ライフサイエンスコーパス: taper

1 tal reductions in antibiotic quantity (dose 'tapering').

2 tapering oral prednisolone (1 mg/kg prior to taper).

3 lent to presurgical oral dosing, followed by taper).

4 the placebo group that underwent the 52-week taper.

5 group that underwent the 26-week prednisone taper.

6 , the adiabatic nanofocusing surface-plasmon taper.

7 group that underwent the 52-week prednisone taper.

8 increased with age, with an unchanged aortic taper.

9 e mofetil twice daily, with a corticosteroid taper.

10 ination of different brain regions along the taper.

11 of tissue and multisite photometry along the taper.

12 After 4 days, the brexanolone dose was tapered.

13 er, relapses are common when prednisolone is tapered.

14 separation and the detection capillaries are tapered.

15 prednisone and topical corticosteroids were tapered.

16 atients (64%), background therapies could be tapered.

17 locking technique based on the longitudinal tapering.

18 tern" transition formed at the distal end by tapering.

19 tly during anti-TNF or concomitant treatment tapering.

20 esponsive to corticosteroids, but recur upon tapering.

21 seizures, and did not result from medication tapering.

22 our data and, furthermore, predicts plus-end tapering.

23 andomly assigned in a 2:1 ratio to receive a tapering 15-day course of oral prednisone (5 days each o

24 The structure of NdCCD revealed a tapered active site cavity markedly different from the b

25 us haploidentical HSCT with a corticosteroid taper alone.

26 ter-long, axisymmetric, silica rods that are tapered along their lengths.

27 d positioning a pair of parallel cone-tipped tapers along the long stem so that the tips touch the se

28 group that underwent the 26-week prednisone taper and 18% of those in the placebo group that underwe

29 f nozzle geometries such as conical, sigmoid taper and multi-tier tapers, we observe that fluid accel

30 P < .001) in withdrawal severity between the taper and post-taper periods for clonidine (taper mean,

31 We retrospectively studied vancomycin taper and pulse treatment on 100 consecutive, evaluable

32 ikewise the time spent with overinflation of tapered and cylindrical cuffs.

33 8 months in complete remission, imatinib was tapered and discontinued in 8 FP and 1 MHES subjects.

34 omly assigned to CBT who had antidepressants tapered and discontinued were significantly less likely

35 pressure control reduced the variability of tapered and spherical cuffs likewise the time spent with

36 methotrexate (and placebo-methotrexate) was tapered and stopped, then tocilizumab (and placebo-tocil

37 cilizumab (and placebo-tocilizumab) was also tapered and stopped.

38 alpha1B/betaI+betaIVb microtubules are less tapered and that these tubulin heterodimers display lowe

39 ppressive agents often allows corticosteroid tapering and improves the efficacy of therapy.

40 to precisely control sequences and suppress tapering and misincorporation errors, thus achieving wel

41 We report here that TH cell somata, tapering and varicose inner plexiform layer neurites, an

42 , two connections (an external hexagon and a tapered), and two load applications (axial and oblique),

43 the placebo group that underwent the 26-week taper, and 25% of those in the placebo group that underw

44 yte globulin (rATG) induction, rapid steroid taper, and maintenance mycophenolate and tacrolimus, to

45 Three other wing shape genes, narrow, tapered, and lanceolate, encode components of a pathway

46 s commonly relapses when glucocorticoids are tapered, and the prolonged use of glucocorticoids is ass

47 hot carriers by slowing down plasmons at the taper apex.

48 c current distributions, with cosine-squared taper are respectively employed to generate predominatel

49 ch the patient's background therapy could be tapered as tolerated, and an extension phase.

50 ortic bifurcation diameters to assess aortic taper (ascending aortic diameter/aortic bifurcation diam

51 Dendritic tapering away from the soma has been suggested to both e

52 n of filopodia-like F-actin networks without tapered barbed ends.

53 n many apicomplexans is the conoid, a hollow tapered barrel structure composed of tubulin fibers.

54 eptor Q, normally linked to myosin VI at the tapered base of stereocilia, was maldistributed along th

55 week followed by oral prednisone 1 mg/kg/d, tapered based on clinical and radiological response plus

56 Prednisone was tapered, beginning at week 1, and discontinued no later

57 ic bifurcation diameter and decreased aortic taper, both of which also associated with abdominal aort

58 oint of weaning successfully off TLAs before tapering brexanolone.

59 GCSF could be discontinued in 2 patients and tapered by 57% and 81%, respectively, in the other 2.

60 eft atrium with a guidewire and 1.8F to 2.6F tapered catheter, a self-expandable, 8x12-mm flexible op

61 Streak-based particle velocimetry in a tapered channel was used to assess particle motion.

62 more likely to be retained at the end of the taper compared with clonidine participants (22 [61.1%]);

63 acuity and intraocular pressure, ability to taper concomitant immunosuppressive regimen, and number

64 the bone tissue (P <0.05) compared with the tapered connection.

65 Patients in arm 1 received tapered corticosteroids, stopped after day 10, whereas p

66 Together with a mode-selective, tapered coupling scheme, we generate coherent mode-locke

67 assigned in a 1:1 ratio to receive a 2-week tapering course of oral dexamethasone, starting at 8 mg

68 ys of pulse methylprednisolone followed by a tapering course of oral prednisone therapy.

69 resulting in high-aspect ratio channels with tapered cross sections as characterized by confocal fluo

70 Tapered cuffs generated higher cuff pressures and increa

71 Tapered cuffs improved cuff sealing performance compared

72 Compared with spherical cuffs, tapered cuffs reduced the microaspiration score without

73 Polyvinyl chloride tapered cuffs sealing enhanced performance at the cost o

74 Forty tapered cylindrical cavities (4-mm diameter, 2-mm depth)

75 al sealing performance of polyvinyl chloride tapered, cylindrical and spherical cuffs.

76 tonomous feature of principal neurons, where tapering dendrites show an inverse distribution of spine

77 e into the parabolic pulses in the waveguide taper designed.

78 The 3D-tapered device provides fluorescence enhancement factors

79 lie differences in firing pattern, while the tapering diameter of AIS may define a trigger zone for a

80 ld be used to model interventions for proper tapering, discontinuation, or follow-up of new start mid

81 ive in the proximal portion of the trunk and tapering distally, with this rind of bark providing most

82 ves the use of systemic corticosteroids with tapering doses extending up to 9 months after the initia

83 rticosteroids were prescribed in 18 eyes and tapered down during the following 4 weeks.

84 The episode started when she tapered down her loteprednol to once a day.

85 ical NSAID was stopped and difluprednate was tapered down to once weekly.

86 ovel junctions has been added to the SRA has tapered dramatically, even to the point of an asymptote.

87 nt population, including the effects of drug taper, drug washout, and placebo administration on mood

88 ll participation in research, including drug tapers, drug-free periods, and placebo-controlled trials

89 ed two tip types in Gh fiber (hemisphere and tapered), each with distinct apical diameter, central va

90 ic field in microfluidic flow cytometer like tapered electrodes, trapezoidal electrode arrays, Interd

91 e microtubule end as a result of an evolving tapered end structure; this leads to a decrease of the c

92 The tapered ends of the capillaries are inserted into the su

93 Thus, tapered fibers permit focal or broad illumination that c

94 This tapered fibre multimode interference spectrometer achiev

95 thylsiloxane open-roof microdevice featuring tapered, fibronectin-coated channels, we followed the mi

96 etoxification included a 7-day buprenorphine taper followed by a week-long delay before administratio

97 ategies: methadone, buprenorphine, methadone taper for detoxification, and no medication to determine

98 ed significant effects of phase (taper, post taper) for the Clinical Opiate Withdrawal Scale (COWS) s

99 Taperin, a second protein near the taper, forms a dense-core-like structure that is disrupt

100 The apices of the narrow and perfectly tapered fossil leaves end in a single tentacle, as in bo

101 mg) or placebo, with a mandatory prednisone taper from week 2.

102 n renal function in follow-up (patients were tapered from 16 mg/day to 8 mg/day over 2 weeks and foll

103 ys before HSCT, and (in the absence of GVHD) tapered from day 96 through to day 150.

104 ise from their neurite geometries (diameters tapering from 10-20 um to < 2 um at their terminal tips)

105 We demonstrate a three-dimensionally-tapered gap plasmon nanocavity that overcomes this funda

106 ion of a molecular layer self-assembled on a tapered gold microelectrode.

107 strate attosecond near-field retrieval for a tapered gold nanowire.

108 dence for the existence of graphene SPs on a tapered graphene-silicon waveguide tip at a NIR waveleng

109 ved FT and 5 of 12 (41.7%) in the vancomycin taper group experienced recurrence of CDI, corresponding

110 immediate discontinuation group (IDG) or the tapered group (TG).

111 Patients undergoing drug taper had a mean increase in symptom severity of 4.2% (S

112 A proprietary tapered hollow phantom that contained a bone-mimicking i

113 The generation of parabolic similaritons in tapered hydrogenated amorphous silicon photonic wires at

114 the coupled dynamics of optical field in the tapered hydrogenated amorphous silicon photonic wires wi

115 We therefore suggest that SSRIs should be tapered hyperbolically and slowly to doses much lower th

116 Tapering immunosuppression led to the recuperation of in

117 terfaces of the commercially available Morse taper implant-abutment units tested were not sufficientl

118 tissue health surrounding a variable-thread tapered implant immediately placed in extraction sites.

119 significantly different from oral vancomycin taper in reducing recurrent CDI.

120 .003) groups and from stabilization to post taper in the buprenorphine group (stabilization mean, 0.

121 ,159 = 30.7, P < .001) from stabilization to taper in the clonidine (stabilization mean, 0.64 [SE, .0

122 Prednisone was successfully tapered in 95% of patients; mean prednisone doses at 1 a

123 Prednisone was tapered in both groups after 1 month.

124 nisone (60 mg/m(2) per day) for 3 weeks plus tapering in induction.

125 and relapse currently observed with agonist tapers in both inpatient and outpatient settings.

126 his biomarker to guide medication trials and tapers in these children and predict seizure risk in oth

127 ntly broadband in nature, has a continuously tapered inhomogeneous dielectric permittivity profile al

128 37 implants was placed, 23 with a cone Morse taper internal connection and 14 with a screw-retained i

129 etween the two coupling regions when a fiber taper is moved laterally above the resonator at fixed ve

130 current transfer in dendrites with arbitrary taper is required.

131 Significantly less metal is lost from the taper junction between Cobalt-Chromium-Molybdenum (CoCrM

132 Corrosion particles from the taper junction can lead to Adverse Reactions to Metal De

133 articulation at the head cup bearing and the tapered junctions of orthopaedic hip implants are known

134 lization of an acoustic metasurface based on tapered labyrinthine metamaterials.

135 A nationwide observational tapered matching study of outcomes of Medicare patients

136 meta-analysis suggests that extended steroid taper may aid the recovery of ophthalmoplegia in the set

137 oup (stabilization mean, 0.46 [SE, .05] post-taper mean, 1.17 [SE, .09]; P = .006), suggesting higher

138 adol ER (stabilization mean, 0.53 [SE, .05]; taper mean, 1.19 [SE, .09]; P = .003) groups and from st

139 onidine (stabilization mean, 0.64 [SE, .05]; taper mean, 1.54 [SE, .10]; P < .001) and tramadol ER (s

140 taper and post-taper periods for clonidine (taper mean, 13.1; post-taper mean, 3.2; P < .001) and tr

141 .001) and tramadol ER (taper mean, 7.4; post-taper mean, 2.8; P = .03), but not buprenorphine (taper

142 eriods for clonidine (taper mean, 13.1; post-taper mean, 3.2; P < .001) and tramadol ER (taper mean,

143 OWS) score (taper mean, 5.19 [SE, .26]; post-taper mean, 3.97 [SE, .23]; F2,170 = 3.6, P = .03) and S

144 SOWS) score (taper mean,8.81 [SE, .40]; post-taper mean, 4.14 [SE, .30]; F2,170 = 15.7, P < .001), bu

145 inical Opiate Withdrawal Scale (COWS) score (taper mean, 5.19 [SE, .26]; post-taper mean, 3.97 [SE, .

146 mean, 2.8; P = .03), but not buprenorphine (taper mean, 6.4; post-taper mean, 7.4).

147 but not buprenorphine (taper mean, 6.4; post-taper mean, 7.4).

148 -taper mean, 3.2; P < .001) and tramadol ER (taper mean, 7.4; post-taper mean, 2.8; P = .03), but not

149 ective Opiate Withdrawal Scale (SOWS) score (taper mean,8.81 [SE, .40]; post-taper mean, 4.14 [SE, .3

150 e propose and numerically demonstrate that a tapered-metal-grating structure (TMGS) can achieve high-

151 In particular, by designing surfaces with tapered micro/nanotextures which behave as harmonic spri

152 in the flow of a concentrated emulsion in a tapered microfluidic channel.

153 counter electrodes (QRCEs), in the end of a tapered micrometer-scale pipet is described.

154 a ~ 6000% increase in EB1 arrivals to open, tapered microtubule tip structures relative to closed la

155 polymers with tapered, uniform, and inverse-tapered molecular "shapes." Small-angle X-ray scattering

156 andomly intubated with cylindrical (n = 26), tapered (n = 24), or spherical (n = 22) polyvinyl chlori

157 Tapered nanopillar structures of different cross-section

158 niformity of the spin current density in the tapered nanowire geometry hinders the excitation of high

159 enosis (the most common findings), smooth or tapered narrowing of lumen, string of pearls appearance,

160 PSD-95, and PSD-93), that TH cell somata and tapering neurites are also immunopositive for a gamma-am

161 Initial high dose and extended taper of antiviral and steroid prophylaxis for MK in hig

162 Initial high-dose and extended taper of combined oral and topical antiviral and steroid

163 by a single 500-mL FT by enema, or a 6-week taper of oral vancomycin.

164 effects arising from the combination of the taper of the cochlear scalae and the spatial variation o

165 s form a circumferential ring near the basal taper of the mechanically sensitive stereocilia of murin

166 ff therapy in 90% of patients, despite rapid tapering of corticosteroids, thus allowing for a major c

167 a high initial dose followed by an extended tapering of doses is found to optimise the use of antibi

168 riments revealed that increasing the outward tapering of microchannel sidewalls improved fluidic seal

169 via tofacitinib enabled disease control and tapering of other immunosuppressive agents.

170 ved a mandatory prednisone burst followed by tapering of prednisone over the course of 15 weeks.

171 This method could have relevance for tapering of SSRIs.

172 of methadone for detoxification followed by tapering of the medication without continuation on disch

173 We experimentally demonstrate that tapering of the nanowire, which serves as the STO active

174 of patients with GCA and PMR, including the tapering of treatment.

175 s with a score of 1 are candidates for rapid tapers of systemic steroid therapy.

176 A 2-week "burst and taper" of oral prednisone is administered with no effect

177 Guidelines recommend short tapers, of between 2 weeks and 4 weeks, down to therapeu

178 siveness after having all asthma medications tapered off and after a study pulmonologist established

179 until day 150, and (in the absence of GVHD) tapered off by day 180.

180 ugh to day 150, and (in the absence of GVHD) tapered off by day 180.

181 was continued at least until day 90 and was tapered off by day 180.

182 s, followed by 200 mg/day for 12 weeks, then tapered off over 3 weeks.

183 medications had their medications gradually tapered off over 4 study visits.

184 ent groups, most marked in the placebo group tapered off study drug.

185 nitially high nursing home or home care that tapered off; 9% had Long-Term Home Care; 13% had Long-Te

186 ), and 20-34 years (61.0-79.3/105), and then tapered off; 93.6% of cases occurred among Samoans < 50

187 After tapering off corticosteroids, he received the fourth dos

188 ast one fifth of the patients despite slowly tapering off the glucocorticoids.

189 Four patients were cured with IS treatment tapering only.

190 isorder from methadone to buprenorphine, and tapering opioids in patients with chronic, non-cancer pa

191 o-optode and optical fiber microsensor) is a tapered optical fiber with an O(2)-sensitive fluorophore

192 used to pattern multiple light windows on a tapered optical fiber.

193 We exploit modal properties of tapered optical fibers (TFs) to enable light collection

194 we developed a methodology based on special tapered optical fibers (TOFs) to deliver highly localize

195 erference from leaky modes along a multimode tapered optical fibre, resulting in spectrally distingui

196 55%) of 29 patients during immunosuppressant taper or discontinuation.

197 We aimed to see whether MBCT with support to taper or discontinue antidepressant treatment (MBCT-TS)

198 s for opioid dependence compared with opioid taper or psychological treatments alone.

199 differences in efficacy compared with opioid taper or psychological treatments alone?

200 vary between centres, but frequently include tapering or substitution of opioids and concomitant co-a

201 Early and/or unnecessary tapering or treatment discontinuation for drug-related a

202 mg, intravenously 3 times daily, followed by taper) or low-dose corticosteroids (LDS; intravenous hyd

203 Using stiffness gradient, aortic taper, or global reflection coefficient in the model pro

204 her week, combined with a 26-week prednisone taper, or placebo combined with a prednisone taper over

205 hin 6 months of completing ATT, inability to taper oral corticosteroids to less than 10 mg/d or topic

206 ticosteroids intravenously for 1 week then a tapering oral dose over 8 weeks.

207 All received a course of tapering oral prednisolone (1 mg/kg prior to taper).

208 lling followed by stepwise condensation with tapered osteotomes.

209 taper, or placebo combined with a prednisone taper over a period of either 26 weeks or 52 weeks.

210 ber varies the light-emitting portion of the taper over several millimeters without movement of the i

211 s seen in patients receiving corticosteroids tapered over 10 days plus an intraoperative corticostero

212 olone phosphate; n = 57); both regimens were tapered over 10 weeks.

213 .5 to 1 mg/kg/day oral prednisolone that was tapered over 4 to 6 weeks.

214 Antidepressants can be gradually tapered over a period of several weeks, but discontinuat

215 As the prednisone dose is slowly tapered over several months, the hearing drops again.

216 Tapers over a period of months and down to doses much lo

217 the placebo group that underwent the 26-week taper (P<0.001 for both comparisons) and 3818 mg in the

218 the placebo group that underwent the 52-week taper (P<0.001 for both comparisons).

219 group that underwent the 52-week prednisone taper (P<0.001 for the comparisons of either active trea

220 d-over to double-blind placebo during a post-taper period.

221 eceded by a titration period, and ended by a tapering period.

222 thdrawal severity between the taper and post-taper periods for clonidine (taper mean, 13.1; post-tape

223 to multichannel photomultiplier tubes via a tapered, pixelated glass lightguide.

224 or oral prednisolone 1 mg/kg daily with slow taper plus IMT within 3 months.

225 rior to either 26-week or 52-week prednisone tapering plus placebo with regard to sustained glucocort

226 a short segment of a porous HF attached to a tapered polypropylene holder.

227 rawal revealed significant effects of phase (taper, post taper) for the Clinical Opiate Withdrawal Sc

228 analysis, failure to use an oral vancomycin taper preceding FMT was associated with a significant ri

229 e shown that with an optimized nanoendoscope taper profile, the light emission and collection was loc

230 oid withdrawal symptoms during a residential tapering program.

231 se dose reductions are done with exponential tapering programmes that reach very small doses.

232 sented with relatively high flow speeds that tapered progressively.

233 Our tapered protocol showed benefits, as patients in the TG

234 solone (2 mg/kg/d for 2 weeks) followed by a tapering protocol for 9 weeks (n = 70) or placebo (n = 7

235 atistical noninferiority of EGP-437 versus a tapered regimen of PA 1% was not achieved.

236 r approximately 4 months, after which a slow tapering regimen was initiated.

237 those of therapeutic minimums, in line with tapering regimens for other medications associated with

238 0 mg/day for GCA, followed by individualized tapering regimens in both diseases.

239 ectively lyse adhered endothelial cells in a tapered region of the channel.

240 d of the invertebrate chordate Ciona forms a tapered rod at tailbud stages consisting of only 40 cyli

241 isting and novel immunomodulatory agents and taper salvage agents are often lacking.

242 s 0 and 7) or self-administered PA 1% daily (tapered schedule, days 0-28).

243 This tapered shape involves differences in notochord cell vol

244 Studies have shown that these tapers show minimal benefits over abrupt discontinuation

245 haped apertures in SU8 photoresist that have tapered sidewalls and a minimum diameter between 60 and

246 demonstrate that photonic lanterns based on tapered single-mode multicore fibres provide an efficien

247 by a single FT by enema with oral vancomycin taper (standard of care) in adult patients experiencing

248 global organ involvement, or the ability to taper steroids, at 14, 28, and 56 weeks.

249 a standard-of-care group given basiliximab, tapered steroids, mycophenolate mofetil, and tacrolimus.

250 Topical corticosteroids could be tapered, stopped, or restarted on the basis of disease a

251 ence of KIF3CC resulted in modulation of the tapered structure typically seen in growing dynamic micr

252 The embodiment consists of a tapered substrate with a hollow inner lumen for holding

253 eitis), suggesting that periodic attempts at tapering suppressive medications is warranted.

254 er results in light emission from the entire taper surface, achieving broader and more efficient opto

255 the geometry of the cochlear duct manifests tapering symmetry, a felicitous design principle that ma

256 ability of four commercially available Morse taper system units to impede bacterial penetration throu

257 The use of Morse taper systems in dental implantology has been associated

258 liver solutes arriving with sharp fronts and tapering tails, whereas thick channels (aspect ratio ~ 1

259 We report planar integration of tapered terahertz (THz) frequency quantum cascade lasers

260 ologic progression after several attempts to taper the steroid dose.

261 treated with adjunctive pulse corticosteroid taper therapy (PCT) consisting of intravenous methylpred

262 rees ) and connections (external hexagon and tapered) through the use of three-dimensional finite ele

263 We demonstrate that optical fibers with tapered tips can be used to illuminate either spatially

264 Gh tapered tips ruptured either at the apex or distantly.

265 o and underwent a protocol-defined mandatory taper to discontinue their oral corticosteroids.

266 Following taper to once-daily vancomycin dosing, 22 of 36 patients

267 of radiologic and cutaneous lesions and was tapered to 10 mg/day, then radiologic lesions worsened.

268 N was given initially at 0.75 mg/kg per day, tapered to 5 to 2.5 mg per day by month 6.

269 eekly for the first 3 months and were slowly tapered to monthly, and then quarterly.

270 ecorded modest increases in the subgroup who tapered to no medications (mean percentage change 5.1% [

271 ith withdrawal, such as benzodiazepenes, are tapered to reduce their biological effect at receptors b

272 A width of 100 mum, tapering to a 1 mum point, and a 40 mum thickness help m

273 rm the extraordinary capability of plasmonic tapers to generate hot carriers by slowing down plasmons

274 In particular, we use waveguide tapers to improve the efficiency of excitation and colle

275 icrostructuring the nonplanar surface of the taper, to optically target multiple sites not only in th

276 treatment, but the optimal initial dose and tapering treatment regimens are unknown.

277 ntrolled (nicotine patch; 21 mg per day with taper) trial of varenicline (1 mg twice a day) and bupro

278 synthesizing AB graft diblock polymers with tapered, uniform, and inverse-tapered molecular "shapes.

279 f hydrocortisone for 5 days followed by dose tapering until day 11 (n = 190) or to receive placebo (n

280 A 7-day taper using clonidine (n = 36), tramadol ER (n = 36), or

281 h as acute coronary syndromes, bifurcations, tapered vessels, overlapping stents, and chronic total o

282 her week, combined with a 26-week prednisone taper was superior to either 26-week or 52-week predniso

283 tituted with CBMPs and mycophenolate mofetil tapering was allowed.

284 n the rates of relapse during glucocorticoid tapering was studied in patients with giant-cell arterit

285 at the fiber input, and the use of a single tapered waveguide minimizes the implant invasiveness.

286 o-colour pumped current source enclosed by a tapered waveguide.

287 um nitride thin films, where chirp-modulated taper waveguides are patterned to ensure a broad phase m

288 ing induced mode coupling, and adiabatically tapered waveguides in the straight region, to avoid exci

289 uch as conical, sigmoid taper and multi-tier tapers, we observe that fluid acceleration suppresses th

290 y-mode (WGM) microdisk resonator and a fiber taper which exchange energies at two distinct regions.

291 isk of relapse of irAE-N, and corticosteroid taper, which are not specifically addressed by current g

292 more, the output multi-layer is horizontally tapered, which further reduces the coupling loss for bot

293 d the funnel design had a constant 5 degrees taper with aspect ratios (funnel tip width to funnel dep

294 cile infection and failure of a 6- to 8-week taper with vancomycin or at least 2 episodes of severe C

295 7-10.7), and COPD (IRR range, 5.89-8.78) and tapered with age.

296 The drug was tapered with disease improvement.

297 atment started at 300 mg.d(-1) for 5 d, then tapered with lower dosing over 3 d.

298 All patients underwent prednisone tapering, with patients in VISUAL-1 receiving an initial

299 methadone treatment or to usual care--forced tapered withdrawal from methadone.

300 e at the time of their incarceration, then a tapered withdrawal regimen (for those on a starting dose