ライフサイエンスコーパス: telomere maintenance

1 iating redox reactions, DNA replication, and telomere maintenance.

2 also contains a STE, which is essential for telomere maintenance.

3 a role in other cellular processes including telomere maintenance.

4 ence and a switch to recombination-dependent telomere maintenance.

5 proteins, ensures unhindered, but regulated telomere maintenance.

6 ring defects in both DNA damage response and telomere maintenance.

7 meres, suggesting that this variant perturbs telomere maintenance.

8 e fragility, indicating a role for RECQL1 in telomere maintenance.

9 helicase but functionally least studied, in telomere maintenance.

10 mpacting the expression of genes involved in telomere maintenance.

11 with exquisitely high affinity to coordinate telomere maintenance.

12 Q helicase family involved in DNA repair and telomere maintenance.

13 llular processes such as gene regulation and telomere maintenance.

14 o finely tune specific mechanisms underlying telomere maintenance.

15 tion, immunoglobulin diversity, meiosis, and telomere maintenance.

16 n which the principal pathology is defective telomere maintenance.

17 luding in heterochromatic gene silencing and telomere maintenance.

18 , restart of collapsed replication forks and telomere maintenance.

19 tures at chromosomal termini participates in telomere maintenance.

20 These data implicate RECQL4 in telomere maintenance.

21 However, only TER1 is required for telomere maintenance.

22 g that BLM and WRN function independently in telomere maintenance.

23 replication, DNA repair, recombination, and telomere maintenance.

24 gy-directed repair, checkpoint signaling and telomere maintenance.

25 lure syndrome disorder because of defects in telomere maintenance.

26 '-C-overhangs in the HR-dependent pathway of telomere maintenance.

27 transcriptional repression, DNA repair, and telomere maintenance.

28 marrow failure syndrome caused by defects in telomere maintenance.

29 e mature hTR accumulation and thereby reduce telomere maintenance.

30 PinX1-TRF1 interaction in the regulation of telomere maintenance.

31 DC genes identified to date are important in telomere maintenance.

32 within hTR can stimulate telomerase-mediated telomere maintenance.

33 replication, double-strand break repair and telomere maintenance.

34 ndle checkpoint, postreplication repair, and telomere maintenance.

35 a new player in the telomere interactome for telomere maintenance.

36 , not in NHEJ or V(D)J recombination, but in telomere maintenance.

37 ruplex secondary structures which may affect telomere maintenance.

38 Okazaki fragment processing, DNA repair, and telomere maintenance.

39 n, which regulates genome activities such as telomere maintenance.

40 athways, have been shown to also function in telomere maintenance.

41 ng protein POT1 are thought to play roles in telomere maintenance.

42 ersity)joining [V(D)J] recombination, and/or telomere maintenance.

43 ential functions for SNL1 in development and telomere maintenance.

44 Telomerase function is critical for telomere maintenance.

45 in the response to DNA damage and regulates telomere maintenance.

46 us recombination, checkpoint activation, and telomere maintenance.

47 cularly and pathophysiologically by abnormal telomere maintenance.

48 effect of season of conception on postnatal telomere maintenance.

49 eta-catenin signalling, Hippo signalling and telomere maintenance.

50 ty is a hallmark of cancer cells governed by telomere maintenance.

51 luding Wnt signaling, Golgi trafficking, and telomere maintenance.

52 es including transcription, replication, and telomere maintenance.

53 bination can provide an alternative means of telomere maintenance.

54 ete loss of repeat addition processivity for telomere maintenance.

55 rocesses such as DNA replication, repair and telomere maintenance.

56 viously undescribed EWSR1 gene fusions), and telomere maintenance.

57 n nevus to malignant melanoma do not support telomere maintenance.

58 -mediated dimerization of SLX4 in genome and telomere maintenance.

59 gth, suggesting an important role of CIRP in telomere maintenance.

60 eric DNA sequences, a function important for telomere maintenance.

61 transcription, replication, translation and telomere maintenance.

62 tumor progression in addition to its role in telomere maintenance.

63 ced replisome orchestrates homology-directed telomere maintenance.

64 rase biogenesis and trafficking pathways for telomere maintenance.

65 restart of collapsed replication forks, and telomere maintenance.

66 a specialized replisome, which underlies ALT telomere maintenance.

67 ding of the diverse contributions of TPP1 in telomere maintenance.

68 ssociates with two other cochaperones, TEL2 (Telomere maintenance 2) and TTI1 (Tel2-interacting prote

69 plexes, including a 2-MDa complex with TEL2 (telomere maintenance 2), called the Triple T complex, an

70 or example, Ku70:Ku86 possesses an essential telomere maintenance activity.

71 d that this function in turn is critical for telomere maintenance after DNA ICL damage.

72 nstrate that alphaIISp is also important for telomere maintenance after ICL damage.

73 a complete holoenzyme that is functional for telomere maintenance, albeit at shortened telomere lengt

74 e and recombination-mediated lengthening for telomere maintenance (ALT).

75 6, and link chromatin regulation by SIRT6 to telomere maintenance and a human premature ageing syndro

76 n decreased expression of genes required for telomere maintenance and an aberrant DNA damage response

77 regulators of telomerase that could disrupt telomere maintenance and cancer cell proliferation are n

78 ions, possibly due to their critical role in telomere maintenance and chromosomal stability.

79 omplex has been implicated in transcription, telomere maintenance and chromosome segregation, but its

80 of seven telomerase proteins is required for telomere maintenance and copurifies active RNP.

81 y, these results identify a role for PARN in telomere maintenance and demonstrate that it is a diseas

82 ring complex encloses DNA ends to facilitate telomere maintenance and DNA break repair.

83 Telomere maintenance and DNA repair are important proces

84 rotein kinase (DNA-PK), which is involved in telomere maintenance and DNA repair by nonhomologous end

85 ty mutants can lead to a profound failure of telomere maintenance and early-onset multisystem disease

86 <0.02) gene sets related to DNA replication, telomere maintenance and elongation, cell cycle progress

87 osylation end product receptor signaling and telomere maintenance and extension pathways.

88 for replication, heterochromatin formation, telomere maintenance and genome stability in eukaryotes.

89 The role of mRtel1 in telomere maintenance and genome stability is poorly unde

90 iological processes such as DNA replication, telomere maintenance and genome stability maintenance.

91 The murine Zscan4 is involved in telomere maintenance and genomic stability of mouse embr

92 that encodes for a DNA helicase important in telomere maintenance and genomic stability.

93 for telomerase-TPP1 interaction required for telomere maintenance and implicate defective telomerase

94 EIL DNA glycosylases may be involved in both telomere maintenance and in gene regulation.

95 Here we show that Zscan4 is involved in telomere maintenance and long-term genomic stability in

96 Telomerase is required for long-term telomere maintenance and protection.

97 omology searching mechanism in ALT-dependent telomere maintenance and provide a molecular basis under

98 mutation (DKC1_A353V), which have defective telomere maintenance and reduced definitive hematopoieti

99 in RTEL1, encoding a helicase essential for telomere maintenance and regulation of homologous recomb

100 Genetic defects in telomere maintenance and repair cause bone marrow failur

101 TC1-STN1-TEN1 (CST) complex is essential for telomere maintenance and resolution of stalled replicati

102 ethylation at repeated sequences, linking to telomere maintenance and self-renewal of ES cells.

103 erase RNA component (TERC) levels to restore telomere maintenance and self-renewal.

104 ate that Tel1p has two separate functions in telomere maintenance and that the Xrs2p-dependent recrui

105 F2 has come to the limelight for its role in telomere maintenance and tumorigenesis.

106 SIRT6 regulates telomere maintenance and VSMC lifespan and inhibits athe

107 (FA)/BRCA DNA repair pathway, (2) defects in telomere maintenance, and (3) abnormal ribosome biogenes

108 We excluded Fanconi anemia, mutations of telomere maintenance, and a family history of BM failure

109 es cell growth through pathways unrelated to telomere maintenance, and a subset of tumors elongate te

110 r the preservation of replication forks, for telomere maintenance, and chromosome segregation in meio

111 gical functions, such as cell proliferation, telomere maintenance, and DNA recombination.

112 plays roles in DNA replication, DNA repair, telomere maintenance, and homologous recombination and t

113 he telomerase pathway and link proteostasis, telomere maintenance, and human disease.

114 EL1 is important in Saccharomyces cerevisiae telomere maintenance, and its kinase activity is require

115 lar functions including DNA damage response, telomere maintenance, and Notch signaling (mediated thro

116 maturation, long-patch base excision repair, telomere maintenance, and stalled replication fork rescu

117 ins that influence nuclear transcription and telomere maintenance, and that associate with nucleoids

118 ss genes involved in DNA repair pathways and telomere maintenance, and the L3 layers express transcri

119 netheless dispensable, whereas Ku70:Ku86 and telomere maintenance are essential.

120 ed that both types of telomerase-independent telomere maintenance are inherited as a non-Mendelian tr

121 Mutations in genes responsible for telomere maintenance are linked to a number of human dis

122 Individuals with deficiencies in telomere maintenance are susceptible to enhanced telomer

123 echanistic details of how they contribute to telomere maintenance are unclear.

124 erevisiae, the Ku heterodimer contributes to telomere maintenance as a component of telomeric chromat

125 novel combinatorial approaches to targeting telomere maintenance as a strategy for cancer therapy.

126 uman patients, suggesting a common defect in telomere maintenance because of the loss of MRN integrit

127 e has established the centrality of Pot1 for telomere maintenance but prohibited elucidation of the i

128 of telomeres are thought to be critical for telomere maintenance, but how they are generated has bee

129 T (alternative lengthening of telomeres) for telomere maintenance, but its function in telomere recom

130 these mutations have significant defects in telomere maintenance, but not in homologous recombinatio

131 xpression of a minimal TPP1 OB-fold inhibits telomere maintenance by blocking access of telomerase to

132 Telomerase promotes telomere maintenance by copying a template within its in

133 Telomere maintenance by minimized telomerase was unaffec

134 Telomere maintenance by telomerase is critical for the u

135 Telomere maintenance by telomerase is impaired in the st

136 cts of the DNA damage response and regulates telomere maintenance by telomerase.

137 ny indication of dominant-negative impact on telomere maintenance by the coexpressed wild-type RNA.

138 Insufficient telomere maintenance can cause stem cell and tissue fail

139 ecomes limited by each individual's inherent telomere maintenance capabilities.

140 ncrease telomerase activity and consequently telomere maintenance capacity in human immune-system cel

141 ng on gene networks related to neurogenesis, telomere maintenance, cell senescence and cytokine produ

142 with LTL variation that map near a conserved telomere maintenance complex component 1 (CTC1; rs302723

143 NA)-binding protein Pot1, a component of the telomere maintenance complex shelterin, which is present

144 form a soluble complex that may be the core telomere maintenance complex.

145 re we report the identification of conserved telomere maintenance component 1 (CTC1) in plants and ve

146 s from mutations in CTC1, encoding conserved telomere maintenance component 1, a member of the mammal

147 uced the more severe defect in both types of telomere maintenance, consistent with their more severe

148 that the lack of dominant-negative impact on telomere maintenance correlates with physiological assem

149 Telomere maintenance critically depends on the distinct

150 of the disease and that the magnitude of the telomere maintenance defect in iPSCs correlates with cli

151 /-) controls, establishing that the TIN2(DC) telomere maintenance defect was not solely due to dimini

152 esponse to DNA damage and conferred moderate telomere maintenance defect.

153 Germline telomere maintenance defects are associated with an incr

154 Correspondingly, patients with germline telomere maintenance defects exhibit DNA damage (gammaH2

155 In human subjects telomere maintenance deficiency leads to dyskeratosis co

156 ation for the connection that exists between telomere maintenance deficiency states and diverse condi

157 roteins have been identified as critical for telomere maintenance, DNA repair, transcription and othe

158 r-based ALT as the only viable mechanism for telomere maintenance during immortalization.

159 ncluding DNA damage repair (Fanconi anemia), telomere maintenance (dyskeratosis congenita), and ribos

160 However, genetically caused variations in telomere maintenance either raise or lower risks and pro

161 ction and expand mechanisms by which altered telomere maintenance engenders human disease.

162 mammary tumorigenesis, telomerase-dependent telomere maintenance facilitates the formation and metas

163 These data suggest that an alternative telomere maintenance function may operate in human tumor

164 Finally, this telomere-maintenance function is not shared by ZRANB3 or

165 les can be used as a means of inhibiting the telomere maintenance functions of telomerase in human ca

166 tions sufficient for Tel1/ATM checkpoint and telomere maintenance functions.

167 of DNA repair molecules H2AX, BRCA1, and the telomere maintenance gene, hTERT.

168 a variety of biological processes including telomere maintenance, gene expression, epigenetic regula

169 fferentiation and population structure of 37 telomere maintenance genes among 53 worldwide population

170 Mutations in telomere maintenance genes are associated with pathologi

171 was analyzed for germline mutations in four telomere maintenance genes associated with telomere biol

172 monary fibrosis (IPF) in patients mutant for telomere maintenance genes.

173 h germline mutations in telomerase and other telomere-maintenance genes.

174 ends is a hallmark of cancer, telomeres and telomere maintenance have been prime drug targets.

175 pacts of different levels of processivity on telomere maintenance have not been examined.

176 for a number of cancers, but its effects on telomere maintenance have not been previously investigat

177 n and the key involvement of this protein in telomere maintenance have suggested directed inhibition

178 didate genes and non-coding RNAs involved in telomere maintenance, immune regulation and tumour progr

179 replication, recombination, mismatch repair, telomere maintenance, immunoglobulin (Ig) gene class swi

180 -dependent regulatory mechanism critical for telomere maintenance in ALT cancer cells.

181 emonstrate that dyskerin also contributes to telomere maintenance in Arabidopsis thaliana.

182 7, like AtTERT, is not haploinsufficient for telomere maintenance in Arabidopsis.

183 Limiting the potential for telomere maintenance in cancer cells has been long been

184 ith the RNA template of telomerase and halts telomere maintenance in cancer cells.

185 increases telomerase activity, and promotes telomere maintenance in cancer cells.

186 hese data indicate that CTC1 participates in telomere maintenance in diverse species and that a CST-l

187 , providing direct evidence of their role in telomere maintenance in humans.

188 assess the role of telomerase activation and telomere maintenance in mammary carcinoma tumorigenesis,

189 In addition, we analyze telomere maintenance in mre11, rad50, nbs1, ku70 and lig

190 telomerase enzymatic activity and long-term telomere maintenance in normal human immune cells.

191 gues identified small molecules that restore telomere maintenance in patient-derived stem cells, offe

192 We used OndexView to investigate telomere maintenance in S. cerevisiae.

193 Telomere maintenance in STAG2 mutant tumor cells occurre

194 the possibility that t-circles contribute to telomere maintenance in stn1-M1 and ALT cells.

195 ed replication (BIR) as well as HR-dependent telomere maintenance in the absence of telomerase found

196 ase is believed to be the sole mechanism for telomere maintenance in the epidermis.

197 conserved shelterin complex is essential for telomere maintenance in the fission yeast Schizosaccharo

198 d mice, indicating a conserved dependence on telomere maintenance in this cell lineage.

199 The recombination-based telomere maintenance in trt1Delta cells is inhibited by

200 eres, but genetic mechanisms responsible for telomere maintenance in tumors have only recently been d

201 of several recombination/repair proteins to telomere maintenance in Ustilago maydis, a fungus that b

202 rase regulatory protein Est3 is required for telomere maintenance in vivo, and shares intriguing stru

203 human cells, suggesting BRD4 plays a role in telomere maintenance in vivo.

204 1 in vitro yet is nevertheless essential for telomere maintenance in vivo.

205 d PPM1D, and repression of genes involved in telomere maintenance, including hPOT1 and PARP1.

206 skerin interacts with telomerase and affects telomere maintenance independently of telomere length.

207 ated with LPC expression of genes related to telomere maintenance, inflammation, and chemokine signal

208 Although the general concept of defective telomere maintenance initiating genomic instability has

209 Telomere maintenance is a highly coordinated process, an

210 These findings suggest that telomere maintenance is a noncanonical caretaker functio

211 Telomere maintenance is determined by genetic factors an

212 We show that somatic telomere maintenance is different in asexual and sexual

213 Telomere maintenance is essential for protecting chromos

214 Telomere maintenance is essential for the long-term prol

215 upregulated in a number of human cancers as telomere maintenance is essential for tumorigenesis.

216 Mammalian telomere maintenance is governed by a number of telomere

217 ALT telomere maintenance is therefore one mechanism by which

218 s congenita, but how PARN deficiency impairs telomere maintenance is unclear.

219 exposure to elevated levels of radiation on telomere maintenance is unknown for natural populations.

220 e telomere repeat-binding factor 2 (TRF2) in telomere maintenance is well-established.

221 in addition to its long-term requirement for telomere maintenance, is also necessary for short-term i

222 group of disorders characterized by impaired telomere maintenance, known collectively as the telomero

223 s that rely on the alternative mechanism for telomere maintenance, LANA expression had minimal effect

224 Despite PARN's critical role in mediating telomere maintenance, little is known about how PARN's f

225 n a model that shares many features with the telomere maintenance machinery of higher eukaryotes.

226 enetic diseases are caused by defects in the telomere maintenance machinery.

227 e underlying mechanisms are largely unknown, telomere maintenance may be involved.

228 s) divide for over 200 PD without engaging a telomere maintenance mechanism (almost four times the "H

229 Activation of a telomere maintenance mechanism (TMM) is permissive for r

230 To comprehensively assess the impact of telomere maintenance mechanism (TMM) on clinical outcome

231 ing necessitates that tumor cells activate a telomere maintenance mechanism (TMM) to support immortal

232 protein (DAXX) have been shown to underlie a telomere maintenance mechanism not involving telomerase

233 e characteristic of a telomerase-independent telomere maintenance mechanism termed ALT (alternative l

234 lomere lengths by the telomerase-independent telomere maintenance mechanism termed alternative length

235 telomeres (ALT) is a telomerase-independent telomere maintenance mechanism that occurs in a subset o

236 telomeres (ALT) is a telomerase independent telomere maintenance mechanism that occurs in approximat

237 in human cells that had not yet activated a telomere maintenance mechanism, suggesting that abrogati

238 ort such long-term growth of HBECs without a telomere maintenance mechanism.

239 gthening of telomeres (ALT) pathway as their telomere maintenance mechanism.

240 Cancers require telomere maintenance mechanisms for unlimited replicativ

241 ecurrent genomic alterations associated with telomere maintenance mechanisms in cancer.

242 Deficiency in telomere maintenance mechanisms leads to the development

243 These findings assess telomere maintenance mechanisms with TERT mRNA and the A

244 Cancer cells survive cellular crisis through telomere maintenance mechanisms.

245 l contribute greatly to better understanding telomere maintenance mechanisms.

246 anism linking cumulative childhood stress to telomere maintenance, observed already at a young age, w

247 This study emphasises the role of defective telomere maintenance on human disease.

248 telomeres constitute a robust mechanism for telomere maintenance, one which has persisted since befo

249 may reflect protective functions other than telomere maintenance or an attempt to maintain shorter t

250 gene expression related to either oxidation, telomere maintenance or glucose, and insulin metabolism

251 in strains that had activated an alternative telomere maintenance pathway (ALT).

252 ely 10%-15% employ a recombination-dependent telomere maintenance pathway known as alternative length

253 ium conditions and reveal steps in the human telomere maintenance pathway that may provide additional

254 ning of telomeres (ALT), a homology-directed telomere-maintenance pathway.

255 structure-function relationships underlying telomere maintenance pathways.

256 Alterations in chromatin-modifying genes and telomere-maintenance pathways were commonly observed, wh

257 y functions of InsPs and PP-InsPs (including telomere maintenance, phosphate sensing, cell migration,

258 al lines of evidence suggest that defects in telomere maintenance play a significant role in the init

259 ells and tissues that further exacerbate the telomere maintenance problems in telomerase-positive ste

260 es an unusual homologous recombination-based telomere maintenance process.

261 We identified Mte1 (Mph1-associated telomere maintenance protein 1) as a multifunctional reg

262 ther supporting an evolutionary link between telomere maintenance proteins and DNA repair complexes.

263 sory complex that, in conjunction with other telomere maintenance proteins, ensures unhindered, but r

264 of cells lacking Ccq1 stem from its role in telomere maintenance rather than from a role in formatio

265 , the FA pathway has a novel function in ALT telomere maintenance related to DNA repair.

266 In most eukaryotes, telomere maintenance relies on telomeric repeat synthesi

267 re crucial to pre-messenger RNA splicing and telomere maintenance, respectively.

268 totic cell cycle," "DNA recombination," and "telomere maintenance," respectively.

269 An enhanced DNA repair and telomere maintenance response by the Mre11/Rad50/Nbs1 (M

270 mutations that affect telomerase function or telomere maintenance result in a variety of diseases col

271 Genetic defects in telomere maintenance result in stem cell exhaustion and

272 ein response, macroautophagy, mitophagy, and telomere maintenance) result in diverse cellular endophe

273 tic organisms, such as membrane trafficking, telomere maintenance, ribosome biogenesis, and apoptosis

274 breaks in meiosis, homologous recombination, telomere maintenance, S-phase checkpoint, and genome sta

275 ng multiple pathways including host defense, telomere maintenance, signaling, and cell-cell adhesion.

276 n but induces RAD51/HR, which contributes to telomere maintenance/stabilization and prevention of apo

277 lar processes, such as energetic metabolism, telomere maintenance, stress responses, and vesicle traf

278 tions in genes encoding factors required for telomere maintenance, such as telomerase reverse transcr

279 h dyskeratosis congenita (DC), a disorder of telomere maintenance, suffer degeneration of multiple ti

280 wth advantage to cancer cells independent of telomere maintenance, suggesting that hTERT makes multip

281 ation by passaging cells lacking any form of telomere maintenance (telomerase and telomere recombinat

282 Given the role of the previous DC genes in telomere maintenance, telomere length was analysed in th

283 Our results reveal a new mode of telomere maintenance that could shed light on how 20% of

284 thening of telomeres (ALT) is a mechanism of telomere maintenance that is observed in many of the mos

285 n replication stress and recombination-based telomere maintenance that may play a role in HPV-16 E7-m

286 propose that the BLM complex contributes to telomere maintenance through its activity in resolving L

287 ls usually engage the telomerase pathway for telomere maintenance to gain immortality.

288 importance of nevogenesis, pigmentation and telomere maintenance, together with identifying potentia

289 i anemia protein SLX4 assembles a genome and telomere maintenance toolkit, consisting of the nuclease

290 we find that a protein known to function in telomere maintenance, TRF2, also plays a functional role

291 se to DNA interstrand crosslinking agent and telomere maintenance, underscoring the contribution of B

292 ong ATRX loss, RS-induced DDR initiation and telomere maintenance via homologous recombination.

293 Telomere maintenance via telomerase reactivation is a ne

294 g that these proteins have opposing roles in telomere maintenance vs. establishment.

295 lving the POT1 and ATM genes responsible for telomere maintenance were detected and may contribute to

296 ), have important functions in physiological telomere maintenance, whereas DDR proteins that arrive l

297 HR is implicated in genomic instability and telomere maintenance, which are critical lifelines of ca

298 ve lengthening of telomeres (ALT) pathway of telomere maintenance, which relies on the homologous rec

299 Drosophila exhibit this variant mechanism of telomere maintenance, which was established before the s

300 alize the therapeutic potential of targeting telomere maintenance with a focus on telomerase are disc