ライフサイエンスコーパス: systemic disease

1 infection, and the host (age, presence of a systemic disease).

2 ogic, oncologic, mechanical instability, and systemic disease).

3 g a causal link between oral pathobionts and systemic disease.

4 doses of L. monocytogenes without developing systemic disease.

5 lf-limiting gastroenteritis that may lead to systemic disease.

6 or both, suggesting that celiac disease is a systemic disease.

7 nts (41.5%) demonstrated a coexisting active systemic disease.

8 eoformans in the environment whilst avoiding systemic disease.

9 teritis, typhoid fever is a life-threatening systemic disease.

10 rocess by which a localized cancer becomes a systemic disease.

11 n preceding any other organ manifestation or systemic disease.

12 required for early surveillance that limits systemic disease.

13 Organomegaly was a strong indicator of systemic disease.

14 distress syndrome probably mirroring severe systemic disease.

15 c disease, and none without organomegaly had systemic disease.

16 cial mucosal infections and life-threatening systemic disease.

17 ined treatment, and survival was extended in systemic disease.

18 o address the potentially serious associated systemic disease.

19 ement can be seen in patients with extensive systemic disease.

20 are described in 3 patients with aggressive systemic disease.

21 ir for bacteria implicated in both local and systemic disease.

22 eria developed moderate to severe additional systemic disease.

23 contributed to suppression and prevention of systemic disease.

24 an influenza virus causes a rapid and lethal systemic disease.

25 for furthering understanding of cancer as a systemic disease.

26 acerbate intestinal inflammation or manifest systemic disease.

27 a risk in inherited and acquired cardiac and systemic disease.

28 ven if they do, most patients will have mild systemic disease.

29 patients and to differentiate localized from systemic disease.

30 in cases of aggressive clinical behavior or systemic disease.

31 types supports the hypothesis that CFS is a systemic disease.

32 c measures but does not treat the underlying systemic disease.

33 ermine the future pathways and timescales of systemic disease.

34 dings or have CLE associated with underlying systemic disease.

35 percentage of B lymphocytes and no signs of systemic disease.

36 during intramacrophage replication promoting systemic disease.

37 clinical course, and risk for progression to systemic disease.

38 ement is rare and associated especially with systemic disease.

39 liferations improved in association with the systemic disease.

40 ations of host epithelium that contribute to systemic disease.

41 elium, causing vascular damage that leads to systemic disease.

42 olated aortitis in patients with unexplained systemic disease.

43 of disease, from mild diarrhea to fulminant systemic disease.

44 inoculation of HPAIV H5N1 resulted in fatal systemic disease.

45 role of bacterial-derived OMVs in mediating systemic disease.

46 3.4% of scleritis patients had an associated systemic disease.

47 nitourinary malignancy, and greater risks of systemic disease.

48 and systemic involvement and the underlying systemic disease.

49 are adult women with chronic (>=6 weeks) and systemic disease.

50 itidis might exit the oral cavity to produce systemic disease.

51 icancer therapy capable of treating local or systemic disease.

52 However, they often fail to impact systemic disease.

53 dings were correlated with the course of the systemic disease.

54 microbiome due to its links with health and systemic disease.

55 fection to severe manifestations of focal or systemic disease.

56 of a number of chronic gastrointestinal and systemic diseases.

57 the role of nucleic acid sensors in various systemic diseases.

58 oroidal parameters in a myriad of ocular and systemic diseases.

59 g may potentially be a link between oral and systemic diseases.

60 (PdD) has been shown to be related to other systemic diseases.

61 es the etiopathologic basis of many oral and systemic diseases.

62 es for treating or preventing both local and systemic diseases.

63 picting fundus pathologic features of common systemic diseases.

64 interrelationship between periodontitis and systemic diseases.

65 brosis and that can occur in isolation or in systemic diseases.

66 orly understood symptom in numerous skin and systemic diseases.

67 pretations of studies of the relationship to systemic diseases.

68 scriminatory biomarkers in saliva and distal systemic diseases.

69 future studies of putative associations with systemic diseases.

70 A minority developed other systemic diseases.

71 of a number of chronic gastrointestinal and systemic diseases.

72 secondary to a wide range of neurological or systemic diseases.

73 l deformities, global airway dysfunction and systemic diseases.

74 ciation with periodontitis, as well as other systemic diseases.

75 they will help to treat their intestinal or systemic diseases.

76 h increased risk of cardiovascular and other systemic diseases.

77 hypertension were the most common associated systemic diseases.

78 n the oral microbiome are linked to multiple systemic diseases.

79 of periodontal diseases that relate to many systemic diseases.

80 l barrier loss is a driver of intestinal and systemic diseases.

81 There was a high burden of systemic disease (95.8%).

82 whether sociodemographic factors and certain systemic diseases affected the odds of KCN.

83 iomyomatosis (LAM) is a rare and progressive systemic disease affecting mainly young women of childbe

84 e for future studies investigating local and systemic diseases affecting human health.

85 CI, 0.2-0.9; P = 0.03) but was greater when systemic disease also was active at baseline (odds ratio

86 We report the associations with systemic disease and describe 3 stages of a CRF-related

87 ed with an H3N2 influenza virus succumbed to systemic disease and encephalitis after H5N1 virus chall

88 idence is emerging regarding the spectrum of systemic disease and illness harbored by infertile men w

89 bally important cause of gastroenteritis and systemic disease and is a useful tool to study immune re

90 shes that gingipains are crucially linked to systemic disease and potentially contribute to CVD.

91 s increasing with the improved management of systemic disease and prolongation of survival.

92 The analysis shows AVNFH to be a multi-systemic disease and provides molecular signatures that

93 volvement occurs in patients with aggressive systemic disease and usually portends a poor prognosis f

94 tients in whom uveitis was associated with a systemic disease and was not influenced by concomitant i

95 Subjects with no known systemic disease and without retinal pathology were incl

96 ive to Argentina and is associated with both systemic disease and, in some patients, neurological sym

97 o examine their relationship with ocular and systemic disease and, in some studies, to calculate the

98 ught to be associated with increased risk of systemic diseases and adverse pregnancy outcomes, includ

99 nto how its dysfunction contributes to multi-systemic diseases and cancer.

100 ht the complex relationship between CRVE and systemic diseases and conditions and the difficulty in d

101 The effect of periodontal infection on systemic diseases and conditions has been the subject of

102 associations between periodontal disease and systemic diseases and conditions specifically respirator

103 sociations between periodontitis and various systemic diseases and conditions, including chronic obst

104 sociations between periodontitis and various systemic diseases and conditions.

105 Periodontitis has been linked to over 50 systemic diseases and conditions.

106 events, which variously manifest within the systemic diseases and disorders discussed.

107 d diabetes mellitus, and 3 had no associated systemic diseases and exhibited no evidence of immune de

108 Various systemic diseases and medications have been associated w

109 idence for the possible relationship between systemic diseases and periodontitis.

110 mation in the oral cavity is associated with systemic diseases and that oral microbial DNA is isolate

111 s in tissue that have major implications for systemic diseases and their progression, while also layi

112 cal levels to the development of a number of systemic diseases and to the development of oral and gas

113 a; 371 had clinical stage I disease, 201 had systemic disease, and 46 had relapses.

114 ogic changes associated with functional use, systemic disease, and aging.

115 sence of hypertension, proteinuria (>1 g/d), systemic disease, and CKD stage (at referral) were asses

116 charts included gender, age at presentation, systemic disease, and clinical presentation in each eye.

117 CAR T-cell expansion, despite the absence of systemic disease, and early response assessments demonst

118 mediator symptoms, all with organomegaly had systemic disease, and none without organomegaly had syst

119 une status, CD4 cell counts, the presence of systemic disease, and the risk of CNS involvement or rel

120 d checkpoint inhibition for the treatment of systemic disease, and the significance of this was explo

121 merican participants aged 5 to 21 y, free of systemic diseases, and diagnosed with LAP.

122 inhibitors [MAOI]), age, sex, smoking, mild systemic diseases, and implant location were obtained fr

123 children with diverse cardiac, pulmonary, or systemic diseases, and therapeutic options are currently

124 were clinical features, associated ocular or systemic diseases, approach towards its management, and

125 All 3 systemic diseases are linked to a decrease in bacterial

126 ss likely to seek care for this multifaceted systemic disease as well as to be aware of reasons for n

127 rahepatic metastases, the notion of HCC as a systemic disease, as detected by imaging, may be reconsi

128 Systemic diseases associated with NAION included hyperte

129 st the involvement of periodontopathogens in systemic diseases associated with periodontal inflammati

130 us uveitic diseases are idiopathic, and most systemic diseases associated with uveitis also are idiop

131 elay in presentation, and follow-up period), systemic disease association (associated disease, potent

132 al inheritance pattern can be masked and the systemic disease associations can be variable or even ab

133 ty-three patients had concurrent undiagnosed systemic disease at presentation and 29 subsequently dev

134 similar in patients with "skin only" or with systemic disease at presentation.

135 t may also be involved in the development of systemic diseases (atherosclerosis, rheumatoid arthritis

136 95% CI, 0.32-0.86), patients with a moderate systemic disease burden (HR, 0.71; 95% CI, 0.69-0.72), a

137 es and within strata of age, gender, region, systemic disease burden, and in patients with versus wit

138 form of uveitis may occur in the absence of systemic disease but has not been reported to present wi

139 eterogeneous disorder that usually occurs in systemic diseases, but less commonly appears as nonsyste

140 Gut microbiota profoundly affect gut and systemic diseases, but the mechanism whereby microbiota

141 wed that gut microbiota remotely regulated a systemic disease by driving the induction and egress of

142 c diseases such as inflammation and of other systemic diseases can also be envisioned.

143 However, certain systemic diseases can cause chronic pruritus, which has

144 Whipple's disease is a rare systemic disease caused by a gram-positive bacillus call

145 trophy (dystrophia myotonica, DM) is a multi-systemic disease caused by expanded CTG or CCTG microsat

146 Together, these data demonstrate that systemic diseases characterized by enhanced inflammation

147 ent cataract surgery without other ocular or systemic disease comprised the controls.

148 ociated with several cardiac, pulmonary, and systemic diseases contributing to morbidity and mortalit

149 d FAZ topography in patients with retinal or systemic disease could negatively impact the accuracy an

150 Systemic diseases, dental use, or smoking were not expla

151 to isolated vision loss or life-threatening systemic disease, depending on a mutation's severity.

152 excluded people with a history of ocular or systemic disease (diabetes or neurodegenerative diseases

153 Scleritis preceded systemic disease diagnosis in 38.7% of patients.

154 and duration, treatment history, associated systemic diseases, diagnostic procedures performed, and

155 ortant biological process, especially in the systemic disease diagnostics and therapeutics, yet the p

156 -cell lymphomas (ALCLs) encompass at least 2 systemic diseases distinguished by the presence or absen

157 da in the early 1990s, an epidemic of severe systemic disease due to PCV2 spread worldwide in the ens

158 Systemic disease due to shigellae is associated with hum

159 HS069Deltacap was unable to cause signs of systemic disease during a pig challenge study and had in

160 e investigated the role of PLA2 in local and systemic disease during S. pneumoniae infection.

161 e majority developed none to mild additional systemic disease during the study period.

162 disease and any associated often-undiagnosed systemic disease (e.g., Sjogren syndrome).

163 on health history, including the presence of systemic diseases (e.g., hypertension, cancer, or immuno

164 lly selected patients without extrapulmonary systemic disease experience similar survival after lung

165 It contrasts with the pathogenesis of systemic disease from the same virus following entry via

166 s with idiopathic dry eye and no evidence of systemic diseases from a dry eye practice have these aut

167 omy were performed in 424 patients; 118 with systemic disease had serial measurements during treatmen

168 of salivary biomarkers for the detection of systemic diseases has been undermined due to the absence

169 unately, the targeted therapies that control systemic disease have diminished efficacy against brain

170 pared with glaucoma secondary to nonacquired systemic diseases (hazard ratio [HR], 12; P = 0.0063), n

171 wo patients showed improvement in ocular and systemic disease, however one of them developed a choroi

172 ch cognitive abnormalities are a function of systemic disease, impaired hepatic function, or virus in

173 eal findings were the first manifestation of systemic disease in 4 patients, and the diagnosis was no

174 gangrenosum is associated with a concomitant systemic disease in 50 to 70 % of cases, including infla

175 ) pathway markedly improves neurological and systemic disease in a mouse model of GD.

176 These studies paint AD as a systemic disease in broad strokes, which may help elucid

177 astomyces helicus causes fatal pulmonary and systemic disease in humans and companion animals.

178 Ebola virus (EBOV) causes severe systemic disease in humans and non-human primates charac

179 Head smut is a systemic disease in maize caused by the soil-borne fungu

180 associated with a severe, potentially fatal, systemic disease in man and great apes.

181 gastroenteritis in humans and a typhoid-like systemic disease in mice.

182 of a neuromuscular condition or as part of a systemic disease in over 400 Mendelian conditions.

183 lbicans is a commensal fungus that can cause systemic disease in patients with breaches in mucosal in

184 cherichia coli (APEC) causes respiratory and systemic disease in poultry.

185 ogen Listeria monocytogenes causes foodborne systemic disease in pregnant women, which can lead to pr

186 radation correlates with host adaptation and systemic disease in Salmonella.

187 es self-resolving diarrhea in the absence of systemic disease in wild-type neonatal mice, thus mirror

188 lla enterica cause both gastrointestinal and systemic diseases in a broad range of mammalian hosts, i

189 ociated with diverse cardiac, pulmonary, and systemic diseases in neonates, infants, and older childr

190 In contrast, systemic disease, in the form of unrestrained lymphoprol

191 d-borne illness and can cause intestinal and systemic disease, including severe renal damage.

192 The association between periodontitis and systemic diseases, including cardiovascular diseases and

193 Oral streptococci have been associated with systemic diseases, including infective endocarditis and

194 Several systemic diseases, including thrombotic thrombocytopenic

195 stically the sophisticated interplay between systemic disease 'initiators' and joint-specific 'locali

196 ore extensive skin inflammation and a severe systemic disease involving infiltration of myeloid cells

197 c diseases worldwide, is complex, as it is a systemic disease involving multiple parasitic stages and

198 ough IL-1R, instigates skin inflammation and systemic disease is not known.

199 but the mechanism whereby microbiota affect systemic diseases is unclear.

200 lthough this supports the notion of AMD as a systemic disease, it also suggests that the adaptive imm

201 In addition to systemic disease, it is thought to contribute to oral di

202 Although atherosclerosis is a systemic disease, its burden varies considerably across

203 In patients with progressive systemic disease, limited treatment options, and poor pe

204 as a framework for consideration of the oral-systemic diseases link.

205 l visual loss or rapid progression of latent systemic disease, making early diagnosis important.

206 diffuse or nodular scleritis with associated systemic disease may respond to IMT or BRMs.

207 the eye; none of the patients developed new systemic disease (median follow-up, 30.3 months).

208 utic treatments as well as several ocular or systemic diseases might induce changes in the mechanical

209 growing interest in salivary biomarkers for systemic diseases, notably cardiovascular disease.

210 Systemic disease occurred more commonly in older patient

211 es (demographic and environmental variables, systemic diseases, ocular traits, and medications).

212 the causative agent of Glasser's disease, a systemic disease of pigs, and is also associated with pn

213 Viruses that cause systemic disease often spread through the bloodstream to

214 mework in which AD may be viewed either as a systemic disease or as a metastatic disorder leading to

215 cularly when inflammation is associated with systemic disease or when bilateral ocular disease is pre

216 diffuse or nodular scleritis with associated systemic disease (OR = 1.57, P = 0.047), mainly potentia

217 osterior maxilla location (OR = 2.911), mild systemic disease (OR = 2.648), and age (OR = 1.037) (P <

218 diffuse or nodular scleritis with associated systemic disease (OR = 3.15, P < 0.001).

219 thout baseline hypertension, proteinuria, or systemic disease (OR, 1.88; 95% CI, 1.27 to 2.79).

220 confidence interval [95% CI], 1.87 to 6.21), systemic disease (OR, 3.13; 95% CI, 1.51 to 6.50), and p

221 Epidemiologic factors, systemic diseases, other ocular pathologic characteristi

222 etween the gut and systemic sites alters the systemic disease outcome.

223 fect of nonsurgical periodontal treatment on systemic disease outcomes.

224 r nonsurgical periodontal treatment improves systemic disease outcomes.

225 ting with solely orbital GPA developed later systemic disease over a median follow-up of 2.7 years.

226 It normally causes localized or disseminated systemic diseases, particularly skin infections and arth

227 tanding the contribution of IFNs to skin and systemic disease pathogenesis is key to development of n

228 (MCI), and MBL and 2) to assess how various systemic diseases, periodontitis, and placement of impla

229 Exclusion criteria were severe systemic disease, pregnancy, contraindications to MRI, o

230 Exclusion criteria were severe systemic disease, pregnancy, contraindications to MRI, o

231 The frequency of hospital admission with systemic disease preinjury and postinjury was higher in

232 s cause CRS, are promoted by CRS, or share a systemic disease process with CRS.

233 Shared risk factors and/or common systemic disease processes might underlie this associati

234 nset of other diseases or is an indicator of systemic disease processes.

235 metastasis form HCC has been considered as a systemic disease, prognosis after resection of them rema

236 D patients affected by glomerulonephritis or systemic diseases ("progressive CKD") are compared with

237 these infections in the aetiology of several systemic diseases, ranging from arthritis to neurodegene

238 o this in the context of cancer as a complex systemic disease, rather than as a simple linearly progr

239 Two of these patients had systemic disease recurrence involving the primary malign

240 The premise for the oral-systemic diseases relationship dates to the early 20th c

241 tive care, the mortality associated with the systemic disease remains high.

242 ection between biotin, lysine metabolism and systemic disease resistance signaling.

243 RS-CoV-2 is present in CSF may depend on the systemic disease severity and the degree of the virus' n

244 Patients with systemic disease showed a trend toward an increased risk

245 whether an association exists between common systemic diseases, sociodemographic factors, and keratoc

246 peripheral neuropathy associated with other systemic diseases), sometimes at the stages at which the

247 d is seen in hepatitis C virus infection and systemic diseases such as B-cell lineage hematologic mal

248 Bone fracture healing impairment related to systemic diseases such as diabetes can be addressed by g

249 sideration the aging population and emerging systemic diseases such as diabetes mellitus and hyperten

250 DR, DMO and RVO, indicating need to control systemic diseases such as diabetes, hypertension, and dy

251 Systemic diseases such as diabetes, rheumatoid arthritis

252 be readily detected upon the development of systemic diseases such as pancreatic cancer, breast canc

253 s or neuromyelitis optica spectrum disorder; systemic diseases such as systemic lupus erythematosus,

254 In addition, all patients showed signs of systemic disease, such as arthritis, lymphopenia, or ant

255 f a gingipain inhibitor (KYT) on Pg-mediated systemic disease, suggesting its potential use therapeut

256 al GPA involvement at presentation developed systemic disease, suggesting that orbital GPA can remain

257 reduce risks for a variety of age-associated systemic diseases, suggesting that such drugs might also

258 lation between toxemia and the occurrence of systemic disease, supporting the hypothesis that systemi

259 Although systemic diseases take the biggest toll on human health

260 phoidal Salmonella serovars causes a febrile systemic disease, termed enteric fever.

261 he overt muscle loss and at this entity as a systemic disease that affects muscles of vital organs in

262 Diabetes mellitus is a systemic disease that increases the risk of infections.

263 aortic stenosis is a complex, multifaceted, systemic disease that is not solely limited to the aorti

264 An emerging view is that breast cancer is a systemic disease that utilizes intrinsic and extrinsic t

265 an infection (which will alter therapy) or a systemic disease that will affect the patient's health.

266 It will also discuss common systemic diseases that manifest in the shoulder as well

267 al process (the "high-risk plaque") and as a systemic disease (the "high-risk patient").

268 ed IL10 microparticles ameliorates local and systemic disease to enhance survival.

269 matic mosaicism are at risk for transmitting systemic disease to their offspring, and all individuals

270 Salmonella enterica serovar Typhi causes the systemic disease typhoid fever.

271 Salmonella enterica causes systemic diseases (typhoid and paratyphoid fever), nonty

272 nd as such are capable of inducing local and systemic disease under specific colonization circumstanc

273 Severity of ocular surface and systemic disease was graded.

274 Underlying systemic disease was identified in 34 (32.7%) patients.

275 The severity of SS ocular and systemic disease was inversely correlated with microbial

276 ) criteria was used to evaluate CNS disease; systemic disease was not required for participation.

277 Lymph-node involvement, as a marker of systemic disease, was also significant on univariate ana

278 s relevant to cutaneous lupus as compared to systemic disease, we generated genome-wide expression da

279 versus infliximab), and inactive concomitant systemic disease were associated with a lower risk of tr

280 associated uveitis, keratitis, glaucoma, or systemic disease were documented over the follow-up peri

281 ious ocular surgery, and/or a high burden of systemic disease were identified as common risk factors.

282 onic periodontitis (CP) (n = 15) without any systemic disease were included in the study.

283 CARD14(E138A)-induced skin inflammation and systemic disease were independent of adaptive immune cel

284 Systemic diseases were common (diabetes: 5.8%; cardiovas

285 ata, clinical manifestations, and associated systemic diseases were recorded.

286 tiglaucoma agents, and those with ocular and systemic diseases were susceptible to further hospitaliz

287 loidosis (ATTR), which is an underrecognized systemic disease whereby the transthyretin protein misfo

288 coccus agalactiae, are an important cause of systemic disease, which is facilitated in part by the pr

289 dry eye disease and rheumatoid arthritis, a systemic disease with a known association with dry eye,

290 These findings suggest that VEDS is a systemic disease with a major inflammatory component.

291 Coronary heart disease is a chronic, systemic disease with a wide range of associated symptom

292 from the mucosal surface, S. aureus produces systemic disease with accompanying morbidity and mortali

293 FMD allowed us to demonstrate that FMD is a systemic disease with alterations in common with the spe

294 patients with HVLPD were less likely to have systemic disease with EBV and had a much better prognosi

295 genus, Iridoviridae family, causing a severe systemic disease with high mortality in mandarin fish (S

296 rbidities, atopic dermatitis (AD) emerges as systemic disease with increased cardiovascular risk.

297 Sepsis is a life-threatening systemic disease with severe microvascular dysfunction.

298 ariants had a significantly higher burden of systemic disease (with earlier onset of dystonia) than t

299 tered only anti-TcdA developed severe GI and systemic disease, with 67%-83% fatality, faring worse th

300 uld be used to selectively target S. suis in systemic disease without interfering with commensal stra