ライフサイエンスコーパス: target for

1 l homeostasis, and an attractive therapeutic target for a broad variety of disease conditions.

2 nchymal transition and is therefore an ideal target for a metastasis inhibitor.

3 ally clinically useful genomic and molecular targets for a subset of recurrent/metastatic SDC.

4 s, CRP testing performed substantially below targets for a TB triage test.

5 nverge on a common set of direct, functional targets for a TF.

6 findings provide new insights and potential targets for a variety of fibrotic and malignant diseases

7 YAP-dependent neuronal necrosis represents a target for AD therapeutics.

8 ms in affective neuroscience and is an ideal target for addressing the pathophysiology of many brain-

9 ts downstream pathway, would provide a novel target for adjuvant therapy when treating pelvic cancers

10 n oncogenesis in GBM, making it an appealing target for advancing novel therapeutics.

11 emerged as a specific, stable, and abundant target for affinity-guided delivery of anticancer drugs.

12 gnostic biomarkers and potential therapeutic targets for age-related human ovarian disorders.

13 d suggest a novel mechanism, and therapeutic target, for aging-induced essential hypertension in huma

14 CeA(GA) as a potential powerful therapeutic target for alleviating chronic pain.

15 atal behavior and identify novel unexploited targets for altering stomatal behavior and improving cro

16 up formation and might constitute a new drug target for amoebic dysentery.

17 tion of inflammation and to NAAA itself as a target for anti-inflammatory medicines.

18 roteolyzes viral polyproteins and has been a target for anti-SARS drug design.

19 embrane expression, and consequently reduced targets for anti-Ly6G-mediated depletion.

20 FAS is an attractive target for antibiotics and many inhibitors are in clinic

21 and the bacterial RNA polymerase is a proven target for antibiotics.

22 essed in cancer and are therefore attractive targets for antibodies.

23 lum (ER) has recently emerged as a promising target for anticancer agents.

24 l roles in excitable cells, and they are key targets for antiepileptic, antiarrhythmic, and analgesic

25 nd suggests that GPVI represents a promising target for antimetastatic therapies.

26 rs of bacterial ureases, important molecular targets for antimicrobial therapies, was developed.

27 -pathogen dialog that may furnish actionable targets for antiparasite therapies or vaccines.

28 Glutamate neurotransmission is a prioritized target for antipsychotic drug development.

29 Thus, RNA cap methylation is an attractive target for antiviral discovery and development of new li

30 This discovery sets HR3 as a new candidate target for antiviral strategies for NiV and likely for r

31 NP but also provide potential anti-influenza targets for antiviral development.

32 functional assays, and potential therapeutic targets for ASD.

33 JNK2 modulation may be a novel therapeutic target for atrial fibrillation prevention and treatment.

34 ignaling axis may be a potential therapeutic target for attenuating chemoresistance signaling in AML.

35 therefore represent a promising therapeutic target for attenuating cognitive impairment in VaD.

36 high QUIN and low KYNA, is also a potential target for AV-101.

37 point to the GPi as a potentially effective target for beta-based adaptive DBS.SIGNIFICANCE STATEMEN

38 uced the enthusiasm for Myc as a therapeutic target for beta-cell regeneration.

39 tion at the cell surface, offering promising targets for blocking the transmission of schistosomiasis

40 Our findings define PTPN2 as a target for bolstering T-cell-mediated anti-tumour immuni

41 brane permeabilization may represent a valid target for boosting radiation therapy immunogenicity in

42 Calcifications were the most common biopsy target for both groups, constituting 89.9% (578 of 643)

43 HER2 kinase as a well-established target for breast cancer (BC) therapy is associated with

44 lnerabilities in these pathways as promising targets for breast cancer subtypes.

45 self-sealing capacity, presents a promising target for breeding or engineering efforts to reduce fru

46 ortant plant pathways and provides potential targets for breeding or biotechnological applications.

47 ation and is an attractive immunotherapeutic target for cancer and inflammatory diseases.

48 Thus, ATR is a major target for cancer therapies in homologous recombination-

49 somatic genomic alterations and are thus key targets for cancer chemoprevention.

50 D-1) has become one of the most investigated targets for cancer immunotherapy.

51 regulation of RyR2 an important therapeutic target for cardiac alternans.

52 c stress, which could make it an interesting target for cardiac therapy.

53 his enzyme has also emerged as a therapeutic target for cardiovascular disease due to its ability to

54 mechanisms that make Muller glia attractive targets for cellular reprogramming and highlighted the p

55 C complex nexus might comprise a therapeutic target for certain laminopathies by preventing damage fr

56 earch, this alkaloid has remained an elusive target for chemical synthesis due to insurmountable issu

57 hese miRNAs play a role in and are potential targets for circumvention of acquired resistance to etop

58 benefits motor skill learning, presenting a target for clinical treatment of movement disorders.

59 tion by experience, which can be potentially targeted for clinical interventions.

60 ion of higher-risk swine strains can then be targeted for control measures to limit the dissemination

61 GPCRs are challenging targets for conventional antibody discovery methods, as

62 n of NETs represents a potential therapeutic target for COVID-19.

63 trophic organs that represent an unexploited target for crop improvement.

64 osynthesis could be an unexploited potential target for crop improvement.

65 tential these mechanisms hold as therapeutic targets for CRPC.

66 ion of Nemo-like kinase (NLK) as a potential target for DBA therapy.

67 etermined whether mTORC1 signaling is also a target for decanoic acid, a key component of the medium-

68 s pallidus internus (GPi), another effective target for deep brain stimulation (DBS).

69 control, but how aggregates are selectively targeted for degradation is unclear.

70 ) and nucleocapsid (N) proteins as promising targets for deoptimization and suggests a roadmap for SA

71 dicating that Pdcd4 might be a new potential target for depressive disorder therapy.

72 non, as its fruit are astomatous and a major target for desiccation resistance to enhance shelf life.

73 it is retrotranslocated into the cytosol and targeted for destruction by the ER--associated degradati

74 GGT is therefore an attractive imaging target for detection of glioblastoma.

75 upled receptor kinases (GRKs) are attractive targets for developing therapeutics for heart failure.

76 ma subunit, and potentially pinpoint a novel target for development of new antibacterials.

77 ancers, suggesting that GCN5 may be a viable target for development of new cancer therapies.

78 ounding depression and potential mechanistic targets for development and reversal of depression assoc

79 gnancy due to the lack of targetable surface targets for development of effective therapy.

80 The brain is a critical target for developmental endocrine disruption, resulting

81 monstrated much promise as novel therapeutic targets for different cancer types.

82 ted mechanisms may provide novel therapeutic targets for disability accrual in multiple sclerosis.

83 anscellular spread of tau, providing a novel target for disease-modifying treatment of AD and other t

84 of dietary information may reveal molecular targets for disease prevention and treatment.

85 in the identification of further therapeutic targets for diseases associated with endothelial barrier

86 druggable pathway as a potential therapeutic target for disorders with reduced SHANK3 dosage, provide

87 a bacterial cell, it would be an appropriate target for down-regulation during the transition from gr

88 n promoting food allergy and may represent a target for drug development.

89 tson-Crick G4 structures make them important targets for drug development.

90 ould represent a novel potential therapeutic target for DS.

91 patients and potentially even a personalized target for each individual patient.

92 may serve both as a marker of risk and as a target for early interventions.

93 ation demonstrated the importance of protein targets for ELISA.

94 lties in choosing the correct combination of targets for engineering increased fruit yield.

95 palm, we sought to identify new therapeutic targets for fibrotic disease.

96 Lucilia sericata using an actuated dummy as target for freely flying males.

97 vel adaptations in East Africa, and abundant targets for functional follow-up.

98 route mediated by Dosmit offers a promising target for future age-related mitochondrial disease ther

99 ition of this structure makes an interesting target for future antidepressant therapies.

100 animal hosts, making Cu-only SODs a possible target for future antifungal drug design.

101 ancer, and therefore represent an attractive target for future development.

102 uced in this process may serve as a critical target for future investigation and immunotherapeutic in

103 s, suggesting that HN13 LTA is an attractive target for future vaccine-development studies.

104 ecific antibodies for TNBC and emerging TNBC targets for future bispecific antibody development.

105 This finding may provide new targets for future mechanistic studies and additional in

106 This firmly suggests hydraulic traits as targets for future research.

107 tients, suggesting that UBE2T is a promising target for GC therapy.

108 iggers for bolting and to identify potential targets for genome editing and breeding.

109 while also indicating potential therapeutic targets for GIN-associated disorders, such as schizophre

110 The receptor kinase c-MET has emerged as a target for glioblastoma therapy.

111 corollary, we propose the AhR as a potential target for HDT in TB in adjunct to canonical chemotherap

112 m has been identified as a novel therapeutic target for headache disorders and migraine.

113 e female genital tract, a dynamic anatomical target for HIV-1 infection throughout all disease stages

114 g CSE or modulating glycolysis are potential targets for host-directed TB control.

115 d that AIF may represent a novel therapeutic target for HPV-induced cervical cancer.

116 pathway provides an interesting therapeutic target for human sensory nerve regeneration.

117 Components of sensing systems are promising targets for human therapeutic intervention and developin

118 with unhealthy honey bee brood and/or brood targeted for hygiene, are triggers of honey bee hygienic

119 pport mTOR activation as a novel therapeutic target for iMCD, which is being investigated through a t

120 tes cancer immune evasion, pointing to a new target for immune potentiation.

121 ry vascular repair and a pharmacotherapeutic target for immune-mediated injury of the coronary vascul

122 is a central molecular axis and a potential target for immune-refractory tumor.

123 nomorphic self-antigens that are proposed as targets for immunotherapeutic approaches to treat malign

124 networks in human T(reg) cells that could be targeted for immunotherapies.

125 Their potential as targets for immunotherapy has been explored for more tha

126 It is imperative to identify new targets for improved vaccines and therapeutics against i

127 e academic leadership positions and identify targets for improvement.

128 icides is a key Sustainable Development Goal target for improving global health.

129 individuals at higher risk of disease to be targeted for in depth diagnostic procedures and early in

130 miR-125a-5p and L-plastin may be relevant targets for increasing in vitro platelet manufacturing a

131 model to develop scope 3 emission reduction targets for individual economic sectors, comparable acro

132 ediated by LC-NE may be a viable therapeutic target for individuals with stress- and trauma-related d

133 st GBP2 may serve as a potential therapeutic target for inhibiting GBM invasion.

134 st that it may represent a valid therapeutic target for inhibiting metastasis.

135 i/di/monophosphate identity, and serves as a target for inhibitors; and we show that one cycle of TL

136 dopamine signaling provides a potential new target for intervention in psychostimulant-shaped behavi

137 lerosis, new exciting concepts and potential targets for intervention are emerging.

138 orks, may represent biomarkers and molecular targets for intervention in PMD.

139 ur data show that PI-PLCbeta1 signaling is a target for iron-induced oxidative stress and suggest tha

140 epresents an interesting and new therapeutic target for its involvement in the first steps of neurode

141 at, in PDAC, MHC-I molecules are selectively targeted for lysosomal degradation by an autophagy-depen

142 receptors (GPCRs) are important therapeutic targets for major diseases.

143 nsmission from humans to mosquitoes, are key targets for malaria elimination.

144 as been considered an attractive therapeutic target for managing cancer since 2005.

145 sensitization and may provide a therapeutic target for many neuroinflammatory pain conditions.

146 d have thus become an attractive therapeutic target for many types of invasive cancers.

147 l markers linked to these QTLs are potential targets for MAS against Phytophthora crown rot in C. mos

148 on-rapid eye movement sleep as a therapeutic target for meaningfully reducing anxiety.

149 The sigma(2) receptor is a potential in vivo target for measuring proliferative status in cancer.

150 DC marker genes CDH2 and PTPRZ1 as potential targets for meningioma therapy using live imaging, singl

151 est that this may be a potential therapeutic target for metabolic disease intervention.

152 ce of peripheral nerves as a new therapeutic target for metabolic disorders.

153 tified abundant inflammatory and immunologic targets for miR-17 and miR-548b that are known mediators

154 ests that the macrophage is a promising drug target for modulating the intestinal immune systems and

155 ion of pDCs, commending Hv1 as an attractive target for modulating type I IFN-driven autoimmunity.

156 ged as a driver of and promising therapeutic target for multiple age-related conditions, ranging from

157 have been used as biomarkers and therapeutic targets for multiple cancers.

158 sively glycosylated, making them challenging targets for native MS.

159 The P2X7 receptor (P2X7R) is a promising target for neuroinflammation.

160 protective pathways may provide therapeutic targets for neurological disorders.

161 ing literature and offer a migraine-specific target for neuromodulatory treatment.

162 rophages, revealing potential peripheral DRG targets for neuropathic pain management.

163 (GPCR) considered as a promising therapeutic target for neuropsychiatric disorders; its pharmacology,

164 n SARS-CoV-2 spike glycoprotein, the primary target for neutralizing antibodies.

165 n loops that has not previously emerged as a target for neutralizing antibodies.

166 deling of NAc D1-MSNs and may prove a useful target for new depression therapeutics.

167 bust performance and is able to predict gene targets for new drugs as well as drugs that potentially

168 e-ring networks and results as a calibration target for next-generation vegetation models.

169 te structure of Hop TPR2A which enables this target for NMR-based screening approaches.

170 by DPTA, suggesting that these tyrosines are targets for NO-dependent downregulation.

171 biosynthesis pathway a promising endogenous target for novel lead-compounds discovery.

172 e cycle renders cellular functions potential targets for novel antivirals.

173 rmogenic program and may present as a future target for obesity therapeutics.

174 lls, identifying them as a novel therapeutic target for obesity-related asthma, a disease that is sub

175 ng pathways could be a potential therapeutic target for obesity.

176 -independent markers of risk and even future targets for optimizing cardiovascular health.

177 New therapeutic targets for oral squamous cell carcinoma (OSCC) are urge

178 r (GPCR) calcitonin receptor (CTR) is a drug target for osteoporosis and diabetes.

179 e development of drug-resistant tumors and a target for overcoming resistance.

180 rolateral pathway are attractive therapeutic targets for pain treatment because nociceptive signals e

181 e results suggest IL-17RB can be a potential target for pancreatic cancer therapy.

182 metabolism, representing a novel therapeutic target for patients with obesity.

183 nd identify Kv1.3 as a potential therapeutic target for PD.

184 mation, suggesting PP(i) metabolism may be a target for periodontal regenerative therapies.

185 hting the REGgamma-proteasome as a potential target for personalized HCC therapy.

186 to emphysema, making it potentially a valid target for pharmacological intervention.

187 As such, BF-PV neurons may represent a novel target for pharmacotherapy in disorders such as schizoph

188 rphin-related circuit may serve as potential targets for potential therapeutic mediation as well as b

189 molecular nature of SHBG makes it a feasible target for preventative or therapeutic interventions.

190 1R has the potential to become a therapeutic target for preventing heart failure-associated ventricul

191 ndrocytes and offers a potential therapeutic target for prevention of diffuse WMI in premature infant

192 genetically-informed prioritization of drug targets for prevention trials.

193 SIV infection and suggest their therapeutic targeting for promoting neuronal recovery.IMPORTANCE Bra

194 The IL-23/T helper type 17 cell axis is a target for psoriasis.

195 tigen (PSMA), making this antigen a suitable target for radioligand therapy of the disease.

196 ighlight that CoV G-N-7 MTase may be a novel target for rational design of live attenuated vaccines a

197 ion and could offer a potential prophylactic target for reducing flavivirus transmission.

198 ance of cognition, perhaps providing another target for refining early identification and interventio

199 urotransmitter release and are physiological targets for regulation during various forms of plasticit

200 f stroke patients, as well as an interesting target for rehabilitation.

201 support for CB1R as a potential therapeutic target for relapse prevention.

202 We identified potential targets for repurposing of licensed medications: using M

203 fungi on these interactions are emerging as targets for research, especially in organisms associated

204 rface height can be adopted as a pre-grazing target for rotational stocking systems to optimize sheep

205 into genomic regions that are otherwise poor targets for SB transposition.

206 and factor XI are potentially tractable new targets for secondary prevention of ischaemic stroke, wh

207 serve as sites for the synthesis of proteins targeted for secretion as EV-associated proteins.

208 biantennary galactose could represent novel targets for selective manipulation of CD11b function and

209 icates that FOXM1 is a potential therapeutic target for selectively eliminating LSCs in MLL-rearrange

210 decades, making MMPs attractive therapeutic targets for several diseases.

211 served here suggests that PrP is a difficult target for small-molecule binders.

212 rategy may lie in identifying virus-specific targets for small molecule-based interventions.

213 mptom control and pain management, effective targets for small-molecule drugs.

214 beta4*nAChRs provide a promising novel drug target for smoking cessation.

215 irus from antibody responses and serves as a target for some highly potent broadly neutralizing antib

216 priate antimicrobial therapy is an important target for stewardship intervention.

217 genes and exosomes are potential therapeutic targets for stopping cancer and attenuating pain.

218 tegral membrane proteins (IMPs), challenging targets for structural determination.

219 vides the rationale for factor XII and XI as targets for such agents, reviews the data on the factor

220 ntricate binding epitopes remain challenging targets for synthetic inhibitors.

221 at least five PPE (Pro-Pro-Glu) proteins are targets for T-cell recognition in Mtb.

222 whereby children of individuals with HIV are targeted for testing, increases HIV yield but relies on

223 litis, indicating that NKG2D is an important target for the amelioration of Th1- and Th17-mediated ch

224 dent inflammasome is a potential therapeutic target for the cutaneous manifestations of autoimmune di

225 ents.IMPORTANCE HIV-1 Env protein is a major target for the development of an HIV-1 vaccine.

226 el in dentate gyrus PV cells may represent a target for the development of cell-type specific, fast-a

227 olecular mechanisms in HFpEF that could be a target for the development of HFpEF therapy in cardiovas

228 enzyme family, offers a unique extracellular target for the development of new anti-infective agents.

229 S proteins play, they represent a vulnerable target for the development of therapeutics.

230 ia TFR1-mediated endocytosis, assessing this target for the first time in DLBCL.

231 NA phosphodiesterase 1 (TDP1) is a molecular target for the sensitization of cancer cells to the FDA-

232 eptor potential vanilloid 1 (TRPV1) is a key target for the spicy taste sensor and analgesic drug dev

233 ibility that VCP may represent a therapeutic target for the treatment of AD.

234 at this system presents as a novel druggable target for the treatment of Alzheimer's disease, and pos

235 and disease states - and reveal a potential target for the treatment of chronic pain.

236 e of Tiam1 KO mice, Tiam1 may be a potential target for the treatment of disorders involving memory i

237 he lung tissue and constitutes an attractive target for the treatment of fibrotic lung diseases.

238 AKT-TBL1XR1-ERK1/2-Sox2 axis may represent a target for the treatment of GC.

239 brain and represents a promising therapeutic target for the treatment of Huntington's disease and sev

240 he cholecystokinin 2 receptor is a promising target for the treatment of MTC with radiolabeled miniga

241 clock itself has the potential for use as a target for the treatment of NAFLD.

242 olic sink for excess fuel and is a promising target for the treatment of obesity and type 2 diabetes

243 licate Na(V)1.7 as a key pharmacotherapeutic target for the treatment of pain.

244 se MALT1 has gained increasing interest as a target for the treatment of subsets of lymphomas as well

245 O as a potential HIF-independent therapeutic target for the treatment of VHL-deficient renal cell car

246 ino acids from human hemoglobin and are drug targets for the design of novel antimalarial agents.

247 n and RNA modifications could serve as novel targets for the development of antivirals.

248 phosphate 4-kinases (PI5P4Ks) are attractive targets for the development of experimental therapeutics

249 ic cancer cells across the BBB, offering new targets for the development of gene and cell therapies a

250 conserved DNA MTases may emerge as promising targets for the development of novel epigenetic inhibito

251 these studies identify HDAC2 and downstream targets for the development of novel therapeutics for bi

252 nters the host immune response would provide targets for the development of therapeutics.

253 esponses to threat and will help to identify targets for the pharmacological modulation of related pa

254 iron-dependent interactome and uncovers new targets for the therapeutic modulation of ferroptosis.

255 CATs have gained attention as potential drug targets for the treatment of diseases such as atheroscle

256 This provides potential therapeutic targets for the treatment of EBV-associated cancers.

257 trafficking represent potential therapeutic targets for the treatment of insulin resistance and type

258 duced PAH to delineate potential therapeutic targets for the treatment of this severe disease.

259 ough scaffolded training and are a promising target for therapeutic and preventive intervention.

260 serine/threonine kinase ALK2 as a potential target for therapeutic intervention.

261 thologies, making this pathway an attractive target for therapeutic intervention.

262 ical NOX2 domain, and p47phox is a potential target for therapeutic intervention.

263 eatic cancer cells, representing a potential target for therapeutic intervention.See related commenta

264 gression of prostate cancer and is a crucial target for therapeutic interventions.

265 lucidating key structural motifs that can be targeted for therapeutic regulation.

266 e detrimental, and agents amenable to tissue targeting for therapeutic application have been lacking.

267 s enhance metastasis, and provides potential targets for therapeutic intervention in this heterogeneo

268 Metalloenzymes are attractive targets for therapeutic intervention owing to their cent

269 Complement factors are being considered as targets for therapeutic intervention.

270 iving HIV-1 pathogenesis and to identify new targets for therapeutic intervention.

271 V-2 infection and indicate that immune-based targets for therapeutic interventions constitute a promi

272 mmune diseases they have gained attention as targets for therapeutic interventions.

273 al flow and bacterial motility are potential targets for therapeutically managing bacterial spatial o

274 decreased in cancers, making it a potential target for therapeutics to limit the progression of thes

275 istance to CG in BTCs and may be tested as a target for therapeutics.

276 IV infection in the gut and may serve as new targets for therapies aimed at curing HIV.

277 yc-regulated fatty acid synthesis is a valid target for therapy and/or prevention of prostate cancer.

278 dominately considered as isolated structural targets for therapy, but their interdependency highlight

279 ypes to more aggressive states represent key targets for therapy.

280 vian-like cellular receptors are the primary target for these viruses.

281 While the histone targets for these enzymes are well characterized, the co

282 of translocator protein (TSPO), the reported target for this small molecule, and instead were driven

283 landscape and identify candidate therapeutic targets for this dismal cancer.

284 ediatric age group and current interventions targeted for those <5 years are appropriate.

285 17 subset of CD4(+) Th cells, is a promising target for treating a host of autoimmune diseases.

286 tic function may represent a new therapeutic target for treating disordered energy metabolism metabol

287 uld be prioritized as a novel candidate drug target for treating dyslipidemia and associated CVD.

288 ing tissue injury and identifying new immune targets for treating thermal injury.

289 lator could serve as a potential therapeutic target for treatment of HCC.

290 Hopkins Motor/Vocal Tic Scale (HM/VTS) were targeted for treatment during HRT.

291 causally linked with depression, so could be targets for treatment and prevention of depression.

292 lts provide novel behavioral and brain-based targets for treatment of pediatric anxiety disorders.

293 regulator of ER homeostasis and a potential target for tumor therapy.

294 viding additional possible novel therapeutic targets for tumors having deregulated Wnt/beta-catenin s

295 As and whole viruses and can be specifically targeted for universal detection.

296 K-inhibitors, suggesting a unified treatment target for up to 80% of DS-ALL.

297 ity might be used to identify an optimal TMS target for use in all patients and potentially even a pe

298 erstanding immune protection and identifying targets for vaccine design.

299 predictive algorithms to identify potential targets for vaccine development.

300 E1, E2, E4, E5, and L1 proteins as dominant targets for virus-specific CD8+ and CD4+ T cells.