ライフサイエンスコーパス: systemically

1 state of inflammation that acts locally and systemically.

2 grade chronic inflammation, both locally and systemically.

3 dividual variation in DNA methylation occurs systemically.

4 eration, tissue macrophage numbers increased systemically.

5 the spleen, from where it spread rapidly and systemically.

6 t would otherwise be too toxic to administer systemically.

7 The vector was delivered systemically.

8 al homeostasis both within local tissues and systemically.

9 s significant clinical toxicities when given systemically.

10 nistration, restoring normal gene expression systemically.

11 act locally and adaptive cells that function systemically.

12 functions locally, at the barrier level, and systemically.

13 siderin iron accumulation-both in tumors and systemically.

14 CA-induced pain in rodents when administered systemically.

15 nsplantation demonstrated no evidence of TLN systemically.

16 ght chain (LC), which affects organ function systemically.

17 in the host both locally in the airways and systemically.

18 to dose-limiting toxicity when administered systemically.

19 secondary T cell response, both locally and systemically.

20 cause severe infection both in the pulp and systemically.

21 ver nonmuscle myosin II (NMII) in the BLA or systemically.

22 kout) mice to induce overexpression of IL-23 systemically.

23 o the lack of carriers that can deliver RNPs systemically.

24 d in 4 different sunscreen formulations were systemically absorbed and had plasma concentrations that

25 s a MOR agonist/DOR antagonist that produced systemically active potent antinociceptive activity in t

26 ly relevant human monoclonal antibodies were systemically administered after acute SCI, and were dete

27 onging circulation and improving delivery of systemically administered agents, we sought to evaluate

28 tratumorally to present a priming signal for systemically administered AND-gate CAR-T cells.

29 Systemically administered antisense oligonucleotide (ASO

30 We previously demonstrated that systemically administered autologous macrophages transfe

31 important implications for studies involving systemically administered cell therapies.

32 Systemically administered chemotherapeutic drugs are oft

33 Next, we demonstrated that the systemically administered CpG-C is taken up by endotheli

34 Off-target effects of systemically administered drugs have been a major hurdle

35 atrix of this tissue make it challenging for systemically administered drugs to reach their target ce

36 Systemically administered EDHB and its active metabolite

37 anslational research on the potential use of systemically administered epigenetic enzyme inhibitors f

38 Immunohistochemical data show that a systemically administered fluorescent GLP-1R agonist acc

39 Biodistribution studies revealed that systemically administered GAd had a selective and robust

40 Systemically administered IL-1 receptor antagonist (IL-1

41 overcoming the low homing efficiency of MSCs systemically administered in inflammatory bowel diseases

42 We previously demonstrated that systemically administered macrophages deliver therapeuti

43 ocused ultrasound (FUS), in conjunction with systemically administered microbubbles, opens the BBB lo

44 Remarkably, systemically administered morphine potently inhibited ac

45 Understanding of the mechanisms by which systemically administered nanoparticles achieve delivery

46 This potent antitumor effect of systemically administered oAd/RLX-PCDP-treated hMSCs was

47 esic systems are complex, and the actions of systemically administered opioids may be mediated by sim

48 ve been developed to improve the delivery of systemically administered pharmaceuticals, which are sub

49 Central nervous system (CNS) transduction by systemically administered recombinant adeno-associated v

50 e identified NMNAT2 positive-modulator, when systemically administered restored NMNAT2 expression in

51 rsistence in the lymph nodes and spleen of a systemically administered serum albumin (SA)-IL-4 fusion

52 In comparison, a systemically administered TGF-beta mAb accumulated at lo

53 an orthotopic TNBC model, we have shown that systemically administered tNLGs mediated >81% CRISPR kno

54 Finally, vectors were switched and systemically administered to the reciprocal group of ani

55 Systemically administered ZT-1a reduces ischemia-induced

56 We found that the GM1 oligosaccharide, systemically administered, reaches the brain and complet

57 denovirus subgroup C serotype 5 (HAd5), when systemically administered, triggers systemic inflammatio

58 drug but subject to low bioavailability when systemically administered.

59 -prescribed miriplatin may serve as a potent systemically-administered agent to target CTCs and reduc

60 In the present study, the role of systemically-administered CAR-DCN in AAA progression and

61 ptomycin, as an 'anti-antibiotic' to disable systemically-administered daptomycin reaching the gut.

62 critical role in psoriasis pathogenesis, and systemically-administered IL-17 inhibitors are highly ef

63 s, as antagonism of mu-opioid receptors with systemically-administered naltrexone does not abolish th

64 1 (AKRGARSTA), as a GBM targeting ligand for systemically-administered nanoparticles.

65 in increased GBM delivery of other types of systemically-administered nanoparticles: silver nanopart

66 in SCID mice were treated with SDT using the systemically-administered nanoparticulate formulation at

67 Here, we show that systemically administering a potent, long-acting PEGylat

68 the guards" between small RNA types that may systemically affect homeostasis in poststroke immune res

69 R was locally effective but was not detected systemically after intracranial delivery of CART.BiTE ce

70 The drugs were administered systemically after predetermination of their blood level

71 e show that cambial development is modulated systemically along the stem.

72 We systemically analysed chronological changes in biochemic

73 man pathogen Escherichia coli, which spreads systemically and caused a rapid, fatal disease in pups.

74 prevent these pathobionts from disseminating systemically and causing sepsis in neonatal mice.

75 Because mast cells can be activated systemically and contribute to sepsis, we examined LA ef

76 tinamide adenine dinucleotide (NAD(+)) moves systemically and induces systemic immunity.

77 The tolerance state systemically and locally suppresses the development of e

78 hanced fibrosis and collagen deposition both systemically and locally within the tumor microenvironme

79 ese data demonstrate the efficiency of BMMC, systemically and noninvasively transplanted, in correcti

80 on the mechanisms of immune cell activation systemically and on the pathways immune cells use to tra

81 d T2D (PD/T2D), or, for flow cytometry, were systemically and orally healthy.

82 ants (n = 150) were divided into groups: (H) systemically and periodontal healthy (control group); (P

83 oth groups at 6 months were compared with 25 systemically and periodontally healthy females (group A)

84 n with GDM and healthy periodontium (Gh), 28 systemically and periodontally healthy women (Hh), and 3

85 women with PCOS and gingivitis (n = 35); 3) systemically and periodontally healthy women (n = 25); a

86 lower in healthy women with gingivitis than systemically and periodontally healthy women or women wi

87 Ingested peanut protein is absorbed systemically and retains its immunoreactive capacity in

88 LLDT-8 would mainly influence the FLS cells systemically and specially in the process of immune rela

89 The bacteria disseminated systemically and spread to several organs at 24 hours af

90 ophylactic treatment with the LY341495, both systemically and via microinjection into the medial pref

91 cally relevant dose of doxorubicin delivered systemically and were euthanized 72 h later.

92 significantly reducing bacterial burden both systemically and within reproductive tissues.

93 Treatment regimens included corticosteroids (systemically and/or locally), immunosuppression, and bio

94 rst pass effect, limiting cytokine induction systemically, and demonstrated the potential for the imm

95 ed in Stage 3 periodontitis both locally and systemically, and non-surgical periodontal therapy was e

96 In this study, we adopted a short-term, systemically applicable co-stimulation blockade-based st

97 can be investigated whether a new, possibly systemically applied drug directed against TRPA1 engages

98 ell responses, liver disease often manifests systemically as immunoglobulin (Ig)-related syndromes du

99 fests initially in the skin and disseminates systemically as the disease progresses.

100 ve molecules with a potential advantage over systemically available compounds that are limited by sys

101 insically biodegradable, well tolerated, and systemically available immunostimulatory NCP promises to

102 to develop sign-tracking behavior if treated systemically before pavlovian conditioned approach train

103 is able to secrete the PD-L1 inhibitor that systemically binds and inhibits PD-L1 on tumor cells and

104 st range mutant (Ad5hr)-SIV recombinants and systemically boosted with ALVAC-SIV(M766)Gag/Pro/gp120-T

105 and division of neural stem cells, regulated systemically by important known stem cell-extrinsic sign

106 n, Fe, Cu, and Ag respectively, are screened systemically by in vitro and in vivo studies.

107 dotoxin, it is unknown whether LPS delivered systemically can also induce neuroprotective microglia i

108 inhibitors administered either topically or systemically can mitigate aspects of the ocular manifest

109 SCD mice were systemically challenged with nanogram quantities of LPS

110 yed metagenomic and phylogenetic analysis to systemically characterize murine Prevotella spp.

111 Inflammatory monocytes and neutrophils systemically circulate and enter inflamed tissue, and ph

112 dipocytes sense systemic nutrient status and systemically communicate this information by releasing a

113 with hosts who were older, male, locally and systemically compromised, and healthcare and antibiotic

114 e circulation increase after O3 exposure and systemically convey signals of O3 exposure to the CNS.

115 n of reproductive aging and somatic aging is systemically coordinated by integrated nutrient-sensing

116 Moreover, when cells were injected systemically, coupled with necrotic lysates, a higher nu

117 t attractive combination partners with other systemically delivered agents by virtue of their highly

118 l development in the lung to inhaled but not systemically delivered allergens but is dispensable for

119 ic affects to the central nervous system, we systemically delivered an adeno-associated virus (AAV) s

120 ning this area rendered animals resistant to systemically delivered anesthetics.

121 In contrast, the effectiveness of systemically delivered anti-HA bNAbs was not dependent o

122 e most treatments for such diseases focus on systemically delivered anti-inflammatory drugs, often le

123 ctious foci from innate immune effectors and systemically delivered antimicrobials.

124 For the treatment of solid tumors, systemically delivered drug carriers face significant ch

125 red in tumors by light, and toxicity of even systemically delivered drug is prevented in nonilluminat

126 Systemically delivered IL-27 efficiently prevents the de

127 Systemically delivered targeted biologics have revolutio

128 ts into an adeno-associated virus vector and systemically delivered them to mdx/Utr(+/-) neonates.

129 on, and narrows viable treatment regimes for systemically delivered therapeutics.

130 NP@mSiO2-ICG with sealed structures could be systemically delivered to brain vessels, with a long cir

131 In this investigation, the use of systemically-delivered versus low dose locally-delivered

132 iR-19a/19b in protecting cardiac function by systemically delivering miR-19a/19b into mice post-MI.

133 However, systemically delivering mRNA to cell types besides hepat

134 ever, a detailed protocol for generating and systemically delivering novel AAV variants was not previ

135 eveal for the first time that MAIT cells are systemically depleted in an AIDS virus infection.

136 fects of resistance exercise, using AKG as a systemically derived molecule for adrenal stimulation of

137 suggest that, in the tumor setting, ECs may systemically direct the function of heterotypic cell typ

138 ve motile coccobacilli were isolated from 15 systemically diseased African bullfrogs (Pyxicephalus ed

139 ons can modulate the ability of HIV-1 Tat to systemically disseminate neuroinflammation.

140 verse ILC subsets are generated in situ from systemically distributed ILCPs in response to local envi

141 ode migration, and blood dissemination, thus systemically distributing type 2 cytokines.

142 tudies demonstrate a surprisingly strong and systemically dominant effect of skeletal muscle MHC expr

143 Systemically elevated cytokines are also known to be car

144 s of pro-oxidation and pro-inflammation were systemically elevated in hyperthermia (P < 0.05), there

145 switched to a long-day (LD) photoperiod plus systemically elevated testosterone (T) levels, compared

146 iments with MC-deficient Kit(W-sh/W-sh) mice systemically engrafted with WT and CRF(2)(-/-) BMMCs dem

147 ficking and highlight the new possibility of systemically enhancing RAI therapy in patients using FDA

148 This central role, however, has not yet been systemically examined.

149 ng various developmental stages has not been systemically examined.

150 ior anti-tumor activity over native IL-2 and systemically expands anti-tumor CD8(+) T cells while ind

151 In addition, the surrogates can be systemically expressed and exhibit Wnt activity in vivo

152 1 by clinical antifungal drugs that are used systemically (fluconazole, voriconazole, ketoconazole, i

153 lism, primarily in the lungs and secondarily systemically followed by renal excretion of byproducts w

154 sary to provide a rapid rate of inactivation systemically following a very low dose.

155 nitiation of RESV or placebo administration (systemically for 30 days) and was continued until the en

156 s cardiovascular outcomes, mice were treated systemically for 6 weeks with antibodies targeting IL-17

157 doses of various tau antibodies administered systemically for several months and have reported reduce

158 Temozolomide (TMZ), an anticancer drug used systemically for treating GBM.

159 sed systems, have been used to deliver drugs systemically for up to 6 months.

160 ese analyses revealed that this pathway acts systemically from shoots to positively regulate nodulati

161 ts suggest that sickle blood flow is altered systemically, from the arterial to the venous circulatio

162 Mice lacking Bmal1 systemically had exacerbated and arrhythmic ISG/Irf7 exp

163 a targeting moiety for the cubilin receptor systemically, has not been investigated.

164 Ten CF (aged 3 to 12 years) and 10 systemically healthy (SH) age- and sex-matched children

165 Systemically healthy adults were recruited.

166 vicular fluid samples were collected from 31 systemically healthy adults with naturally occurring pla

167 flammatory disease were studied along with a systemically healthy control group (HC, n = 57, F:M = 40

168 ts with polycystic ovary syndrome (PCOS) and systemically healthy controls in the presence or absence

169 with gestational diabetes mellitus (GDM) and systemically healthy counterparts with different statuse

170 Sixty-four systemically healthy individuals were divided into Group

171 er in CP patients with type-2 DM compared to systemically healthy individuals with and without period

172 diabetes mellitus (type-2 DM) than controls (systemically healthy individuals without CP.

173 t type 2 diabetes with peri-implantitis than systemically healthy individuals without peri-implant di

174 serum MMP-9 levels and MMP-9/TIMP-1 ratio in systemically healthy patients (P <0.05).

175 y, 12 gingivitis, eight periodontitis] in 15 systemically healthy patients were investigated by immun

176 and periodontally healthy women (Hh), and 37 systemically healthy women with gingivitis (Hg) were eva

177 periodontally healthy women (n = 25); and 4) systemically healthy women with gingivitis (n = 20).

178 l as MMP-9/TIMP-1 ratios, were higher in the systemically healthy women with gingivitis compared with

179 d from gingiva of people who had PD and were systemically healthy, had PD and T2D (PD/T2D), or, for f

180 (control group); (P) with periodontitis, but systemically healthy; (DL-P) with dyslipidemia and perio

181 Tumor suppressor genes remain to be systemically identified for lung cancer.

182 e-wide CRISPR knockout screening approach to systemically identify the genetic factors involved in th

183 act of ultrafine jet-milling did however not systemically impact more TEAC values than cryo-milling.

184 onents from the intestinal microbiota spread systemically in a healthy host, posing the threat of ina

185 uced both in the tumour microenvironment and systemically in distant tissues.

186 r non-coding RNA that replicates and spreads systemically in host plants.

187 The first pleuromutilin to be used systemically in humans, lefamulin has a unique mechanism

188 As GLP-1 mimetics are administered systemically in humans, we evaluated whether peripherall

189 When administered systemically in mouse models of skin graft rejection, th

190 First, when Xist is deleted systemically in post-XCI embryonic cells using the Meox2

191 elp for IgG production in vivo, and expanded systemically in pristane-induced lupus-like disease.

192 When dosed systemically in swine, 13d provided a 15-fold enhanced C

193 ate across the intestinal epithelium, spread systemically in the circulation, and reach the fetoplace

194 we describe the routes used by STM to spread systemically in the period immediately postinfection.

195 olysis occurred at the site of infection and systemically in the severe cases.

196 raprolin-deficient macrophages and increased systemically in tristetraprolin-deficient mice.

197 defense pathways at the inoculation site and systemically in uninoculated tissues can help in the dev

198 mmation, SAA1.1/2.1 was elevated locally and systemically in wild-type (WT) mice.

199 s (pharynx, rectum, conjunctiva and, rarely, systemically) in both sexes.

200 Whereas bilorphin is systemically inactive, a glycosylated analog, bilactorph

201 Regnase-3 deficiency systemically increased IFN signaling, which increased th

202 destruction of cytosolic constituents and is systemically induced by starvation.

203 We find that systemically induced memory T cells are restricted to th

204 umour burden and CAR T cell therapy within a systemically induced mouse tumour model.

205 Here we show that, through a process termed systemically induced root exudation of metabolites (SIRE

206 is could lead to reduced levels of inherent, systemically inducible defensive compounds in Bt cotton

207 r mechanically inoculated rosette leaves and systemically infected cauline leaves and inflorescence.

208 sis was performed using the first and second systemically infected leaves (termed 1 SL and 2 SL, resp

209 , exhibits decreased kidney fungal burden in systemically infected mice.

210 In contrast, RAGE(-/-) mice systemically infected with A. baumannii exhibit increase

211 ited humanized NOD-scid IL2rgamma(null) mice systemically infected with HIV-1 to generate a wide vari

212 rmal SMI (51%), had a low SMD (62%) and were systemically inflammed (mGPS 1/2, 51%).

213 nidation is thought to limit its utility for systemically inhibiting HA synthesis.

214 zation induces neutrophil release of CG that systemically inhibits hapten-presenting dendritic cell p

215 We systemically inject engineered ultrasound-controllable d

216 evidenced by their ability to interact with systemically injected antibodies and form localized immu

217 ith sciatic nerve crush were immediately and systemically injected BMMC through the caudal artery.

218 emonstrate a novel delivery paradigm wherein systemically injected cells release microparticles that

219 Systemically injected drug delivery systems distribute i

220 These macrophages were then systemically injected into mice with fluorescent human t

221 report the design and in vivo performance of systemically injected lipid-polymer nanoparticles encaps

222 However, over 90% of systemically injected nanocarriers typically accumulate

223 ts pointed out a significant accumulation of systemically injected nanoparticles in the skin.

224 We reviewed results from recent studies of systemically injected PAMs and NAMs of mGluRs in rodents

225 Systemically injected T-lymphocyte cell line Jurkat deli

226 Here we evaluate the impact of a systemically injected, near-infrared fluorescently-label

227 somes derived from three cell lines injected systemically into C57BL/6 mice revealed these exosomes p

228 Systemically introduced exosomal PD-L1 rescues growth of

229 mnifera and the present study is designed to systemically investigate the anti-HCC efficacy of WA.

230 138511 individuals of European ancestry and systemically investigated pleiotropy between PD and type

231 We systemically investigated the stability of BCM in serum

232 Pases in adipogenesis, however, has not been systemically investigated.

233 ow-grade inflammation of VAT, and eventually systemically, is one of the major drivers of obesity-ass

234 utant HTT is ubiquitously expressed and acts systemically, meaning blood, which is readily available

235 an intermediate state between localised and systemically metastasised disease.

236 lants that heterologously produce one of the systemically migrating Ya transcripts as a long noncodin

237 critically ill patients without the need to systemically monitor ionized calcium.

238 sis that this region contains the CoV FP, we systemically mutated every residue in the pFP of Middle

239 agonist reduces alcohol drinking, when given systemically or directly into the DMS.

240 ature responses in 5-CSRTT when administered systemically or directly into VTA.

241 nally, we demonstrated that JZL184 delivered systemically or directly to the NAc also normalized SI d

242 The JAK2 inhibitor AG490 given systemically or into the OFC at the time of ketamine inj

243 In contrast, only memantine, administered systemically or intra-PLmPFC, interacted with prior alco

244 In RPT, radiation is systemically or locally delivered using pharmaceuticals

245 Despite its inability to spread systemically, PA14::hepP formed perivascular cuffs aroun

246 ced SI leads to blunted cytokine surges both systemically (plasma) and centrally (NTS and RVLM) and r

247 e intestine to initiate infection and spread systemically prior to shedding in stool.

248 We found that when APR systemically quenched the blood sugar level in diet-indu

249 ics datasets, and functional perturbation to systemically reconstruct regulatory networks underlying

250 The primary tumor systemically recruits IFNgamma-producing immune effector

251 tions between graphene and peptides, here we systemically redesigned an important protein for better

252 unction arising during mental processes that systemically reduce hippocampal activity.

253 of guest molecules as proton carriers and to systemically regulate the proton concentration and mobil

254 ajor source of circulating sIL-6R and, thus, systemically regulated IL-6 signaling.

255 ant KRAS bearing tumour cells upregulate and systemically release chemokine ligand 2 (CCL2) into the

256 Tape stripping caused keratinocytes to systemically release interleukin-33 (IL-33), which syner

257 The approach can identify systemically relevant providers.

258 unological tone of tissues, both locally and systemically, requires tonic sensing of microbes and com

259 lopment, facilitating the plant's ability to systemically respond to environmental changes.

260 suppressed TNFalpha levels, both locally and systemically, resulting in reduced expression of tumor e

261 nvestigated whether IL-4Ralpha disruption in systemically sensitized mice can prevent the onset of th

262 mune activation was evident in the tumor and systemically shortly after effective therapy was adminis

263 to Bowman's layer), and the differences are systemically sorted.

264 that such oral replication-competent vaccine systemically spread all over the body.

265 Herein, the growth kinetics of BNNTs were systemically studied for this purpose.

266 Agents administered systemically that target nerve-specific moieties have sh

267 ased targeted proteomic approach to quantify systemically the changes in expression of small GTPase p

268 increased in disease, the tears and the LG (systemically), the peptide-based inhibitor, Z-FL-COCHO (

269 Systemically, the proportion of activated CD4(+)-T cells

270 Systemically, these adaptations include increased ventil

271 Systemically, this production resulted in highly elevate

272 gh the lymphatic system before metastasizing systemically through the blood(1-4); however, the reason

273 components of the florigenic signal and move systemically through the phloem to reach the shoot apica

274 firing and behavioral performance when given systemically to aged monkeys.

275 y, circulating RBP4 is increased and may act systemically to cause insulin resistance and glucose int

276 platform based on AAV9 that can be injected systemically to deliver therapeutic transgenes site-spec

277 ptake of fluorescently loaded ECVs delivered systemically to mice before and after administration of

278 D-serine was administered systemically to mice to evaluate its effect on fear exti

279 cy and efficacy in vitro, but when delivered systemically to mice, the 5-phosphate is removed within

280 are released from tissues and act locally or systemically to promote insulin sensitivity and glucose

281 the anti-solTNF peptide, XPro1595, injected systemically, to normalize morphine-induced CNS neuroinf

282 different nutrient sources, both locally and systemically, to overcome metabolic limitations and prom

283 Ps were perfused into normal microvessels or systemically transfused into normal rats, MPs immediatel

284 rived endothelial progenitor cells (hBMEPCs) systemically transplanted into G93A mice at symptomatic

285 gs, which were either left untreated or were systemically treated with either dexamethasone, aminophy

286 This should be considered when systemically treating cancer patients with heparanase in

287 CAR-DCN or vehicle was administrated systemically until day 15.

288 osine stress imaging protocols have not been systemically validated for absolute myocardial perfusion

289 study is the first to examine the effect of systemically varying the anionic charge density of nanop

290 to the extracellular matrix (ECM) as well as systemically via circulating metabolic mediators (e.g.,

291 antiviral immune protection both locally and systemically via stimulation of CD8 cellular immune resp

292 Type I IFNs act systemically, whereas type III IFNs act preferentially a

293 highlights that sickle blood flow is altered systemically, which can drive numerous pathologies, and

294 rocess is accelerated when hosts are treated systemically with an ALK3 agonist.

295 umans; however, wild-type (WT) mice infected systemically with conventional doses of Brucella do not

296 brain phenotype, we treated 5XFAD/Tg197 mice systemically with infliximab, an anti-huTNF-alpha antibo

297 Treating wild-type mice systemically with the small molecule HS-antagonist surfe

298 Brain ischemia inhibits immune function systemically, with resulting infectious complications.

299 to load into the vascular phloem and spread systemically within a host is an essential step in estab

300 can elicit a local effect, or deliver drugs systemically without hepatic first pass metabolism.