ライフサイエンスコーパス: systemic administration

1 mutation Ush1c c.216G > A following a single systemic administration.

2 cation is limited by potential toxicity from systemic administration.

3 ctivity of drugs with payloads too toxic for systemic administration.

4 more than those reported following repeated systemic administration.

5 enter the skin microcirculation and achieve systemic administration.

6 -30 min (drug-on) and 5-6 h (drug-off) after systemic administration.

7 ipheral tissues in severe SMA mice following systemic administration.

8 val in mice bearing PC micrometastases after systemic administration.

9 ption in a mouse model of visceral pain upon systemic administration.

10 n vivo, and antagonizes KOR in the CNS after systemic administration.

11 tic properties that render it unsuitable for systemic administration.

12 ies without the side effects associated with systemic administration.

13 uired FG7142-induced negative bias following systemic administration.

14 onic stress paradigms in rats within 24 h of systemic administration.

15 d unprecedented uptake by many tissues after systemic administration.

16 signal enhancement in tumor xenografts after systemic administration.

17 ity in mouse lungs and cerebral cortex after systemic administration.

18 sively target the tumor of living mice after systemic administration.

19 bolic agents on a fracture surface following systemic administration.

20 mise to reduce severe side effects caused by systemic administration.

21 ogo-B protein suppression in the liver after systemic administration.

22 bulk tissue and cellular distribution after systemic administration.

23 NP size in determining biodistribution after systemic administration.

24 ted relative to working memory, as seen with systemic administration.

25 nging to deliver effectively by conventional systemic administration.

26 fts in real time after both intracranial and systemic administrations.

27 Anxiolytic effects of an acute systemic administration (1.5 mg/kg, intraperitoneally) o

28 albumin-binding analog of CpG ODN, following systemic administration 3days after tumor irradiation.

29 After systemic administration, a 2-fold higher transduction in

30 After systemic administration, a 4-fold higher transduction in

31 ic murine Panc02 model of PDAC, we show that systemic administration allowed immuno-NPs to deposit in

32 ated macrophages (TAMs) in glioblastoma from systemic administration and exhibits triggered release u

33 mouse hippocampi, appears in the brain after systemic administration and increases synaptic plasticit

34 Acute systemic administration and intra-mPFC infusion of RS673

35 Of note, 21 compounds, showed aptness for systemic administration and limited toxic effects, were

36 For the first time, safe systemic administration and systematic renal clearance w

37 l pain; however, insufficient efficacy after systemic administration and undesired effects preclude t

38 endency and does not transduce the CNS after systemic administration and, instead, transduces the vas

39 yma of mice in greater amounts in vivo after systemic administration compared with similar high-avidi

40 he same cancer with chemotherapy drugs after systemic administration due to individual biopharmaceuti

41 Upon systemic administration, exogenous Mn exhibited varying

42 Systemic administration had a more pronounced effect on

43 rug delivery has a number of advantages over systemic administration; however, for the past 20 years,

44 Upon systemic administration in a rabbit model of pediatric T

45 into striated muscles of DM1 mice following systemic administration in comparison with unconjugated

46 erization of this probe after both local and systemic administration in living mice.

47 Systemic administration in mice followed by local light-

48 to target prostate carcinoma cells following systemic administration in mouse models.

49 duction and cytolytic activity in vitro Upon systemic administration in vivo, chNKG2D T cells migrate

50 sue concentration of free l-fucose following systemic administration, in order to block ligand bindin

51 e tumor by 5 and 8 folds at 6 and 24 h after systemic administration into orthotopic MB tumor bearing

52 Here, we show that upon systemic administration into tumor-bearing mice, CRV sel

53 -life of the GB1107 surrogate indicated that systemic administration is possible for monosaccharides.

54 Systemic administration of 1.4 mg kg(-1) of mRNA into mi

55 Both natural fluctuations and systemic administration of 17beta-estradiol (E2) alter s

56 ere shown to mimic human prodrug metabolism, systemic administration of 6 delivered 11-fold higher DO

57 Systemic administration of 6 doses of CH-3-8 and LDC loa

58 Moreover, systemic administration of a 5-HT6 receptor inverse agon

59 Here, delayed systemic administration of a blood-brain barrier-permeab

60 Systemic administration of a brain-penetrant selenopepti

61 Altogether, our data show that systemic administration of a brain-penetrant TrkB antago

62 Our study provides first-time evidence that systemic administration of a brain-penetrant TrkB antago

63 Whether repeated systemic administration of a CB2-preferring agonist enga

64 e development of integrated models that link systemic administration of a drug to the probability of

65 Previously, we showed that, systemic administration of a GABA reuptake blocker in ME

66 Moreover, we have demonstrated that systemic administration of a GLP-1R agonist (liraglutide

67 Systemic administration of a HIF-prolyl hydroxylase inhi

68 of sustained weight reduction in response to systemic administration of a long-acting analog of the g

69 After systemic administration of a MET kinase inhibitor, we pr

70 l spermine followed by a seeking test, or 3) systemic administration of a mGluR1 positive allosteric

71 Consistently, systemic administration of a pan-PP2A inhibitor disrupts

72 Furthermore, systemic administration of a PKD inhibitor protects d-ga

73 e results of these studies clearly show that systemic administration of a selective NR2B NAM can caus

74 We further show that systemic administration of a single dose of dendrimer-N-

75 Systemic administration of AAV92YF-RdCVF improved cone f

76 Moreover, one-time systemic administration of Ac2-26 Col IV NPs accelerated

77 Moreover, systemic administration of acetazolamide immediately aft

78 We found that systemic administration of acetazolamide, a CA inhibitor

79 duction of lamin A/progerin by a single-dose systemic administration of adeno-associated virus-delive

80 DTCs persist in distant tissues despite systemic administration of adjuvant chemotherapy.

81 Although chronic systemic administration of aducanumab in 22-month-old mi

82 This can be achieved by systemic administration of Ag-specific Treg cells, which

83 Single-cell RNA-seq of microglia after acute systemic administration of AL002c showed induction of pr

84 or D2R MSNs, we show that repeated cycles of systemic administration of alcohol or alcohol consumptio

85 We show that intranasal but not systemic administration of alpha-GalCer to piglets infec

86 We show that a single systemic administration of alpha-synuclein pff triggers

87 Systemic administration of alphaASGR1-RSPO2-RA in mice s

88 Antiallodynic efficacy of systemic administration of AM1710 was absent in CB2KO mi

89 We tested the hypothesis that systemic administration of an A2AR agonist will reduce m

90 Following systemic administration of an AAV-uUtro to neonatal dyst

91 Furthermore, we show that systemic administration of an agonist Notch3 antibody pr

92 toration of SHANK3 expression in the ACC, or systemic administration of an alpha-amino-3-hydroxy-5-me

93 ve modulation of hippocampal transmission by systemic administration of an alpha5-GABA(A) receptor ne

94 he work described herein was to test whether systemic administration of an antagonist of miR-467 woul

95 Neutrophil depletion by systemic administration of an anti-Gr1 antibody improved

96 Here, we show in rats that systemic administration of an aromatase (estrogen syntha

97 Notably, systemic administration of an EGFL6-neutralizing antibod

98 hat inhibition of monocyte brain invasion or systemic administration of an EP2 receptor antagonist re

99 Systemic administration of an HDAC inhibitor rescues the

100 Systemic administration of an immuno-nanoparticle in a m

101 Systemic administration of an in vivo imaging probe inco

102 Also, systemic administration of an MAP kinase kinase inhibito

103 First, we studied the effects of systemic administration of an OT receptor (OTR) antagoni

104 Systemic administration of anti-C5- or anti-C5a-blocking

105 This article will focus on the systemic administration of anti-cancer agents and their

106 These data indicate that systemic administration of anti-CD40Ab may be particular

107 As we expected, systemic administration of anti-DC-STAMP-mAb downregulat

108 nsection (L5SNT; modified Chung's model) and systemic administration of anti-ganglioside Abs.

109 d that blocking of interleukin 11 (IL-11) by systemic administration of anti-IL-11 antibodies attenua

110 r than 20% intratumoral accumulation and (b) systemic administration of anti-MG1 HNPs can enlarge a t

111 Systemic administration of anti-RXRB antibodies also res

112 Systemic administration of anti-VCAM1 antibody or geneti

113 In Nrf2 wild-type mice, systemic administration of artemisitene strongly inhibit

114 nsection (to remove sympathetic influences), systemic administration of atropine increased left ventr

115 We have shown that systemic administration of Bacille Calmette-Guerin (BCG)

116 e agonist NMDA) or inflammation in vivo (via systemic administration of bacterial lipopolysaccharides

117 The systemic administration of BB-94 alone at the same dose

118 Systemic administration of BGA002 downregulated N-Myc an

119 Systemic administration of Bifidobacterium leads to its

120 ction in vitro We show that local as well as systemic administration of BK1.3 potently blocks inflamm

121 Local and systemic administration of both dexamethasone and cedira

122 Either intrarenal or systemic administration of C-21 prevented Ang II-mediate

123 Systemic administration of C-miR146a oligonucleotide all

124 However, systemic administration of CCR2 antagonists is associate

125 We show that systemic administration of CD34(+) cells homed to the wo

126 anoencapsulation has been shown to allow for systemic administration of cGAMP and other cyclic dinucl

127 cells were detected in the cervix following systemic administration of ChAdOx1-5GHPV3 / MVA-5GHPV3 a

128 s reducing many side effects associated with systemic administration of chemotherapeutic drugs.

129 108 (20 nmol/day per 5 days), similar to the systemic administration of CLO, corrects the altered beh

130 al suppression of macrophage infiltration by systemic administration of clodronate-incorporated lipos

131 e glutamate levels following intracranial or systemic administration of clozapine N-oxide (CNO) and t

132 Systemic administration of CNO inhibited cue-induced rei

133 Systemic administration of cocaine is thought to decreas

134 confirmed VTA DA neurons that is excited by systemic administration of cocaine.

135 Systemic administration of compounds that block the acti

136 tricular leptin infusion was not impacted by systemic administration of corticosterone at a dose that

137 ad hoc behavioral protocol for rats in which systemic administration of CP55940 produced kinematic im

138 A drug delivery system suitable for systemic administration of CPA is needed before CPA can

139 Acute and chronic systemic administration of CpG-C reduced tumor cell seed

140 used for the treatment of psoriasis; however systemic administration of CsA is potentially life threa

141 Systemic administration of CTDP-32476 alone produced a s

142 Either systemic administration of DCs loaded with allogeneic-Ig

143 Strikingly, systemic administration of Del-1-Fc ameliorated clinical

144 repopulating HSCs and progenitor cells, and systemic administration of Dkk1 to irradiated mice incre

145 Systemic administration of drugs that improve respirator

146 reason for functional impairment of BSEP is systemic administration of drugs, which as a side effect

147 Systemic administration of enkephalinase inhibitors or N

148 Systemic administration of epidermal growth factor (EGF)

149 Systemic administration of Etanercept inhibited MHC-I(hi

150 In vivo systemic administration of F. major sphingolipids change

151 OIHP was induced in vivo by systemic administration of fentanyl and confirmed by pro

152 Using an animal model of CIPS, we found that systemic administration of FK506 in male and female mice

153 continuous stimulation of bone growth using systemic administration of fracture-targeted bone anabol

154 Furthermore, systemic administration of gabapentin or intrathecal inj

155 Systemic administration of GDNF-macrophages at a severe

156 Furthermore, systemic administration of GluR or GLP-1R agonists and a

157 Systemic administration of GMSC-EVs attenuated aging-ass

158 ipulation, when tested pharmacologically via systemic administration of group III mGluR antagonists,

159 ial injection, epicardial patch delivery, or systemic administration of growth molecules, these studi

160 We obtained similar results in vivo after systemic administration of HDL NPs in mouse lymphoma xen

161 To determine whether the systemic administration of HER2-specific chimeric antige

162 Current treatment strategies are based on systemic administration of high doses of antibiotics, wh

163 findings demonstrate for the first time that systemic administration of hNSC-derived EV abrogates RIC

164 Following systemic administration of HPPH liposomes, near infrared

165 Systemic administration of huPMN310 in mice resulted in

166 Treatment of tumor bearing mice with systemic administration of IL-12 in combination with int

167 potentially lethal toxicity associated with systemic administration of IL-12 precludes its clinical

168 al phenotypes of ASD, to test the effects of systemic administration of insulin-like growth factor II

169 ease in the orthotopic MB tumor burden after systemic administration of JQ1 loaded ApoE- NPs at the d

170 Systemic administration of JWH133, a highly selective CB

171 Systemic administration of JZL184 [4, 8 and 16 mg/kg, in

172 tral CA1 pyramidal cells 24 h after a single systemic administration of L-655,708 revealed a signific

173 atty liver is partially recapitulated by the systemic administration of low-dose carboxyatractyloside

174 Additional systemic administration of low-dose PMO25 at 2-week inte

175 revent symptoms and suggests that subsequent systemic administration of low-dose PMO25 in SMA mice ca

176 enhanced cutaneous inflammation on local and systemic administration of LPS.

177 Hippocampal or systemic administration of mannose-6-phosphate, like IGF

178 A single systemic administration of MDSC markedly prolonged survi

179 Systemic administration of methylxantines improves respi

180 Systemic administration of micelles carrying paclitaxel

181 Systemic administration of monomethyl fumarate, another

182 r knowledge, this is the first report of the systemic administration of mRNA for delivery to the lung

183 We find that systemic administration of MS0021570_1 attenuates anxiet

184 ivity and tolerability profiles of effective systemic administration of MSA-2.

185 target dormant breast cancer cells based on systemic administration of MSC loaded with antagomiR-222

186 showed, in aged female rhesus monkeys, that systemic administration of MSC-EVs enhances recovery of

187 in counteracts the behavioral effects of the systemic administration of mu-opioid receptor (MOR) agon

188 Using systemic administration of nanoparticle-formulated miRNA

189 Systemic administration of nicotinamide, a conversion pr

190 t time, we investigated the effects of acute systemic administration of nicotinic acid on sleep in mi

191 Systemic administration of nilotinib at a low dose (0.5

192 Systemic administration of nonionic SPs effectively supp

193 s bone osteopenia that can be ameliorated by systemic administration of Notch2 ASOs.

194 However, systemic administration of oAd is severely restricted by

195 Furthermore, systemic administration of oAd/DCN/LRP-PEG-NT significan

196 Furthermore, systemic administration of oAd/RLX-PCDP-treated hMSCs el

197 After systemic administration of oxotremorine, an unselective

198 duced epilepsy: intrahippocampal kainate and systemic administration of paraoxon.

199 The chosen systemic administration of PEA stabilized the amplitude

200 would not diffuse to the periphery), but not systemic administration of PF-06655075 (i.e., it would n

201 ar cells stimulated with PG(Bb) In addition, systemic administration of PG(Bb) in BALB/c mice elicits

202 This study examined if systemic administration of Piribedil, a dopamine agonist

203 We have previously reported that systemic administration of pNaKtide which targets the Na

204 We tested the hypothesis that systemic administration of porphyrin precursors to zebra

205 Acute systemic administration of pregabalin in vivo also selec

206 I (DW-MRI) in wild-type (WT) mice, the acute systemic administration of pregabalin increased the thre

207 ced changes in mPFC firing were mitigated by systemic administration of propranolol (10 mg/kg, i.p.),

208 uced increase in BLA firing was prevented by systemic administration of propranolol.

209 Systemic administration of PTH(1-34) augmented bone volu

210 t migration and mineralization in vitro, and systemic administration of PTHrP1-17 augments ectopic bo

211 Systemic administration of QW-296 loaded nanoparticles i

212 Systemic administration of R-flurbiprofen preferentially

213 In rats, systemic administration of R-MOD alone (10-30 mg/kg i.p.

214 However, systemic administration of R848 often results in strong

215 Importantly, we found that systemic administration of recombinant FGF2 (rFGF2) in m

216 Finally, systemic administration of recombinant IL-27 in Treg-spe

217 present investigation studied the effects of systemic administration of resveratrol (RSV) on the deve

218 inergic neurons and either local infusion or systemic administration of retigabine normalized neurona

219 Systemic administration of RT53 inhibited the growth of

220 In vivo, systemic administration of RTD-1, initiated at the time

221 We found systemic administration of SB-334867 (0, 7.5, 15, 30 mg/

222 In conclusion, systemic administration of Scl-Ab promotes bone and ceme

223 that impair hippocampal function, including systemic administration of scopolamine, a muscarinic-cho

224 We show that systemic administration of siMGMT-SNAs via single tail v

225 Systemic administration of sodium 4-phenylbutyrate (PBA)

226 m load, which was significantly decreased by systemic administration of specific blockers of the angi

227 Previous research showed that systemic administration of TAAR1 agonists could attenuat

228 Our recent studies showed that systemic administration of TAAR1 agonists decreased abus

229 In response to systemic administration of TFLLR-NH(2), LPS-primed Podxl

230 exibility on this task is improved following systemic administration of the 5-HT reuptake inhibitor c

231 Systemic administration of the AROM inhibitor letrozole

232 d female monkeys were severely attenuated by systemic administration of the aromatase inhibitor, letr

233 Strikingly, a single systemic administration of the beta-adrenoreceptor (AR)

234 Systemic administration of the bispecific DVD-Ig or the

235 Systemic administration of the BMP antagonist LDN-193189

236 Importantly, systemic administration of the CaMKII inhibitor tatCN21

237 Systemic administration of the CCR3 antagonists GW766994

238 onists, we examined the cognitive effects of systemic administration of the CRF1 receptor selective a

239 Finally, we show that systemic administration of the CRMP-2 inhibitor lacosami

240 Following systemic administration of the Cy5-labeled dendrimer (D-

241 Systemic administration of the dopamine transporter inhi

242 the neuroinflammatory response produced by a systemic administration of the Escherichia coli lipopoly

243 Importantly, systemic administration of the FGFR1 inhibitor PD173074

244 t increase in alcohol intake, and found that systemic administration of the Fyn inhibitor, AZD0503 bl

245 aking and -seeking behaviors, we showed that systemic administration of the GLP-1 receptor agonist ex

246 reinstated cocaine seeking was prevented by systemic administration of the group II metabotropic glu

247 Systemic administration of the growth factor FLT3L follo

248 In conclusion, systemic administration of the heme precursors PP-IX or

249 Systemic administration of the high-affinity Sig1R ligan

250 Systemic administration of the KOR agonist U50,488 incre

251 Systemic administration of the KOR agonist U69,593 inhib

252 e drinking (Experiment 1) while, conversely, systemic administration of the KOR antagonist nor-BNI re

253 mouse intranasal virus challenge study, and systemic administration of the mAb markedly reduced vira

254 Finally, systemic administration of the mGlu2/3 agonist LY379268

255 Systemic administration of the MIF inhibitor ISO-1 signi

256 The data show that systemic administration of the miR-467 antagonist could

257 ed on rats bearing melanoma xenografts after systemic administration of the N-cadherin antagonist, AD

258 Systemic administration of the nAChRa7 agonist PNU-28298

259 We now report that systemic administration of the novel mGlu5 positive allo

260 Systemic administration of the orexin-1 receptor (OX1R)

261 in the DLS, as well as intra-DLS infusion or systemic administration of the p75NTR modulator, LM11A-3

262 Systemic administration of the peptides for five weeks i

263 d positron emission tomography imaging after systemic administration of the plasmid in vivo.

264 , and repetitive behaviors, we report that a systemic administration of the polypeptide insulin-like

265 Systemic administration of the PTPsigma inhibitor, DJ001

266 RNAs against HuR with FA-3DNA and found that systemic administration of the resultant FA-3DNA-siHuR c

267 gnal mediator Smoothened (Smo) as well as by systemic administration of the Smo inhibitor vismodegib,

268 sion of follistatin in skeletal muscle or by systemic administration of the soluble form of the activ

269 Acute systemic administration of the TAT-4BB reversed M3G-indu

270 refrontal cortex of the Met68BDNF mice or by systemic administration of the tropomyosin receptor kina

271 Furthermore, systemic administration of the vectors results in widesp

272 Systemic administration of these agonists to monkeys per

273 Systemic administration of TP-10 (3.2 mg/kg) robustly in

274 Systemic administration of TRAILPEG after disease onset

275 present a tumor-detection strategy based on systemic administration of tumor-activatable minicircles

276 Systemic administration of Y4 effectively inhibits growt

277 Moreover, we demonstrate that systemic administration of young plasma into aged mice r

278 ns were made selectively zolpidem-sensitive, systemic administration of zolpidem shortened sleep late

279 Intrathecal, but not systemic, administration of the Hsp90 inhibitors 17-AAG

280 plant, this work analyzed the effect of BMMC systemic administration on nerve repair and pain behavio

281 After systemic administration, optical imaging suggests that t

282 High-dose systemic administration or local injection of recombinan

283 premature responses; motor impulsivity) upon systemic administration or microinfusion directly into t

284 By contrast, systemic administration or overexpression of Rspo3 in th

285 evable using engineered MSCs, strategies for systemic administration require further modeling.

286 In mice, systemic administration resulted in the specific co-loca

287 ss an immature blood-brain barrier following systemic administration, showing more robust initial eff

288 mouse blood plasma proteome, and upon their systemic administration, study the BBB with its physiolo

289 27853 and no nephrotoxicity was found after systemic administration, suggesting it to be a potential

290 Upon systemic administration to mice bearing uPA-overexpressi

291 Systemic administration to mice of FRCs that were expand

292 ralizes TNF-alpha and is used principally by systemic administration to treat many inflammatory disor

293 NP1 efficacy in vivo was evaluated by systemic administration to tumor-bearing mice.

294 red for effectiveness when delivered through systemic administration (typically intravenous infusion)

295 the validated gRNA combinations, we employed systemic administration via adeno-associated virus serot

296 Central mGluR1 target engagement after systemic administration was demonstrated by a dose-depen

297 After systemic administration we demonstrate a robust ability

298 e it bypasses the challenges associated with systemic administration which suffers from enzymatic deg

299 s, co-solvent delivery is required for their systemic administration, which is usually associated wit

300 valuable cell tropisms to allow efficacious systemic administration, yet basic aspects of AAV cellul