ライフサイエンスコーパス: telomerase activity

1 ruitment to telomeres, and the regulation of telomerase activity.

2 d is still used for routine determination of telomerase activity.

3 letion is independent of telomere length and telomerase activity.

4 ulated kinase 2 (Dyrk2) negatively regulates telomerase activity.

5 1 Vpr (viral protein R) negatively modulates telomerase activity.

6 cit correlated with the mutations' impact on telomerase activity.

7 ate that PTBP1 reduces hTERT FL splicing and telomerase activity.

8 fected individuals on cART via inhibition of telomerase activity.

9 NA (hTR/TERC), thereby inhibiting endogenous telomerase activity.

10 t is not clear how these elements coordinate telomerase activity.

11 events have been shown previously to inhibit telomerase activity.

12 erentiated from these mESCs contained little telomerase activity.

13 ed all detectable cardiac telomerase RNA and telomerase activity.

14 Here, we tested the effects of human TIN2 on telomerase activity.

15 9 ribose 2'-OH as a potential contributor to telomerase activity.

16 sensors, aptasensors, and a sensor following telomerase activity.

17 the effect of BCR stimulation on modulating telomerase activity.

18 ttractive strategy for the inhibition of the telomerase activity.

19 TERT serves as the major limiting agent for telomerase activity.

20 sential N-terminal (TEN) domain and roles in telomerase activity.

21 sence of very short telomeres despite normal telomerase activity.

22 p1 implicates these proteins in restraint of telomerase activity.

23 nce are located at telomeres irrespective of telomerase activity.

24 decreased ability to associate with TERC and telomerase activity.

25 homologs in related yeast species influence telomerase activity.

26 and thereby stimulating hTERT expression and telomerase activity.

27 icipate in the TPP1-dependent recruitment of telomerase activity.

28 n is a highly useful approach for modulating telomerase activity.

29 elusive because TRF1 has no direct effect on telomerase activity.

30 nd interhelical dynamics are correlated with telomerase activity.

31 en endogenous estrogens, telomere length and telomerase activity.

32 T mRNA and stabilizes it, leading to greater telomerase activity.

33 tential contribution that Est3 might make to telomerase activity.

34 cell cycle-regulated changes independent of telomerase activity.

35 in C33A cells had no effect on hTERT mRNA or telomerase activity.

36 sibly reversed by reactivation of endogenous telomerase activity.

37 e aspects of aging, including an increase in telomerase activity.

38 h numbers of telomere-bound proteins inhibit telomerase activity.

39 tards cytokine profile changes, and enhances telomerase activity.

40 ate (5-MeCITP), functions as an inhibitor of telomerase activity.

41 ons and transcript fusions and predictive of telomerase activity.

42 ree specialized retroelements rather than by telomerase activity.

43 he mechanisms by which cancer cells increase telomerase activity.

44 , and they have opposing roles in regulating telomerase activity.

45 acts with a regulatory lncRNA that represses telomerase activity.

46 th upregulated TERT expression and enzymatic telomerase activity.

47 ease in TERT transcription with no impact on telomerase activity.

48 en the core and CR4/5 significantly increase telomerase activity.

49 sively pursued ligands for inhibition of the telomerase activity.

50 factor overexpression and/or a reduction in telomerase activity.

51 P-dependent manner to compensate for reduced telomerase activities.

52 d unlimited self-renewal ability with robust telomerase activities.

53 s through simultaneous targeting of multiple telomerase activities.

54 number of telomerase-extended products (i.e. telomerase activity; 57.8 +/- 7.5) in a single HeLa cell

55 Telomerase activity--a well-recognized universal cancer

56 also show that recombinant Est3p stimulates telomerase activity above basal levels in vitro in a man

57 tion of telomerase activity in single cells, telomerase activity across several common telomerase pos

58 ons or insertions that eliminated or reduced telomerase activity also enhanced cell proliferation.

59 n of hTERT, resulting in cells with enhanced telomerase activities and increased telomere length.

60 RISPR-Cas9 or siRNA knockdown led to reduced telomerase activities and shortened telomere length, sug

61 tion at 0.6 M NaCl, despite the retention of telomerase activity and a comparable yield of hTR.

62 ence TERT expression, resulting in increased telomerase activity and aberrantly long telomeres.

63 ral infections and has been shown to inhibit telomerase activity and accelerate T cell differentiatio

64 rase activity or on the relationship between telomerase activity and antidepressant response.

65 exclusively associated with the reduction of telomerase activity and attrition of telomeres, whereas

66 e cGVHD have fewer Treg with lower levels of telomerase activity and Bcl-2 expression.

67 We show that telomerase activity and cardiomyocyte telomere length de

68 Tenofovir was the most potent inhibitor of telomerase activity and caused greatest shortening of TL

69 ne proximal signaling responses to HB57-dex, telomerase activity and cell proliferation, when inducib

70 n, whereas GRHL2 knockdown notably repressed telomerase activity and cell proliferation.

71 t tumor suppressor essential for maintaining telomerase activity and chromosome stability.

72 stability and demonstrate proportionality of telomerase activity and expression with the number of ap

73 Our analysis integrates TERT abnormalities, telomerase activity and genomic alterations with telomer

74 Estradiol (E2) induced telomerase activity and hTERT mRNA expression in the est

75 selective inhibitor of MEK1/MEK2, inhibited telomerase activity and hTERT mRNA expression induced by

76 r-CEH constructs do not, consistent with the telomerase activity and in vivo complementation results.

77 Depleting TERRA increases telomerase activity and induces telomeric pathologies, i

78 We also used direct telomerase activity and nucleic acid binding assays to e

79 knockdown of PABPCs decreased hTERT mRNA and telomerase activity and overexpression of PABPC4 increas

80 stigated whether certain threshold levels of telomerase activity and processivity are required to mai

81 osome end-binding protein complex stimulates telomerase activity and processivity provide incentive f

82 ngs support motif 3 as a key determinant for telomerase activity and processivity.

83 s nucleic acid substrates leading to loss of telomerase activity and processivity.

84 on of TER1, but not TER2, leads to decreased telomerase activity and progressive telomere shortening

85 gated anti-mu mAb HB57 (HB57-dex), increased telomerase activity and promoted cell survival and proli

86 ificant growth reserve as documented by high telomerase activity and relatively long telomeres.

87 Although both TER1 and TER2 copurify with telomerase activity and serve as templates for telomeras

88 ded forms, which was accompanied by impaired telomerase activity and shortened telomeres.

89 injury, and, given the relationship between telomerase activity and stem cell populations, suggests

90 Telomerase activity and telomere length (TL) were measur

91 These variants might regulate telomerase activity and telomere length because it is th

92 01, a specific PAPD5 inhibitor that restored telomerase activity and telomere length in DC patient in

93 nship between mutation status and downstream telomerase activity and telomere length remains convolut

94 f ZNF148 results in reduced TERT expression, telomerase activity and telomere length.

95 at BRCA1 overexpression caused inhibition of telomerase activity and telomere shortening in breast an

96 rch has demonstrated that HSV-1 can increase telomerase activity and that expression of the catalytic

97 nstream of the template may be important for telomerase activity and that the region could fold into

98 T mRNA and stabilizes it, leading to greater telomerase activity and the avoidance of cellular senesc

99 omeric DNA replication stress is resolved by telomerase activity and the DDR in two parallel pathways

100 ompounds is a therapeutic path to regulating telomerase activity and thereby selectively inhibit canc

101 ividuals with relatively lower pre-treatment telomerase activity and with relatively greater increase

102 10% to 15% of human cancers lack detectable telomerase activity, and a subset of these maintain telo

103 The relationship between NRTI, reduced telomerase activity, and accelerated aging requires furt

104 relation between thermodynamic stability and telomerase activity, and are consistent with the identif

105 in overall proliferative potential, reduced telomerase activity, and blunted IL-2 gene transcription

106 x17, Sox10 and S100beta, are cloneable, have telomerase activity, and can differentiate into neural c

107 Treg number, telomerase activity, and expression of Bcl-2 were each i

108 , population-doubling time, telomere length, telomerase activity, and insulin-like growth factor-1 re

109 Many cancer cells express high telomerase activity, and mutations in telomerase subunit

110 an enhancer of FL hTERT splicing, increases telomerase activity, and promotes telomere maintenance i

111 D27- T cells have short telomeres, defective telomerase activity, and reduced capacity for proliferat

112 sponsible for reduced TERC levels, decreased telomerase activity, and short telomeres.

113 associated with increases in TERC stability, telomerase activity, and telomere elongation.

114 telomerase reverse transcriptase expression, telomerase activity, and telomere length; but studies ut

115 the triggering of senescence, a decrease in telomerase activity, and the down-regulation of genes in

116 While most human cancers express telomerase activity, approximately 10%-15% employ a reco

117 prolonged exposure to estrogen and increased telomerase activity are associated with endometrial carc

118 Here we show that telomere length and telomerase activity are impaired in primary lymphocyte s

119 ne synthase that modifies rRNA and regulates telomerase activity, are associated with ribosomal dysfu

120 g individual subunits, which increased total telomerase activity as measured by the direct enzyme ass

121 Somatic stem cells require telomerase activity, as evidenced by progressive stem ce

122 ral interactions that are also important for telomerase activity, as previously observed for the Kluy

123 To develop a new method for telomerase activity assay that is fast, simple, and cost

124 is structured and has unexpected base pairs, telomerase activity assays with nucleotide substitutions

125 Using direct telomerase activity assays, we discovered that TIN2 stim

126 he structural basis of human and Tetrahymena telomerase activity, assembly, and interactions.

127 ave found that CIRP is necessary to maintain telomerase activities at both 32 degrees C and 37 degree

128 ces cellular senescence but does not inhibit telomerase activity at the nanomolar dosage levels requi

129 By measuring telomerase activity at the single-cell level using quant

130 In yeast grown at elevated temperatures, telomerase activity becomes limiting: haploid cell popul

131 Moreover, TSI requires telomerase activity but is independent of the functional

132 ine-modification of P6.1 slightly attenuates telomerase activity but slightly increases processivity

133 d porcine OCT4, NANOG, and SOX2 and had high telomerase activity, but also continued to express the 4

134 nked dyskeratosis congenita severely impairs telomerase activity by blocking telomerase assembly and

135 We found that Vpr inhibited telomerase activity by down-regulating TERT protein, a c

136 Our results suggest that Vpr inhibits telomerase activity by hijacking the host E3 ligase comp

137 ermore, our study implies that inhibition of telomerase activity by some G-quadruplex ligands is not

138 measured using a quantitative PCR method and telomerase activity by TRAP (Telomere-Repeats Amplificat

139 Whereas telomerase activity can be reconstituted in vitro with o

140 We further show that endogenous telomerase activity cannot overcome telomere dysfunction

141 suppressing c-Myc expression, or inhibiting telomerase activity, caused telomere dysfunction and pro

142 response in U-CLL than M-CLL cells, whereas telomerase activity, cell survival, and proliferation we

143 derived CD34(+) cells to androgens increased telomerase activity, coincident with higher TERT mRNA le

144 an isoform of gamma-TERT that has increased telomerase activity compared with wild-type (WT) TERT.

145 vascular flow-mediated dilation, and loss of telomerase activity contributes to the change of mediato

146 identifies the cells responsible for cardiac telomerase activity, demonstrates a significant diminuti

147 Despite the biomedical importance of telomerase activity, detailed structural models for the

148 , this approach affords high sensitivity for telomerase activity detection and it can be regarded as

149 werful tool for cost-effective and sensitive telomerase activity detection in urinary bladder cancer.

150 wed by native gel electrophoresis and in-gel telomerase activity detection to query the composition o

151 how that the mechanisms underlying excessive telomerase activity differ markedly between taz1Delta an

152 e telomerase enzyme, MST-312, to investigate telomerase activity during HSV infection.

153 vity and with relatively greater increase in telomerase activity during treatment, showed superior an

154 Moreover, significant telomerase activity elevation was also measured from pat

155 ll phenotype defined by long telomeres, high telomerase activity, enhanced cell proliferation, and at

156 g protocol and achieves ultrafast detection: telomerase activity equivalent to a single HeLa cancer c

157 Here, we show that targeting telomerase activity eradicates AML LSCs.

158 lastic somatic cells are mortal, express low telomerase activity, expand for an extensive but finite

159 Differences between telomerase activity expression levels or telomere length

160 Using this strategy, the telomerase activity extracted from 10 cultured cancer ce

161 ree, and highly sensitive detection of human telomerase activity, extracted from A549 cells.

162 mplexes with similar CD spectra and enhances telomerase activity for all DNA substrates tested, regar

163 vel cancer detection platform which measures telomerase activity from live CTCs captured on a parylen

164 might make to enzyme catalysis, we compared telomerase activity from wild type and est3-Delta strain

165 es (TERT, WRAP53 and MYC) and an independent telomerase activity gene (ZSCAN4).

166 At 5 years, telomerase activity had decreased from baseline by 0.25

167 er assembly of TERT and TER is essential for telomerase activity; however, a detailed understanding o

168 ated for 4 mo with MZ-5-156 showed increased telomerase activity, improvement in some measures of oxi

169 As a consequence of insufficient telomerase activities in prior generations, both mTert (

170 pacts on many biological functions including telomerase activities in the telomere region.

171 abine, and tenofovir significantly inhibited telomerase activity in activated PBMCs in vitro.

172 To date, there is no direct evidence of telomerase activity in adult lung epithelial cells, but

173 stages of hematopoietic stem cells, reduced telomerase activity in bone marrow cells, and altered th

174 -27, but there are no significant changes of telomerase activity in both Alt and non-Alt cells.

175 , and reliable in vitro method for measuring telomerase activity in cell extracts.

176 Low telomerase activity in circulating peripheral blood mono

177 This is the first report characterizing telomerase activity in depressed individuals.

178 eportedly shortened in major depression, but telomerase activity in depression has not been previousl

179 In the prolonged absence of telomerase activity in dividing cells, telomeres eventua

180 n the MAPK pathway and estrogen induction of telomerase activity in endometrial cancer cells.

181 multicolor DNA detection and the analysis of telomerase activity in extracts from cancer cells.

182 s loss coincided with a dramatic decrease in telomerase activity in G2 atr mutants.

183 In contrast, the reduced telomerase activity in highly differentiated CD8+CD28(-)

184 omprehensive lifestyle changes and increased telomerase activity in human immune-system cells.

185 the first demonstration of the detection of telomerase activity in human urine on the chip-based sys

186 abilities, to increase hTERT mRNA levels and telomerase activity in keratinocytes expressing HPV16 E6

187 o data showing dGTP-dependent stimulation of telomerase activity in multiple organisms and suggest th

188 predict that crowding can partially restore telomerase activity in mutants with decreased PK stabili

189 ntify the cell types responsible for cardiac telomerase activity in neonatal, adult, and cryoinjured

190 s the dominant mechanism conferring the high telomerase activity in proliferating cells, such as embr

191 ns we observe demonstrate indefinite somatic telomerase activity in proliferating stem cells during r

192 lomerase activity, including quantitation of telomerase activity in single cells, telomerase activity

193 lines were treated with imetelstat in vitro, telomerase activity in the bulk tumor cells and CSC subp

194 e reverse transcriptase (TERT) reconstitutes telomerase activity in the majority of human cancers.

195 ngth of HT use was not associated with TL or telomerase activity in this study.

196 Telomerase activity in TOE1-deficient cells could be res

197 f telomerase, is limiting for reconstituting telomerase activity in tumors.

198 NA has been demonstrated to be important for telomerase activity in vertebrates, ciliates, and yeast.

199 tutions that disrupt the base triples reduce telomerase activity in vitro NMR studies also reveal tha

200 doknot (t/PK) and CR4/5 domains required for telomerase activity in vitro.

201 Furthermore, telomerase activity in vivo depends on a functional MRT-

202 ethylation into telomerase RNA can influence telomerase activity in vivo.

203 rom telomere elongation, but also from other telomerase activities, including cellular lifespan exten

204 of a droplet digital TRAP (ddTRAP) assay for telomerase activity, including quantitation of telomeras

205 remature vascular aging, as shown by reduced telomerase activity, increased beta-galactosidase-positi

206 helial cancer cell line results in decreased telomerase activity, indicating the mutation is causal f

207 er telomeres and in general possessed higher telomerase activity indicative of greater proliferative

208 Genetic lesions that reduce telomerase activity inhibit stem cell replication and ca

209 The determination of urinary telomerase activity is a promising tool for the diagnosi

210 Notably, telomerase activity is affected in a gene dose-dependent

211 However, increased telomerase activity is associated with approximately 90%

212 Telomerase activity is characterized by the expression o

213 ation and experimental results indicate that telomerase activity is maximized on AuNP surface under g

214 These findings suggest that E2-induction of telomerase activity is mediated via the MAPK pathway in

215 ivity in multiple organisms and suggest that telomerase activity is modulated in vivo by dGTP levels.

216 Telomerase activity is not readily detected in resting h

217 Human telomerase activity is often determined by the expressio

218 In contrast, telomerase activity is silenced in most adult somatic ce

219 It is possible that a small deficit in telomerase activity is sufficient to cause telomere shor

220 Typical assay for telomerase activity is the telomeric repeat amplificatio

221 Telomerase activity is well documented in embryonic stem

222 transcriptase (Tert), which is essential for telomerase activity, is limiting in many types of cells

223 fovir at therapeutic concentrations, inhibit telomerase activity leading to accelerated shortening of

224 Although telomerase activity levels were unperturbed, telomeres w

225 if1alpha levels, as well as Tert expression, telomerase activity levels, and telomere length.

226 mpanied by a reduction in both Tert mRNA and telomerase activity levels.

227 fore plays an important role in establishing telomerase activity levels.

228 ning was not accompanied by changes in total telomerase activity, localization of TIN2, or telomere e

229 These results suggest that high telomerase activity may be a better marker of aggressive

230 ease increases with age, telomere length and telomerase activity may play a role in its progression.

231 ropose that the exquisite kinetic control of telomerase activity may play important roles in both cel

232 PBMC telomerase activity might reflect a novel aspect of depr

233 CD8+ T cells increased their proliferation, telomerase activity, mitochondrial biogenesis, and fitne

234 We examined the hypothesis that telomerase activity modulates microvascular flow-mediate

235 ugh both anti-BCR stimuli induced comparable telomerase activity, normal CD5(+) B cells preferentiall

236 this study, we examined telomere length and telomerase activity of Treg and conventional CD4(+) T ce

237 se assays, which measure telomere length and telomerase activity of tumor extracts, are conventionall

238 Several TER mutants exhibited telomerase activity only in the presence of p65, reveali

239 ncer cells maintain telomere lengths through telomerase activity or by alternative lengthening of tel

240 in protein-protein interactions, regulating telomerase activity or DNA-binding.

241 reports of the effects of antidepressants on telomerase activity or on the relationship between telom

242 tabilize human telomeric GQ (hGQ) to inhibit telomerase activity, or non-telomeric GQs to manipulate

243 t units of telomers allowed the detection of telomerase activity originating from 380 +/- 20 cancer 2

244 activation and low expression of independent telomerase activity pathway during cell division may be

245 cells even though neither has any effect on telomerase activity per se.

246 lanced not only by temporal expansion of the telomerase activity period, but also by markedly increas

247 s on FEN1 depletion, suggesting that ongoing telomerase activity protected telomeres.

248 ng effects of PinX1 loss appear to depend on telomerase activity, raising new models and questions fo

249 Consistently, addition of Pop1 allows for telomerase activity reconstitution with wild-type telome

250 natural compound with anti-carcinogenic and telomerase activity-reducing properties.

251 th telomere elongation in NSE than SE: three telomerase activity-related genes (TERT, WRAP53 and MYC)

252 Sustained telomerase activity represents one of the oncogenic step

253 Minimally, telomerase activity requires a templating RNA and a cata

254 and exhibiting active WNT signaling or high telomerase activity, respectively.

255 e show that 2'-O methylation at U809 reduces telomerase activity, resulting in telomere shortening, w

256 Loss of telomerase activity results in shortening of telomeric D

257 .06, Wald chi(2)=3.7, p=0.04) and with lower telomerase activity (standardized beta=-0.09, Wald chi(2

258 urally occurring AS TERT variants which lack telomerase activity stimulate cell proliferation.

259 esence of secondary structures necessary for telomerase activity, such as a yeast-like template bound

260 ocin treatment also triggered a reduction in telomerase activity, suggesting that the prolonged absen

261 Signaling via this pathway inhibited telomerase activity, T cell proliferation and the expres

262 Here we explored telomere length (TL) and telomerase activity (TA) in primary cutaneous T-cell lym

263 e combination of shorter telomeres with high telomerase activity (TA) may be indicative of active cel

264 leukocyte telomere length (TL) and leukocyte telomerase activity (TA), in 434 men and women from the

265 activating hTERT transcription and inducing telomerase activity (TA).

266 bally profile the contribution of kinases to telomerase activity (TA).

267 eletion of Fancc (Fancc(-/-)) did not affect telomerase activity, telomere length or telomeric end-ca

268 Telomere length, cellular senescence rate, telomerase activity, telomeric aberration, and DNA repai

269 aining cART (n = 39) had significantly lower telomerase activity than HIV-uninfected patients (n = 47

270 s that are ADA(+) have significantly greater telomerase activity than those that do not express ADA a

271 unmutated IGHV genes (U-CLL) exhibit greater telomerase activity than those with mutated IGHV genes (

272 e, we uncovered an unanticipated gradient of telomerase activity that also enables isolation of more

273 elterin protein, TPP1, which also influences telomerase activity through interaction with the Est2p h

274 uman papillomavirus (HPV) E6 protein induces telomerase activity through transcriptional activation o

275 The therapeutic value of altering telomerase activity thus provides ample impetus to study

276 subsets of HBECs that activate low levels of telomerase activity to maintain short telomeres.

277 to human fibroblasts and myoblasts increases telomerase activity transiently (24-48 h) and rapidly ex

278 trogen exposure and telomere length (TL) and telomerase activity, two biomarkers of cellular aging, i

279 nt core and CR4/5 domains completely abolish telomerase activity, unveiling mechanistically critical

280 t only a subset of CD28+ T-cells have robust telomerase activity upon stimulation and are capable of

281 tor biosensor to detect label-free, PCR-free telomerase activity using telomerase extracted from two

282 Psis could have a subtle influence on human telomerase activity via impact on TER-TERT or TER-TER in

283 Peripheral blood mononuclear cell (PBMC) telomerase activity was assessed in 20 medication-free d

284 Telomerase activity was evaluated by a telomeric repeat

285 Treg telomere length was shorter and Treg telomerase activity was increased compared with Tcon (P

286 rs into telomerase-deficient cell lines, and telomerase activity was measured in cell lysates.

287 n an open-label manner for 8 weeks, and PBMC telomerase activity was reassessed in 15 of these indivi

288 Pre-treatment telomerase activity was significantly elevated in the de

289 uish the two SCC telomere phenotypes, as did telomerase activity, we found a trend for a higher degre

290 Higher proliferation potential and telomerase activity were observed in the P-MSCs compared

291 e aryl hydrocarbon receptor (AhR) and induce telomerase activity, which elongates LTL.

292 e describe a strategy to detect CTC based on telomerase activity, which is elevated in nearly all tum

293 an ESCs, the engineered mESCs contained high telomerase activity, which was repressed upon their diff

294 us for telomerase mutations had low baseline telomerase activity, which was restored to normal levels

295 ates of several cell types without enhancing telomerase activity, while decreasing the endogenous exp

296 rget recognition, embodied by assay of human telomerase activity with DNA-conjugated gold nanoparticl

297 Match oligonucleotides inhibited telomerase activity with high potency, which was not obs

298 ric hybrid G-quadruplex and strongly inhibit telomerase activity with IC50 of 600 nM.

299 o functional improvements in TERC levels and telomerase activity, with concomitant telomere elongatio

300 ago in human telomerase RNA, is required for telomerase activity, yet its mode of action is unknown.