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1 potent taxoids were termed "third-generation taxoids".
2 nsitivity to Taxol and Taxotere, a synthetic taxoid.
3 ution of the 3-phenylisoserine side chain of taxoids.
4  tubulin at a site distinct from that of the taxoids.
5 3 (DW-2), which consist of a next-generation taxoid, 1 (SB-T-1214), and camptothecin as two warheads,
6                                    Moreover, taxoid 19 exhibited excellent in vivo efficacy against h
7                                              Taxoids 19 and 14g also showed excellent cytotoxicity ag
8                 We formulated 3rd generation taxoids, able to avoid common drug resistance mechanisms
9     Competition studies versus a fluorescent taxoid across a temperature range, in comparison with pa
10                  However, the composition of taxoids across the whole stem and the stem tissue-specif
11  of 0.42 mM and 0.40 mM for the N-deacylated taxoid and benzoyl-CoA, respectively.
12                      These data suggest that taxoids and camptothecin analogs could have activity in
13                                              Taxoids and other microtubule-damaging drugs are known t
14 earing methyldisulfanyl(alkanoyl) groups for taxoid-antibody immunoconjugates were designed, synthesi
15 say, i.e., the IC50 values of almost all the taxoids are in the subnanomolar level.
16                      Several new nonaromatic taxoids are synthesized by means of the beta-lactam synt
17 bulin poisons (maytansinoids auristatins and taxoids) are undergoing clinical evaluation or are in pr
18                                              Taxoids bearing methyldisulfanyl(alkanoyl) groups for ta
19 tropic profile as compared with those of the taxoid binding reactions, which are characterized more b
20 es that have a Phe270-to-Val mutation in the taxoid binding site of beta-tubulin.
21 , which has a 3-fold higher affinity for the taxoid binding site than paclitaxel, indicated that 6-ep
22 ived from Taxus cuspidata cells (induced for taxoid biosynthesis with methyl jasmonate) was undertake
23 at cyclostreptin formed a pharmacophore with taxoids but formed hydrogen bonds only with the S9-S10 a
24    A cDNA clone (designated TAX7) encoding a taxoid C-13 O-phenylpropanoyltransferase was isolated wh
25 lear cooperative effect was observed for the taxoid-camptothecin combination when two drugs were deli
26                           Differences in the taxoid composition of different stem tissues suggest tha
27 y conjugating a specific microtubule-binding taxoid core to the tetrazole/alkene prefluorophores, rob
28                              A series of new taxoids derived from 14 beta-hydroxy-10-deacetylbaccatin
29 ts, we assessed the in vitro activity of the taxoid docetaxel (Taxotere; Rhone-Poulenc Rorer, Antony,
30 nd interaction partner with C19ORF5, and the taxoid drug family.
31                          A number of the new taxoids exhibit remarkable activity (IC50 = 2.1-9.1 nM)
32                            A number of these taxoids exhibited exceptionally high potency against mul
33  multidrug-resistant cell lines, and several taxoids exhibited virtually no difference in potency aga
34  products with minimal structural analogy to taxoids, have effects similar to those of paclitaxel (Ta
35 o previously uncharacterized cytochrome P450 taxoid hydroxylases, and provided candidate genes for al
36 t solubilization of different 3rd generation taxoids irrespective of the drug's chemical structures w
37   The observed exceptional activity of these taxoids may well be ascribed to an effective inhibition
38 the oxygenation steps of taxane diterpenoid (taxoid) metabolism.
39 toxy-14 beta-(2-methyl)butyrate (7), a major taxoid metabolite isolated from Japanese yew heart wood.
40            This strategy yielded a family of taxoid-metabolizing enzymes and revealed the taxane 10 b
41                                These include taxoids modified with 3-methylbut-2-enoate, 3-methylbuta
42 by peloruside, which targets a distinct, non-taxoid pocket on beta-tubulin.
43                     All but one of these new taxoids possess better activity than paclitaxel and doce
44                   Two of the fully aliphatic taxoids possess similar or stronger activity than paclit
45  means of attaching modified aroyl groups to taxoid precursors for the purpose of improving drug effi
46                                      The new taxoid SB-T-1213 (4a) shows an excellent activity (T/C =
47    Moreover, a selected formulation with the taxoid SB-T-1214 is about one to two orders of magnitude
48                       Among these, three new taxoids, SB-T-1213 (4a), SB-T-1214 (4b), and SB-T-1102 (
49 F-7) cancer cell lines, and several of these taxoids show subnanomolar IC50 values which are severalf
50 ntly enhance the structural diversity of the taxoid side chain library obtained (16 additional taxoid
51 d side chain library obtained (16 additional taxoid side chains).
52 s could act synergistically with a number of taxoid site agents [paclitaxel, epothilones A/B, discode
53                                  None of the taxoid site compounds showed any synergism with each oth
54 laulimalide site, which is distinct from the taxoid site.
55 onds only with the S9-S10 and M loops in the taxoid site.
56 on tubulin polymer that is distinct from the taxoid site.
57 , K(m) values of 0.64 mM and 0.30 mM for the taxoid substrate and benzoyl-CoA, respectively, and is a
58 o screening of oxygenase activity by feeding taxoid substrates.
59 ated with a long-wavelength photoactivatable taxoid-tetrazole probe.
60      Highly efficient photoactivation of the taxoid-tetrazoles inside the mammalian cells was also ob
61                              Most of the new taxoids thus synthesized possess excellent cytotoxicity
62                                      The new taxoids thus synthesized show excellent cytotoxicity aga
63 ctive inhibition of the binding of these new taxoids to P-glycoprotein that is responsible for MDR.
64 hly cytotoxic C-10 methyldisulfanylpropanoyl taxoid was conjugated to monoclonal antibodies recognizi
65                                        These taxoids were found to possess exceptional activity in pr
66                   These exceptionally potent taxoids were termed "third-generation taxoids".
67  complex mixture of chemical analogs, termed taxoids, which complicates its production in pure form,
68 n of prodrug modules of an anticancer agent (taxoid with a cleavable linker) that is activated to its
69  11(12)-diene has been utilized to prepare a taxoid with oxygenation in the B and C rings.
70                                 In addition, taxoids with 2-methylprop-1-enyl, 2-methylpropyl, (E)-pr
71 ppropriate alkyl and alkenyl groups provides taxoids with equivalent or superior activity.
72 2-methyl-1-propenyl) and 3'-(2-methylpropyl) taxoids with modifications at C-10 was synthesized by me
73                      Novel second-generation taxoids with systematic modifications at the C2, C10, an