ライフサイエンスコーパス: telomere length

1 can occur independently of cell division and telomere length.

2 on but without a significant effect on AECII telomere length.

3 mutations are associated with alterations in telomere length.

4 blasts showed comparable and extremely short telomere length.

5 Binge drinking may reduce telomere length.

6 cantly associated with shorter preinternship telomere length.

7 (TERT), but through differential effects on telomere length.

8 s from its internal RNA template to maintain telomere length.

9 histone chaperone function, independently of telomere length.

10 ding of the mechanism by which Rif2 controls telomere length.

11 yet overexpression of TLC1 failed to restore telomere length.

12 e RG7834, rescued TERC 3' end maturation and telomere length.

13 ced TERT expression, telomerase activity and telomere length.

14 (95% CI, -19.3% to -6.7%) shorter placental telomere length.

15 nship between aortic pulse wave velocity and telomere length.

16 elomere trimming, setting the upper limit of telomere length.

17 ing is separable from its role in regulating telomere length.

18 of PM2.5 gave birth to newborns with shorter telomere length.

19 through telomerase-catalyzed maintenance of telomere length.

20 gth as reflected by cord blood and placental telomere length.

21 tor, and interleukin 6 and shorter leukocyte telomere length.

22 evels, telomere sister chromatid exchange or telomere length.

23 on but had no appreciable impact on absolute telomere length.

24 ylation status may play a role in regulating telomere length.

25 cate TIN2, a shelterin subunit that controls telomere length.

26 lication complex, and again saw no change in telomere length.

27 ogical age, mortality, mitotic divisions, or telomere length.

28 ons and deletions, methylation profiles, and telomere length.

29 nt loss of both RAD51 genes has no effect on telomere lengths.

30 Regulator of telomere length-1 (RTEL1) and telomerase reverse transcr

31 ntraclass correlation coefficients of 6% for telomere length, 3.4% for waking cortisol levels, and 5.

32 the relationship between early adversity and telomere length, a marker of cellular senescence.

33 Leukocyte telomere length, a marker of immune system function, is

34 We quantified relative telomere length, a molecular marker for cellular age, an

35 her mammographic density is related to blood telomere length, a potential marker of susceptibility to

36 meditation is linked to longevity and longer telomere length, a proposed biomarker of human aging.

37 We observed substantial variation in telomere length according to sex and self-identified eth

38 elomere shortening rate, but not the initial telomere length alone, is a powerful predictor of specie

39 genetic changes (including gene regulation), telomere length alterations, and microbiome shifts.

40 ting to ameliorate stress-related decline in telomere length among at-risk individuals.

41 y weaken the intra-individual correlation in telomere length among tissues in voles exposed to radion

42 plain a higher proportion of the variance in telomere length amongst chronic lifetime lithium users (

43 th and the association between birth weight, telomere length and cardiometabolic phenotype in adultho

44 nic risk scoring for the prediction of adult telomere length and consequently lithium's anti-ageing e

45 girls and 35 boys) significant variation in telomere length and cortisol functioning was observed at

46 We investigated telomere length and DNA double-strand breaks (histone va

47 We measured lymphocyte telomere length and DNA sequencing, and assessed CMV-spe

48 by post-translational mechanisms to maintain telomere length and ensure proliferation of ALT+ cancer

49 t, significant negative associations between telomere length and fasting glucose (P = 0.003) and HbA1

50 We observed fluctuating changes in telomere length and fluctuations in the rates of chromos

51 Leucocyte telomere length and gene expression related to either ox

52 excessive oxidative stress can affect sperm telomere length and integrity of sperm DNA.

53 TPP1) plays an important role in maintaining telomere length and integrity, and any alteration in tel

54 ohol consumption associated with the longest telomere length and least telomere length attrition.

55 ironment and Health study, of whom leukocyte telomere length and mtDNA content were determined using

56 evaluate the effects of pistachio intake on telomere length and other cellular aging-related paramet

57 Decline in both telomere length and physical fitness over the life cours

58 Here we show that telomere length and telomerase activity are impaired in

59 Telomere length and telomere proteins play important rol

60 Telomere length and telomere shortening are associated w

61 Also, significant increases in telomere length and TERT were observed in the silica gro

62 te the relationship between birth weight and telomere length and the association between birth weight

63 to assess the effect of silica inhalation on telomere length and the regulation of RTEL1 and TERT.

64 Here, we study the genetic architecture of telomere length and the repositioning potential of lithi

65 enylalanine concentration is associated with telomere length and, therefore, potentially with the agi

66 pes (i.e., a small fraction of heterogeneous telomere lengths and formation of C circles) are rapidly

67 sidase activity (p < 0.01) but no changes in telomere lengths and p16(INK4a) levels were observed.

68 ation between telomere length, the change in telomere length, and circulating amino acids.

69 TIN2 is an important regulator of telomere length, and mutations in TINF2, the gene encodi

70 i telomerase plays a key role in maintaining telomere length, and T. brucei telomeres terminate in a

71 Mitochondrial DNA (mtDNA) content and telomere length are putative aging biomarkers and are se

72 The data suggest that telomere lengths are highly variable and variability bet

73 mulates copy number variants (CNVs), and its telomere lengths are short but constant.

74 Using telomere length as a marker of age and health, these dat

75 Therefore, we assessed sperm telomere length as a potential marker of paternal genome

76 r of paternal genome integrity and leukocyte telomere length as an internal control (real-time PCR),

77 sure to particulate matter (PM) with newborn telomere length as reflected by cord blood and placental

78 infection as indices of immune function, and telomere lengths as an overall measure of metabolic cost

79 ood sample collection for immunophenotyping, telomere length assessments, and genetic testing.Measure

80 between prenatal air pollution exposure and telomere length at birth could provide new insights in t

81 Telomere length at birth has been related to life expect

82 Telomerase maintains telomere length at the ends of linear chromosomes using

83 btelomere and haplotype-resolved analysis of telomere lengths at the single-molecule level.

84 sed to examine associations between absolute telomere length (aTL) and estimated annual average resid

85 sociated with longer telomere length or less telomere length attrition over time.

86 d with the longest telomere length and least telomere length attrition.

87 There was no difference in telomere length between LBW and NBW subjects.

88 ciated with increased cellular senescence or telomere length but is a result of a failure to maintain

89 d beta-galactosidase activity, lower average telomere lengths but retained the capacity to undergo mu

90 r tankyrase 1 or 2 is sufficient to maintain telomere length, but both are required to resolve telome

91 ellular senescence develops independently of telomere length, but is evoked by DNA damage, which pref

92 nced in adulthood is associated with shorter telomere length, but is limited to mostly cross-sectiona

93 home was associated with a decrease in mean telomere length by 0.004 for each additional liquor stor

94 We also describe how to quantify telomere length by means of the fluorescence intensity a

95 cial and financial burden is associated with telomere length change over a 5-year period (years 15 an

96 al approach), and telomere dynamics (rate of telomere length change over time, longitudinal approach)

97 ons of adversity demonstrated more extensive telomere length changes.

98 used to investigate the relationship between telomere length, child gender, ethnicity, paternal age a

99 tor, interleukin 1beta, 6, and 10, leukocyte telomere length, chronic disease status, and frailty.

100 WS cells exhibit shorter telomere length compared to normal cells, but it is not

101 s Nup1 modification by maintaining a minimal telomere length compatible with proliferation through ra

102 ta with a large longitudinal dataset of mean telomere lengths, consisting of 1,808 samples from 22 co

103 eased appreciation of the multiple levels of telomere length control and their differentiation from d

104 dicating that TINF2 is haploinsufficient for telomere length control.

105 ch, TPP1's telomerase interaction domain, to telomere length control.

106 Thus, assessment of leukocyte telomere length could be taken as an indicator of antiox

107 associations among PFAS congeners, absolute telomere length (cross-sectional approach), and telomere

108 Telomere length decreased in PBMCs at 24 wk compared to

109 sed to chronic hypoxia in utero have reduced telomere length, decreased mitochondrial DNA biogenesis

110 Throughout the life course, telomere length decreases with age and is influenced by

111 tion in hPSCs and cancer cells, resulting in telomere length defects.

112 Recent observations further reveal telomere length-dependent gene regulation and epigenetic

113 Telomere length determines the replicative capacity of m

114 say can be used to identify and characterize telomere length distributions of 30-35 discrete telomere

115 r postnatal influences of factors decreasing telomere length during life.

116 ulation and are capable of maintaining their telomere lengths during induced proliferation.

117 s examining the impacts of chronic stress on telomere length exist.

118 Heritable natural variation in telomere length exists in yeast, mice, plants and humans

119 esses that are caused by both short and long telomere length extremes.

120 s suggesting the mutation causes a defect in telomere length feedback regulation.

121 We found that telomere length fluctuation is associated with transient

122 proximately 90% of human cancers to maintain telomere length for cell immortalization.

123 omote molecular longevity, as exemplified by telomere length, from early life onward.

124 LD score regression applied to the largest telomere length genome-wide association study to-date, r

125 Although average telomere length, global gene expression, and microbiome

126 Telomere length has been correlated with various disease

127 old air pollution from solid fuel stoves and telomere length have not been evaluated.

128 adaptation of telomere proteins to maintain telomere length homeostasis and protection.

129 findings suggest Ku's DEB activity maintains telomere length homeostasis by preserving Est1's interac

130 losomes), telomeric origins of replications, telomere length homeostasis, and telosome epigenetics.

131 d by POT1-TPP1 heterodimers to help regulate telomere length homeostasis.

132 omerase-mediated telomere synthesis and thus telomere length homeostasis.

133 (nc)RNAs are emerging as major regulators of telomere length homeostasis.

134 t genetically influenced common variation in telomere length impacts hematologic traits in the popula

135 We use qPCR to measure relative telomere length in 389 blood samples (n = 318 individual

136 These findings reveal a critical role for telomere length in a mouse model of age-dependent human

137 associated with leukocyte mtDNA content and telomere length in adults.

138 factors that are associated with changes in telomere length in an aging population.

139 sk scoring capturing 4.4% of the variance in telomere length in an independent cohort (p = 6.17 x 10(

140 merase activity and genomic alterations with telomere length in cancer.

141 recipients compared with their donors, with telomere length in CH vs non-CH CFUs showing varying pat

142 ibitor that restored telomerase activity and telomere length in DC patient induced pluripotent stem c

143 fic children may reflect the heritability of telomere length in genetically less complex populations.

144 copy-gene-sequence ratio method to determine telomere length in genomic DNA extracted from buccal sme

145 of PTBP1 results in progressively shortened telomere length in H1299 and H920 lung cancer cells.

146 ut molecular mechanisms of how ALT maintains telomere length in human cancer is poorly understood.

147 The distribution of telomere length in humans is broad, but it has finite up

148 itive abnormalities associated with aberrant telomere length in humans.

149 om a genome-wide association (GWA) study for telomere length in individuals of European ancestry (n =

150 increased MPN risk is associated with longer telomere length in leukocytes and other clonal haematopo

151 PR31 and SERPINB9 genes were associated with telomere length in long-term meditators with a strong st

152 were found between TERT levels in plasma and telomere length in PBMC and the prognostic variables.

153 Telomere length in PBMCs decreased in the HF diet group

154 (MUC5B rs35705950 and TOLLIP rs5743890) and telomere length in peripheral blood leucocytes, and asse

155 While telomere length in peripheral blood mononuclear cells (P

156 We measured relative telomere length in pretransplant recipient blood samples

157 ge, no correlation was found between age and telomere length in SM.

158 Therefore, shortened telomere length in sperm and leukocytes is likely associ

159 Notably, age showed no association with telomere length in the group of long-term meditators.

160 Among 1267 patients >=40 years old, telomere length in the shortest quartile was associated

161 ctive and prognostic role of TERT levels and telomere length in tissues and peripheral blood in patie

162 gh several methods have been used to measure telomere length in tissues as a whole, the assessment of

163 ive technique to test hypotheses implicating telomere length in various cardiac pathologies.

164 erved between aortic pulse wave velocity and telomere length in younger and older individuals suggest

165 We report telomere lengths in 18,430 samples, including tumors and

166 This study aimed to determine the relative telomere lengths in a diverse cohort of about 4000 four-

167 Telomere lengths in a yku70-R456E strain were nearly as

168 this overall pattern of shortening, bouts of telomere length increase occur in some individuals.

169 deviation increase in genetically influenced telomere length increased red blood cell and white blood

170 articipants suggest that genetically shorter telomere length increases the risk of hypothyroidism and

171 By proposing that the 1st Hit is largely telomere length-independent, while the 2nd Hit is largel

172 Telomere length is a heritable marker of cellular age th

173 Telomere length is a marker of biological aging that may

174 Telomere length is a molecular marker of biological agin

175 of biological age and health, and a shorter telomere length is a predictor of increased mortality.

176 Telomere length is a promising biomarker for age-related

177 Because leukocyte telomere length is a quantifiable and objectively measur

178 Short telomere length is a risk factor for age-related disease

179 However, whether telomere length is a universal determinant of species lo

180 Leukocyte telomere length is an emerging quantifiable marker of bi

181 This study provides evidence that shortened telomere length is associated with familial risk for BD.

182 Telomere length is considered a biomarker of biological

183 The maintenance of telomere length is critical to longevity and survival.

184 They suggest that short telomere length is sufficient to drive premature age-rel

185 myces cerevisiae telomerase, which maintains telomere length, is comprised of an RNA component, TLC1,

186 Telomere length, long-term black carbon exposure, and co

187 air pollution was associated with leukocyte telomere length (LTL) at 8 y of age.

188 Reported associations between leukocyte telomere length (LTL) attrition, diet and cardiovascular

189 en various indices of obesity with leukocyte telomere length (LTL) in childhood, data from 1,396 moth

190 xposures at time of conception and leukocyte telomere length (LTL) in their offspring.

191 Leukocyte telomere length (LTL) is a heritable biomarker of genomi

192 udy was to examine whether shorter leukocyte telomere length (LTL) is associated with more rapid pulm

193 e at conception (PAC) on offspring leukocyte telomere length (LTL) is well established, with older fa

194 Genetic factors underlying leukocyte telomere length (LTL) may provide insights into telomere

195 Leukocyte telomere length (LTL) might be causal in cardiovascular

196 valuated the role of pretransplant leukocyte telomere length (LTL) on survival outcomes in patients w

197 Epstein-Barr virus) with change in leukocyte telomere length (LTL) over 3 years in 400 healthy indivi

198 s with comparatively short or long leukocyte telomere length (LTL) typically continue to display comp

199 To determine whether age-adjusted leukocyte telomere length (LTL) was associated with the harmful ef

200 Leukocyte telomere length (LTL) was measured with the use of quant

201 ocesses driving the association of leukocyte telomere length (LTL) with age-related diseases, we inve

202 We studied the associations of leukocyte telomere length (LTL) with all-cause, cardiovascular dis

203 onal associations of mean relative leukocyte telomere length (LTL) with objective measures of aerobic

204 e health events, may be related to leukocyte telomere length (LTL).

205 association of sedentary time with leukocyte telomere length (LTL).

206 between CBs and nucleoplasm uniquely impacts telomere length maintenance and identify Nopp140 as a no

207 into the factors and mechanisms that mediate telomere length maintenance and survival of ALT cancer c

208 o determine the role of Ku's DEB activity in telomere length maintenance by utilizing yku70-R456E mut

209 d binding (DEB) protein, also contributes to telomere length maintenance.

210 d C-strand fill-in are equally important for telomere length maintenance.

211 was associated with increased expression of telomere-length maintenance molecules [telomerase RNA co

212 t-versus-host disease, suggesting that short telomere length may limit regenerative potential of muco

213 n the shortest telomeres with more sensitive telomere length measurement assays, we show that only a

214 ocol provides comparative cell-type-specific telomere-length measurements in relatively small human c

215 Short telomere length, mediated by inherited or acquired facto

216 ric lagging strands leading to heterogeneous telomere lengths observed in most ALT cancers.

217 ongevities, here we measured in parallel the telomere length of a wide variety of species (birds and

218 sly thought, our technique revealed that the telomere lengths of chromosomes harboring the integrated

219 consumption that was associated with longer telomere length or less telomere length attrition over t

220 th high chronic burden do not show decreased telomere length over the 5-year period.

221 ia had significantly reduced somatic ovarian telomere length (P < 0.05) and reduced ovarian protein e

222 In this group, telomere length positively correlated with TP53 and RB1

223 whole, the assessment of cell-type-specific telomere length provides valuable information on individ

224 no significant association with age-adjusted telomere length reduction was documented.

225 sis of these results, we propose a model for telomere length regulation in mammalian cells: The reduc

226 e expression of genes responsible for normal telomere length regulation.

227 tary evidence, we studied three orthologs of telomere length regulators in a Caenorhabditis elegans m

228 tatus and downstream telomerase activity and telomere length remains convoluted.

229 , the mechanism through which TIN2 regulates telomere length remains unclear.

230 Telomere length, RTEL1 and TERT expression may serve as

231 Relative telomere length (RTL) was quantified using a modified re

232 of human pluripotent stem cells, while their telomere length set point determines the proliferative c

233 manipulations to identify genes controlling telomere length set point in a multi-parent Arabidopsis

234 d elongation, but its role in establishing a telomere length set point remains elusive.

235 al genes RPL5A and RPL5B establish a shorter telomere length set point than wild type.

236 us locus of human stem cells with an altered telomere length set point.

237 Telomere length shortened significantly over the course

238 sistently correlate with TERT expression and telomere length suggests an alternative method whereby t

239 itative FISH (Q-FISH) protocol for measuring telomere length that bypasses the previous limitations b

240 We studied the longitudinal relation between telomere length, the change in telomere length, and circ

241 of other bodily ageing biomarkers, including telomere length, the epigenetic clock, and grip strength

242 Cancer cells maintain telomere lengths through telomerase activity or by alter

243 Telomere length (TL) analysis represents a promising mol

244 re, we investigated the relationship between telomere length (TL) and aortic stiffness in well-charac

245 Shorter childhood telomere length (TL) and more rapid TL attrition are wid

246 Leukocytes with longer telomere length (TL) are more responsive to inflammatory

247 Telomere length (TL) can serve as a potential biomarker

248 matic investigation to explain the different telomere length (TL) features between NSE (n = 48) and S

249 In adults, shorter telomere length (TL) has been reported in association wi

250 Telomere length (TL) in blood cells has been studied ext

251 We quantified telomerase expression and telomere length (TL) in different tissues of the bank vo

252 Telomere length (TL) in offspring is positively correlat

253 Telomere length (TL) is a marker of biological age that

254 Telomere length (TL) is a marker of biological aging, an

255 nsively studied biological markers of aging, telomere length (TL) provides a valuable tool to underst

256 Leukocyte telomere length (TL) shortens with age and is associated

257 ational studies have found shorter leukocyte telomere length (TL) to be a risk factor for coronary he

258 Telomere length (TL) trajectories in somatic tissues dur

259 Within an individual, telomere length (TL), an established marker of cellular

260 We also compared our biomarker findings with telomere length (TL), another well-established biologica

261 erminants of the initial, newborn setting of telomere length (TL), it is increasingly evident that ma

262 unication is on a potential biomarker, short telomere length (TL), that might serve to identify patie

263 s to measure the shortest (not just average) telomere lengths (TLs) are needed.

264 The altered relationship of telomere length to age in SM compared with PBMC suggests

265 ploinsufficient tumor suppressor that limits telomere length to ensure a timely Hayflick limit.

266 al status, copy number, gene expression, and telomere length to provide a comprehensive analysis of t

267 Telomere length tracking in children and their parents:

268 We assessed proliferative capacity and telomere length using flow-fluorescence in situ hybridiz

269 ct several QTL explaining 63.7% of the total telomere length variation in the Arabidopsis MAGIC popul

270 Telomere length varied markedly among cohorts.

271 45) was significantly associated with longer telomere length via a recessive model in our cohort (P =

272 Telomere length was also shorter in relatives (regardles

273 Oviductal telomere length was assayed using Southern blotting.

274 Shorter telomere length was associated with disability independe

275 Leukocyte telomere length was determined using a high-throughput q

276 In conclusion, no significant difference in telomere length was found between LBW and NBW men.

277 Telomere length was longer in females compared to males

278 The telomere length was negatively associated with glucose c

279 Telomere length was not associated with percent mammogra

280 In the entire sample, telomere length was positively associated with left and

281 Telomere length was positively associated with temporal

282 Oviductal telomere length was reduced in the gestational hypoxia-e

283 Shorter telomere length was significantly associated with older

284 ctivity and activated telomeric origins, yet telomere length was unchanged.

285 udinal changes in individuals' body mass and telomere length, we demonstrated that the fitness costs

286 established link between DNA replication and telomere length, we tested whether firing of telomeric o

287 ed lag models, both cord blood and placental telomere length were associated with average weekly expo

288 Individually, all BAs except for telomere length were associated with mortality risk inde

289 or genetic variants strongly associated with telomere length were extracted from a genome-wide associ

290 ns, cord blood and placental tissue relative telomere length were measured.

291 In 641 newborns, cord blood and placental telomere length were significantly and inversely associa

292 Early adversity and telomere length were significantly associated (Cohen's d

293 ans of sperm parameters, sperm and leukocyte telomere length were significantly lower, while means of

294 there was a significant 5-year shortening in telomere length, whereas no significant relationships be

295 the relationship between early adversity and telomere length while exploring factors affecting the as

296 re were positively associated with leukocyte telomere length, while urinary copper (-3.52%, -6.60, -0

297 MDS patients with shorter telomere length, who have inferior survival driven by ex

298 DS patients and evaluated the association of telomere length with MDS disease characteristics and tra

299 analysis identified 13 genes associated with telomere length, with the most significant being the leu

300 hematological malignancy, smoking behavior, telomere length, Y-chromosome loss, and other phenotypic