ライフサイエンスコーパス: tectal

1 o and in vitro demonstrated that spontaneous tectal activity increased to 150% of normal during refin

2 v neurons form a pathway by which integrated tectal activity rapidly feeds back to the GLv and exerts

3 After refinement at 3 months, tectal activity was again highly dependent on ongoing re

4 retinal activity had no detectable effect on tectal activity.

5 ation in goldfish, we examined its effect on tectal activity.

6 as an organiser/signalling centre to pattern tectal and cerebellar compartments.

7 results suggest that a unique integration of tectal and cortical inputs may contribute to the respons

8 ("second-order") that integrates convergent tectal and cortical inputs.

9 Tectal and retinal afferents terminate homotopically wit

10 Recruitment of small tectal assemblies appears to link perception to action b

11 erence on the spatiotemporal organization of tectal assemblies, their composition and the logic of th

12 ns and redirect their extension along the LM tectal axis, away from their proper termination zones (T

13 RGC axons lack DV ordering along the LM tectal axis, but directionally extend interstitial branc

14 ral retinal mapping along the lateral-medial tectal axis.

15 f retinal axons along the anterior-posterior tectal axis.

16 o generate appropriate mapping along the A-P tectal axis.

17 zone (TZ) along the anterior-posterior (A-P) tectal axis; temporal axons overshoot the greatest dista

18 By E7.5-E8.0, the tectal axons innervated the ipsilateral Rt, in which som

19 ons receive input from multiple cortical and tectal axons.

20 ans (HSPGs) are normally associated with the tectal basement membrane but are dispersed in the dragne

21 revious studies demonstrated that increasing tectal BDNF levels promotes RGC axon terminal arborizati

22 Increasing tectal BDNF levels resulted in a significant increase in

23 Neutralizing endogenous tectal BDNF with function-blocking antibodies significan

24 c branching, whereas neutralizing endogenous tectal BDNF with function-blocking antibodies significan

25 ynaptic transmission regulates Xenopus optic tectal cell dendritic arbor development in vivo by expre

26 We now demonstrate that tectal cell expression of CPG15 significantly increases

27 Pairing light stimuli with spiking of the tectal cell induced persistent enhancement or reduction

28 resented similarly in both the RGC input and tectal cell populations illustrating feature-dependent d

29 to an overlapping cardinal representation by tectal cell populations.

30 ng changes in brain morphology and increased tectal cell proliferation.

31 methimazole, led to corresponding changes in tectal cell proliferation.

32 count for the asymmetric modification of the tectal cell receptive field induced by moving bar.

33 r-induced temporally specific changes in the tectal cell responses.

34 sing the temporal coherence and precision of tectal cell spiking.

35 st, we identify an emergent population of DS tectal cell with a direction preference not explicitly p

36 rgic and GABAergic inputs (E/I ratio) to the tectal cell: LTP is induced only when the E/I ratio is a

37 sponse results in larger receptive fields of tectal cells and a degradation of the retinotopic map.

38 protein labelling in non-sensory cells, the tectal cells and inner border cells of the rat organ of

39 etinal ganglion cells and Wnt secretion from tectal cells are specifically responsible for the enhanc

40 It required spiking of postsynaptic tectal cells as well as activation of NMDA receptors, an

41 osely corresponds to that of the bottlebrush tectal cells described previously for chickens and squir

42 ude that spontaneous retinal activity drives tectal cells in normal fish and after regeneration but n

43 ntal plasticity of receptive fields (RFs) of tectal cells in the developing Xenopus optic tectum.

44 e of substance P-like immunoreactive (SP-IR) tectal cells in the untreated lobe while disrupting topo

45 trate by in vivo time-lapse imaging of optic tectal cells in Xenopus laevis tadpoles that enhanced vi

46 The changes in excitability also rendered tectal cells more responsive to synaptic burst stimuli,

47 ed plasticity of AMPAR transmission in optic tectal cells of tadpoles with low levels of previous syn

48 Cs purified to 100% shows that RGCs, but not tectal cells, express NT-3 mRNA.

49 axis requires chemorepellent signalling from tectal cells, expressing ephrin-A ligands, to retinal gr

50 ile other studies have shown that in Xenopus tectal cells, GABA(C) receptors mediate inhibition, in r

51 ncing presynaptic RGC axons and postsynaptic tectal cells.

52 e for crosstalk between Rho GTPases in optic tectal cells.

53 dendritic arbor growth rate of Xenopus optic tectal cells.

54 al ganglion cell (RGC) inputs represented in tectal cells?

55 ection and the spatiotemporal progression of tectal cellular development onto Eph/ephrin expression p

56 n of the labeled optic nerve alone increased tectal CG-1 fluorescence whereas electrical stimulation

57 g of the scene, can induce adaptation of the tectal circuitry to the common orientation and thus achi

58 ng the possible roles of SIN function in the tectal circuitry.

59 neuronal dendritic arbors suggest that optic tectal circuits are extremely plastic during early stage

60 orm for understanding emergent properties in tectal circuits associated with visually driven behavior

61 We show that tectal circuits can perform multisensory computations in

62 trating feature-dependent differences in how tectal circuits process their inputs.

63 or the correct wiring of direction-selective tectal circuits, but it is crucial for the rapid assembl

64 correlates with the increased complexity of tectal dendrites and more restricted distribution of den

65 rmore, we show that structural plasticity of tectal dendrites and RGC axons compensates for the loss

66 ), a cholinergic nucleus thought to modulate tectal-dependent, goal-directed behaviors.

67 react in opposing manners to retinal- versus tectal-derived BDNF.

68 etics we show that at increased firing rates tectal-derived dLGN-INs generate a powerful form of toni

69 the degree of visual encoding during retino-tectal development and how it dynamically evolves from a

70 rgic synapses are present at early stages of tectal development and, when activated by optic nerve st

71 We found that during a critical time in tectal development, network activity becomes increasingl

72 ld for neuronal migration at early stages of tectal development.

73 in the tectum, which may have other roles in tectal development.

74 most specific phenotypes: intact retinal and tectal differentiation but multiple neurite targeting de

75 However, tectal direction selectivity is severely perturbed at ea

76 help gate omnipause activity and allow other tectal drives to induce the bursts of firing in premotor

77 Tectal EphB expression becomes uniform at later stages a

78 the spatial extent and tuning profile of the tectal excitatory RF barely changed after intratectal ex

79 truct graded gene expression, a quantitative tectal explant assay was developed.

80 The tectal feature map originates from a linear combination

81 tive means of alleviating these stresses are tectal foliation and the formation of pial holes.

82 These projections originate from widefield tectal ganglion cells (TGCs) located in layer 13 in the

83 inating from a distinct neuronal population, tectal ganglion cells (TGCs), of the optic tectum/superi

84 dendritic bottlebrushes of motion detecting tectal ganglion cells (TGCs).

85 s has the appropriate connections to support tectal gating of OPN activity.

86 ephrin-As, normally in posterior > anterior tectal gradients, showed graded upregulation.

87 tectum and pretectum or bilaterally to both tectal hemispheres.

88 intertectal neurons (ITNs), that connect the tectal hemispheres.

89 ituting the neuronal substrate for the tecto-tectal inhibition.

90 RGCs were prelabeled by bilateral tectal injection of 5% Fluoro-Gold (FG).

91 Tectal injection of the NMDA receptor antagonists APV or

92 verlap with previously identified regions of tectal input to the pulvinar.

93 2) Tectal inputs to Ipc and SLu are Brn3a-immunoreactive ne

94 natomical substrate for the inhibitory tecto-tectal interaction.

95 Short-interval time-lapse images reveal that tectal interneuron arbors have rapid rates of branch add

96 of cells, largely comprised of glutamatergic tectal interneurons with non-stratified morphologies, th

97 Tectal interneurons, like projection neurons, develop fr

98 ression of a number of key genes involved in tectal-isthmo-cerebellum development.

99 induction of different structures within the tectal-isthmo-cerebellum region.

100 in was present after formation of definitive tectal laminae, but was diffuse and not aligned along RG

101 had dendrites oriented perpendicular to the tectal laminae, extending superficially into the retino-

102 dendrites that were oriented parallel to the tectal laminae.

103 olume and ventricular surface area, disturbs tectal lamination, and creates small discontinuities in

104 abnormalities would generate disturbances in tectal lamination.

105 uditory AI, revealed a massive projection to tectal layer 13 and other tectal related areas, sparing

106 ateral projection originating from this same tectal layer.

107 feature is the presence of terminals in deep tectal layers 11-13.

108 s was present only at intermediate levels in tectal layers 8 and 9, and undetectable in the deeper te

109 phologies and axonal projections to specific tectal layers and extratectal targets.

110 lusters of cells that fail to integrate into tectal layers and of atypical long-range projections, wh

111 chanisms underlying the precise targeting of tectal layers by ingrowing retinal axons are largely unk

112 NT-3 immunolabel in these tectal layers is largely reduced or abolished after trea

113 The p75 label in the neuropil of superficial tectal layers is largely reduced or eliminated by inject

114 48 hours, the ultrastructure of superficial tectal layers was analyzed and compared with samples fro

115 rise the majority of synapses in superficial tectal layers, as demonstrated by destruction of retinot

116 ructures in the superficial and intermediate tectal layers, establishing asymmetric synapses with sev

117 ), send synchronized feedback signals across tectal layers.

118 llowing for subsequent innervation of deeper tectal layers.

119 yers 8 and 9, and undetectable in the deeper tectal layers.

120 d by a pathway that relays activity from one tectal lobe to the other.

121 Chronic treatment of one tectal lobe with the non-NMDA receptor antagonist, 6-cya

122 disrupted the topographic map in the treated tectal lobe.

123 ields in the Rt tend to synchronize with the tectal location receiving the "winning" feedback from Ip

124 the feedback from Ipc but not from SLu to a tectal location suppresses visual responses to moving st

125 In midbrain tectal map development, FGFs can induce an entire midbra

126 s RGC axon branching during retinocollicular/tectal map formation via upregulation of miRNA-132, whic

127 y play a role in the formation of the mature tectal map.

128 ons branch equally on anterior and posterior tectal membranes, indicating that the level of ephrin-As

129 n their topographically appropriate anterior tectal membranes.

130 ptosis, increased neural differentiation and tectal migration.

131 1) and peak (E15) of gliogenesis in an avian tectal model of penetrating embryonic brain trauma, with

132 ctivation are critical for the maturation of tectal network dynamics during visual system development

133 zing the temporal response properties of the tectal network, and provides a substrate for rapid modul

134 ns make synaptic contact with these or other tectal neural elements remains undetermined.

135 immunohistochemical labeling of retinal and tectal neurites to detect patterning errors.

136 We first altered tectal neuron activity by selectively manipulating excit

137 ining-induced changes require spiking of the tectal neuron and activation of a NMDA (N-methyl-D-aspar

138 mechanosensory inputs to specific regions of tectal neuron dendrites in the tadpole optic tectum requ

139 um significantly increased synapse number in tectal neuron dendritic arbors within 24 hours, without

140 These results suggest that spike output of a tectal neuron plays an important instructive role in dev

141 We show that in development tectal neuron properties not only change on average, but

142 provides a substrate for rapid modulation of tectal neuron receptive-field properties.

143 Tectal neuron recordings, 4 h after the initial seizure,

144 etween the total level of synaptic input and tectal neuron spike output is conserved.

145 Using in vivo time-lapse imaging of tectal neuron structure and visually evoked Ca(2+) respo

146 al connectivity and indicate that changes in tectal neuron synaptic connectivity are secondary to the

147 The second tectal neuron type labeled by the id2b:gal4 transgene is

148 ion pattern enabled us to characterize three tectal neuron types with distinct morphologies and conne

149 complexity seen in d-serine-treated animals, tectal neuron visual receptive fields were expanded, sug

150 The pattern of visual inputs onto a tectal neuron was tracked over time by rapid reverse cor

151 mpanied by an asymmetric modification of the tectal neuron's receptive field.

152 ession (LTD) of GABAergic inputs to the same tectal neuron.

153 r unstimulated converging inputs on the same tectal neuron.

154 When optic drive was not altered and tectal neuronal activity was instead increased or decrea

155 d rhythmic post-CS activities among specific tectal neuronal ensembles, with a regular interval that

156 ent refinement and visual inputs strengthen, tectal neurons adapt their intrinsic excitability such t

157 on ([Cl-]i) was found to be high in immature tectal neurons and then falls over a period of several w

158 Individual tectal neurons are known to receive converging inputs fr

159 itatory and inhibitory inputs in more mature tectal neurons are spatially matched, with each spot sti

160 Analysis of mutant tectal neurons at late developmental stages reveals that

161 Altering normal spiking activity of tectal neurons by either blocking or elevating GABA(A) r

162 retinotectal system, the receptive field of tectal neurons can be 'trained' to become direction-sens

163 In vivo imaging of single optic tectal neurons coexpressing tdTomato and PSD-95-GFP reve

164 Tectal neurons containing Ca2+-AMPARs form a gradient al

165 It thus appears that some tectal neurons could project to rUva and PL via branched

166 n contrast, overexpression of GFP-TrkB.T1 in tectal neurons did not alter synaptic number or the morp

167 At the onset of vision, many tectal neurons do not exhibit visual spiking behavior, d

168 suppression of sprouting in cultured Xenopus tectal neurons during an early period when neither AMPA/

169 his translates into functional properties of tectal neurons during development.

170 NMDARs exhibit low magnesium sensitivity in tectal neurons during the first few days in culture.

171 Thus, tectal neurons exhibit archetypical homeostasis, one of

172 ults primarily from a shift in the tuning of tectal neurons for interaural time difference.

173 Tectal neurons had significantly fewer dendrite branches

174 collected time-lapse images of single optic tectal neurons in albino Xenopus tadpoles expressing dom

175 We use in vivo patch-clamp recordings of tectal neurons in developing Xenopus tadpoles to control

176 we recorded light-evoked responses in optic tectal neurons in living Xenopus tadpoles.

177 unctions in the morphological development of tectal neurons in living Xenopus tadpoles.

178 onse properties of populations of developing tectal neurons in response to visual stimuli.

179 imentally in neocortical pyramidal cells and tectal neurons in vitro.

180 ility or synapse strengthening in developing tectal neurons in vivo by electroporation of a leak K+ c

181 c synapses, we prematurely reduced [Cl-]i in tectal neurons in vivo by expressing the Cl- transporter

182 Whole-cell recordings from optic tectal neurons indicate that CPG15 expression promotes r

183 morphology and neurotransmitter phenotype of tectal neurons labeled by an id2b:gal4 transgene.

184 fish, while performing two-photon imaging of tectal neurons loaded with a fluorescent calcium indicat

185 minished the deprivation effects observed on tectal neurons of Stage 45 tadpoles.

186 GluR1 (GluR1Ct) and GluR2 (GluR2Ct) in optic tectal neurons of the Xenopus retinotectal system.

187 Here, in vivo whole-cell recordings from tectal neurons of young Xenopus tadpoles reveals activit

188 Tectal neurons possess well-defined spatial receptive fi

189 Tectal neurons projecting on Ipc possess "shepherd's cro

190 Single tectal neurons receive converging visual and electrosens

191 intrinsic properties allow developing optic tectal neurons to remain within a stable dynamic range,

192 Tectal neurons transfected with dominant-negative insuli

193 f retinotectal synapses, spike visual RFs of tectal neurons underwent a two-stage developmental modul

194 g rates, indicating that the responsivity of tectal neurons was altered.

195 When excitatory synaptic drive to tectal neurons was eliminated by blocking optic fibers,

196 Many tectal neurons were also time-locked to licking, but the

197 Single optic tectal neurons were labeled with DiI and imaged at daily

198 es of a genetically identified population of tectal neurons with a defined axonal projection to a sec

199 will require tools to monitor and manipulate tectal neurons with cell type specificity.

200 bining in vivo time-lapse imaging of Xenopus tectal neurons with electron microscope reconstructions

201 We identified a subset of tectal neurons with similar highly selective tuning, whi

202 We show that tectal neurons with similar spiking profiles often have

203 rinsic adaptations function together to keep tectal neurons within a constant operating range, while

204 o produce a unilateral focal injury to optic tectal neurons without damaging retinotectal axons.

205 ases dendritic arbor growth rates in control tectal neurons, a weak postsynaptic response to visual e

206 p layers, as well as the dendrites of single tectal neurons, are preferentially activated by small vi

207 y inhibited the activity of the lick-related tectal neurons, disrupted their licking-related oscillat

208 o not influence the functional properties of tectal neurons, one prediction is that the RF positions

209 and led to extensive retrograde labeling of tectal neurons, predominantly in layer 13.

210 etrograde labeling of predominantly layer 13 tectal neurons, retrograde labeling of PL neurons, and a

211 e output was dampened in a small subgroup of tectal neurons, starting from developmental stages 44-46

212 gether with the timescale of the response by tectal neurons, suggest that the effects of BDNF on dend

213 BDNF shapes synaptic connectivity by imaging tectal neurons, the postsynaptic partners of RGCs.

214 le-cell voltage-clamp recording from Xenopus tectal neurons, we found that RFs determined by excitato

215 tric calcium imaging, we show that posterior tectal neurons, which serve to detect prey at a distance

216 ers and forms synapses onto the dendrites of tectal neurons.

217 3a determines the laminar fate of subsets of tectal neurons.

218 on and increased GABAergic synaptic input to tectal neurons.

219 y of excitatory and inhibitory inputs to the tectal neurons.

220 ncreases the intrinsic excitability of optic tectal neurons.

221 ceptor function by decreasing cAMP levels in tectal neurons.

222 in changes in the integrative properties of tectal neurons.

223 s an early neurite sprouting response of the tectal neurons.

224 nd mutant isoforms of Homer in Xenopus optic tectal neurons.

225 l, synapse formation, or dendritic growth of tectal neurons.

226 but not GABAergic or glycinergic inputs, on tectal neurons.

227 n order to characterize the RF properties of tectal neurons.

228 at forms a stratified dendritic arbor in the tectal neuropil and an axon that exits tectum to form a

229 thin the optic tract and adhesion within the tectal neuropil are regulated by vrt, coma, bluk, clew a

230 Laser-induced lesions of the tectal neuropil impaired the behavior.

231 Here we report brain activity in the tectal neuropil ipsilateral to the visually stimulated e

232 ree-dimensional reconstructions of the optic tectal neuropil of Xenopus laevis tadpoles to detect and

233 of the SIN cell body along the depth of the tectal neuropil or with the orientation of its neurites.

234 The superficial layers of the tectal neuropil receive input from retinal axons, while

235 lation and the intrinsic organization of the tectal neuropil, have been less accessible to investigat

236 of DS cells at the superficial border of the tectal neuropil, one of which is an emergent population.

237 t the labeled retinal fibers demarcating the tectal neuropil, the larval tectum could be selectively

238 ly dynamic filopodial protrusions within the tectal neuropil, the motility of which has previously be

239 the retinal inner plexiform layer (IPL) and tectal neuropil.

240 nd brek, are required for confinement of the tectal neuropil.

241 kdown produce similar increases in FUNCAT in tectal neuropil.

242 rbors and one stratified axonal arbor in the tectal neuropil.

243 Staining of pretectal nuclei, tectal nuclei, and other areas of the mesencephalon beca

244 ricle or into the eye, selectively increased tectal or retinal cell proliferation, respectively.

245 t, in birds, Ipc axons control the ascending tectal outflow of retinal signals through direct synapti

246 in-A family members in the retinal axons and tectal parenchyma that may help guide regenerating fiber

247 However, ephrin-A expression in the tectal parenchyma was not significantly elevated by eith

248 ould be a relay station in an indirect tecto-tectal pathway constituting the neuronal substrate for t

249 propose a model for how temporal dynamics in tectal periventricular neurons might arise from computat

250 We found marked Tbeta4 expression in the tectal plate and in all neuronal layers of later develop

251 1-year-old male with a history of metastatic tectal plate low-grade glioma who was diagnosed at age 2

252 end columnar axon terminals back to the same tectal position receiving the retinal input.

253 synchrony rapidly lost the ability to drive tectal postsynaptic partners while their axons grew and

254 ow that SHH is a mitogen for neocortical and tectal precursors and that it modulates cell proliferati

255 g demonstrated that local TH first increased tectal progenitor cell proliferation, expanding the prog

256 y changes in visual experience that increase tectal progenitor cell proliferation.

257 Injury induces a burst of proliferation of tectal progenitor cells based on phospho-histone H3 immu

258 ify the daughter neurons derived from single tectal progenitor cells in Xenopus laevis tadpoles.

259 eriments showing that Musashi-immunoreactive tectal progenitors incorporate the thymidine analog chlo

260 in the axons and growth cones of retinal and tectal projection neurons.

261 srupts synaptic pruning of developing retino-tectal projections in larval zebrafish.

262 al ganglia are evolutionarily conserved, the tectal projections of the SNr may show a similar pattern

263 l connections coincides with the schedule of tectal projections onto the contralateral intrinsic nucl

264 Pulvino-tectal (Pul-T) cells lie at the caudal pole of the PulC,

265 the optic tectum of other teleost fish: the tectal pyramidal neuron (PyrN).

266 It begins in the tectal regions in which the initial connections of isthm

267 high levels of ligand (dorsal) projecting to tectal regions with high receptor expression (ventral).

268 ecause temporal RGC axons innervate anterior tectal regions, PTPmu may regulate the formation of topo

269 sive projection to tectal layer 13 and other tectal related areas, sparing auditory, and trigeminal o

270 to have reduced responsiveness to posterior tectal repellent activity in vitro and to shift more pos

271 t accompanied by increased responsiveness to tectal repellent activity, in contrast to the comparable

272 rby stimulus locations produced intermingled tectal responses, and decoding based on map topography y

273 vious work, we have proposed a striatonigral-tectal-reticular neural pathway mediating the effects of

274 ir axon terminals in the medial sublamina of tectal retino-recipient layer of immobilized cyprinid fi

275 arborize, and form synapses within distinct tectal retinorecipient layers.

276 Thus, thalamic and tectal sensory relays work synergistically to detect low

277 (g) There are no adult cerebellar and tectal shh-GFP cells confirming their exclusive role dur

278 competing representations across the entire tectal space map.

279 that, in contrast to reticulospinal neurons, tectal steering/turning command neurons should have mini

280 ast, Mek1(DD) expression fails to rescue the tectal stem zone and the inferior colliculus in the abse

281 (DD)), the known ERK activator, restores the tectal stem zone and the inferior colliculus without Ptp

282 elies on the provision of new cells from the tectal stem zone.

283 irst, it is highly expressed in thalamic and tectal structures.

284 , which indicates facilitation by the retino-tectal subcortical pathway.

285 t affect the extent of axon outgrowth on the tectal surface but instead caused ectopic arborization p

286 ITNs are GABAergic, establish tectal synapses bilaterally and respond to small moving

287 l stimulation regulates glutamatergic retino-tectal synapses in Xenopus tadpoles.

288 its known short-latency connections with the tectal system, mediates temporally defined auditory-visu

289 nt of axon behavior during multiple steps of tectal target innervation.

290 ish vs. mammals, with direct guidance to the tectal target zone in the former and overshoot followed

291 E6 and E8, when retinal axons grow to their tectal targets, and gradually declines at later developm

292 op-down modulations specifically directed to tectal targets, just like the auditory and trigeminal AI

293 onnectivity between DS-RGCs and their normal tectal targets.

294 organization of tracer-labeled cortical and tectal terminals and terminals labeled with antibodies a

295 PN, cortical terminals are located distal to tectal terminals and that vGLUT1 and vGLUT2 antibodies m

296 dies may be used as markers for cortical and tectal terminals, respectively.

297 rformed bilateral anterograde and retrograde tectal tracing combined with GABA immunohistochemistry i

298 ng retinal activity with TTX rapidly reduced tectal unit activity by >90%.

299 emonstrate that the functional refinement of tectal visual RFs results primarily from a selective eli

300 FGF2 treatment also increases tectal volume and ventricular surface area, disturbs tec