ライフサイエンスコーパス: telomerase RNA component

1 locus that includes TERC, which encodes the telomerase RNA component.

2 copying a short template sequence within its telomerase RNA component.

3 igoadenylate)-linked antisense against human telomerase RNA component (2-5A-anti-hTER) was investigat

4 able cell line overexpressing both the human telomerase RNA component and the N-terminally biotinylat

5 omoter interactions (7SK), telomere biology (telomerase RNA component) and inflammatory gene regulati

6 DKC1, while heterozygous mutations in TERC (telomerase RNA component) and TERT (telomerase reverse t

7 s that cause reduced levels of TERC/hTR, the telomerase RNA component, are found in most TBD patients

8 of NP oligonucleotide (GRN163) against human telomerase RNA component as a telomerase inhibitor and p

9 ng telomerase activity and for targeting the telomerase RNA component as an anti-cancer therapy.

10 he regulation of telomerase activity and the telomerase RNA component as leukocytes were stimulated t

11 Reduced levels of TERC, the telomerase RNA component, cause dyskeratosis congenita (

12 The template domain of the telomerase RNA component dictates synthesis of species-s

13 yethyl oligonucleotides complementary to the telomerase RNA component diffuse across cell membranes w

14 in the telomerase reverse transcriptase and telomerase RNA component genes have been observed at a h

15 Telomerase RNA components have been identified from many

16 erase activity in combination with the human telomerase RNA component hTR.

17 tion, telomerase activity, expression of the telomerase RNA component (hTR) and telomere length were

18 ribonucleoprotein complex that includes the telomerase RNA component (hTR) and the telomerase cataly

19 The human telomerase RNA component (hTR) is present in normal soma

20 s we found a heterogeneous expression of the telomerase RNA component (hTR) within the basal layer, w

21 ound to regulate the maturation of the human telomerase RNA component (hTR), a noncoding RNA required

22 complex controls the stability of the human telomerase RNA component (hTR/TERC).

23 In addition to the human telomerase RNA component (hTR; ref.

24 Overexpression of the telomerase RNA component, hTR, demonstrated that this pr

25 The discovery of telomerase RNA components in the plant kingdom and some

26 UC1 and PyMT (MMT mice) but deficient in the telomerase RNA component, mTerc, on the C57BL/6 backgrou

27 ns of telomerase-deficient mice null for the telomerase RNA component, mTERC.

28 and expression of the recently cloned mouse telomerase RNA component (mTR) in two different transgen

29 omerase in normal and neoplastic growth, the telomerase RNA component (mTR) was deleted from the mous

30 stions regarding the mechanisms by which the telomerase RNA component supports tumorigenesis.

31 h respect to both Wrn and Terc (encoding the telomerase RNA component), telomere dysfunction elicits

32 1 (rs9419958 P = 9.1 x 10(-11)) and with the telomerase RNA component TERC (rs1317082, P = 1.1 x 10(-

33 receptor tyrosine kinase, downregulates the telomerase RNA component TERC, confers genomic stability

34 on of telomere-length maintenance molecules [telomerase RNA component ( Terc; P < 0.01), P23 ( P = 0.

35 We measured long non-coding (nc) RNA telomerase RNA component (TERC) and RNAs involved in the

36 In addition, we confirmed the telomerase RNA component (TERC) as a gene associated wit

37 The telomerase RNA component (Terc) constitutes a non-coding

38 r telomerase reverse transcriptase (Tert) or telomerase RNA component (Terc) genes.

39 The telomerase RNA component (TERC) is a critical determinan

40 d DC cells overcome a critical limitation in telomerase RNA component (TERC) levels to restore telome

41 lomerase reverse transcriptase (TERT) or the telomerase RNA component (TERC) telomerase genes.

42 the synthesis and enzymatic stabilization of telomerase RNA component (TERC), a therapeutically relev

43 telomerase reverse transcriptase (TERT), the telomerase RNA component (TERC), and the TERC-binding pr

44 Telomerase RNA component (TERC), the RNA component and T

45 merase that oligoadenylates and destabilizes telomerase RNA component (TERC).

46 is required for the 3'-end maturation of the telomerase RNA component (TERC).

47 sm level in mice doubly null for Atm and the telomerase RNA component (Terc).

48 Determination of the structure of the yeast telomerase RNA component TLC1 has been hampered by its l

49 When the yeast telomerase RNA component, TLC1, is deleted, telomeres sh

50 Here we show that genetic depletion of the telomerase RNA component (TR) in the zebrafish results i

51 d cultured cells from mice deficient for the telomerase RNA component, we found that G-strand overhan

52 s new function for TERT does not require the telomerase RNA component, which encodes the template for