1 Systemic administration of 1.4 mg kg(-1) of mRNA into mi
2 Both natural fluctuations and
systemic administration of 17beta-estradiol (E2) alter s
3 ffects of alcohol was confirmed, as both the
systemic administration of 3-Cyano-N-(1,3-diphenyl-1H-py
4 ere shown to mimic human prodrug metabolism,
systemic administration of 6 delivered 11-fold higher DO
5 Systemic administration of 6 doses of CH-3-8 and LDC loa
6 Moreover,
systemic administration of a 5-HT6 receptor inverse agon
7 Here, delayed
systemic administration of a blood-brain barrier-permeab
8 Systemic administration of a brain-penetrant selenopepti
9 Altogether, our data show that
systemic administration of a brain-penetrant TrkB antago
10 Our study provides first-time evidence that
systemic administration of a brain-penetrant TrkB antago
11 Whether repeated
systemic administration of a CB2-preferring agonist enga
12 e development of integrated models that link
systemic administration of a drug to the probability of
13 Previously, we showed that,
systemic administration of a GABA reuptake blocker in ME
14 Subsequent experiments showed that
systemic administration of a GABA(B)R antagonist, CGP558
15 Repeated
systemic administration of a ghrelin receptor agonist en
16 tion correlated with FOS induction following
systemic administration of a GLP-1 receptor agonist, exe
17 Moreover, we have demonstrated that
systemic administration of a GLP-1R agonist (liraglutide
18 Systemic administration of a HIF-prolyl hydroxylase inhi
19 of sustained weight reduction in response to
systemic administration of a long-acting analog of the g
20 the circulation during EAE induction through
systemic administration of a mAb against PC/activated PC
21 After
systemic administration of a MET kinase inhibitor, we pr
22 l spermine followed by a seeking test, or 3)
systemic administration of a mGluR1 positive allosteric
23 Consistently,
systemic administration of a pan-PP2A inhibitor disrupts
24 Furthermore,
systemic administration of a PKD inhibitor protects d-ga
25 e results of these studies clearly show that
systemic administration of a selective NR2B NAM can caus
26 We further show that
systemic administration of a single dose of dendrimer-N-
27 Our data suggest that
systemic administration of AAT can be a promising therap
28 D from the cardiac troponin-T promoter after
systemic administration of AAV9 provides significant pro
29 Systemic administration of AAV92YF-RdCVF improved cone f
30 Moreover, one-time
systemic administration of Ac2-26 Col IV NPs accelerated
31 Moreover,
systemic administration of acetazolamide immediately aft
32 We found that
systemic administration of acetazolamide, a CA inhibitor
33 duction of lamin A/progerin by a single-dose
systemic administration of adeno-associated virus-delive
34 DTCs persist in distant tissues despite
systemic administration of adjuvant chemotherapy.
35 sed adrenal size and elevated CORT following
systemic administration of adrenocorticotropic hormone.
36 Although chronic
systemic administration of aducanumab in 22-month-old mi
37 This can be achieved by
systemic administration of Ag-specific Treg cells, which
38 No safety concerns were identified after
systemic administration of AKB-9778 for 4 weeks in patie
39 Single-cell RNA-seq of microglia after acute
systemic administration of AL002c showed induction of pr
40 or D2R MSNs, we show that repeated cycles of
systemic administration of alcohol or alcohol consumptio
41 We show that intranasal but not
systemic administration of alpha-GalCer to piglets infec
42 We show that a single
systemic administration of alpha-synuclein pff triggers
43 Systemic administration of alphaASGR1-RSPO2-RA in mice s
44 Antiallodynic efficacy of
systemic administration of AM1710 was absent in CB2KO mi
45 We tested the hypothesis that
systemic administration of an A2AR agonist will reduce m
46 Following
systemic administration of an AAV-uUtro to neonatal dyst
47 Furthermore, we show that
systemic administration of an agonist Notch3 antibody pr
48 toration of SHANK3 expression in the ACC, or
systemic administration of an alpha-amino-3-hydroxy-5-me
49 ve modulation of hippocampal transmission by
systemic administration of an alpha5-GABA(A) receptor ne
50 he work described herein was to test whether
systemic administration of an antagonist of miR-467 woul
51 Neutrophil depletion by
systemic administration of an anti-Gr1 antibody improved
52 Here, we show in rats that
systemic administration of an aromatase (estrogen syntha
53 Notably,
systemic administration of an EGFL6-neutralizing antibod
54 hat inhibition of monocyte brain invasion or
systemic administration of an EP2 receptor antagonist re
55 Systemic administration of an HDAC inhibitor rescues the
56 Systemic administration of an immuno-nanoparticle in a m
57 Systemic administration of an in vivo imaging probe inco
58 Also,
systemic administration of an MAP kinase kinase inhibito
59 cue-induced craving are high, we found that
systemic administration of an mGluR1 PAM attenuated the
60 First, we studied the effects of
systemic administration of an OT receptor (OTR) antagoni
61 Systemic administration of anti-C5- or anti-C5a-blocking
62 This article will focus on the
systemic administration of anti-cancer agents and their
63 These data indicate that
systemic administration of anti-CD40Ab may be particular
64 As we expected,
systemic administration of anti-DC-STAMP-mAb downregulat
65 nsection (L5SNT; modified Chung's model) and
systemic administration of anti-ganglioside Abs.
66 d that blocking of interleukin 11 (IL-11) by
systemic administration of anti-IL-11 antibodies attenua
67 r than 20% intratumoral accumulation and (b)
systemic administration of anti-MG1 HNPs can enlarge a t
68 Systemic administration of anti-RXRB antibodies also res
69 Systemic administration of anti-VCAM1 antibody or geneti
70 In Nrf2 wild-type mice,
systemic administration of artemisitene strongly inhibit
71 nsection (to remove sympathetic influences),
systemic administration of atropine increased left ventr
72 We have shown that
systemic administration of Bacille Calmette-Guerin (BCG)
73 e agonist NMDA) or inflammation in vivo (via
systemic administration of bacterial lipopolysaccharides
74 The
systemic administration of BB-94 alone at the same dose
75 Systemic administration of BGA002 downregulated N-Myc an
76 Systemic administration of Bifidobacterium leads to its
77 ction in vitro We show that local as well as
systemic administration of BK1.3 potently blocks inflamm
78 Local and
systemic administration of both dexamethasone and cedira
79 We found that the
systemic administration of brain lipid rafts induced a m
80 Either intrarenal or
systemic administration of C-21 prevented Ang II-mediate
81 Systemic administration of C-miR146a oligonucleotide all
82 However,
systemic administration of CCR2 antagonists is associate
83 We show that
systemic administration of CD34(+) cells homed to the wo
84 anoencapsulation has been shown to allow for
systemic administration of cGAMP and other cyclic dinucl
85 cells were detected in the cervix following
systemic administration of ChAdOx1-5GHPV3 / MVA-5GHPV3 a
86 s reducing many side effects associated with
systemic administration of chemotherapeutic drugs.
87 108 (20 nmol/day per 5 days), similar to the
systemic administration of CLO, corrects the altered beh
88 al suppression of macrophage infiltration by
systemic administration of clodronate-incorporated lipos
89 e glutamate levels following intracranial or
systemic administration of clozapine N-oxide (CNO) and t
90 Systemic administration of CNO inhibited cue-induced rei
91 Systemic administration of CNO suppresses focal seizures
92 Systemic administration of cocaine is thought to decreas
93 confirmed VTA DA neurons that is excited by
systemic administration of cocaine.
94 Systemic administration of compounds that block the acti
95 at are notoriously difficult to eliminate by
systemic administration of conventional antifungal agent
96 tricular leptin infusion was not impacted by
systemic administration of corticosterone at a dose that
97 ad hoc behavioral protocol for rats in which
systemic administration of CP55940 produced kinematic im
98 A drug delivery system suitable for
systemic administration of CPA is needed before CPA can
99 Acute and chronic
systemic administration of CpG-C reduced tumor cell seed
100 used for the treatment of psoriasis; however
systemic administration of CsA is potentially life threa
101 Systemic administration of CTDP-32476 alone produced a s
102 Both local and
systemic administration of CTLA4(apt)-STAT3 siRNA dramat
103 Notably,
systemic administration of CYM51010 induced antinocicept
104 Systemic administration of DAR decreases hepatic ischemi
105 Either
systemic administration of DCs loaded with allogeneic-Ig
106 Strikingly,
systemic administration of Del-1-Fc ameliorated clinical
107 We hypothesized that
systemic administration of DHA-derived SPMs [resolvin D2
108 After
systemic administration of diaCEST liposomes to mice bea
109 repopulating HSCs and progenitor cells, and
systemic administration of Dkk1 to irradiated mice incre
110 , while inactivating the VTA or the combined
systemic administration of dopamine D1 and D2 antagonist
111 Systemic administration of drugs that improve respirator
112 reason for functional impairment of BSEP is
systemic administration of drugs, which as a side effect
113 We demonstrated that
systemic administration of endogenous nitric oxide donor
114 In rodents,
systemic administration of endogenous or synthetic neuro
115 Systemic administration of enkephalinase inhibitors or N
116 Systemic administration of epidermal growth factor (EGF)
117 Weekly
systemic administration of ESTA-MSV/STAT3 siRNA signific
118 Systemic administration of Etanercept inhibited MHC-I(hi
119 In vivo
systemic administration of F. major sphingolipids change
120 OIHP was induced in vivo by
systemic administration of fentanyl and confirmed by pro
121 In this study, we showed that
systemic administration of FK506 (1.5 mg kg(-1) day(-1))
122 Using an animal model of CIPS, we found that
systemic administration of FK506 in male and female mice
123 ansgene into the hippocampus and reversed by
systemic administration of fluoxetine.
124 continuous stimulation of bone growth using
systemic administration of fracture-targeted bone anabol
125 Furthermore,
systemic administration of gabapentin or intrathecal inj
126 Systemic administration of GDNF-macrophages at a severe
127 Furthermore,
systemic administration of GluR or GLP-1R agonists and a
128 Systemic administration of GMSC-EVs attenuated aging-ass
129 ipulation, when tested pharmacologically via
systemic administration of group III mGluR antagonists,
130 ial injection, epicardial patch delivery, or
systemic administration of growth molecules, these studi
131 We obtained similar results in vivo after
systemic administration of HDL NPs in mouse lymphoma xen
132 To determine whether the
systemic administration of HER2-specific chimeric antige
133 Current treatment strategies are based on
systemic administration of high doses of antibiotics, wh
134 findings demonstrate for the first time that
systemic administration of hNSC-derived EV abrogates RIC
135 Following
systemic administration of HPPH liposomes, near infrared
136 These findings suggest that high-dose
systemic administration of human cultured MSCs can resto
137 t while local infusion of HSA or saline, and
systemic administration of human PRP lysate, compared to
138 We discovered that
systemic administration of human recombinant CSF1 amelio
139 Systemic administration of huPMN310 in mice resulted in
140 MRI of the TNBC xenograft tumor after
systemic administration of ICAM-IONPs, coupled with iron
141 weights, both transgenic overexpression and
systemic administration of IGF-1 combined with Bax-inhib
142 Treatment of tumor bearing mice with
systemic administration of IL-12 in combination with int
143 potentially lethal toxicity associated with
systemic administration of IL-12 precludes its clinical
144 ph nodes, both of which could be reversed by
systemic administration of IL-1R antagonist (anakinra).
145 Systemic administration of insulin delays the death of c
146 Interestingly,
systemic administration of insulin has been shown to del
147 al phenotypes of ASD, to test the effects of
systemic administration of insulin-like growth factor II
148 ease in the orthotopic MB tumor burden after
systemic administration of JQ1 loaded ApoE- NPs at the d
149 In a murine periodontitis model,
systemic administration of JQ1 significantly inhibited i
150 Systemic administration of JWH133 attenuated these marke
151 Systemic administration of JWH133, a highly selective CB
152 Systemic administration of JZL184 [4, 8 and 16 mg/kg, in
153 tral CA1 pyramidal cells 24 h after a single
systemic administration of L-655,708 revealed a signific
154 atty liver is partially recapitulated by the
systemic administration of low-dose carboxyatractyloside
155 Additional
systemic administration of low-dose PMO25 at 2-week inte
156 revent symptoms and suggests that subsequent
systemic administration of low-dose PMO25 in SMA mice ca
157 enhanced cutaneous inflammation on local and
systemic administration of LPS.
158 Hippocampal or
systemic administration of mannose-6-phosphate, like IGF
159 A single
systemic administration of MDSC markedly prolonged survi
160 rathecal injection of an NMDAR antagonist or
systemic administration of memantine effectively reverse
161 Systemic administration of methylxantines improves respi
162 Systemic administration of micelles carrying paclitaxel
163 Both
systemic administration of miR-124 or adoptive miR-124-t
164 Systemic administration of monomethyl fumarate, another
165 r knowledge, this is the first report of the
systemic administration of mRNA for delivery to the lung
166 We find that
systemic administration of MS0021570_1 attenuates anxiet
167 ivity and tolerability profiles of effective
systemic administration of MSA-2.
168 target dormant breast cancer cells based on
systemic administration of MSC loaded with antagomiR-222
169 showed, in aged female rhesus monkeys, that
systemic administration of MSC-EVs enhances recovery of
170 in counteracts the behavioral effects of the
systemic administration of mu-opioid receptor (MOR) agon
171 Behavioral studies show that
systemic administration of muscarinic acetylcholine rece
172 Using
systemic administration of nanoparticle-formulated miRNA
173 Systemic administration of neutralizing Abs to either TN
174 Systemic administration of nicotinamide, a conversion pr
175 t time, we investigated the effects of acute
systemic administration of nicotinic acid on sleep in mi
176 Systemic administration of nilotinib at a low dose (0.5
177 ease of B cells in the spleen in response to
systemic administration of Nod1 agonists in a TNF-alpha-
178 Systemic administration of nonionic SPs effectively supp
179 s bone osteopenia that can be ameliorated by
systemic administration of Notch2 ASOs.
180 Systemic administration of NRG demonstrated efficacy in
181 However,
systemic administration of oAd is severely restricted by
182 Furthermore,
systemic administration of oAd/DCN/LRP-PEG-NT significan
183 Furthermore,
systemic administration of oAd/RLX-PCDP-treated hMSCs el
184 After
systemic administration of oxotremorine, an unselective
185 animals reduces muscle regeneration, whereas
systemic administration of oxytocin rapidly improves mus
186 duced epilepsy: intrahippocampal kainate and
systemic administration of paraoxon.
187 The chosen
systemic administration of PEA stabilized the amplitude
188 In rats,
systemic administration of PF-04859989 dose-dependently
189 would not diffuse to the periphery), but not
systemic administration of PF-06655075 (i.e., it would n
190 ar cells stimulated with PG(Bb) In addition,
systemic administration of PG(Bb) in BALB/c mice elicits
191 In the context of inflammatory disorders,
systemic administration of pharmacological doses of synt
192 This study examined if
systemic administration of Piribedil, a dopamine agonist
193 Here, we found that
systemic administration of pleiotrophin (PTN), a protein
194 We have previously reported that
systemic administration of pNaKtide which targets the Na
195 We tested the hypothesis that
systemic administration of porphyrin precursors to zebra
196 Acute
systemic administration of pregabalin in vivo also selec
197 I (DW-MRI) in wild-type (WT) mice, the acute
systemic administration of pregabalin increased the thre
198 ced changes in mPFC firing were mitigated by
systemic administration of propranolol (10 mg/kg, i.p.),
199 uced increase in BLA firing was prevented by
systemic administration of propranolol.
200 Systemic administration of PTH(1-34) augmented bone volu
201 t migration and mineralization in vitro, and
systemic administration of PTHrP1-17 augments ectopic bo
202 was noticed over periods of months after the
systemic administration of QDs.
203 Systemic administration of QW-296 loaded nanoparticles i
204 Systemic administration of R-flurbiprofen preferentially
205 In rats,
systemic administration of R-MOD alone (10-30 mg/kg i.p.
206 However,
systemic administration of R848 often results in strong
207 Importantly, we found that
systemic administration of recombinant FGF2 (rFGF2) in m
208 7 was more effective than either LL-IL-10 or
systemic administration of recombinant IL-27 in reducing
209 Finally,
systemic administration of recombinant IL-27 in Treg-spe
210 Systemic administration of recombinant MK completely res
211 present investigation studied the effects of
systemic administration of resveratrol (RSV) on the deve
212 inergic neurons and either local infusion or
systemic administration of retigabine normalized neurona
213 Systemic administration of rimonabant precipitated anxie
214 Systemic administration of RT53 inhibited the growth of
215 In vivo,
systemic administration of RTD-1, initiated at the time
216 a within-subjects design, of male rats given
systemic administration of saline or lipopolysaccharide
217 We found
systemic administration of SB-334867 (0, 7.5, 15, 30 mg/
218 In conclusion,
systemic administration of Scl-Ab promotes bone and ceme
219 that impair hippocampal function, including
systemic administration of scopolamine, a muscarinic-cho
220 Performance was assessed following
systemic administration of selective D(2), D(3), and D(4
221 We show that
systemic administration of siMGMT-SNAs via single tail v
222 atform may afford the specificity lacking in
systemic administration of small-molecule inhibitors.
223 Systemic administration of sodium 4-phenylbutyrate (PBA)
224 We examined the effects of local and
systemic administration of sodium nitrite on the radial
225 m load, which was significantly decreased by
systemic administration of specific blockers of the angi
226 immunosuppressive signals can be achieved by
systemic administration of supporting adjuvant drugs suc
227 Previous research showed that
systemic administration of TAAR1 agonists could attenuat
228 Our recent studies showed that
systemic administration of TAAR1 agonists decreased abus
229 motor hyperactivity was attenuated following
systemic administration of TAT-C24WT but not TAT-C24Scr.
230 In response to
systemic administration of TFLLR-NH(2), LPS-primed Podxl
231 ilocarpine model of status epilepticus (SE),
systemic administration of TG6-10-1 completely recapitul
232 We found that
systemic administration of the 4-1BB aptamer-raptor siRN
233 exibility on this task is improved following
systemic administration of the 5-HT reuptake inhibitor c
234 f unfavorable outcomes were tested following
systemic administration of the 5-HT1A receptor agonist,
235 Systemic administration of the alpha2-AR agonists dexmed
236 The
systemic administration of the anti-Kras nanobeacons res
237 Systemic administration of the AROM inhibitor letrozole
238 d female monkeys were severely attenuated by
systemic administration of the aromatase inhibitor, letr
239 Strikingly, a single
systemic administration of the beta-adrenoreceptor (AR)
240 Simultaneous
systemic administration of the bioorthogonal IONPs in tu
241 Systemic administration of the bispecific DVD-Ig or the
242 Systemic administration of the BMP antagonist LDN-193189
243 Importantly,
systemic administration of the CaMKII inhibitor tatCN21
244 Systemic administration of the CB2 receptor agonist JWH1
245 Systemic administration of the CCR3 antagonists GW766994
246 onists, we examined the cognitive effects of
systemic administration of the CRF1 receptor selective a
247 Finally, we show that
systemic administration of the CRMP-2 inhibitor lacosami
248 Following
systemic administration of the Cy5-labeled dendrimer (D-
249 and that this disruption was reversed by the
systemic administration of the dopamine D2/D3 receptor a
250 Systemic administration of the dopamine transporter inhi
251 to the dose-limiting side effects following
systemic administration of the drugs.
252 the neuroinflammatory response produced by a
systemic administration of the Escherichia coli lipopoly
253 Importantly,
systemic administration of the FGFR1 inhibitor PD173074
254 t increase in alcohol intake, and found that
systemic administration of the Fyn inhibitor, AZD0503 bl
255 aking and -seeking behaviors, we showed that
systemic administration of the GLP-1 receptor agonist ex
256 reinstated cocaine seeking was prevented by
systemic administration of the group II metabotropic glu
257 Systemic administration of the growth factor FLT3L follo
258 Systemic administration of the Hcrtr-1 antagonist SB3348
259 In conclusion,
systemic administration of the heme precursors PP-IX or
260 Systemic administration of the high-affinity Sig1R ligan
261 Systemic administration of the KOR agonist U50,488 incre
262 Systemic administration of the KOR agonist U69,593 inhib
263 e drinking (Experiment 1) while, conversely,
systemic administration of the KOR antagonist nor-BNI re
264 mouse intranasal virus challenge study, and
systemic administration of the mAb markedly reduced vira
265 Finally,
systemic administration of the mGlu2/3 agonist LY379268
266 Systemic administration of the MIF inhibitor ISO-1 signi
267 The data show that
systemic administration of the miR-467 antagonist could
268 ed on rats bearing melanoma xenografts after
systemic administration of the N-cadherin antagonist, AD
269 Systemic administration of the N/OFQ receptor (NOP) anta
270 Systemic administration of the nAChRa7 agonist PNU-28298
271 We now report that
systemic administration of the novel mGlu5 positive allo
272 Systemic administration of the orexin-1 receptor (OX1R)
273 in the DLS, as well as intra-DLS infusion or
systemic administration of the p75NTR modulator, LM11A-3
274 Systemic administration of the peptides for five weeks i
275 d positron emission tomography imaging after
systemic administration of the plasmid in vivo.
276 , and repetitive behaviors, we report that a
systemic administration of the polypeptide insulin-like
277 Systemic administration of the PTPsigma inhibitor, DJ001
278 RNAs against HuR with FA-3DNA and found that
systemic administration of the resultant FA-3DNA-siHuR c
279 Noteworthy,
systemic administration of the S1PR1 modulator FTY720 (F
280 DOX and TMZ microcapsules are compared with
systemic administration of the same treatments in a rode
281 Systemic administration of the selective cyclin-dependen
282 gnal mediator Smoothened (Smo) as well as by
systemic administration of the Smo inhibitor vismodegib,
283 sion of follistatin in skeletal muscle or by
systemic administration of the soluble form of the activ
284 Acute
systemic administration of the TAT-4BB reversed M3G-indu
285 refrontal cortex of the Met68BDNF mice or by
systemic administration of the tropomyosin receptor kina
286 Furthermore,
systemic administration of the vectors results in widesp
287 Intrathecal, but not
systemic, administration of the Hsp90 inhibitors 17-AAG
288 Systemic administration of these agonists to monkeys per
289 Systemic administration of this probe to mice bearing S.
290 Knockdown of vascular DHCR24 and HO-1 and
systemic administration of tin-protoporphyrin-IX, an HO
291 Systemic administration of TP-10 (3.2 mg/kg) robustly in
292 Systemic administration of TRAILPEG after disease onset
293 present a tumor-detection strategy based on
systemic administration of tumor-activatable minicircles
294 al enhancement of endocannabinoid levels via
systemic administration of URB597, an inhibitor of endoc
295 Systemic administration of vitamin D during regeneration
296 earing metastatic colon tumors compared with
systemic administration of wild-type VSV alone.
297 Systemic administration of Y4 effectively inhibits growt
298 At the cognitive level,
systemic administration of young blood plasma into aged
299 Moreover, we demonstrate that
systemic administration of young plasma into aged mice r
300 ns were made selectively zolpidem-sensitive,
systemic administration of zolpidem shortened sleep late