ライフサイエンスコーパス: tanycyte

1 (+), tyrosine hydroxylase (TH)(+)] and glia (tanycytes).

2 ulated in specific neurons, but not in glia (tanycytes).

3 a specialized glial/ependymal cell type, the tanycyte.

4 ed by specialized ependymal cells called the tanycytes.

5 he cell bodies of all DARPP-32-immunolabeled tanycytes.

6 tion, the ependymal region has fewer sensory tanycytes.

7 ction-mediated metabolic networks by arcuate tanycytes.

8 protein 2 (VAMP2)-dependent exocytosis from tanycytes.

9 he regenerative and tumorigenic potential of tanycytes.

10 s increases the glucose transporter GLUT1 in tanycytes.

11 nucleus (ARC) astrocytes, ependymocytes and tanycytes.

12 diate-, and 15 high-level POMC expression in tanycytes.

13 indicate that they correspond to subtypes of tanycytes.

14 the vast majority of alpha2, beta, and gamma tanycytes.

15 cidate the physiologic importance of POMC in tanycytes.

16 ormed by specialized ependymal cells, called tanycytes.

17 a subset of closely located beta and alpha2 tanycytes.

18 ble channelrhodopsin (CatCh) specifically to tanycytes.

19 tricle, transducing ependymal wall cells and tanycytes.

20 ssing cells were mainly AgRP-NPY neurons and tanycytes.

21 hypothalamic ependymal cell layer containing tanycytes.

22 pressed in hypothalamic progenitor cells and tanycytes.

23 T4-to-T3 conversion between thyrotrophs and tanycytes.

24 es DBI expression in hypothalamic glial-like tanycytes.

25 Hypothalamic tanycytes, a radial glial-like ependymal cell population

26 Furthermore tanycytes also respond to non-metabolisable analogues of

27 Earlier studies suggested that tanycytes, an ependymoglial cell type of the median emin

28 s show that Rax is required for hypothalamic tanycyte and ependymal cell differentiation.

29 third ventricular wall and reduction of both tanycyte and ependymal markers.

30 ta has shown a metabolic interaction between tanycytes and AN neurons through lactate that may also b

31 n could alter the metabolic coupling between tanycytes and AN neurons, altering feeding behavior.

32 rmone (TH) and retinoic acid (RA) within the tanycytes and ependymal cells of the hypothalamus have b

33 Tanycytes and ependymal cells were the most FGF1-respons

34 fferentiation and patterning of hypothalamic tanycytes and ependymal cells, as well as for maintenanc

35 and its receptors were localised within the tanycytes and ependymal cells, with higher expression un

36 s composed of two distinct cell populations: tanycytes and ependymal cells.

37 odinase enzymes (DIO2 and DIO3) expressed in tanycytes and is the key regulator of seasonal cycles of

38 ss Sonic hedgehog (Shh) and Wnt signaling in tanycytes and modulation of these pathways blocks prolif

39 ate the neuroanatomical associations between tanycytes and neural cells present in the hypothalamic p

40 ence that some dual-labeled glial cells were tanycytes and radial glia.

41 ility that these two proteins may coexist in tanycytes and that DARPP-32 may modulate type 2 deiodina

42 lk/caudal median eminence, termed here gamma tanycytes, and a subset of closely located beta and alph

43 ax) is selectively expressed in hypothalamic tanycytes, and showed a complementary pattern of express

44 Together, our results suggest that tanycytes are a characteristic feature of all CVOs and y

45 Tanycytes are a specialized cell type along the wall of

46 Here we show that tanycytes are activated upon acute thermal challenge and

47 a provide further support for the notion the tanycytes are an important component of the mechanism by

48 Hypothalamic tanycytes are chemosensitive glial cells that contact th

49 Hypothalamic tanycytes are considered to function as sensors of perip

50 orate previous findings that third ventricle tanycytes are functionally heterogeneous.

51 Tanycytes are glucosensitive and are able to respond to

52 Tanycytes are highly specialized ependymal cells that fo

53 Tanycytes are highly specialized ependymal cells that li

54 A subset of tanycytes are located close to, and send processes towar

55 (T2) conditional driver indicates that alpha-tanycytes are self-renewing cells that constitutively gi

56 At least some tanycytes are stem cells and, in the median eminence, ma

57 tnatal and adult life, and identify Fgf10(+) tanycytes as a source of parenchymal neurons with putati

58 Here, we identify alpha-tanycytes as key components of a hypothalamic niche in t

59 These in vitro results identify tanycytes as targets of TGFalpha action and demonstrate

60 g cells that constitutively give rise to new tanycytes, astrocytes and sparse numbers of neurons.

61 factor 10 (Fgf10) from Fgf10-expressing beta-tanycytes at postnatal days (P)4-5 results in the genera

62 pithelial cells of the choroid plexus and in tanycytes at the third ventricle, both peaking near the

63 ility studies to investigate the presence of tanycyte barriers along the ventricular walls of other b

64 ration, the ependymal region is enriched for tanycytes bearing sensory cilia and receptors implicated

65 s of tanycytes, which may help to manipulate tanycyte biology for regulating hypothalamic function an

66 orters, suggesting dense tanycyte/neuron and tanycyte/blood vessel communications.

67 Oligodendrocytes and third ventricle tanycytes, both of which we have previously described as

68 orarily attenuates the amplification of beta-tanycytes but also appears to delay the exit of their al

69 y for the colocalization of these factors to tanycytes but not the pituitary gland, may explain the h

70 In vitro studies demonstrate that alpha-tanycytes, but not beta-tanycytes or parenchymal cells,

71 Selective stimulation by glucose of tanycyte cell bodies evokes robust ATP-mediated Ca2+ res

72 mited T3 signaling due to D2 ubiquitination, tanycytes coexpressing USP33 amplify T3 signaling by res

73 blast growth factor 10-expressing (Fgf10(+)) tanycytes constitute a population of progenitor cells in

74 Hypothalamic tanycytes contact the cerebral spinal fluid of the third

75 All tanycytes containing DARPP-32-IR also contained CREB-IR

76 to the CSF and can receive signals via this tanycyte-controlled pathway.

77 Despite near-complete loss of brain D2, tanycyte D2 was preserved in astro-D2 KO mice at levels

78 ns and the molecular mechanisms that control tanycyte-derived neurogenesis are unknown.

79 n of these pathways blocks proliferation and tanycyte-derived neurogenesis in Nfia/b/x-deficient mice

80 s identify molecular mechanisms that control tanycyte-derived neurogenesis, which can potentially be

81 bustly stimulates tanycyte proliferation and tanycyte-derived neurogenesis.

82 lso appears to delay the exit of their alpha-tanycyte descendants from the germinal 3V wall.

83 Two weeks after alloxan injection, 3v tanycyte destruction was reversed along with restoration

84 The quest is on to understand how tanycytes detect and respond to changes in energy balanc

85 We observed that tanycyte development was severely disrupted when Lhx2 fu

86 To test the function of Lhx2 in tanycyte development, we used an intersectional genetic

87 of Rax, an essential homeodomain factor for tanycyte development.

88 To determine whether Rax controls tanycyte differentiation and function, we generated Rax

89 ntifies Lhx2 as a key intrinsic regulator of tanycyte differentiation, sustaining Rax-dependent activ

90 that Rax is selectively required for alpha2 tanycyte differentiation.

91 t that transience of cells through the alpha-tanycyte domain is a key feature, and Fgf10 is a negativ

92 ic the morphological plasticity displayed by tanycytes during the hours encompassing the preovulatory

93 eurons of the parabrachial nucleus innervate tanycytes either directly or through second-order hypoth

94 ird ventricle in the hypothalamus, including tanycytes, ependymal cells, and certain neuron types in

95 hat is, cortical astrocytes and hypothalamic tanycytes, establishing the anatomical basis for a poten

96 Activation of tanycytes ex vivo depolarized orexigenic (neuropeptide Y

97 ltrastructural analysis revealed that mutant tanycytes exhibited a hybrid identity, retaining radial

98 Distinct subpopulations of alpha-tanycytes exist, amongst which only GFAP-positive dorsal

99 In tanycytes, exposure to T4 sustained D2 activity, leading

100 The LoC-associated tanycytes express both p75 and trkA receptors.

101 Here we show that cultured tanycytes express erbB-1 and erbB-2, two of the four mem

102 Here, we show that Fgf10(+) tanycytes express markers of neural stem/progenitor cell

103 The specific expression of tdTomato in tanycytes first allowed the observation of peculiar subc

104 Our results suggest that alpha-tanycytes form the critical component of a hypothalamic

105 The NGF extracted by tanycytes from the CSF has physiological effects on LoC

106 fate mapping, we found that median eminence tanycytes generate newborn neurons.

107 Nfia/b/x-deficient tanycytes give rise to multiple mediobasal hypothalamic

108 Furthermore, normally beta-tanycytes give rise to parenchymal cells via an intermed

109 Tanycytes, glial-like cells that line the third ventricl

110 Although tanycytes have been proposed as glucosensors, our study

111 Tanycytes have recently been considered as potential som

112 egulate the specification and maintenance of tanycyte identity are unknown, but are critical for unde

113 Here we found that Rax+ tanycytes in ME of mice are largely quiescent but quickl

114 Hypothalamic tanycytes in median eminence (ME) are emerging as a cruc

115 released along the parenchymal processes of tanycytes in the arcuate nucleus.

116 The strong GLAST expression by the ventral tanycytes in the hypophysiotropic area suggests a role o

117 f neurons throughout the brain as well as in tanycytes in the mediobasal hypothalamus.

118 tnatal rodent hypothalamus, with a subset of tanycytes in the third ventricular (3V) wall serving as

119 vels lead to enhanced proliferation of alpha-tanycytes in vivo.

120 c activation is sufficient to transform Rax+ tanycytes into actively dividing tumor cells that eventu

121 Mechanistically, Igf1r signaling in tanycytes is required for tissue repair under injury con

122 Remarkably, these tanycyte-like cells display well-organized tight junctio

123 consequent TSH receptor-mediated effects on tanycytes lining the 3(rd) ventricle of the mediobasal h

124 The results show that most tanycytes lining the ventral third ventricle and many as

125 d in a group of specialized ependymal cells, tanycytes, lining the wall and floor of the third ventri

126 we define a multimodal neurocircuit in which tanycytes link parabrachial sensory relay to the long-te

127 Lhx2-deficient tanycytes lost expression of tanycyte-specific genes, su

128 physiological effects after transcytosis in tanycytes mediated by the leptin receptor and EGFR.

129 the hypophysiotropic area suggests a role of tanycyte-mediated glutamate transport in neuroendocrine

130 irst direct demonstration of this hypothesis.Tanycytes must therefore now be considered as active sig

131 ur results lay the neuroanatomical basis for tanycyte/neural cell interactions, which will be useful

132 vesicles, and transporters, suggesting dense tanycyte/neuron and tanycyte/blood vessel communications

133 That tanycytes, not astrocytes, are the cells within the MBH

134 ttern whereby low and high POMC syntheses in tanycytes occur periodically in each brain, or marked in

135 SOD immunoreactivity, EC-SOD localization in tanycytes occurred in a region lacking a blood-brain bar

136 Here, we established that tanycytes of the arcuate nucleus of the hypothalamus, sp

137 ation, we demonstrate GLAST mRNA labeling in tanycytes of the ventral floor and lateral walls in the

138 roid hormone deiodinases in ependymal cells (tanycytes) of the fetal hypothalamus, and hence neuroend

139 also enriched, with Na,K-ATPase, in certain tanycytes or ependymal cells of the ventricle wall.

140 monstrate that alpha-tanycytes, but not beta-tanycytes or parenchymal cells, are neurospherogenic.

141 Fbeta1 have dramatically opposite effects on tanycyte plasticity.

142 Astrocytes, microglia, and tanycytes play active roles in the regulation of hypotha

143 ese results indicate that MCT1 expression in tanycytes plays a role in feeding behavior regulation.

144 ct Arc-ME cell populations, including a rare tanycyte population at the Arc-ME diffusion barrier, a n

145 GLT-1 and GLAST protein are expressed in the tanycyte populations as well.

146 amate transporters GLT-1 and GLAST in unique tanycyte populations of the third ventricle in rat brain

147 ongst which only GFAP-positive dorsal alpha2-tanycytes possess stem-like neurospherogenic activity.

148 The neuronal descendants of Fgf10(+) tanycytes predominantly populate the arcuate nucleus, a

149 on of peculiar subcellular protrusions along tanycyte processes and at their endfeet such as spines,

150 nase mRNA and DARPP-32-IR also extended into tanycyte processes that ramified in the arcuate nucleus

151 of the 3rd ventricle and in the processes of tanycytes projecting to the median eminence.

152 ption factors (Nfia/b/x) robustly stimulates tanycyte proliferation and tanycyte-derived neurogenesis

153 n microscopy, we finally observed that these tanycyte protrusions contain ribosomes, mitochondria, di

154 In addition, endothelial cells, tanycytes, radial glia, ependymal cells, microglia, and

155 Hypothalamic tanycytes, radial glial cells that share many features w

156 d, unlike other known POMC-expressing cells, tanycytes rarely contained detectable levels of adrenoco

157 s were associated with the destruction of 3v tanycytes, reduced glial fibrillary acidic protein-immun

158 Tanycytes regulate many aspects of hypothalamic physiolo

159 Tanycytes release ATP in response to glucose.

160 Nevertheless the signalling properties of tanycytes remain largely unstudied.

161 The functional role of GLT-1 in dorsal wall tanycytes remains to be explored.

162 Furthermore, the GLT-1-expressing tanycytes represent a population of tanycytes that, to d

163 ithin ventral tanycyte subpopulations; alpha-tanycytes require fibroblast growth factor signalling to

164 ultured cortical astrocytes and hypothalamic tanycytes revealed cell-type-specific responses to T4.

165 axonal routes of NGF trafficking to LoC, the tanycyte route is significantly more effective.

166 uggest high levels of neuronal plasticity in tanycytes, SCN, and ICj.

167 This programming effect depends on tanycyte sensitivity to thyroid stimulating hormone (TSH

168 First, the radial glia-like, hypothalamic tanycytes show high DCL expression that partly colocaliz

169 We now demonstrate that tanycytes signal via waves of intracellular Ca2+; they r

170 trong GLT-1 mRNA labeling in a population of tanycytes situated in the dorsolateral walls of caudal t

171 In this study, we show that tanycyte-specific disruption of the NFI family of transc

172 tion, sustaining Rax-dependent activation of tanycyte-specific genes while also inhibiting expression

173 Lhx2-deficient tanycytes lost expression of tanycyte-specific genes, such as Rax, while also display

174 Lhx2 resulted only in loss of expression of tanycyte-specific genes.

175 handwritten digits and between hypothalamic tanycyte subpopulations.

176 18 are expressed specifically within ventral tanycyte subpopulations; alpha-tanycytes require fibrobl

177 Heat-dependent Fos expression in tanycytes suggested their ability to produce signalling

178 hows that DII is localized in astrocytes and tanycytes, supporting the hypothesis that these cells pl

179 pressing tanycytes represent a population of tanycytes that, to date, has not been recognized as func

180 olecules into the parenchyma of the ME while tanycyte tight junctions control their diffusion into th

181 Prolonged (>12 hr) exposure of tanycytes to TGFalpha resulted in focal tanycytic retrac

182 aphy at the ultrastructural level shows that tanycytes transcytose and deliver NGF to LoC neurons via

183 In vivo, activation of tanycytes triggered acute hyperphagia only in the fed st

184 Stage-specific lineage-tracing of Fgf10(+) tanycytes using Fgf10-creERT2 mice, reveals robust neuro

185 The sustained D2 activity in tanycytes was linked to rapid deubiquitination by USP33,

186 pression of tdTomato in AgRP-NPY neurons and tanycytes, were significantly decreased by food deprivat

187 er 1 (MCT1) is the main isoform expressed by tanycytes, which could facilitate lactate release to hyp

188 study offers insights into the properties of tanycytes, which may help to manipulate tanycyte biology

189 ells via an intermediate population of alpha-tanycytes with transient amplifying cell characteristics

190 tein was largely confined to a population of tanycytes within the infundibular stalk/caudal median em