering RNA (siRNA)/mi

287 ients age 60 years or older without previous systemic treatment for progressive advanced or metastati

288 nonbiologic, and 10% were not receiving any systemic treatment for psoriasis.

289 We found that systemic treatment with an mGlu(2) or mGlu(3) NAM rapidl

290 be candidates for escalated or de-escalated systemic treatment.

291 especially for large tumors, and established systemic treatments are lacking.METHODSWe used next-gene

292 Ts) investigating the safety and efficacy of systemic treatments for AD up to February 2020.

293 ry mouth and considerably higher than use of systemic treatments for serious manifestations of the di

294 ction of immunogenic micronuclei, leading to systemic tumor response with potential future clinical b

295 The systemic tumor-specific and cell-mediated immunotherapy

296 There is mounting evidence that systemic uptake of food allergens is key to triggering a

297 ional safety profile of the vector vis-a-vis systemic utility.

298 ck in patients with HFrEF leads to increased systemic vascular resistance, which constrains stroke vo

299 essive end-organ damage, partly related to a systemic vasculopathy, is increasingly recognised.

300 iferation and differentiation, as well as in systemic versus localized signaling.