ライフサイエンスコーパス: tedious

1 with a perturbed lipid content are slow and tedious.

2 trometry (MS) where it is time-consuming and tedious.

3 As to As(III) is difficult in the field and tedious.

4 intact brain tissue; however, the method was tedious.

5 ands of effectors is sometimes difficult and tedious.

6 n mutations in specific genes or proteins is tedious.

7 ess proteins for their purification is often tedious.

8 ns and HPLC, is extremely time consuming and tedious.

9 r, rendering structure--function correlation tedious.

10 s because the genotyping procedure is rather tedious.

11 volumes measured by edging techniques can be tedious.

12 feeding tube placement can be difficult and tedious.

13 is available; for others, typing methods are tedious.

14 have multiple harmful side effects, and are tedious.

15 the preparation of these conjugates is often tedious.

16 in-MOF interactions in aqueous media remains tedious.

17 geometric and dielectric configurations are tedious.

18 rd, and using it to build large maps, can be tedious.

19 ical functional interactions can be slow and tedious.

20 ty of the matrix which is time-consuming and tedious.

21 ls or identifying correctly edited clones is tedious.

22 onstruction of complex oligosaccharides less tedious, a high level of technical expertise is still ne

23 aps are complex sensitive systems, requiring tedious alignment to achieve perfect symmetry with rathe

24 ut capabilities and freeing researchers from tedious analyses.

25 Since culture is tedious and also detects nontoxigenic C. difficile, we c

26 etal contamination are often very expensive, tedious and can only be handled by trained personnel.

27 dling 3D cells/hydrogel culture construct is tedious and cellular response is difficult to be quantit

28 ered by the identification of metabolites, a tedious and challenging task.

29 sc (LoD) system with a potentiostat is often tedious and challenging.

30 methods for DNA analysis involve a series of tedious and complicated steps, in which important geneti

31 RLM construction and features extraction are tedious and computationally intensive while the images a

32 ials in functional biomaterials, and yet the tedious and costly covalent peptide modification and the

33 m crude leaf and stem extracts, avoiding the tedious and costly isolation of high-quality RNA.

34 However, Congo red staining is tedious and costly to perform, and prone to false diagno

35 mutagenic compounds in cell-based assays is tedious and costly.

36 from radiometric-based assays that are both tedious and discontinuous.

37 he classical synthesis of these compounds is tedious and does not allow the regioselective introducti

38 process of model specification, avoiding the tedious and error prone task of manually enumerating all

39 the DNA on the level of nucleotides becomes tedious and error prone, requiring a new generation of c

40 Manual creation of these files is tedious and error-prone, and a graphical input tool is d

41 mbiguously identifying the active agent is a tedious and expensive endeavor.

42 sponse curve for each analyte of interest, a tedious and expensive proposition.

43 irus (HSV)-specific CD8(+) T lymphocytes are tedious and indirect.

44 s during the course of an immune response is tedious and indirect.

45 clude at least one such step, although it is tedious and inefficient.

46 urrently designed by a process that involves tedious and laborious filtering of potential candidates

47 ds from LNPs; therefore, they are subject to tedious and lengthy procedures, LNP stability, and unpre

48 To avoid such tedious and lengthy procedures, vacuum matrix-assisted l

49 However, the resulting protocol is tedious and lengthy, and requires too many user steps to

50 crystal provide complete information but are tedious and limited in applicability.

51 n kinetics, yet current techniques are often tedious and limited in sensitivity.

52 Very often, chemical transformations require tedious and long procedures, which, sometimes, can be av

53 ssigning E3s to their cognate substrates are tedious and low throughput.

54 ins from inclusion bodies, a process that is tedious and may lead to significant loss of yield.

55 This traditional procedure is tedious and not easily reproducible, especially when wor

56 However, manual curation is tedious and not readily scalable or standardized.

57 purified CdTe nanoparticle samples, avoiding tedious and often impossible purification and fractionat

58 It is a tedious and practically impossible task to visually insp

59 tion of multiple gene fusions are limited by tedious and prolonged experimental protocols, thus limit

60 nation by trained pathologists, which can be tedious and prone to human error.

61 of these methods are usually time-consuming, tedious and require special or expensive equipment.

62 s-phase and manual Edman sequencing, is very tedious and requires about 10 pmol of pure, labeled glyc

63 nown invariant T cell populations has been a tedious and slow process, identifying them one by one.

64 newborn screening and other applications are tedious and slow, with limited options for automated ana

65 However, this process is tedious and subject to inter- and intra-reader variabili

66 t manual methodology for image analysis is a tedious and subjective approach, there is clearly a need

67 and by scoring every sample in a screen via tedious and subjective visual inspection.

68 As manual cancer annotation is tedious and subjective, there have been a number of publ

69 counts of organisms in aerial imagery can be tedious and subjective.

70 cutoff and scored accordingly, which can be tedious and subjective.

71 uclei on massive histopathological images is tedious and the counting results might vary due to the s

72 mbers of organoids with current protocols is tedious and the level of hepatic differentiation is limi

73 aide of current software tools, but this is tedious and time consuming for the high marker density d

74 des ago, still mostly practiced by following tedious and time consuming manual processes.

75 of the many known inhibitory compounds is a tedious and time consuming task, yet it can be achieved

76 ch makes manual chromatogram inspection very tedious and time consuming, especially for large dataset

77 nium metal for determining D/H ratio is both tedious and time consuming.

78 cells randomly for high producing clones is tedious and time consuming.

79 results within 24h, but they are expensive, tedious and time consuming.

80 e, and most methods to disperse CNTs rely on tedious and time-consuming acid-based oxidation.

81 urified virus preparation without relying on tedious and time-consuming cesium chloride gradient sepa

82 g features in the acquired mass spectra is a tedious and time-consuming challenge.

83 thesis conditions for these materials can be tedious and time-consuming due to the large number of pa

84 A once tedious and time-consuming glycan analysis workflow is n

85 small neuronal processes and accelerate the tedious and time-consuming human proofreading effort.

86 s and targets are usually investigated using tedious and time-consuming immunofluorescence imaging.

87 ully automated, and one must rely on manual, tedious and time-consuming manipulation of sequences.

88 molecular diagnostic applications is still a tedious and time-consuming procedure.

89 prior information, therefore ruling out the tedious and time-consuming process of modeling all the e

90 T angiography (CTA) by physicians which is a tedious and time-consuming process that is susceptible t

91 g such collection and analysis manually is a tedious and time-consuming process.

92 However, the measurement is tedious and time-consuming since it requires thousands o

93 This system can bypass the tedious and time-consuming steps of conventional protein

94 al identification of catalytic residues is a tedious and time-consuming task, which can be expedited

95 egy should reduce the number of error-prone, tedious and time-consuming weighing procedures required

96 The correlation process, however, is often tedious and time-consuming with low throughput and limit

97 This tedious and time-consuming work can be lessened with aut

98 nately, the manual assignment of residues is tedious and time-consuming, and can represent a signific

99 s or automated single-worm tracking would be tedious and time-consuming, but the MWT system allowed r

100 arameterizing CG force fields, which is both tedious and time-consuming, is often necessary.

101 ata formats, frequently making Hi-C analyses tedious and time-consuming.

102 ted, replenishing the gels after each run is tedious and time-consuming.

103 Analyzing global experimental data can be tedious and time-consuming.

104 - typical in a macromolecular assembly - is tedious and time-consuming.

105 and identifying novel genes encoding them is tedious and uncertain without a phenotype in culture.

106 ally requires exquisite manual skills and is tedious and unreliable.

107 topologies, the synthesis methods are often tedious and unscalable, hampering practical applications

108 e current methods to detect anti-PEG abs are tedious and usually lack quantification.

109 However, this strategy is tedious, and coexisting proteoforms with potentially dif

110 development for 2D-LC more systematic, less tedious, and less reliant on user expertise.

111 ot-stretching-induced orientation process is tedious, and oriented molecular chains tend to revert to

112 ng methodologies which tend to be expensive, tedious, and time-consuming for many applications.

113 However, patient privacy constraints, tedious annotation processes, and the limited availabili

114 say could circumvent some of the complex and tedious antigen-adjuvant desorption methods.

115 cology has long relied on animal models in a tedious approach to understanding risk of exposure to an

116 vents, which has so far been addressed via a tedious approach, collectively referred to as the "organ

117 analysis of biological matrices is, however, tedious as well as logistically and financially demandin

118 es into CHARMMing helps automate many of the tedious aspects of constructing a CG Go model.

119 ment of FBA models can be time consuming and tedious because of the difficulty in assembling complete

120 the cloning of viral DNA fragments, and are tedious because of the laborious process of multiple pla

121 nging, involving either invasive implants or tedious behavioural training.

122 id chromatography not only was laborious and tedious but also could introduce uneven losses of molecu

123 been recoded and renumbered can be not only tedious but also quite daunting, in the case of very lar

124 r, reimplementation of these algorithms is a tedious but important task to enable comparison of exist

125 eveloped to enable rapid detection and avoid tedious calibration.

126 tive, which has potentials to facilitate the tedious, cell-specific protocol screening process in cur

127 Compared to multistep lab-tedious chemical synthesis, this route, relying on natur

128 on-MNFs) traditionally require expensive and tedious chromatographic methods.

129 selectivity/specificity that do not require tedious chromatographic purification, topochemical polym

130 g quantitative analysis without the need for tedious chromatographic separation.

131 igh isomeric purity and without the need for tedious chromatography to remove the minor isomer.

132 arison between the recommended technique and tedious clinical approaches.

133 ct isolation/purification without the aid of tedious column chromatography, good to excellent yields,

134 Currently, this is done through a tedious combination of searches through the literature a

135 mmon amplification methods, relying on long, tedious, complex, or expensive procedures.

136 h-performance parts, the empirical and often tedious composition rules, and the requirements for subs

137 are incorporated into a single DNA molecule, tedious conjugation procedures required for protein-DNA

138 ation of RE elements, which has evolved from tedious crystallization to highly engineered solvent ext

139 aenoic acid (EPA) from cell extracts without tedious derivatization, lengthy sample preparation, and

140 The existing standard method requires a tedious, destructive, and costly sample preparation proc

141 ransgenic animals, require careful and often tedious documentation by multiple methodologies.

142 s for immediate NMR analysis while bypassing tedious drying processes and minimizing analyte degradat

143 In addition to bypassing tedious drying processes and minimizing analyte degradat

144 ent for multistep sample preconditioning and tedious electrode modification.

145 for membrane-associated receptors is often a tedious empirical process.

146 photomorphogenesis field, by replacing many tedious, error-prone manual measurements with a precise,

147 process of prototyping device designs can be tedious, error-prone, and time-consuming.

148 ivation in suboptimal growth media, which is tedious especially when working with slow growing DSB re

149 , current microbial monitoring practices are tedious, expensive, and slow.

150 al diagnostic techniques are time consuming, tedious, expensive, less sensitive, and unsuitable for f

151 via fluorescent images requires a series of tedious experimental procedures and often impacts the vi

152 refusion-stabilized spike immunogens involve tedious experimental work and heavily rely on structural

153 l largely depends on empirical knowledge and tedious experimentation-especially on rodents.

154 In absence of predictive tools, tedious experiments have to be conducted to screen prope

155 The NIR method avoids the tedious extraction and TPC assay procedures, making it m

156 , insufficient cell-matrix interactions, and tedious fabrication procedures have compromised their th

157 of multiple breaksites per reaction without tedious fractionation of PCR products by gel electrophor

158 that have been identified typically through tedious functional assays.

159 ly column-purified, eliminating the need for tedious gel purification.

160 lesions, but previous applications involved tedious genetic mapping to pinpoint the causative mutati

161 , it is imperative not to be confined to the tedious growth and cumbersome manipulation of molecular

162 followed by sequencing (ChIP-seq) remains a tedious (>2 d), manually intensive, low-sensitivity and

163 Here, to solve this problem but avoid tedious guess-and-check experimentation, we built a virt

164 However, tedious in vitro selection procedures combined with labo

165 protection and deprotection steps as well as tedious ion-exchange and column chromatographic techniqu

166 branes and living cells without the need for tedious isolation and purification steps.

167 Tedious isolation/purification protocols and uncertainty

168 yield and purity and without the need for a tedious isomer separation step.

169 tive and has the potential to circumvent the tedious labeling steps typically required.

170 ing RIAs of large numbers of tubes remains a tedious laboratory chore due to the need to individually

171 ection and identification have been based on tedious laboratory procedures, with delays of more than

172 Evidently, all these approaches are tedious, labour intensive and inaccurate.

173 and/or gene-edited plants largely depends on tedious, lengthy, and costly in vitro regeneration proto

174 nocomposites that are typically prepared via tedious, low-yield approaches.

175 disorder (ASD), often requiring detailed and tedious management methods.

176 ampered by the requirements of extensive and tedious manual curation.

177 on-coupled electron transfer (PCET), yet the tedious manual nature of its experimental operation redu

178 ans larval development traditionally require tedious manual observations because larvae must move to

179 It replaces previously tedious manual protocols to obtain exhaustive informatio

180 and locate individual molecules, but require tedious manual validation of each spot.

181 rders, a clinical pathologist must perform a tedious, manual process of locating and identifying indi

182 oxidative phosphorylation system has been a tedious matter.

183 to typical screening procedures that require tedious method development, because the synthesized libr

184 Fluorescence in situ hybridization is a tedious method for analyzing tissues, and localization o

185 Hydraulic micromanipulation is a very tedious method.

186 supramolecular 2D materials are assembled by tedious methodologies, with complex surface chemistry an

187 oglial profiles in rat remain elusive due to tedious methodology and limited availability of reagents

188 onic stem (ES) cell-based gene targeting and tedious micromanipulations of mouse embryos.

189 st-cell invasion, has traditionally involved tedious microscopic observations of individual parasites

190 relying solely on doping, and thus avoiding tedious modification of side-chain or main-chain structu

191 prevention with less bleeding risk and less tedious monitoring requirements compared with Warfarin.

192 -layer epitaxial growth without the need for tedious multiple reactions for generating tunable shell

193 ck of commercially available standards or by tedious multistep in-house standard production procedure

194 are difficult to generalize, or necessitate tedious multistep reactions and purification.

195 it is a natural product and does not require tedious multistep synthesis unlike many other chiral aux

196 igomers can be obtained in low quantities by tedious, multistep iterative methods.

197 s and microfibers) can be achieved without a tedious, multistep synthesis of shape-persistent molecul

198 riable, and inevitably errors arise from the tedious nature of the task.

199 ved that HMRFO can effectively cope with the tedious nonlinearities and complexities of the governing

200 urry as an alternative to crude estimates or tedious nonspecific, off-site laboratory analysis.

201 g of microbial food safety, a task for which tedious operations, destructive sampling, and the inabil

202 ligand adsorption, and this process requires tedious optimization.

203 fication of circuits that would be extremely tedious or impossible to study with other methods and ca

204 ds for milk oxidases are either insensitive, tedious or not cost-effective.

205 cy and quality of their work by carrying out tedious or repetitive tasks while enabling easy control

206 these complexes in a purified state is often tedious owing to their compositional complexity and the

207 arge molecules often can only be obtained by tedious point mutations that may interfere with function

208 milk thereby eliminating time consuming and tedious pre-treatment procedures of the sample.

209 ls avoided the aggregation of conjugates and tedious preparation time, which were often met in the tr

210 gs such as high cost, high time consumption, tedious pretreatment steps and the requirements for high

211 polymers with a limited number of blocks but tedious procedures.

212 procedures, such as multistep workflows and tedious procedures.

213 on of bacterial genetic materials requires a tedious process but is associated with a high false posi

214 nzymes, or ribozymes, typically involves the tedious process of collecting and quenching reaction tim

215 al elucidation of protein glycosylation is a tedious process often involving several techniques.

216 Analyzing the data from FISH images is a tedious process that invokes an element of subjectivity.

217 y, conventional serotype identification is a tedious process which can take a week or longer.

218 arameter evaluation can be a time-consuming, tedious process.

219 al and biochemical analyses is a lengthy and tedious process.

220 of bioactive constituents can be a long and tedious process.

221 n of the best column sets is one of the most tedious processes in comprehensive two-dimensional gas c

222 e amounts of starting material, and involves tedious processing of each individual sample.

223 coated membranes requires multiple steps and tedious processing.

224 ish between coexisting proteoforms requiring tedious production of enriched proteoforms.

225 tended to generate scientific images without tedious prompt modifications.

226 hemical transformations without the need for tedious protection and deprotection chemistry that is ve

227 c LewisX octasaccharide without the need for tedious protective group manipulation to achieve exact a

228 d expensive laboratory equipment or long and tedious protocols.

229 onal studies involves the time-consuming and tedious purification of a large number of mutant protein

230 ly reported enzymatic methods either require tedious purification steps or use thermostable ligases t

231 ng polymerization in good yields without any tedious purification steps.

232 bypassing the need for elaborate syntheses, tedious purifications, and organic solvents.

233 However, panning rounds are followed by the tedious re-screening of the clones obtained to evaluate

234 These methods can be tedious; require complex, expensive instrumentation; nec

235 hese ligands, which have confronted long and tedious routes that employ toxic and often difficult to

236 ALDI-target glycan derivatization eliminates tedious sample preparation and avoids sample loss.

237 lamines and analytical interferences require tedious sample preparation and long chromatographic runs

238 ique enables rapid quantification freed from tedious sample preparation and shows more than 95% recov

239 s vital to understanding embryogenesis; yet, tedious sample preparation makes it difficult to acquire

240 phisticated analytical instrumentation and a tedious sample preparation method is a challenge for env

241 etection of methylmercury without the use of tedious sample preparation procedures or complex and exp

242 llar diluent (demonstrating the reduction of tedious sample preparation requirements for biological s

243 at animals be sacrificed and tend to involve tedious sample preparation steps.

244 human serum and cell culture medium without tedious sample preparation was demonstrated, consuming m

245 lly time-consuming, require bulky equipment, tedious sample preparation, a trained operator, cannot b

246 interference in the mass range of interest, tedious sample preparation, and various crystallization

247 vel the complexity of a flat, on first sight tedious SAR.

248 The theory also rationalizes the tedious search required to find good separation conditio

249 und the rim of the dried sample and requires tedious searching of this rim with the laser.

250 s detection with phosphotyrosine antibodies, tedious separation of phosphorylated peptides with phosp

251 heir synthesis, however, commonly involves a tedious sequence that controls particle size and surface

252 of the analyses while obviating the need for tedious sessions of microdissection and collection of ha

253 enying that they can be inherently boring or tedious, something that "vigilance tasks" were intention

254 Unfortunately, time-consuming and tedious specimen processing is an inherent problem which

255 Eliminating the tedious step of separating the cleared lysate significan

256 the past, they usually suffer from multiple, tedious steps and often result in poor structure control

257 n though both are time-consuming techniques, tedious steps can be avoided and real-time readout can b

258 dium, was established in order to circumvent tedious steps from previous methods.

259 er, biosensor discovery is slow and requires tedious steps in rational design, screening, and charact

260 browser-based selection tools, ameliorating tedious steps involved in defining ranges to fit in gene

261 etry (MS) technologies that merge all of the tedious steps of the classical methods into a simple, ef

262 Once installed, workflows facilitate the tedious steps required to run rapid intra- and inter-dat

263 phase extraction was also proposed to avoid tedious steps such as saponification or derivatization b

264 sequence-targeted regions, thereby bypassing tedious subcloning steps.

265 However, visual stage determination can be a tedious, subjective and time-consuming task prone to err

266 The supplemental tests are tedious, subjective, and expensive.

267 are known to have limitations including the tedious synthesis and interdrop molecular transport whic

268 However, this requires tedious synthesis and produces complicated multi-shell n

269 The tedious synthesis of quantum rods and fabrication of ori

270 bromine at the C5 position of pyrimidines), tedious synthesis of specialized nucleosides is not requ

271 article labels and avoid the complicated and tedious synthesis process of conventional nanoparticle l

272 rs often require intricate molecular design, tedious synthesis, and significant time and resource con

273 ture-to-property capacity but with typically tedious synthetic protocols.

274 IH and RNA polymerase II (pol II) has been a tedious task by conventional chromatography.

275 ve developed a Web server that automates the tedious task of locating such sites in eukaryotic genome

276 ts importance, measuring DNA DSBs is still a tedious task that is normally carried out by gel electro

277 uating MS1-aware algorithms is difficult and tedious task, and better software for creating such data

278 hing M. bovis from M. tuberculosis relies on tedious testing of biochemical parameters, including nat

279 Although tedious, these methods have been used for more than thre

280 for IgA N- and O-glycosylation analysis are tedious, thus limiting such analyses to small sample siz

281 ditional methods for their determination are tedious, time consuming and require analysis in decentra

282 water, the CO2-H2O equilibration method, is tedious, time consuming, and involves the use of custom-

283 rver performance and may reduce the need for tedious, time-consuming studies with human observers.

284 oligonucleotides for these approaches can be tedious, time-consuming, and may not be practical for la

285 f indicator molecules and do not require the tedious titration of reagents into a sample.

286 These measurements are tedious to perform, difficult to replicate, and typicall

287 -derived (SMB) antigen used in this assay is tedious to prepare and has a risk of exposing personnel

288 rlying optimal normalization, which requires tedious trial and error.

289 on of each material system still relies on a tedious trial-and-error approach in a multiparametric sp

290 of suitable algorithms, a time consuming and tedious undertaking addressed by the automated machine l

291 fic bioactive HS structures a cumbersome and tedious undertaking that requires laborious and careful

292 eling the biochemistry of these compounds is tedious using traditional analyses, which also fall shor

293 orescence under infrared excitation and many tedious washing steps, as the free dye molecules are phy

294 Since experiments for such designs are tedious, we used molecular-dynamics simulations to ident

295 synthesis of these vital components is often tedious, whereas natural enzymes capable of anomeric pho

296 ever, their processing steps are notoriously tedious with the final materials often displaying inferi

297 testing enhancer activity in animals remains tedious, with a minority of enhancers having been charac

298 h-end mass spectrometer is not required, and tedious work or deliberate interpretation can be avoided

299 er meet patient expectations, expedites many tedious work processes (such as prescription writing and

300 omical, simple, generalizable, and free from tedious workflows.