ライフサイエンスコーパス: systemic effect

1 on induced a local host response with little systemic effect.

2 rfactant and the lidocaine derivative, not a systemic effect.

3 or VMH under normoglycemic conditions had no systemic effect.

4 25 days), suggesting that topical VEGF had a systemic effect.

5 sms and evoke a host response could elicit a systemic effect.

6 ions was the best outcome variable to assess systemic effect.

7 r crypt-restricted level with no discernable systemic effect.

8 g leukocytes, suggesting a local rather than systemic effect.

9 e requirement of an intact pituitary for the systemic effect.

10 icular (i.a.) administration, and it induces systemic effects.

11 the skin, whereas others are not, indicating systemic effects.

12 asis, which in turn translates positively to systemic effects.

13 that affect inflammation with both local and systemic effects.

14 pproach to treating obesity while minimizing systemic effects.

15 ssive, bilateral conditions that do not have systemic effects.

16 a dose (4.6 mug) that was too low to produce systemic effects.

17 efficacy as oral propranolol while reducing systemic effects.

18 ectin can exert such a variety of beneficial systemic effects.

19 ffectors outside the treatment field and has systemic effects.

20 O by systemic delivery is low with potential systemic effects.

21 y be useful for tissue repair and minimizing systemic effects.

22 properties but exhibits significant adverse systemic effects.

23 pressures without any adverse cardiovascular systemic effects.

24 ile minimizing the confounding influences of systemic effects.

25 f the potential for local destruction and/or systemic effects.

26 ow by 24+/-4% (n=8, P<0.001) without causing systemic effects.

27 ripheral muscular insulin resistance through systemic effects.

28 stoperatively, with no signs of tolerance or systemic effects.

29 nged use is not associated with tolerance or systemic effects.

30 Thus, catecholamines may have both local and systemic effects.

31 ioplasty in pigs without causing significant systemic effects.

32 and was well tolerated, with no evidence of systemic effects.

33 onse that differ depending upon the local or systemic effects.

34 nist can cause coronary vasodilation without systemic effects.

35 e propionate are mediated through topical or systemic effects.

36 topical effects in the lungs and not through systemic effects.

37 otent pulmonary vasodilator without apparent systemic effects.

38 tissue-specific effect rather than to other systemic effects.

39 ne the role of the cortex in mediating their systemic effects.

40 r release into the circulation may also have systemic effects.

41 to the left main coronary artery to minimize systemic effects.

42 ecessary to see more pronounced clinical and systemic effects.

43 aging is the immune system, which has broad systemic effects.

44 n the epidermal layers of skin, can generate systemic effects.

45 thies after OQ treatment, suggesting adverse systemic effects.

46 the production of metabolites that can have systemic effects.

47 ghlights direct human exposure and potential systemic effects.

48 he E2F loss exerts both tissue-intrinsic and systemic effects.

49 benefits of IL-12 are achieved with minimal systemic effects.

50 also raises the question of potential wider systemic effects.

51 ages to release potent mediators, leading to systemic effects.

52 etreatment, and the possibility of long-term systemic effects.

53 f variable severity with little or no direct systemic effects.

54 reduce the risk of radiation-related adverse systemic effects.

55 acute inflammation and determine beneficial systemic effects.

56 cell-mediated cytotoxic immune response with systemic effects.

57 the impact on liver parenchyma and avoiding systemic effects.

58 t rejection is not long lasting and can have systemic effects.

59 er growth and progression locally or through systemic effects.

60 Exercise has a wide range of systemic effects.

61 cells, or a heightened immune reaction with systemic effects.

62 , extracellular dsRNA induces both local and systemic effects.

63 te in the skin and require the pituitary for systemic effects.

64 ic full dose administration but with minimal systemic effects.

65 triglyceride and VAT may be because of toxic systemic effects.

66 ces can cause these effects along with other systemic effects.

67 cardiovascular disease prevention, but their systemic effects across lipoprotein subclasses, fatty ac

68 Here, we present supportive evidence on systemic effects after (211)At administration.

69 e (10 mg/kg) caused lung inflammation but no systemic effects after 6 h of ventilation.

70 timulate antitumor immunity in situ to exert systemic effects against distant tumors.

71 than to HH tissues, reflecting a colony-wide systemic effect and provides insight into the metabolic

72 umulating evidence indicates that asthma has systemic effects and affects brain function.

73 n the cardiovascular system result from both systemic effects and direct actions of the hormone on th

74 te its widespread use, little is known about systemic effects and kinetics associated to SLIT, as wel

75 should aid the further understanding of the systemic effects and neurological complications of viral

76 ponse in relation to baseline, adjusting for systemic effects and skewed data, we expressed the hyper

77 anisms of action, efficacy, adverse effects, systemic effects, and comparisons with standard treatmen

78 questions have arisen about their local and systemic effects, and their effects upon the optic nerve

79 There is increasing evidence that leptin has systemic effects apart from those related to energy home

80 Both local and systemic effects are likely to contribute to the develop

81 medications suppress arrhythmias, but their systemic effects are often poorly tolerated and their pr

82 a 3-D tissue architecture while eliminating systemic effects as can be seen with in vivo models.

83 for 2 hours is below the threshold for acute systemic effects as detected by these endpoints.

84 2D-regulating hormone FGF23, and the broader systemic effects associated with abnormalities of calciu

85 on has significant systemic effects, but the systemic effects associated with ventilator-induced lung

86 e endotoxin-exposed preterm lung resulted in systemic effects at a low endotoxin dose and without hig

87 hildren may be at a greater risk for adverse systemic effects because they can receive higher mg/kg d

88 In parallel, as cancer grows, it induces systemic effects beyond the primary tumour site and affe

89 Such agents, having negligible systemic effects but active at sites of inflammation, re

90 -activated CD4(+) T lymphocytes had positive systemic effect, but failed to improve control of tuberc

91 ssure mechanical ventilation has significant systemic effects, but the systemic effects associated wi

92 greater patient compliance and less adverse systemic effects, but there are still significant issues

93 To assess whether this is a local or a systemic effect, C57BL/6 mice were infected simultaneous

94 iver and plasma, providing insights into the systemic effects caused by early decline in beta-cells.

95 se locally induced responses may also have a systemic effect, clearing additional tumors throughout t

96 balance between local effects increasing and systemic effects decreasing insulin action.

97 and generalized) associated with nonspecific systemic effects, diaphoresis, and less commonly other a

98 fying mechanism of action for the beneficial systemic effects exerted by adiponectin, with sphingolip

99 d new inhalers also affect the potential for systemic effects following inhaled administration.

100 dothelial cells also contributes to unwanted systemic effects from IL-2 therapy.

101 ulation should be aware of potential serious systemic effects from ophthalmic use of the drug and be

102 The systemic effects from the excessive use of alcohol incre

103 ce of disease and unknown adverse ocular and systemic effects have caused concern from some clinician

104 In addition to potential systemic effects, IL-17 is expressed locally in AT by le

105 dolent cells, these activated BMCs mimic the systemic effects imparted by instigating tumors.

106 ced local IFN-I responses and did not induce systemic effects, implying good tolerability and a favor

107 ogeneic islet transplantation had a positive systemic effect in diabetic rats and induced regression

108 Spider bites cause fewer systemic effects in children than adults.

109 summary, Plin4 deficiency results in subtle systemic effects in diet-obese mice, affecting hepatic l

110 ation settings induced pronounced persistent systemic effects in mice, which resulted from even short

111 tissue destruction and/or of importance for systemic effects in other tissues or organs.

112 heel running resulted in multiple beneficial systemic effects in rats with CKD and improved their phy

113 i.a. injection of HA-sCT did not trigger any systemic effects in rats.

114 ronavirus 2 (SARS-CoV-2) has pleiotropic and systemic effects in some individuals(1-3), many others e

115 Systemic effects include transient volume expansion, nat

116 energy imbalance frequently associated with systemic effects including insulin resistance, altered h

117 e may be related to paracrine properties and systemic effects, including anti-inflammatory activities

118 nhances Ca2+ and Mg2+ excretion and leads to systemic effects, including bone loss.

119 hese local changes of IRE induce more robust systemic effects, including both tumorigenic and immunog

120 These treatments also displayed systemic effects, including reversal of the tumor-induce

121 flammatory reactions may lead to detrimental systemic effects, including septic shock and autoimmunit

122 le-specific genetic interventions can induce systemic effects indirectly, via changes in the mass and

123 Systemic effects induced by DEX and CLEN + DEX but not C

124 mental stimulus to skin results in local and systemic effects is an area of active research.

125 ent on both dose and duration; the degree of systemic effects is dependent on pharmacokinetic propert

126 However, better understanding of systemic effects is essential in unraveling key molecula

127 However, knowledge of systemic effects is still rudimentary.

128 ce that the neuropeptide SP, among its broad systemic effects, is a potent neuroimmunoregulator that

129 New therapeutic strategies with global systemic effects may offer advances in treatment and out

130 cantly higher in patients on treatments with systemic effects/mental health diagnoses than in control

131 and can cause severe skin lesions and rarely systemic effects; most bites are unremarkable.

132 In addition to its systemic effects, obesity causes subclinical white adipo

133 Adverse systemic effects occurred in 9 of 40 (23%) patients rece

134 A decrease in splenic weight (evidence of a systemic effect) occurred at all doses of budesonide.

135 ese prefrontal regions alone may mediate the systemic effect of ADHD medications on impulsive choice.

136 nt in the sexual dimorphism, we examined the systemic effect of IL-17 by genetically ablating Il-17 i

137 parasite-induced protection was not due to a systemic effect of infection on autoimmunity as previous

138 Pharmacodynamic assessment of the systemic effect of inhaled corticosteroids (ICSs) is oft

139 tokine levels were assessed to determine the systemic effect of locally delivered VEGF and showed sim

140 Higher circulatory HGF levels indicate a systemic effect of periodontitis.

141 To date, few studies have characterized the systemic effect of sepsis on DC populations in lymphoid

142 ion, and this appears to be unrelated to any systemic effect of the treatment regimen.

143 using several murine tumors, we examined the systemic effects of 4-1BB mAb on the growth of s.c., int

144 RPV1 to OA-related pain, we investigated the systemic effects of a selective TRPV1 receptor antagonis

145 a method to examine directly the deleterious systemic effects of absent renal clearance in ARF withou

146 However, the systemic effects of adiponectin in humans are unknown.

147 Potential systemic effects of alcohol relapse were assessed by cha

148 Systemic effects of anesthesia on the dynamics of the ap

149 The devastating systemic effects of bacterial superantigens may be expla

150 hanisms of tumorigenesis with both local and systemic effects of cancer.

151 bloodstream infection at removal; local and systemic effects of catheters were assessed.

152 g in the hippocampus could contribute to the systemic effects of cholinergic drugs, we infused physos

153 blood substitutes have been appreciated, the systemic effects of chronic hemolysis on nitric oxide bi

154 In addition to the systemic effects of cigarette smoking, ocular effects ar

155 rmalities on arrhythmias without the complex systemic effects of diabetes mellitus and obesity, we st

156 ioxin, we design the template to capture the systemic effects of dioxin on the body's handling of cho

157 In Group 2 we measured the pulmonary and systemic effects of dipyridamole while the patients were

158 n shown to cause forearm vasodilatation, the systemic effects of endothelin receptor blockade in heal

159 inical and clinical studies will examine the systemic effects of endurance and resistance exercise ac

160 rs are hypothesized to transduce some of the systemic effects of exercise.

161 nt glucocerebrosidase (GCase) ameliorate the systemic effects of GD, the lack of efficacy for the neu

162 peritoneal cavity and lung, consistent with systemic effects of HpBARI.

163 acteristics of the individual drug influence systemic effects of ICS.

164 a more sensitive pharmacodynamic measure of systemic effects of ICSs than 24-hour UFC excretion and

165 n the circulation to prevent the deleterious systemic effects of Il-18.

166 The present study results link the systemic effects of induced periodontitis with changes i

167 xistence of a gut-muscle axis, mediating the systemic effects of intestinal dysbiosis on skeletal mus

168 tudy validates a new tool to study local and systemic effects of leukocytes in pancreatitis as well a

169 NMES is an effective tool to investigate the systemic effects of local muscle strengthening.

170 ral, untreated joints, indicating beneficial systemic effects of local suppression of NF-kappaB.

171 these findings were not attributable to the systemic effects of medications or the postoperative sta

172 pite recent advances in understanding of the systemic effects of methylglyoxal, the full significance

173 In this study, to understand the long-term systemic effects of non-severe burns in children, target

174 Gauging the systemic effects of non-synonymous single nucleotide pol

175 h the role of hepatocyte NAD levels from any systemic effects of NR, we generated mice overexpressing

176 tructure and function are independent of the systemic effects of obesity and visceral adiposity has n

177 These results suggest that the systemic effects of obesity on cardiac structure and fun

178 will be imperative to clinically address the systemic effects of PD in people with obesity.

179 be potential intervention targets to prevent systemic effects of periodontal disease if further studi

180 s both the local inflammation as well as the systemic effects of periodontal disease might be a more

181 current knowledge regarding the deleterious systemic effects of phosphate and FGF23 excess, identifi

182 s technologies provide new insights into the systemic effects of physical activity, including the int

183 mor effects of antibodies and reduce adverse systemic effects of potent cytotoxic drugs.

184 of PPARalpha in vivo can be masked by other systemic effects of PPARalpha activators.

185 ing of the pathogenesis of psoriasis and the systemic effects of psoriatic inflammation has allowed f

186 l mice, which may contribute to the observed systemic effects of PT.

187 rradiation of multiple tumors might optimize systemic effects of radiotherapy.

188 nd prevention of CRC; and, further, that the systemic effects of resistant starch may be important fo

189 We evaluated the systemic effects of SLIT in a longitudinal analysis of h

190 3-/- phenotype may be, in part, secondary to systemic effects of Smad3 deletion.

191 inhibition had no effect on the coronary and systemic effects of SNP and adenosine.

192 Here, we examined the systemic effects of spaceflight and fracture surgery/hea

193 he need to further investigate the potential systemic effects of specific 5-HT(2A)R agonists, such as

194 he current study, we evaluated the local and systemic effects of staphylococcal enterotoxin B (SEB) a

195 To gain more insight into the systemic effects of such cellular search precision modul

196 thway analyses were performed to predict the systemic effects of the altered metagenome and metabolit

197 actions could be attributed to local and not systemic effects of the antagonists.

198 h a number of biochemical changes indicating systemic effects of the cancer.

199 pendent monitoring of both the localized and systemic effects of the disease.

200 ntralesional therapy is used to minimize the systemic effects of the drug.

201 Life-threatening intestinal and systemic effects of the Shiga toxins produced by enteroh

202 well investigated, little is known about the systemic effects of the stress response mechanism.

203 portunity to mechanistically investigate the systemic effects of the surgical interventions, such as

204 (MC5-R), suggested non-steroidally mediated systemic effects of these peptides.

205 To more fully assess the systemic effects of this primary virus infection, specim

206 NF-alpha synthesis and limits TNFRI-mediated systemic effects of TNF-alpha originating in the lung.

207 With respect to systemic effects of topical ocular medications, there wa

208 tudies investigating the pathophysiology and systemic effects of transient hyperglycemia in nondiabet

209 ey might provide the possibility to evaluate systemic effects of treatments.

210 In this Review, we discuss systemic effects of tumorigenesis that are now being app

211 Purpose To compare both periablational and systemic effects of two mechanistically different types

212 roves that CPB is a major contributor to the systemic effects of type C infections and provides new m

213 The role of Rho-kinase in the renal and systemic effects of vasopressin was investigated through

214 Here, we discuss the local and systemic effects of VEGF on tumor immunity and propose a

215 Methods of limiting visceral ischemia or the systemic effects of visceral ischemia may decrease both

216 The importance of nontargeted (systemic) effects of ionizing radiation is attracting in

217 administered CAR enhanced pulmonary, but not systemic, effects of the vasodilators, fasudil and imati

218 To avoid secondary systemic effects often associated with embryonic gene de

219 ects on bone resorption and only a transient systemic effect on bone formation.

220 cemia in SCHAD CHI can be uncoupled from the systemic effect on fatty acid oxidation.

221 fferences in bacterial burdens, indicating a systemic effect on host innate immunity from production

222 irectly and autonomously, in addition to its systemic effect on lifespan.

223 ulation, causing a localized response and/or systemic effect on phloem transportation.

224 al effects in the arterial wall as well as a systemic effect on plasma lipoproteins.

225 488 injections partially mimicked the drug's systemic effect on reinstatement.

226 leaves (i.e. local effects), but they had no systemic effect on rust of leaves not inoculated with en

227 indicate that tumor cells exert an aberrant systemic effect on the bone marrow microenvironment and

228 The results indicate a tumor systemic effect on the elemental profiles of both serum

229 Induction of IL-2 had no systemic effect on the frequency or activational status

230 a models, suggesting that cancers, through a systemic effect on the host, can induce an increase in p

231 e potential of the skin microbiome to have a systemic effect on the human body.

232 This demonstrates long-term systemic effect on the regulatory immune system that was

233 till know little about ovarian aging and its systemic effects on aging trajectories.

234 nses to cockroach allergen challenge despite systemic effects on allergen-specific skin tests, induct

235 Because this pancreatic peptide has systemic effects on bone resorption and blood ionized ca

236 dipogenesis by bone marrow stromal cells and systemic effects on bone resorption.

237 les and metabolites that have both local and systemic effects on cancer onset, progression and therap

238 xamined whether psoriasis is associated with systemic effects on epidermal Langerhans cell (LC) funct

239 mune response to chronic viral infection has systemic effects on epithelial turnover through a myeloi

240 amine (DA) agonists were evaluated for their systemic effects on firing rates of DA neurons in rat su

241 metabolism in order to reveal its local and systemic effects on host health and aging.

242 actions at the mucosal interface have broad, systemic effects on host immunity and the development of

243 ila, an intestinal bacterium associated with systemic effects on host metabolism and PD-1 checkpoint

244 a has been robustly associated with positive systemic effects on host metabolism, favourable outcomes

245 n addition, vitamin D has been shown to have systemic effects on insulin resistance, dyslipidemia, an

246 between local effects in the artery wall and systemic effects on lipid metabolism.

247 Lebrikizumab exerted systemic effects on markers of Th2 inflammation, reducin

248 ave been linked to chronic lung diseases and systemic effects on multiple organs.

249 contraindicated for obesity treatment due to systemic effects on multiple organs.

250 ead to altered exposure to Notch signals and systemic effects on neurogenesis in the retina.

251 tohormone in plant-microbe interactions with systemic effects on resistance and susceptibility.

252 Systemic effects on skeletal muscle and the heart and in

253 t discovery is that food antigens have major systemic effects on T cells, similar in many ways to tho

254 patients treated with AMG319, suggestive of systemic effects on T(reg) cells.

255 ynovium, suggesting the T cells may have had systemic effects on the B cell response as well as local

256 Major stress has systemic effects on the body that can have adverse conse

257 olized EPI-2010 did not have any significant systemic effects on the cardiovascular system as determi

258 peripheral injection of alpha-syn has acute systemic effects on the central nervous system such that

259 late in the bloodstream, where they can have systemic effects on the host.

260 periodontitis and damage caused through its systemic effects on the liver.

261 al or processive), rather than to any direct systemic effects (pain, blood loss, infection, etc.) of

262 hough most studies focus on the influence of systemic effects, recent studies indicate that ultrafine

263 travitreal anti-CCR3 antibody yielded strong systemic effects, reducing CNV in the untreated, contral

264 role for the immune system in both local and systemic effects resulting from HSV-tk treatment, the ca

265 e results suggest potentially more important systemic effects.See related article by Murphy et al., p

266 lated under various conditions to illustrate systemic effects such as catabolite repression, the aero

267 Systemic effects, such as myocarditis and neuropathy, wh

268 ates BAT energy expenditure with fewer other systemic effects, suggesting that cold activates specifi

269 In addition to its systemic effects, TGF-beta regulates infiltration of inf

270 in human lung S9 fraction, showed much lower systemic effects than budesonide in the thymus involutio

271 lic deactivation and may have less prolonged systemic effects than other compounds with arotinoid-lik

272 of L. donovani by infected hosts, owing to a systemic effect that exposure to bites has on the parasi

273 Local radiation also triggers systemic effects that can be used in combination with im

274 expressed in the red blood cell, leading to systemic effects that exacerbate the intrinsic anemia in

275 at air pollution components reach the brain; systemic effects that impact lung and cardiovascular dis

276 mone epinephrine is known to elicit multiple systemic effects that include changes in cardiovascular

277 study suggests that 5113 treatment provides systemic effects that involve metabolic and regulatory f

278 can causally induce long-lasting beneficial systemic effects that lead to life span extension in a v

279 lysosomes of macrophages in the lesions; (2) systemic effects that mediate the liver to reduce the he

280 Therefore, to control for these systemic effects, the current studies utilized microinje

281 The microbiome exerts its systemic effect through a diverse range of metabolites,

282 which UV-induced DNA damage in the skin has systemic effects throughout the body are not clear.

283 icular injection of insulin led to a greater systemic effect to improve glucose tolerance and insulin

284 ing VEGFA into the cerebrospinal fluid for a systemic effect, VEGFA was released along the parenchyma

285 immunostimulatory DNA sequences likely exert systemic effects via IL-12 and IFN-gamma-dependent mecha

286 In addition, bacterial ATP has systemic effects via its transport in outer membrane ves

287 ere no significant differences in markers of systemic effects (vital signs, potassium, and blood gluc

288 in diverse syngeneic cancer models, and the systemic effect was dependent on the injected tumor, ind

289 Systemic effect was evaluated by hourly plasma cortisol

290 The contribution of local versus systemic effects was evaluated using hemibody (left vers

291 To overcome treatment evasion and reduce systemic effects, we developed CXCR4-targeted nanopartic

292 To model systemic effects, we used the human monocytic cell line

293 Systemic effects were also observed, including diarrhea,

294 No considerable systemic effects were observed with epinephrine treatmen

295 No serious adverse events or systemic effects were observed.

296 Systemic effects were then assessed by comparing tumor f

297 duce cancer cell apoptosis but cause adverse systemic effects when administered to mice.

298 chondria of tumor cells, or through indirect systemic effects, which remain to be identified.

299 To avoid these systemic effects while stimulating glucagon-like peptide

300 delivery of drugs to the skin for local and systemic effects without the need for hypodermic needles