ライフサイエンスコーパス: tRNA synthetase

1 mammalian cells by S207-phosphorylated Lysyl-tRNA synthetase.

2 artamidyl-adenylate, which inhibits aspartyl-tRNA synthetase.

3 nucleotide antibiotic that inhibits aspartyl-tRNA synthetase.

4 Its genome encodes a single copy of tyrosyl-tRNA synthetase.

5 on-canonical function of L. donovani tyrosyl-tRNA synthetase.

6 aspartyl-adenylate, which inhibits aspartyl-tRNA synthetase.

7 ibit a new antimalarial target, phenylalanyl-tRNA synthetase.

8 yl-thioribosyl pyrimidine that targets seryl-tRNA synthetase.

9 aspartyl-adenylate, which inhibits aspartyl-tRNA synthetase.

10 known valine cytoplasmic-localized aminoacyl-tRNA synthetase.

11 s activated by both human prolyl- and alanyl-tRNA synthetases.

12 is editing of misacylated tRNAs by aminoacyl-tRNA synthetases.

13 on with other class I and class II aminoacyl-tRNA synthetases.

14 ccus jannaschii and Escherichia coli tyrosyl-tRNA synthetases.

15 ability to be aminoacylated onto tRNAs by aa-tRNA synthetases.

16 lected amino acid transporters and aminoacyl-tRNA synthetases.

17 ssay coupled to MS, which identified alanine tRNA synthetase 1 (AARS1) as a direct substrate of METTL

18 and p.Arg403Trp disrupted QARS-RARS (arginyl-tRNA synthetase 1) interaction.

19 identified as the binding partner of arginyl-tRNA synthetase, a polypeptide of the multi-aminoacyl tR

20 While aminoacyl-tRNA synthetase (AARS) editing potentially provides a me

21 fied mutations in the nuclear-encoded alanyl-tRNA synthetase (AARS) in these two unrelated families:

22 we sought to determine whether any aminoacyl-tRNA synthetase (aaRS) utilizes BMAA as a substrate for

23 Saccharomyces cerevisiae, a single aminoacyl-tRNA synthetase (aaRS), MST1, aminoacylates two isoaccep

24 teins is the scalable discovery of aminoacyl-tRNA synthetase (aaRS)-tRNA pairs that are orthogonal in

25 ption to the cognate mitochondrial aminoacyl-tRNA synthetase (aaRS).

26 we show that a second-generation amino-acyl tRNA synthetase (aaRS)/tRNA(CUA) pair for site-specific

27 Aminoacyl-tRNA synthetases (aaRS) catalyze both chemical steps tha

28 etic code is maintained in part by aminoacyl-tRNA synthetases (aaRS) proofreading mechanisms that ens

29 mammalian cells, eight cytoplasmic aminoacyl-tRNA synthetases (AARS), and three non-synthetase protei

30 lating ribosomes, and are then re-charged by tRNA synthetases (aaRS).

31 e: This work indicates that mutations in the tRNA synthetase AARS2 gene cause a recessive form of ALS

32 Aminoacyl-tRNA synthetases (AARSs) are a superfamily of enzymes re

33 Aminoacyl-tRNA synthetases (aaRSs) are ancient enzymes that play a

34 Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes that cata

35 Aminoacyl-tRNA synthetases (aaRSs) are housekeeping enzymes essent

36 Among these, we identified the aminoacyl tRNA synthetases (aaRSs) as essential mediators of Myc g

37 Aminoacyl-tRNA synthetases (AARSs) catalyze an early step in prote

38 Aminoacyl-tRNA synthetases (aaRSs) charge tRNAs with their cognate

39 The 20 aminoacyl tRNA synthetases (aaRSs) couple each amino acid to their

40 tRNAs with correct amino acids by aminoacyl-tRNA synthetases (aaRSs) dictates the fidelity of transl

41 Aminoacyl-tRNA synthetases (aaRSs) have long been viewed as mere h

42 Aminoacyl-tRNA synthetases (aaRSs) play a key role in deciphering

43 We evolved chromosomal aminoacyl-tRNA synthetases (aaRSs) with up to 25-fold increased pr

44 ors involved in this exclusion are aminoacyl-tRNA synthetases (aaRSs), elongation factor thermo-unsta

45 Aminoacyl-tRNA synthetases (aaRSs), the enzymes responsible for co

46 Key players in this process are aminoacyl-tRNA synthetases (aaRSs), which not only catalyse the at

47 ion for an enzyme family, we chose aminoacyl tRNA synthetases (AARSs).

48 of the nuclear-encoded mitochondrial tyrosyl-tRNA synthetase (Aatm) and the mitochondrial-encoded tyr

49 Here, we examine an N(epsilon)-acetyl-lysyl-tRNA synthetase (AcKRS), which is polyspecific (i.e., ac

50 haracterized PylRS variants (N()-acetyllysyl-tRNA synthetase [AcKRS], 3-iodo-phenylalanyl-tRNA synthe

51 hat reshaped the TMSiPhe-specific amino-acyl tRNA synthetase active site to selectively accommodate t

52 ed that BMAA is a substrate for human alanyl-tRNA synthetase (AlaRS) and can form BMAA-tRNA(Ala) by e

53 hic mutation in the editing domain of alanyl-tRNA synthetase (AlaRS), resulted in accumulation of mis

54 Expression of CMT-mutant tyrosyl-tRNA synthetase also impairs translation, suggesting a c

55 RARS encodes the cytoplasmic arginyl-tRNA synthetase, an enzyme essential for RNA translation

56 e find that downregulation of yars-2/tyrosyl-tRNA synthetase, an NMD target transcript, by daf-2 muta

57 initially aminoacylated with serine by seryl-tRNA synthetase and the resulting seryl moiety is conver

58 rexpression of nearly all of the cytoplasmic tRNA synthetases and associated ARS-interacting multifun

59 This role is specific to SerRS among all tRNA synthetases and is independent of its well-known am

60 al-type but not by eukaryotic-type isoleucyl-tRNA synthetases and might also be a determinant for the

61 omains exist in certain eukaryotic aminoacyl-tRNA synthetases and play roles in tRNA or protein bindi

62 specific substrates of eukaryotic aminoacyl-tRNA synthetases and ribosomes.

63 e substrate specificity of natural aminoacyl-tRNA synthetases and ribosomes.

64 ables the bulk purification of the aminoacyl-tRNA synthetases and translation factors necessary for a

65 lation apparatus, including tRNAs, aminoacyl-tRNA synthetases and translation factors.

66 stitutive protein complex composed of leucyl-tRNA-synthetase and folliculin, which regulates mTOR tet

67 inhibitor of the Plasmodium falciparum lysyl-tRNA synthetase, and exhibits activity against both bloo

68 are biologically active and target aspartyl-tRNA synthetase, and that the carboxymethyl group preven

69 Purified E. coli RNA polymerase and lysyl-tRNA synthetase are both capable of adding such 5' caps.

70 Mutations in genes encoding aminoacyl-tRNA synthetases are known to cause leukodystrophies and

71 Aminoacyl-tRNA synthetases are predominantly cytoplasmic, but are

72 Aminoacyl-tRNA synthetases are ubiquitous and essential enzymes fo

73 acid (AA) limitation of the entire aminoacyl-tRNA synthetase (ARS) gene family revealed that 16/20 of

74 Mutations in several aminoacyl-tRNA synthetase (ARS) genes have been implicated in inhe

75 Aminoacyl-tRNA synthetases (ARS) are ubiquitously expressed, essen

76 Aminoacyl-tRNA synthetases (ARSs) are critical for protein transla

77 Aminoacyl-tRNA synthetases (ARSs) are essential enzymes for protei

78 Aminoacyl-tRNA synthetases (ARSs) are essential enzymes responsibl

79 Aminoacyl-tRNA synthetases (ARSs) are responsible for charging ami

80 Aminoacyl-tRNA synthetases (ARSs) are ubiquitous, ancient enzymes

81 Aminoacyl-tRNA synthetases (ARSs) are universal enzymes that catal

82 Aminoacyl-tRNA synthetases (ARSs) catalyze the attachment of speci

83 Aminoacyl-tRNA synthetases (ARSs) function to transfer amino acids

84 Aminoacyl tRNA synthetases (ARSs) link specific amino acids with t

85 election is facilitated by cognate aminoacyl-tRNA synthetases (ARSs), which bind tRNAs and ligate the

86 also comprise the identification of aspartyl-tRNA synthetase as a receptor of the priming activator b

87 gating Asn to tRNA(Asn) using an asparaginyl-tRNA synthetase (AsnRS) or by synthesizing Asn on the tR

88 ations in a tRNA gene, aspT, in an aminoacyl tRNA synthetase, AspRS, and in a translation factor need

89 rstitial lung disease and myositis with anti-tRNA synthetase autoantibodies.

90 oacyl-tRNA synthetase), FARSB (phenylalanine-tRNA synthetase, beta-subunit), and NPC2 (Niemann-Pick d

91 neered a Caenorhabditis elegans phenylalanyl-tRNA synthetase capable of tagging proteins with the rea

92 Cysteinyl-tRNA synthetase (CARS) encodes the enzyme that charges t

93 lyzed by prokaryotic and mammalian cysteinyl-tRNA synthetases (CARSs).

94 In contrast to functionally diverse tRNA synthetase catalytic nulls created by alternative s

95 Aminoacyl-tRNA synthetases catalyze ATP-dependent covalent couplin

96 Aminoacyl-tRNA synthetases catalyze the attachment of cognate amin

97 ons formed via a pathway involving methionyl-tRNA synthetase-catalyzed metabolic conversion of Hcy to

98 Dominant mutations in five tRNA synthetases cause Charcot-Marie-Tooth (CMT) neuropa

99 drial forms of Caenorhabditis elegans glycyl-tRNA synthetase (CeGlyRS) are encoded by the same gene (

100 Urzymes from both aminoacyl-tRNA synthetase classes possess sophisticated catalytic

101 hat wild-type E. coli EF-Tu and phenylalanyl-tRNA synthetase collaborate with these mutant ribosomes

102 The mammalian cytoplasmic multi-tRNA synthetase complex (MSC) is a depot system that reg

103 d in a high-molecular-weight multi-aminoacyl-tRNA synthetase complex (MSC), restricting the pool of f

104 is normally sequestered in a multi-aminoacyl-tRNA synthetase complex (MSC).

105 synthetase proteins, reside in a large multi-tRNA synthetase complex (MSC).

106 tein (zinc finger protein 746) and aminoacyl tRNA synthetase complex interacting multifunctional prot

107 orm is a component of the multiple aminoacyl-tRNA synthetase complex, and the other is an N-terminal

108 AP II), one component of the multi-aminoacyl tRNA synthetase complex, plays multiple roles in physiol

109 s, in the case of a heterotrimeric aminoacyl-tRNA synthetase complex, the aggregated proteins remain

110 es targeting individual members of the multi-tRNA synthetase complex, we were able to detect all memb

111 hetase, a polypeptide of the multi-aminoacyl tRNA synthetase complex.

112 targeting Plasmodium falciparum phenylalanyl-tRNA synthetase comprise one promising new class of anti

113 The aminoacyl-tRNA synthetases constitute the largest protein family i

114 Cys codons due to the inability of cysteinyl-tRNA synthetase (CysRS) to discriminate against Sec.

115 tRNA synthetase deficiencies are a growing group of gene

116 Here we present a pyrrolysyl-tRNA synthetase-derived, engineered enzyme BtaRS that en

117 Here we describe a mutant murine methionyl-tRNA synthetase (designated L274GMmMetRS) that charges t

118 ally severe in comparison to other aminoacyl-tRNA synthetase disorders.

119 s releasing asynchronously the two aminoacyl-tRNA synthetases display aberrant expression of nuclear

120 tor of hsp90 ATPase protein 1 (Aha1), alanyl-tRNA synthetase domain containing 1 (Aarsd1), cell divis

121 nslation through evasion of one but not both tRNA synthetase editing systems.

122 Here we identify glutamyl-prolyl-tRNA synthetase (EPRS) as an mTORC1-S6K1 target that con

123 inducible phosphorylation of glutamyl-prolyl tRNA synthetase (EPRS) by S6K1 in monocytes and adipocyt

124 found that the MSC component glutamyl-prolyl-tRNA synthetase (EPRS) switched its function following v

125 tly, the EN1-iPeps bound the glutamyl-prolyl tRNA synthetase (EPRS) target, which has been associated

126 with their cognate amino acids, by aminoacyl-tRNA synthetases, establishes the genetic code.

127 Many human tRNA synthetases evolved alternative functions outside o

128 capable of aberrant interactions, links the tRNA synthetase family to CMT.

129 or alpha-subunit), MARS (methionyl aminoacyl-tRNA synthetase), FARSB (phenylalanine-tRNA synthetase,

130 phisticated structural plasticity of a human tRNA synthetase for architectural reorganizations that a

131 Here we investigate thirty-one aminoacyl-tRNA synthetases from infectious disease organisms by co

132 MT2D), caused by dominant mutations in Glycl tRNA synthetase (GARS), present with progressive weaknes

133 out the primary sequence of the human glycyl-tRNA synthetase (GARS).

134 phila model for CMT with mutations in glycyl-tRNA synthetase (GARS).

135 T2D), caused by dominant mutations in glycyl-tRNA synthetase (GARS).

136 In this study, a novel group of isoleucyl-tRNA synthetase gene (ileS) T box leader sequences found

137 Translation of the glutamyl-prolyl-tRNA synthetase gene EPRS is enhanced in response to eIF

138 ectrum of human diseases due to mutations in tRNA synthetase genes.

139 o acid specificities of TrpRS and glutaminyl-tRNA synthetase (GlnRS) by mutagenesis without extensive

140 The glutaminyl-tRNA synthetase (GlnRS) enzyme, which pairs glutamine wi

141 Cytosolic glutaminyl-tRNA synthetase (GlnRS) is the singular enzyme responsib

142 E. coli HipA inactivates the glutamyl-tRNA synthetase GltX, which inhibits translation and tri

143 onary phase by phosphorylating the aminoacyl-tRNA synthetases GltX and TrpS.

144 r protein A) kinase, which inhibits glutamyl tRNA synthetase (GltX).

145 eukaryotes from a nondiscriminating glutamyl-tRNA synthetase (GluRS) that aminoacylates both tRNA(Gln

146 n that forms a ternary complex with glutamyl-tRNA synthetase (GluRSc) and methionyl-tRNA synthetase (

147 Glycyl tRNA synthetase (GlyRS) provides a unique case among cla

148 GARS, encoding the ubiquitous enzyme, glycyl-tRNA synthetase (GlyRS), cause peripheral nerve degenera

149 housekeeping gene GARS, which encodes glycyl-tRNA synthetase (GlyRS), mediate selective peripheral ne

150 tously expressed enzyme glycyl-transfer RNA (tRNA) synthetase (GlyRS).

151 Recently, a mutation in histidyl-tRNA synthetase (HARS) was identified in a single patien

152 of p53 to expression of an editing-defective tRNA synthetase has a critical role in promoting genome

153 Mutations in genes encoding aminoacyl-tRNA synthetases have been implicated in peripheral neur

154 his important biological function, aminoacyl-tRNA synthetases have been the focus of anti-infective d

155 m involving a plasmid-encoded CysS cysteinyl-tRNA synthetase, highlighting the power of large-scale c

156 identity element for the histidyl aminoacyl tRNA synthetase (HisRS).

157 Human lysyl-tRNA synthetase (hLysRS) is essential for aminoacylation

158 volutionary-related IleRS, leucyl- and valyl-tRNA synthetases (I/L/VRSs), all efficiently hydrolyze N

159 In cattle, cytosolic isoleucyl-tRNA synthetase (IARS) missense mutations cause heredita

160 n in Arabidopsis is mediated by the aspartyl tRNA synthetase IBI1, which activates priming of multipl

161 tRNA synthetase [AcKRS], 3-iodo-phenylalanyl-tRNA synthetase [IFRS], a broad specific PylRS variant [

162 Escherichia coli isoleucyl-tRNA synthetase (IleRS) exploits both the tRNA-dependent

163 Isoleucyl-tRNA synthetase (IleRS) is an aminoacyl-tRNA synthetase

164 Isoleucyl-tRNA synthetase (IleRS) is unusual among aminoacyl-tRNA

165 show that in the synthetic site of isoleucyl-tRNA synthetase (IleRS), Nva and Val are activated and t

166 Like some other aminoacyl-tRNA synthetases, IleRS can mischarge tRNA(Ile) and corr

167 While having multiple aminoacyl-tRNA synthetases implicated in Charcot-Marie-Tooth (CMT)

168 nthesis and must be cleared by phenylalanine-tRNA synthetase in order to prevent cellular toxicity ca

169 synthetase (PylRS), a polyspecific aminoacyl-tRNA synthetase in wide use, has facilitated incorporati

170 erichia coli and Staphylococcus aureus seryl-tRNA synthetases in complex with aminoacyl adenylate ana

171 ynthetase (IleRS) is unusual among aminoacyl-tRNA synthetases in having a tRNA-dependent pre-transfer

172 rstanding the role of mutations in aminoacyl-tRNA synthetases in neurological diseases.

173 nately dictated by the accuracy of aminoacyl-tRNA synthetases in pairing amino acids with correct tRN

174 ts of the translational machinery, primarily tRNA synthetases, in response to the SF3B1 K700E mutatio

175 localized proteins, including many aminoacyl-tRNA synthetases, in which a leaky AUG start codon is fo

176 17452, has been found to be the active seryl-tRNA synthetase inhibitor component of albomycin delta(2

177 The bacterial tryptophanyl-tRNA synthetase inhibitor indolmycin features a unique o

178 e tested the efficacy of prokaryote-specific tRNA synthetase inhibitors, indolmycin and AN3365, to mi

179 we discovered genetic abnormalities in lysyl-tRNA synthetase (KARS).

180 cases may be driven by the presence of lysyl-tRNA synthetase (KRS) in the medium.

181 ase-induced expression of a mutant methionyl-tRNA synthetase (L274G) enables the cell-type-specific l

182 es the twin attributes of Leishmania tyrosyl-tRNA synthetase (LdTyrRS) namely, aminoacylation, and as

183 analyses, we identified two distinct leucyl-tRNA synthetase (LeuRS) genes within all genomes of the

184 e tRNA-dependent mechanism to inhibit leucyl-tRNA synthetase (LeuRS), while the TM84-producer prevent

185 able such efforts, flexizymes (transfer RNA (tRNA) synthetase-like ribozymes that recognize synthetic

186 from cancer-associated MTOR mutations.Leucyl-tRNA synthetase (LRS) is a leucine sensor of the mTORC1

187 Leucyl-tRNA synthetase (LRS) is known to function as leucine se

188 d by decreased protein content of the leucyl tRNA synthetase (LRS) leucine sensor.

189 tion primer via an interaction between lysyl-tRNA synthetase (LysRS) and the HIV-1 Gag polyprotein.

190 Moreover, similarly disrupted lysyl-tRNA synthetase (LysRS) proteins showed reduced enzymati

191 tation in the KARS gene, which encodes lysyl-tRNA synthetase (LysRS), a moonlight protein with a cano

192 Aminoacyl-tRNA synthetases maintain the fidelity during protein sy

193 the identification of its cognate aminoacyl-tRNA synthetase makes it possible to map transient prote

194 idence implicating the multienzyme aminoacyl-tRNA synthetase (mARS) complex and its AIMp1 structural

195 ation and suggests that editing by aminoacyl-tRNA synthetases may be important for survival under sta

196 tamyl-tRNA synthetase (GluRSc) and methionyl-tRNA synthetase (MetRS) in the cytoplasm to regulate the

197 f tRNA(Leu) with methionine by the methionyl-tRNA synthetase (MetRS).

198 is and antibiotic exposure via the methionyl-tRNA synthetase (MetRS).

199 (NM_020745.2) encoding mitochondrial alanyl-tRNA synthetase (mt-AlaRS) were first described in patie

200 Mitochondrial aminoacyl-tRNA synthetases (mt-aaRSs) are essential components of

201 ch are aminoacylated by Class I mt-aminoacyl-tRNA synthetases (mt-aaRSs).

202 The Neurospora crassa mitochondrial tyrosyl-tRNA synthetase (mtTyrRS; CYT-18 protein) evolved a new

203 The mitochondrial tyrosyl-tRNA synthetases (mtTyrRSs) of Pezizomycotina fungi, a s

204 in vivo functional verification of a tyrosyl-tRNA synthetase mutant for the genetic encoding of sulfo

205 gous and bi-allelic mutations in asparaginyl-tRNA synthetase (NARS1).

206 irect pathway, a non-discriminating aspartyl-tRNA synthetase (ND-AspRS) attaches Asp to tRNA(Asn) and

207 lly restricting the expression of the mutant tRNA synthetase, NLL-MetRS, to hippocampal neurons.

208 rthogonal nonsense suppressor tRNA/aminoacyl-tRNA synthetase pair in Escherichia coli.

209 Methanocaldococcus jannaschii tRNA:aminoacyl-tRNA synthetase pair into the chromosome of a GRO derive

210 dification with (R)-beta-lysine by the lysyl-tRNA synthetase paralog PoxA.

211 um has shown that cladosporin inhibits lysyl-tRNA synthetase (PfKRS1).

212 d binding and recognition step, phenylalanyl-tRNA synthetase (PheRS) faces the challenge of discrimin

213 quality control (QC) function of phenyalanyl-tRNA synthetase (PheRS) is required for resistantce to m

214 Phenylalanyl-tRNA synthetase (PheRS) maintains specificity via an edi

215 For example phenylalanyl-tRNA synthetase (PheRS) proofreads the non-protein hydro

216 by the proofreading activity of phenylalanyl-tRNA synthetase (PheRS).

217 ination in the synthetic active site, prolyl-tRNA synthetase (ProRS) misactivates and mischarges Ala

218 nto proteins due to misrecognition by prolyl-tRNA synthetase (ProRS).

219 Pyrrolysyl-tRNA synthetase (PylRS), a polyspecific aminoacyl-tRNA s

220 ) by using modified ribosomes and pyrrolysyl-tRNA synthetase (PylRS).

221 Pyrrolysyl-tRNA synthetase (PylRS)/(Pyl)tRNA pairs are the most wid

222 ation of the Methanosarcina mazei pyrrolysyl-tRNA synthetase (PylRS)/tRNA(Pyl)CUA pair (and its deriv

223 on of mutations in QARS (encoding glutaminyl-tRNA synthetase [QARS]) as the causative variants in two

224 Aminoacyl-tRNA synthetases recognize tRNA anticodon and 3' accepto

225 e genetic and clinical spectrum of aminoacyl-tRNA synthetase-related human disease.

226 f tRNA recognition from the parent aminoacyl-tRNA synthetase, relaxed tRNA specificity leading to sem

227 Bacterial aminoacyl-tRNA synthetases represent attractive and validated targ

228 ly expressed cytoplasmic Class IIa family of tRNA synthetases required for protein translation.

229 y-terminal domain (Cterm) of human mt-leucyl tRNA synthetase rescues the pathologic phenotype associa

230 A putative lysyl-tRNA synthetase resistance gene was identified in the cl

231 ganism that expresses two different threonyl-tRNA synthetases, responsible for Thr-tRNA(Thr) synthesi

232 kinetic analyses of CHO cytoplasmic tyrosyl-tRNA synthetase revealed a 25-fold lower specificity for

233 mparisons of mammalian and bacterial tyrosyl-tRNA synthetase revealed key differences at residues res

234 lso substrates, including multiple aminoacyl tRNA synthetases, ribosomal proteins, protein chaperones

235 ense codon, and an orthogonal tRNA/aminoacyl-tRNA synthetase (RS) pair is used to generate amber supp

236 -step indirect pathway, where O-phosphoseryl-tRNA synthetase (SepRS) catalyzes the ligation of a mism

237 tudies suggested an essential role for seryl-tRNA synthetase (SerRS) in vascular development.

238 During vascular development, seryl-tRNA synthetase (SerRS) regulates angiogenesis through a

239 specific tRNA (tRNA(Sec)) catalyzed by seryl-tRNA synthetase (SerRS)-is unclear.

240 that BMAA is not a substrate for human seryl-tRNA synthetase (SerRS).

241 n system components, in particular aminoacyl-tRNA synthetases, shows that, at a stage of evolution wh

242 Inhibition of EPRS using a PRS (prolyl-tRNA synthetase)-specific inhibitor, halofuginone, signi

243 promoter and to reengineer the tryptophanyl tRNA-synthetase:suppressor tRNA pair from Saccharomyces

244 mmalian cells using an engineered pyrrolysyl-tRNA synthetase system.

245 ement of TARS2, but not cytoplasmic threonyl-tRNA synthetase TARS, for this effect demonstrates an ad

246 ese include angiogenesis, and human threonyl-tRNA synthetase (TARS) represents a potent pro-angiogeni

247 tion of an NPS-TTD-associated gene, threonyl-tRNA synthetase (TARS), found by next-generation sequenc

248 nine (Thr) levels via mitochondrial threonyl-tRNA synthetase TARS2.

249 , but not LeuRS-I, functions as an essential tRNA synthetase that accurately charges leucine to tRNA(

250 We evolved a pyrrolysyl-tRNA synthetase that incorporates site-specifically PheK

251 Here we present newly developed aminoacyl-tRNA synthetases that enable genetic encoding of SF(5)Ph

252 e models of muscle inflammation suggest that tRNA synthetases themselves may act to trigger an initia

253 re we show that in addition to ATD, threonyl-tRNA synthetase (ThrRS) can clear the error in cellular

254 through the selective inhibition of threonyl-tRNA synthetase (ThrRS).

255 thway utilizes a non-discriminating glutamyl-tRNA synthetase to synthesize Glu-tRNA(Gln) and a glutam

256 the scientific community requested aminoacyl-tRNA synthetases to be targeted in the Seattle Structura

257 ransfer activated amino acids from aminoacyl-tRNA synthetases to the ribosome, where they are used fo

258 SelA converts Ser-tRNA(Sec), formed by seryl-tRNA synthetase, to Sec-tRNA(Sec).

259 d CRISPR-Cas systems, transfer RNAs (tRNAs), tRNA synthetases, tRNA-modification enzymes, translation

260 approach for directly discovering aminoacyl-tRNA synthetase-tRNA pairs that selectively incorporate

261 the direct, scalable discovery of aminoacyl-tRNA synthetase-tRNA pairs with mutually orthogonal subs

262 ion in coordination with a mutant pyrrolysyl-tRNA synthetase-tRNA(Pyl) pair, azidonorleucine is genet

263 ) using the recently evolved M. jannaschii Y-tRNA synthetase/tRNA pair.

264 eins displayed on phage using the pyrrolysyl-tRNA synthetase/tRNA pair.

265 ducing orthogonal amber suppressor aminoacyl-tRNA synthetase/tRNA pairs into a thiocillin producer st

266 on mutually orthogonal engineered aminoacyl-tRNA synthetase/tRNA pairs that suppress different nonse

267 teins using established orthogonal aminoacyl-tRNA synthetase/tRNA systems.

268 y encoded Tet-v2.0 with an evolved aminoacyl-tRNA synthetase/tRNA(CUA) pair.

269 n suppression using the wild-type pyrrolysyl-tRNA synthetase/tRNA(CUA) pair.

270 application of the pyrrolysyl-transfer RNA (tRNA) synthetase/tRNA pair for unnatural amino acid inco

271 tion approach, we discover a phosphothreonyl-tRNA synthetase-tRNACUA pair and create an entirely bios

272 ency, and we develop an optimized pyrrolysyl-tRNA synthetase/tRNACUA expression system, with optimize

273 from E. coli containing a mutated orthogonal tRNA synthetase/tRNACUA pair enabling site-specific inse

274 We have evolved orthogonal aminoacyl-tRNA synthetase/tRNACUA pairs that genetically encode th

275 iated expression of an orthogonal pyrrolysyl-tRNA synthetase-tRNAXXX pair in a cell type of interest

276 neered Saccharomyces cerevisiae tryptophanyl tRNA-synthetase (Trp-RS):suppressor tRNA pair to insert

277 with tryptophan for binding to tryptophanyl-tRNA synthetase (TrpRS) enzymes.

278 .His257Arg), in the cytoplasmic tryptophanyl-tRNA synthetase (TrpRS) gene (WARS) that co-segregates w

279 ary Bacillus stearothermophilus tryptophanyl-tRNA synthetase (TrpRS) over that of TrpRS Urzyme result

280 ct of three CMT-causing mutations in tyrosyl-tRNA synthetase (TyrRS or YARS).

281 e we show that a nuclear function of tyrosyl-tRNA synthetase (TyrRS) is implicated in a Drosophila mo

282 Tyrosyl-tRNA synthetase (TyrRS) is known for its essential amino

283 rk demonstrated that RSV facilitates tyrosyl-tRNA synthetase (TyrRS)-dependent activation of PARP1.

284 ly deleted, SVs of homodimeric human tyrosyl-tRNA synthetase (TyrRS).

285 Because human tyrosyl transfer-RNA (tRNA) synthetase (TyrRS) translocates to the nucleus und

286 nt overexpression of editing-defective valyl-tRNA synthetase (ValRS(ED)) activated DNA break-responsi

287 viously reported biallelic variants in valyl-tRNA synthetase (VARS) in ten patients with a developmen

288 Mitochondrial tryptophanyl-tRNA synthetase (Wars2), encoding an L53F protein varian

289 With recent data on another CMT-linked tRNA synthetase, we suggest that an inherent plasticity,

290 Orthogonal tRNA-synthetases were evolved to genetically encode PSCa

291 in YARS2 gene encoding mitochondrial tyrosyl-tRNA synthetase, which interacts with m.11778G>A mutatio

292 bacterial GlyRS is closely related to alanyl tRNA synthetase, which led us to define a new subclassif

293 mon ancestor related to glutaminyl aminoacyl-tRNA synthetases, which may have been one of the key fac

294 d deacylated tRNAs is catalyzed by aminoacyl-tRNA synthetases, which use quality control pathways to

295 e caused by editing defects of transfer RNA (tRNA) synthetases, which preserve genetic code fidelity

296 ucyl-tRNA synthetase (IleRS) is an aminoacyl-tRNA synthetase whose essential function is to aminoacyl

297 ors that selectively inhibit bacterial seryl-tRNA synthetases with greater than 2 orders of magnitude

298 s study, we identified two class-I aminoacyl-tRNA synthetases with high similarities to consensus ami

299 vides a unique case among class II aminoacyl tRNA synthetases, with two clearly widespread types of e

300 n homozygous for a novel mutation in tyrosyl-tRNA synthetase (YARS, c.499C > A, p.Pro167Thr) identifi