ライフサイエンスコーパス: systolic function

1 lic function vs. LV GLS >=7.0%, preserved LV systolic function).

2 me less than $30,000, and 23% with preserved systolic function).

3 le drugs in patients with normal ventricular systolic function.

4 2) and tau (rs=-0.59; P=0.002), but not with systolic function.

5 ion and improved both membrane integrity and systolic function.

6 sis severity, and status of left ventricular systolic function.

7 naling and improves cardiac left ventricular systolic function.

8 global longitudinal strain, a measure of LV systolic function.

9 ent and diastolic dysfunction with preserved systolic function.

10 n SDB severity and subclinical markers of LV systolic function.

11 gressive ventricular enlargement and reduced systolic function.

12 post-PPCM women with apparent recovery of LV systolic function.

13 and 10 days proved superior toward improving systolic function.

14 the progressive decline in left ventricular systolic function.

15 damage precedes decline in left ventricular systolic function.

16 ved cardiac function through improvements in systolic function.

17 largement, and hyperdynamic left ventricular systolic function.

18 of lifelong exercise, with little change in systolic function.

19 reduced peak right ventricular longitudinal systolic function.

20 tients with nonobstructive HCM and preserved systolic function.

21 cular origin about biventricular volumes and systolic function.

22 ongestive heart failure (HF) and with normal systolic function.

23 , larger right ventricular size, and reduced systolic function.

24 he number of patients with severely impaired systolic function.

25 ntricular volumes and mass and normal global systolic function.

26 GGF2 treatment was associated with improved systolic function.

27 ntrol in heart failure patients with reduced systolic function.

28 h HF across the spectrum of left ventricular systolic function.

29 rom 2004 to 2009 and had normal preoperative systolic function.

30 significant improvement in LV diastolic and systolic function.

31 alpha1AMPK, without any further decrease in systolic function.

32 arterial coupling ratio, reflecting impaired systolic function.

33 e of passive stiffening rather than enhanced systolic function.

34 icantly related to level of left ventricular systolic function.

35 nfarcted rats preserves cardiac geometry and systolic function.

36 ediatric cancer survivors with normal global systolic function.

37 significant impairment in right ventricular systolic function.

38 GGF2 induced improvement in left ventricular systolic function.

39 with left ventricular dysfunction, improves systolic function.

40 gh global afterload and reduced longitudinal systolic function.

41 y that attenuates LV remodeling or preserves systolic function.

42 populations with preserved left ventricular systolic function.

43 ongestive heart failure (HF) and with normal systolic function.

44 ion in LV myofibre stress and more efficient systolic function.

45 g adults before any significant reduction in systolic function.

46 the regenerated ventricular apex had normal systolic function.

47 n accurate and reproducible assessment of RV systolic function.

48 associated with recovery of left ventricular systolic function.

49 ventional echocardiographic parameters of RV systolic function.

50 ificantly reduced infarct sizes and improved systolic function.

51 fibrosis and improvement of left ventricular systolic function.

52 l contractility than traditional measures of systolic functions.

53 tes mellitus and normal stress perfusion and systolic function (0.3%/y versus 0.5%/y; P=0.65).

54 g the subset with preserved left ventricular systolic function (1144 deaths [4.42%]; adjusted absolut

55 ompared with patients with more preserved LV systolic function (5%, 14%, and 31%, respectively).

56 years), intermediate for HF but preserved LV systolic function (5.32; 7.24), and lowest in patients w

57 ion myocardial infarction in terms of global systolic function, adverse remodeling, scar size, and my

58 for cardiac PGD comprising severely impaired systolic function affecting one or both ventricles accom

59 ients with LVEF <50%, 6 had normalization of systolic function after a median of 20 days.

60 he adult heart and improves left ventricular systolic function after adult MI.

61 ardiac function; however, they display lower systolic function after I/R compared to wild-type animal

62 r inhibited cardiac hypertrophy and improved systolic function after pressure overload.

63 size, resulting in sustained improvements in systolic function after STEMI.

64 ulmonary resuscitation, and left ventricular systolic function after weaning.

65 ection fraction showed a similar decrease in systolic function (all P<0.05).

66 imaging, usually with rapid return to normal systolic function, although delayed >2 months in 5%.

67 o pressure overload, LNA-antimiR-34 improved systolic function and attenuated lung congestion, associ

68 in patients with poor left ventricular (LV) systolic function and broad QRS complex in the surface e

69 termed dyssynchrony, this further decreases systolic function and chamber efficiency and worsens mor

70 ion, further worsen myocardial diastolic and systolic function and contribute to the major remodeling

71 complications, most patients maintain normal systolic function and exercise capacity.

72 Recent guidelines recommend assessment of systolic function and filling pressures to augment angio

73 gnificant deterioration of right ventricular systolic function and greater tricuspid regurgitation, w

74 ndices to characterize left ventricular (LV) systolic function and its relationship to activation of

75 c arch angle, left ventricular (LV) mass, LV systolic function and left atrial (LA) volumes, and LA p

76 led patients with preserved left ventricular systolic function and low symptom burden, and excluded p

77 Global systolic function and LS are only mildly reduced in pedi

78 associated with reduced global and septal LV systolic function and LV fibrosis at the RV-LV hinge poi

79 tricular apex+LV and LV-only pacing enhanced systolic function and LV synchrony at individually optim

80 ite measure of left ventricular longitudinal systolic function and maximum left atrium volume before

81 mon form of heart failure occurs with normal systolic function and often involves cardiac hypertrophy

82 me catheterization studies revealed impaired systolic function and prolonged diastolic relaxation com

83 autologous CSCs is effective in improving LV systolic function and reducing infarct size in patients

84 of cardiac myosin-improves left ventricular systolic function and remodeling and reduces natriuretic

85 er HT with most significant impairment in RV systolic function and RV and LV early-diastolic filling.

86 mbled the ARVC phenotype (impaired global RV systolic function and RV regional wall motion abnormalit

87 ocardiography revealed transiently increased systolic function and unaltered diastolic function 1 day

88 By echocardiography, it was found that systolic function and ventricular geometry were maintain

89 would be a reliable method for assessing RV systolic function and whether strain values were associa

90 th acutely and chronically increases cardiac systolic function and work, yet it also reduces long-ter

91 mproving myocardial energetics, enhancing LV systolic function, and ameliorating adverse LV remodelin

92 odeling or fibrosis, normal left ventricular systolic function, and aorta stiffness).

93 lnesses, laboratory values, left ventricular systolic function, and characteristics of the index admi

94 ar (LV) volume, mass, left atrial (LA) size, systolic function, and diastolic function were made at b

95 ith pericardial edema, decreased ventricular systolic function, and embryonic mortality.

96 nd points included mean SVRI, cardiac index, systolic function, and lactate levels.

97 ith AS have impaired diastolic, longitudinal systolic function, and left atrial dilatation compared w

98 pathological cardiac hypertrophy, depressed systolic function, and lung congestion.

99 tly associated with higher LV mass, lower LV systolic function, and reduced left atrial function over

100 uced infarct size, improved left ventricular systolic function, and reduced left ventricular remodeli

101 nary artery disease, better left ventricular systolic function, and similar processes and quality of

102 ars later to quantify LV diastolic function, systolic function, and structure.

103 luble ST2 prevents eosinophilia and improves systolic function, and that IL-33 independently adversel

104 hypertrophy, worse LV and right ventricular systolic function, and worse LV diastolic function.

105 [Irbesartan in Heart Failure With Preserved Systolic Function], and CHARM Preserved [Candesartan Cil

106 contrast, impaired relaxation and preserved systolic function appear to be the predominant early man

107 on patients with heart failure and preserved systolic function are another group in whom maintenance

108 maladaptive cardiac remodeling and decreased systolic function are common clinical consequences, begg

109 Subtle abnormalities in systolic function are present in subclinical DCM mutatio

110 LV size and systolic function are typically normal, whereas isolated

111 oorer than men in terms of right ventricular systolic function as tested by cardiac magnetic resonanc

112 splay a marked reduction in left ventricular systolic function, as evidenced by decreases in ejection

113 dings have implications for left ventricular systolic function ascertainment in patients with HF and

114 early and delayed gadolinium enhancement and systolic function assessment.

115 Poor RV systolic function at 14 months predicts worse late survi

116 In patients with reduced systolic function, AVNA demonstrates small but significa

117 Abnormal LV structure, systolic function (based on LV ejection fraction and lon

118 Right ventricular (RV) size and systolic function between baseline and last follow-up we

119 pared with patients with HF but preserved LV systolic function; both had a greater risk than patients

120 USP20-KO mice showed normal baseline systolic function but impaired beta(1)AR-induced contrac

121 viated follow-up, there was good recovery of systolic function but persistence of diastolic dysfuncti

122 All patients had normal systolic function, but impaired diastolic function.

123 rce in normal hearts and models of depressed systolic function, but the structural basis of these eff

124 Cpt) reduced LV hypertrophy and protected LV systolic function, but we had not evaluated the clinical

125 lantation, two patients had normalization of systolic function by hospital discharge, while the systo

126 were significant increases in all metrics of systolic function by three- to fourfold, including cardi

127 e myocardial segments, despite normal global systolic function by transthoracic echocardiography and

128 tions show markedly reduced left ventricular systolic function, cardiac output, and functional work c

129 118C corrected the significant depression of systolic function caused by cTnT exon 7 deletion, and th

130 d matrix remodeling can impair diastolic and systolic function caused by excess deposition of interst

131 cally relevant differences in LV volumes and systolic function changes among the quintiles of trabecu

132 dentified six clusters including ventricular systolic-function cluster, diastolic-hemodynamic cluster

133 heart rate with unaffected left ventricular systolic function compared with 36 degrees C.

134 restored contractile synchrony and improved systolic function compared with DHF.

135 Notably, cotransplantation improved systolic function compared with hearts receiving either

136 demonstrate any significant difference in LV systolic function compared with patients with normal tro

137 from TgRR mice had elevated left ventricular systolic function compared with wild-type (WT) mice, bot

138 Quantification of diastolic and systolic function continues to be a major focus in echoc

139 After transplantation, systolic function continues to improve and may reach nor

140 treated with bortezomib with improvement in systolic function, conversion of biopsy to C4d negative

141 Impaired right, left, or biventricular systolic function derived from baseline CMR and resting

142 Strain imaging detects impaired systolic function despite preserved global LVEF in HFpEF

143 Indices of systolic function did not differ between groups.

144 Left ventricular systolic function did not differ between the 2 groups.

145 and hypertrophied ventricles with preserved systolic functions due to compensatory hemodynamic remod

146 MNs) but also reduces fibrosis and preserves systolic function during EAM.

147 al hypertension and is closely related to RV systolic function during exercise, maximal exercise capa

148 tween echocardiographic left ventricular(LV) systolic function (E-function) and pulmonary artery cath

149 he sepsis episode demonstrated low-normal LV systolic function (EF, 53%; SF, 27%), and she subsequent

150 Systolic function (EF, end-systolic and end-diastolic vo

151 r, no significant change was observed in the systolic function (EF-weighted mean difference, 1.26; 95

152 r heart transplant, including 20 with normal systolic function (ejection fraction >/=50%).

153 s; male, 59%) and preserved left ventricular systolic function (ejection fraction >/=55%) were prospe

154 iogram revealed normal left ventricular (LV) systolic function (ejection fraction [EF], 60%; shorteni

155 There was also no effect of oxygen on systolic function (ejection fraction pre oxygen, 34+/-1%

156 size and normal conventional measures of LV systolic function (end-diastolic dimension, 42 +/- 6 mm;

157 rally accepted load-independent parameter of systolic function, end systolic elastance (Ees), require

158 3,623 patients with stable CAD and preserved systolic function enrolled in the PEACE (Prevention of E

159 pontin and NOX4 gene expression), and normal systolic function, filling pressures, and diastolic stif

160 re disassembly and improved left ventricular systolic function following myocardial infarction, as de

161 heart failure, in the presence of preserved systolic function, for whom heart transplant is the sole

162 gnificantly improves LV volumes, LV mass, LV systolic function, functional capacity, and quality of l

163 Impairment in left ventricular systolic function has been described in heart failure (H

164 rval: 2.44 to 12.0; p < 0.0001) and impaired systolic function (hazard ratio: 2.37; 95% confidence in

165 The present study showed that impaired RV systolic function, hypertrophy, and dilation were presen

166 in patients with heart failure and preserved systolic function (I-Preserve) trial.

167 ; Irbesartan in Heart Failure With Preserved Systolic Function [I-PRESERVE]; NCT00095238; Candesartan

168 for Adults With Heart Failure and Preserved Systolic Function], I-PRESERVE [Irbesartan in Heart Fail

169 performed before MI, prevented HR increase, systolic function impairment, baroreflex sensitivity dro

170 LV systolic function improved as early as 30 days, the grea

171 y in patients with impaired left ventricular systolic function improves when performed early in the n

172 rtantly, ACCT exerted the greatest effect on systolic function, improving the end-systolic pressure-v

173 Systolic function in 32 patients with isolated moderate-

174 dolinium enhancement occurred with normal LV systolic function in 35% (8/23) of patients with DSP.

175 prognostic value of GLS as a new index of LV systolic function in a large cohort of patients with chr

176 et of symptoms, despite frequently preserved systolic function in about one quarter of the patients.

177 hy and diastolic dysfunction, with preserved systolic function in Ang II- and PE-treated mice.

178 d diastolic dysfunction with preservation of systolic function in association with myocyte hypertroph

179 eart failure treatment that improves chamber systolic function in both the short-term and long-term y

180 sonance imaging was able to detect preserved systolic function in EHM-treated animals compared with c

181 ity, dimerisation, and its relationship with systolic function in ICM.

182 hood are associated with worse indices of LV systolic function in midlife.

183 onary load is an important determinant of RV systolic function in PAH, there remains a significant va

184 We aimed to study RV systolic function in patients with Chagas disease using

185 erload stress induces a deeper impairment of systolic function in patients with more advanced degrees

186 eometric confounders, strain better reflects systolic function in patients with preserved EF.

187 e-dependent augmentation of left ventricular systolic function in response to omecamtiv mecarbil and

188 These data provide an explanation for slowed systolic function in the intact heart in response to RLC

189 ferential strain predicts the recovery of LV systolic function in the longer term.

190 is the unexplained loss of maternal cardiac systolic function in the period surrounding parturition.

191 ased on measurements of the left ventricular systolic function in treated mice.

192 Omecamtiv mecarbil (OM) enhances systolic function in vivo by directly binding the myosin

193 on to detect differences in left ventricular systolic function in women with and without preeclampsia

194 coronary artery disease (CAD) and preserved systolic function in women, which contrasts with greater

195 d with adverse LV remodeling and impaired LV systolic function in women.

196 Prevalence of impaired right ventricular systolic function increased from 1% in 2001 to 17% in 20

197 re treatment that enhances acute and chronic systolic function, increases cardiac work, and reduces m

198 ssure-volume relationships despite preserved systolic function indexes, denoting heart failure with p

199 ociated with improvement in left ventricular systolic function, irrespective of treatment, but such i

200 n the midrange LVEF HF population, recovered systolic function is a marker of more favorable prognosi

201 Impaired left ventricular systolic function is a powerful predictor of HF hospital

202 Decreased systolic function is central to the pathogenesis of hear

203 LV systolic function is enhanced in cirrhosis due to augmen

204 the impact of AVNA in patients with reduced systolic function is of growing interest.

205 ns for which assessment of right ventricular systolic function is particularly important, and review

206 In contrast, LV systolic function is preserved in RA patients, indicatin

207 In COVID-19 infection, LV systolic function is preserved in the majority of patien

208 ure, particularly when left ventricular (LV) systolic function is preserved.

209 infarct size and preserving left ventricular systolic function is primary percutaneous coronary inter

210 The ability to dynamically alter systolic function is significantly diminished, while the

211 SevAS) develop otherwise unexplained reduced systolic function is unclear.

212 individuals with preserved left ventricular systolic function is unclear.

213 diastolic function are impaired in obesity, systolic function is usually preserved.

214 ntain left ventricular and right ventricular systolic function, isolation from electromagnetic interf

215 ntercellular junctions) for left ventricular systolic function; ITGA9 (receptor for VCAM1 [vascular c

216 itative assessment of right ventricular (RV) systolic function largely depends on right ventricular e

217 mary outcome measures: left ventricular (LV) systolic function (left ventricular ejection fraction),

218 LV systolic function (LV ejection fraction and echocardiogr

219 Left ventricular (LV) systolic function, LV mass, left atrial volumes, and blo

220 arct size by magnetic resonance imaging, and systolic function (LVEF) at 6 months were compared.

221 s, 86+/-41 [46-195] g/m(2)) was progressive, systolic function mainly preserved (cardiac index 2.8+/-

222 Left ventricular (LV) systolic function may be overestimated in patients with

223 AAS users demonstrated relatively reduced LV systolic function (mean+/-SD left ventricular ejection f

224 Among patients with preserved systolic function (n = 4,153), beta-blockers were associ

225 include classic and novel agents to improve systolic function, neurohormonal modulators, heart rhyth

226 ers with nonhypertrophied hearts with normal systolic function (normal healthy volunteer, n=30), and

227 g-term therapy with elamipretide improves LV systolic function, normalizes plasma biomarkers, and rev

228 to providing a reliable determination of RV systolic function, nuclear-imaging techniques are emergi

229 e required PDE9a inhibitor dose also impairs systolic function, observed as a decline in ventricular-

230 Improvement of LV systolic function occurs early after initiating therapy.

231 rresponded to a fitness value from improving systolic function of the heart.

232 ic function by hospital discharge, while the systolic function of the remaining four patients normali

233 When the systolic functions of the NE/Ang II-treated cells were m

234 F of 40% to 55%, and the impact of recovered systolic function on the clinical features, functional c

235 in LV diastolic function but no effect on LV systolic function or LV mass.

236 nylephrine was inversely related to baseline systolic function (P < 0.05) and associated with markers

237 on, and subtle reduction in left ventricular systolic function (P</=0.01 for all).

238 plane<17 mm): pattern 1, normal RV size and systolic function; pattern 2, dilated RV with preserved

239 nction; pattern 2, dilated RV with preserved systolic function; pattern 3, normal RV size with systol

240 Secondary outcomes included changes in LV systolic function, peak oxygen consumption, and quality

241 the role of nuclear imaging in assessing RV systolic function, perfusion, and metabolism.

242 1-9) gene therapy preserved left ventricular systolic function post-MI, restoring cardiac function.

243 erate heart failure and reduced or preserved systolic function, randomized from the Chicago metropoli

244 r afterload, and may be because of intrinsic systolic function rather than enhanced pulmonary vascula

245 Consecutive patients with preserved systolic function referred for CMR were eligible.

246 d RV function normalize in 6 to 9 months, RV systolic function remains abnormal 1 year-post-transplan

247 diastolic volume=101+/-26 mL/m(2)) with good systolic function (right ventricular ejection fraction=5

248 atients with RV failure showing decreased RV systolic function (RV fractional area change, 26.6+/-3.1

249 patients with RV hypertrophy with normal RV systolic function (RV fractional area change, 47.3+/-3.8

250 However, RV systolic function (RV S' z score -1.2+/-1.1) remained im

251 = 0.33, p < 0.0001), right ventricular (RV) systolic function (RV s': r = -0.30, p < 0.0001), and RV

252 unction with most prominent impairment in RV systolic function (S' z score -2.7+/-0.8), RV early-dias

253 LV systolic function (S' z score) and late-diastolic fillin

254 n seems to be influenced by left ventricular systolic function, stress-induced myocardial ischemia, a

255 ameters traditionally considered to describe systolic function, such as ejection fraction and longitu

256 ough thapsigargin decreased left ventricular systolic function sufficient to reduce cardiac output by

257 ared to monotonic pacing, via improvement in systolic function that persisted beyond the pacing treat

258 for Adults With Heart Failure and Preserved Systolic Function [TOPCAT]; NCT00094302; Irbesartan in H

259 ar size reduction and restores diastolic and systolic function toward normal after MI.

260 lysis included 21 cohorts for structural and systolic function traits (n = 32,212) and 17 cohorts for

261 e Irbesartan in Heart Failure with Preserved systolic function trial (I-Preserve), the Candesartan in

262 (Irbesartan in Heart Failure With Preserved Systolic Function trial) or TOPCAT trial (Treatment of P

263 (Irbesartan in Heart Failure with Preserved Systolic Function Trial), with patients of similar age,

264 In patients with normal systolic function undergoing bovine pericardial aortic v

265 hied, non-pressure-loaded hearts with normal systolic function undergoing cardiac surgery and donatin

266 inants of right ventricular (RV) volumes and systolic function using a modern imaging sequence in a c

267 ssociations between SDB and LV diastolic and systolic function using data from 1506 adults aged 18 to

268 ne curve analysis (LV GLS <7.0%, impaired LV systolic function vs. LV GLS >=7.0%, preserved LV systol

269 V and right ventricular pressure curves, and systolic function was assessed as LV dP/dtmax.

270 LV systolic function was assessed by LV ejection fraction a

271 Systolic function was assessed by transthoracic echocard

272 Left ventricular systolic function was impaired but stable in 21% of pati

273 7%+/-5.1% vs. 23.6%+/-6.2%); however, normal systolic function was not achieved before transplantatio

274 Systolic function was preserved in both cases and contro

275 eration, and isovolumic relaxation times; LV systolic function was preserved.

276 Longitudinal systolic function was reduced in affected males (radial

277 alities with reduced diastolic but preserved systolic function was seen in subclinical HCM.

278 Systolic function was significantly decreased in HIV-inf

279 Right ventricular systolic function was significantly lower in patients wi

280 Right ventricular (RV) systolic function was worse in patients with significant

281 ents with CKD and preserved left ventricular systolic function, we report a high prevalence of PH.

282 cardiographic assessment of left ventricular systolic function were addressed at follow-up.

283 dimension, and RV and left ventricular (LV) systolic function were determined by RV fractional area

284 anthracycline dose >/=200 mg/m(2) and normal systolic function were studied 2.5 to 26.9 years after a

285 A reduced infarct size and partially rescued systolic function when administered either before surger

286 ns, mild diastolic dysfunction, and enhanced systolic function, whereas KI-TnC-A8V(+/-) mice displaye

287 results in cardiac hypertrophy and impaired systolic function, which could severely limit the therap

288 ressive and reversible depression of cardiac systolic function, which is readily distinguished from o

289 and LV diastolic dysfunction with preserved systolic function, which subsequently led to elevated LV

290 be able to minimize effects on fibrosis and systolic function while improving the diastolic function

291 atients with preserved left ventricular (LV) systolic function who may also require consideration for

292 There was a significant improvement of systolic function with CRT in all LV pacing configuratio

293 stablished cardiac hypertrophy and preserved systolic function with N-acetylcysteine or a placebo for

294 : 1.06 to 1.41) and in patients with reduced systolic function with no insurance.

295 monstrated their ability to improve muscular systolic function, with no impact on diastolic propertie

296 All survivors regained normal systolic function within 6 months of surgery.

297 Variation of left ventricular systolic function within the normal range was not associ

298 OM dosing is critical for eliciting enhanced systolic function without excessive prolongation of syst

299 otropic reinforcement significantly improved systolic function without impairing diastolic function,

300 This was most apparent for systolic function; young adults born preterm had signifi