ライフサイエンスコーパス: tachykinin

1 ortant role in the inactivation of mammalian tachykinins.

2 arge diameter nonnociceptive neurons express tachykinins.

3 arily conserved family of neuropeptides, the tachykinins.

4 Within these subtypes, activation of tachykinin 1 (Tac1)-expressing neurons triggers specific

5 Levels of neuropeptide Y and tachykinin 1 showed similar patterns.

6 okinin, corticotropin-releasing hormone, and tachykinin 1) label sleep-promoting neurons.

7 peptide Y, neurotensin, preproenkephalin and tachykinin 1; this involved a critical period at the com

8 rete PSTN subpopulations, those that express tachykinin-1 (PSTN(Tac1) neurons) and those that express

9 sing hormone, and substance P encoded by the Tachykinin-1 (Tac1) gene.

10 ses, 88%) and the substance P precursor gene tachykinin-1 (TAC1; 16 of 34 cases, 47%).

11 0.58; 95% CI, 0.44-0.77; P-score = .96) and tachykinin-1 antagonists (RR, 0.69; 95% CI, 0.52-0.93; P

12 meta-analysis, oral dopamine antagonists and tachykinin-1 antagonists were more efficacious than plac

13 lthough NK1R immunoreactivity was increased, tachykinin-1 receptor (Tacr1) mRNA was not increased in

14 ecently we determined that activation of the tachykinin 2 (Tac2) pathway in the central amygdala (CeA

15 regulates the expression of the neuropeptide tachykinin 2 (Tac2).

16 e report that spinal interneurons expressing Tachykinin 2-Cre (Tac2(Cre)) receive direct Abeta low th

17 We characterized the role of a tachykinin 2-expressing D1 MSN subtype (Tac2(+)), presen

18 tuned neural subtype diversity to generate a tachykinin 3 (TAC3)-expressing striatal interneuron type

19 obial and enteroendocrine peptides including tachykinin, a repressor of intestinal lipid synthesis.

20 s been mounting for peripheral functions for tachykinins, a family of neuropeptides including substan

21 motor neurons that release acetylcholine and tachykinins acting on muscarinic and NK1 receptors, resp

22 tion in response to superfusion of different tachykinin agonists (neurokinins A (NKA) and B (NKB), SP

23 revealed a similar profile of sensitivity to tachykinin agonists and antagonists for both receptors;

24 ed actions of several peptide neurohormones, tachykinin among them.

25 targets that are differentially modulated by tachykinin, an aggression-promoting neuropeptide in Dros

26 controls on central neurons, and blockade of tachykinin and glutamate receptors.

27 okinin receptor are homologous to vertebrate tachykinin and its receptor, and injection of tachykinin

28 These results indicate that tachykinin and opioid neuropeptides contained in NA proj

29 d genetic mutant analyses revealed that both Tachykinin and Tachykinin-like receptor (DTKR99D) are re

30 However, such relationship between tachykinins and kisspeptins has not been demonstrated in

31 sin C-terminal motifs to those of vertebrate tachykinins and of tachykinin-related peptides in arthro

32 post-COVID-19 condition to the functions of tachykinins and propose a putative pathogenic mechanism.

33 The neuropeptide tachykinins and their receptors have been implicated in

34 Furthermore, we examined the coexpression of tachykinins and two kisspeptin genes in the brain of zeb

35 Glycine treatment during tachykinin- and acetylcholine-induced contractions signi

36 Tachykinins are a family of neuropeptides that inhibit s

37 The tachykinins are a family of neuropeptides that share a c

38 The tachykinins are a family of neuropeptides, including sub

39 Tachykinins are widely distributed in the central nervou

40 Neurokinins (or tachykinins) are peptides that modulate a wide variety o

41 refore suitable pharmacological tools in the tachykinin area to elucidate further the pathophysiologi

42 duce this effect (termed sub-threshold), the tachykinin attenuated AMG stimulation-evoked glutamaterg

43 ive regulatory role of serotonin on striatal tachykinin biosynthesis, PPT and PPE gene regulation in

44 receptors) on microglia and shown that this tachykinin can significantly elevate bacterially induced

45 gous functions of 3 classes of neuropeptides-tachykinins, cholecystokinins, and neuropeptide Y/F-in t

46 g the receptors were closely associated with tachykinin-containing nerve fibers.

47 nnervation of the airways by sympathetic and tachykinin-containing sensory nerve fibers.

48 tomy is mediated by sequential activation of tachykinin-containing spinal afferent and sympathetic ef

49 Tachykinin-containing, capsaicin-sensitive C-fibres also

50 Tachykinins contribute to the control of gastrointestina

51 Since reduced synthesis of tachykinins could not account for increased appetite, we

52 Tachykinins depolarize guinea pig intracardiac neurons b

53 histamine, prostaglandins, leukotrienes and tachykinins do not appear to be essential.

54 lobe glomerulus wired for attraction, while tachykinin (DTK) suppresses activity of a glomerulus wir

55 eness to inhaled CS, and that the endogenous tachykinins evoked by CS-induced activation of lung C fi

56 iliative allogrooming and identify a select, tachykinin-expressing subpopulation of MeA GABAergic (y-

57 (3) Imp regulates the specification of Tachykinin-expressing ventral FB input neurons.

58 es trsn function to neurons that produce the tachykinin family neuropeptide Leucokinin.

59 Substance P (SP) belongs to the tachykinin family of bioactive peptides and exerts its m

60 Substance P (SP) belongs to the tachykinin family of molecules.

61 The tachykinin family of neuropeptides, which includes subst

62 ructure of substance P (SP), a member of the tachykinin family of neuropeptides.

63 ted by neurokinin-3 receptors (NK3Rs) of the tachykinin family of neuropeptides.

64 Substance P (SP), a member of the tachykinin family of neurotransmitters and neuromodulato

65 for peripherally distributed members of the tachykinin family of peptides, namely substance P and th

66 an 11-amino acid peptide that belongs to the tachykinin family of peptides.

67 Tac1 gene encodes peptides belonging to the tachykinin family with substance P being the predominant

68 Proinflammatory neuropeptides of the tachykinin family, including substance P (SP) and hemoki

69 ance P (SP), a neuropeptide belonging to the tachykinin family, is expressed in gastrointestinal trac

70 Substance P (SP), a member of the tachykinin family, is widely distributed in the central

71 osely related neuropeptides belonging to the tachykinin family.

72 ression-promoting neuropeptide in Drosophila Tachykinin from a single male-specific neuronal type rec

73 We conclude that the release of tachykinins from primary afferent pain-sensing receptors

74 dure which results in permanent depletion of tachykinins from the lungs and airways as well as degene

75 These findings indicate that tachykinin gene expression is inducible within slice cul

76 (arcuate) nucleus, accompanied by increased tachykinin gene expression.

77 tion of the location of neurons that express tachykinin gene transcripts in the human hypothalamus.

78 Two distinct but functionally overlapping tachykinins govern inflammation through NK-1R at sites o

79 Because tachykinins have been identified as neurotransmitters in

80 eripherally, adds support to the notion that tachykinins have physiologic/endocrine roles in the peri

81 Protease-activated receptors (PARs) and tachykinin-immunoreactive fibers are located in the lung

82 alysis has shown that during the first week, tachykinin-immunoreactive profiles appeared as round or

83 hypotension-induced release of an endogenous tachykinin in SON and evidence suggesting a role for NK3

84 NKB was the predominant tachykinin in the rostral hypothalamus, whereas SP mRNA

85 ines, which highlights the important role of tachykinins in neuroimmune communication.

86 ublications have demonstrated a key role for tachykinins in the positive feedback regulation of plate

87 udy we report a fundamental new function for tachykinins in the regulation of platelet function.

88 To determine the involvement of tachykinins in the reproduction in teleosts, we identifi

89 igh affinities for other naturally occurring tachykinins including neurokinin A, neuropeptide K, neur

90 Tachykinins including substance P and cytokines includin

91 Tachykinins including the most studied substance P are n

92 99D receptor and is recruited primarily when tachykinin is overexpressed in the source neurons.

93 whether an increase in endogenously released tachykinins is involved.

94 he pattern of distribution and appearance of tachykinin-labelled fibers in the dorsal lateral genicul

95 ypothesis, the binding affinities of natural tachykinin ligands may be largely determined by their co

96 A set of novel tachykinin-like peptides has been isolated from bullfrog

97 t analyses revealed that both Tachykinin and Tachykinin-like receptor (DTKR99D) are required for dama

98 heart failure - has shown that serotonin and tachykinins may be the key mediators.

99 Tachykinins may be the main excitatory neurotransmitters

100 These data suggest that tachykinins mediate their pressor activity by increasing

101 minor peripheral nervous system component to tachykinin-mediated vomiting.

102 These results validate the least shrew as a tachykinin model at the molecular level.

103 functional protein containing the signature tachykinin motif.

104 These targets include receptors for tachykinins, motilin, ghrelin, corticotropin-releasing f

105 situ hybridization showed no coexpression of tachykinins mRNA with kisspeptins mRNA in hypothalamic n

106 Although decreased tachykinin-mRNA levels are observed in natriorexic sodiu

107 he interaction between the G protein-coupled tachykinin neurokinin 1 (NK(1)) receptor, expressed in a

108 ng existing agents that have such properties-tachykinin neurokinin 3 receptor antagonists-is proposed

109 The tachykinin neurokinin B (NKB) has been implicated in the

110 senktide analogue, but not significantly by tachykinin neurokinin-1 or neurokinin-2 receptor-selecti

111 ndogenous tachykinins or exogenous selective tachykinin neurokinin-3 receptor activation with senktid

112 ide analogue were inhibited by the selective tachykinin neurokinin-3 receptor antagonists, SB 223412

113 is of lung disease, although the role of the tachykinin neurokinin-3 receptor has not been elucidated

114 response was mimicked by exogenously applied tachykinin neurokinin-3 receptor-selective agonist, senk

115 Using confocal microscopy, we identified tachykinin neurokinin-3 receptors on human bronchial par

116 We provide the first evidence that tachykinin neurokinin-3 receptors regulate human bronchi

117 -A), which encodes substance P and a related tachykinin, neurokinin A.

118 Substance P (SP), a tachykinin neuropeptide, has been associated with neurog

119 Substance P (SP) is a tachykinin neuropeptide, implicated in the pathogenesis

120 removal of extracellular calcium, but not by tachykinin neuropeptide, voltage-sensitive calcium chann

121 One capped peptide, CAP-TAC1, is a tachykinin neuropeptide-like molecule and a nanomolar ag

122 members respond specifically to a Drosophila tachykinin neuropeptide.

123 ated peptides, including somatostatin (SST), tachykinin, neuropeptide Y (NPY) and cortistatin, in a p

124 Tachykinin neuropeptides, including Neuromedin K (NK), K

125 The tachykinin neuropeptides, substance P and substance K, a

126 -AbetaP antibody, zinc, and Tris, but not by tachykinin neuropeptides.

127 sly injected (125)I-albumin in wild-type and tachykinin NK(1) receptor knockout mice.

128 ve radioligand for in vivo quantification of tachykinin NK(1) receptors with PET.

129 ated with apoptosis, 2) decreased macrophage tachykinin NK(1)-dependent phagocytosis, 3) substantiall

130 urokinin-1 receptor and selectivity over the tachykinin NK(2) and NK(3) receptor subtypes.

131 The tachykinin NK1 receptor antagonist, GR205171 (100 microg

132 Muscarinic M3 receptor antagonists and tachykinin NK1 receptor antagonists inhibit neurogenic s

133 penetration and the antiemetic potential of tachykinin NK1 receptor antagonists.

134 the neuropeptide substance P (SP) acting via tachykinin NK1 receptor inhibition of GABA(A) currents.

135 e P release and activity because blockade of tachykinin NK1 receptors (66.3+/-13.7% inhibition, n=6;

136 role in emesis via the activation of central tachykinin NK1 receptors during the delayed phase of vom

137 Phe8]-substance P (SENK; 25, 100, 200 ng), a tachykinin NK3 receptor agonist, and [Sar9, Met(O2)11]-s

138 , and NK1-R and NK2-R mediate the effects of tachykinins on interstitial and smooth muscle cells, res

139 The pro-thrombotic effects of tachykinins on platelets are mediated through the neurok

140 Responses to endogenous tachykinins or exogenous selective tachykinin neurokinin

141 clinical studies have shown that blockers of tachykinin pathways, such as the Tac2 pathway, attenuate

142 Tachykinin, PBAN, and sNPF were among the peptides with

143 Substance P is the prototype tachykinin peptide and triggers a variety of biological

144 Substance P (SP), a member of the tachykinin peptide family, has been found in high concen

145 ), an 11-residue peptide that belongs to the tachykinin peptide family.

146 Rana catesbeiana, and their homology to the tachykinin peptide family.

147 The tachykinin peptide innervation of the developing dorsal

148 rimary effector of this pathway, co-released tachykinin peptides and their respective nigral tachykin

149 The reasons why the three tachykinin peptides behave so differently when mixed wit

150 The rank order of tachykinin peptides competing for [3H]senktide binding a

151 The tachykinin peptides include substance P (SP), neurokinin

152 esent and previous findings, we suggest that tachykinin peptides not only play a role as putative neu

153 Tachykinin peptides stimulated both inositol phospholipi

154 and the structure of two naturally occurring tachykinin peptides, substance P (SP, RPKPQQFFGLM-NH2) a

155 e piscine Tac3 gene encodes for two putative tachykinin peptides, the mammalian ortholog encodes for

156 directed to the C-terminal of the mammalian tachykinin peptides.

157 mice lacking SP signaling by deletion of the tachykinin precursor 1 (Tac1) gene or coadministration o

158 Additionally, we show that tachykinin precursor 1 (Tac1)-expressing neurons exhibit

159 the neuropeptide substance P (encoded by the tachykinin precursor 1 or Tac1).

160 pes with up-regulated neurokinin-1 receptor, tachykinin precursor 1, and down-regulated membrane meta

161 Tachykinin production also has been implicated in RSV pa

162 areas of the brain normally associated with tachykinin production.

163 RUNX Family Transcription Factor 3 (RUNX3), Tachykinin Receptor 1 (TACR1) and NADH:Ubiquinone Oxidor

164 d analysis of sialyltransferase 4A (SIAT4A), tachykinin receptor 1 (TACR1), and gamma-aminobutyric ac

165 are needed for gastroparesis; antagonists of tachykinin receptor 1 (TACR1, also called NK1R) can redu

166 rotein-coupled receptor, previously known as tachykinin receptor 86C (also known as the neurokinin K

167 ulphonic acid (PPADS; 10 microM) or an NK(3) tachykinin receptor antagonist (Neurokinin A 4-10; 100 n

168 To this end, we used the tachykinin receptor antagonist Spantide I to eliminate t

169 tamate receptor antagonist; L733,060, an NK1 tachykinin receptor antagonist, and chelerythrine, a pro

170 The use of the selective tachykinin receptor antagonists SR 140333, SR 48986, and

171 By contrast, tachykinin receptor antagonists, which abolished capsaic

172 There have been proposals that the tachykinin receptor classification should be extended to

173 hought to be premature to extend the current tachykinin receptor classification.

174 15 and CG7887 by showing these two suspected tachykinin receptor family members respond specifically

175 The NK(3) subtype of tachykinin receptor is a G protein-coupled receptor that

176 rpolarization or current was mimicked by the tachykinin receptor NK1 agonist Ac-[Arg6, Sar9, Met(O2)1

177 ith DOCA once daily for 11 days and analyzed tachykinin receptor subtype, neurokinin 3 (NK3r)-immunor

178 ent studies determined to what extent nigral tachykinin receptor subtypes contribute to striatal D1-m

179 lammatory response is altered by alternative tachykinin receptor usage.

180 we have attempted to: (1) define the type of tachykinin receptor which mediates the negative chronotr

181 n C3aR, whereas C3a levels were unchanged in tachykinin receptor-null animals.

182 been implicated in RSV pathophysiology, and tachykinin receptor-null mice were similarly protected f

183 antigen challenge appears to unmask an NK-2 tachykinin receptor.

184 reference to the existence of a novel human tachykinin receptor.

185 GIR shares 31-34% amino acid identity to the tachykinin receptors (substance P receptor, neurokinin A

186 SP acted on tumoral tachykinin receptors (TACR1) to drive death of a small p

187 human ileum, we examined a possible role of tachykinin receptors and neurokinin (NK) A in neurally i

188 hykinin peptides and their respective nigral tachykinin receptors are also in position to influence m

189 The present results suggest that the tachykinin receptors are downregulated after subchronic

190 The down-regulation of neurokinin-tachykinin receptors is accomplished by a rapid internal

191 The tachykinin receptors neurokinin 1 (NK1R) and neurokinin

192 The tachykinin receptors neurokinin 1 (NK1R) and neurokinin

193 We demonstrate the presence of the tachykinin receptors NK1 and NK3 in platelets and presen

194 ivities of human and mouse HK-1 on the three tachykinin receptors, neurokinin-1-3 (NK1-3).

195 salt appetite was due to a downregulation of tachykinin receptors.

196 mmation were mediated by neurokinin-2 (NK-2) tachykinin receptors.

197 olecule and a nanomolar agonist of mammalian tachykinin receptors.

198 The antagonism of tachykinins receptors can be a potential treatment targe

199 achykinin and its receptor, and injection of tachykinins reduces food consumption.

200 local interneurons express allatotropin and tachykinin-related neuropeptides (TKRPs).

201 olin, but only MCN1 contains Cancer borealis tachykinin-related peptide (CabTRP Ia).

202 ro(5)-Asp(6)-Asn(7)-Pro(8)-Gly(9)-NH2) and a tachykinin-related peptide (CabTRP Ia, Ala(1)-Pro(2)-Ser

203 entrating hormone (RPCH) and Cancer borealis tachykinin-related peptide (CabTRP) are colocalized in a

204 wo closely related neuropeptidergic systems, tachykinin-related peptide (TRP) and natalisin (NTL), an

205 show by immunocytochemistry that GABA and a tachykinin-related peptide (TRP) are localized in the am

206 Cancer borealis tachykinin-related peptide 1a, a peptide that does not a

207 and extrinsic application of Cancer borealis tachykinin-related peptide Ia (CabTRP Ia), a substance-P

208 and five additional modulators [C. borealis tachykinin-related peptide Ia (CabTRP Ia), crustacean ca

209 MCN1 also contains Cancer borealis tachykinin-related peptide Ia (CabTRP Ia).

210 of the peptide cotransmitter Cancer borealis tachykinin-related peptide Ia (CabTRP Ia).

211 neuromodulators [proctolin, Cancer borealis tachykinin-related peptide Ia, crustacean cardioactive p

212 to regions of the neuropil that also display tachykinin-related peptide immunoreactivity.

213 This endopeptidase cleaved another insect tachykinin-related peptide, CavTK-II, in a predictable m

214 in, allatostatin, serotonin, Cancer borealis tachykinin-related peptide, cholecystokinin, and crustac

215 Here, we describe the signaling system for tachykinin-related peptides (TKRPs) in a protostome, mol

216 fs to those of vertebrate tachykinins and of tachykinin-related peptides in arthropods led us to iden

217 bound NEP is involved in the inactivation of tachykinin-related peptides in the brain of the cockroac

218 onserved role for NEP in the inactivation of tachykinin-related peptides in the brain.

219 t neuropeptide F, myoinhibitory peptide, and tachykinin-related peptides were found to be expressed i

220 suggesting that the peptidase can hydrolyse tachykinin-related peptides with different structures.

221 MRFamides], crustacean cardioactive peptide, tachykinin-related peptides).

222 own to receive neuronal processes containing tachykinin-related peptides.

223 ke significant action potential discharge or tachykinin release from bronchopulmonary C-fibre termina

224 d substantial action potential discharge and tachykinin release from bronchopulmonary C-fibre termina

225 Tachykinin release was absent in mice deficient in C3aR,

226 nfection where initial C3a production causes tachykinin release, followed by activation of the IL-17A

227 Understanding the physiological role of tachykinins requires precise cellular and subcellular lo

228 lammation provokes phenotypic changes in the tachykinin responsiveness of nodose neurons.

229 the insect world as having a vertebrate-like tachykinin sequence and is absent from Anopheles mosquit

230 ociceptive signaling pathways we examined SP/Tachykinin signaling in a Drosophila model of tissue dam

231 Our results highlight a conserved role for Tachykinin signaling in regulating nociception and the p

232 nstrated and exemplified by the deuterostome tachykinin signaling system, although the role of phosph

233 This study examines the impact of truncated tachykinin SP and NKA analogs on signaling activity.

234 dogenous opioid endomorphin-2 (EM-2) and the tachykinin SP, respectively.

235 Together our data implicate tachykinins, specifically SP and EKA/B, in the regulatio

236 There is increasing evidence that the tachykinin substance P (SP) can augment inflammatory imm

237 The tachykinin substance P (SP) represents the prototypic sp

238 By comparison, the tachykinin substance P induced only minimal plasma extra

239 The tachykinin substance P was recovered from the commissura

240 We also demonstrate TAC1 (encoding the tachykinins substance P and neurokinin A) to be strongly

241 tion on enkephalin (Met5-enkephalin; ME) and tachykinin (substance P; SP) systems of basal ganglia of

242 The tachykinin, substance P (SP), is well known to augment i

243 Tachykinin/Substance P has been implicated in aggression

244 The results show that (a) the tachykinin subtypes are not equally involved in the cont

245 Here, tachykinin supports cholinergic excitatory synaptic tran

246 Our results suggest that the roles of the tachykinin system in regulating food intake might be evo

247 nctions of neurokinin B (NKB), we identified tachykinin (tac) and tac receptor (NKBR) genes from many

248 cells (BCCs) is caused by the enhancement of tachykinin (TAC)1 translation by cytosolic factor.

249 Hemokinin (HK) is another tachykinin that binds NK-1R.

250 Substance P is a tachykinin that enhances pathways of inflammation.

251 st that natalisin is an ancestral sibling of tachykinin that evolved only in the arthropod lineage.

252 ropin (AT), short neuropeptide F (sNPF), and tachykinin (TK) as potential candidates.

253 Tachykinin (TK) peptides influence neuronal activity in

254 ruM(+) neurons that express the neuropeptide tachykinin (Tk).

255 evertheless, the ability of pro-inflammatory tachykinins to affect the immune functions of DCs remain

256 traction since leukotriene C4, histamine and tachykinins, which all caused a similar contraction to a

257 Hemokinin is another tachykinin with homology to substance P.

258 NK1-R and NK3-R mediate neurotransmission by tachykinins within enteric nerve plexuses, and NK1-R and