ライフサイエンスコーパス: telomere-binding protein

1 at EV71 3C directly interacted with PinX1, a telomere binding protein.

2 cilitate structural characterization of this telomere binding protein.

3 ed it was predicted to be another structural telomere-binding protein.

4 telomeric silencing and mislocalize Rap1p, a telomere-binding protein.

5 has been shown to modify itself and TRF1, a telomere-binding protein.

6 the idea that hPot1 is a bona fide mammalian telomere-binding protein.

7 instead, is complexed with a heterodimeric, telomere-binding protein.

8 at is distinct from monitoring the number of telomere binding proteins.

9 , Sir4p, and Cdc13p were found to be in vivo telomere binding proteins.

10 viously to bind telomeres in vivo are indeed telomere binding proteins.

11 ation about the evolution of single-stranded telomere binding proteins.

12 haracteristics as the Euplotes and Oxytricha telomere-binding proteins.

13 aining a Myb-like motif similar to two human telomere-binding proteins.

14 ene, and/or the activity and distribution of telomere-binding proteins.

15 uited to telomeres through interactions with telomere-binding proteins.

16 shortening or disruptions in the function of telomere-binding proteins.

17 The interaction with telomere-binding protein 1 was found to be mediated thro

18 In particular, mutations of the telomere binding proteins alpha thalassemia/mental retar

19 uence similarity to the first OB fold of the telomere-binding protein alpha subunit of Oxytricha nova

20 We describe a one-hybrid assay for telomere binding proteins and use it to establish that s

21 ain homologous to the second OB-fold of POT1 telomere-binding proteins and a C-terminal SNM1 family n

22 tability requires the coordinated actions of telomere-binding proteins and the DNA replication and re

23 The known viral replication proteins, a telomere binding protein, and a protein kinase were asso

24 vely studied in many species: actin I, alpha-telomere binding protein, and DNA polymerase alpha.

25 promoted apoptosis through cleaving PinX1, a telomere binding protein, and that this cleavage facilit

26 function of telomerase and its regulation by telomere-binding proteins, and these strains will serve

27 We conclude that rTP and the telomere-binding proteins are members of a class of prot

28 ue to telomerase deficiency or by removal of telomere-binding proteins are recognized as DSBs.

29 YS EARLY proteins AtALY2 and AtALY3, and two telomere binding proteins AtTBP1 and AtTRP2/TRFL1 as SNL

30 uclear gene encoding the beta-subunit of the telomere-binding protein (beta-TP) are not conserved in

31 nd that in the absence of accessory factors, telomere binding proteins can inhibit multiple, distinct

32 we exploited the rapidly evolving Drosophila telomere-binding protein, cav/HOAP, which protects chrom

33 by multiple independent mechanisms involving telomere binding protein Ccq1 cooperating with Taz1 and

34 In Saccharomyces cerevisiae, the telomere binding protein Cdc13 mediates telomere replica

35 Inactivation of the budding yeast telomere binding protein Cdc13 results in abnormal telom

36 biochemical interaction between Est1 and the telomere binding protein Cdc13 that recapitulates the pr

37 between the Est1 telomerase subunit and the telomere-binding protein Cdc13 is essential for telomera

38 The essential budding yeast telomere-binding protein Cdc13 is required for telomere

39 een the catalytic core of telomerase and the telomere-binding protein Cdc13.

40 interacted with the putative single-stranded telomere-binding protein Cdc13p.

41 lytic subunit of telomerase and the nematode telomere-binding protein CeOB2.

42 A telomere-binding protein complex from human sperm (hSTBP

43 lot3-uv3 carries a mutation in Taz1, a telomere-binding protein containing a Myb-like motif sim

44 bility through loss-of-function mutations in telomere binding proteins contributes to genomic instabi

45 to ssDNA at unprotected telomeres (in Cdc13 telomere-binding protein defective strains).

46 RAP1 and TRF2 are telomere binding proteins essential to protect telomeres

47 Although telomere binding proteins from evolutionarily distant sp

48 Gbp1p is a putative telomere-binding protein from Chlamydomonas reinhardtii

49 Protection of telomere 1 (POT1), a telomere binding protein, has an OB domain like single-s

50 lpha and beta subunits of the Oxytricha nova telomere binding protein have been investigated by Raman

51 Telomere-binding proteins have crucial roles in controll

52 The human telomere binding protein hPot1 binds to the most distal

53 e second and first OB folds of the mammalian telomere binding protein hPOT1, respectively.

54 ng different mutations in this domain to the telomere binding protein hTRF2 redirected the mutated hT

55 It is generally assumed that telomere-binding proteins impede replication fork progre

56 uggesting that there could be other abundant telomere binding proteins in fission yeast.

57 or instance, we show that TERF1 evolved as a telomere-binding protein in the common stem lineage of m

58 The protein hPot1 shares homology with telomere-binding proteins in lower eukaryotes and associ

59 ic DNA in vitro as well as colocalizing with telomere-binding proteins in vivo.

60 omere maintenance is governed by a number of telomere binding proteins, including the newly identifie

61 eraction with specific DNA-damage sensors or telomere-binding proteins, including RPA, MRE11-RAD50-NB

62 riments with mutants defective in the Cdc13p telomere-binding protein indicate that ssDNA formation i

63 Telomere binding proteins interact with numerous protein

64 Interaction with telomere binding proteins is not sufficient to prevent a

65 tudies which demonstrate that when Cdc13p, a telomere-binding protein, is disabled, loci close to the

66 We hypothesize that these telomere binding proteins may play a role in the initiat

67 he identification of the first mitochondrial telomere-binding protein (mtTBP) that specifically binds

68 Work on the RAP1 telomere-binding protein now indicates that silencing sp

69 During the examination of ceramide-regulated telomere-binding proteins, nuclear glyceraldehyde-3-phos

70 A and the alpha subunit of the heterodimeric telomere binding protein of Oxytricha nova have been pro

71 distinct from candidate genes encoding known telomere-binding proteins or telomerase components.

72 tered by mutation, by changing the levels of telomere binding proteins, or by increasing the amount o

73 ne-rich hexameric DNA together with specific telomere-binding proteins, play essential roles in prote

74 ility to complementary C-rich strand and the telomere binding protein POT1, reflecting a less stably

75 to complementary single stranded DNA and to telomere binding protein POT1.

76 Mutations in the telomere-binding protein POT1 are associated with solid

77 RecQ helicases WRN and BLM and telomere-binding protein POT1 are thought to play roles

78 Alterations in the single-stranded telomere-binding protein POT1 have recently been identif

79 rocessivity and decreased the binding of the telomere-binding protein POT1.

80 pathogenic variants in three genes encoding telomere-binding proteins: POT1, TINF2, and ACD.

81 re, the authors show in murine HSCs that the telomere binding protein POT1a inhibited the production

82 s, such as the beta-subunit of the Oxytricha telomere-binding protein, promote the formation of G-qua

83 Deficiency for the POT-2 telomere binding protein promoted ALT in telomerase muta

84 Telomere binding proteins protect chromosome ends from d

85 s efficiently duplicated in vitro unless the telomere binding protein Rap1 is present.

86 In mammals, the conserved telomere binding protein Rap1 serves a diverse set of no

87 of the homeodomain-like motifs of the yeast telomere binding protein RAP1.

88 that with critical telomere shortening, the telomere-binding protein Rap1 (repressor activator prote

89 PIAS1 SUMOylated the telomere-binding protein RAP1, which disrupted its inter

90 ut affecting plasmid colocalization with the telomere-binding protein Rap1.

91 cerevisiae, the RAP1 gene encodes the major telomere binding protein Rap1p.

92 e function and alter the localization of the telomere binding protein Rap1p.

93 ent evidence suggests that the silencer- and telomere-binding protein Rap1p initiates silencing by re

94 The yeast telomere-binding protein Rap1p negatively regulates telo

95 s eliminated in cells that overexpressed the telomere-binding protein Rap1p, a condition that also in

96 rough its association with the silencer- and telomere-binding protein Rap1p.

97 omeric repeats attenuates the binding of the telomere binding protein, Rap1p, to telomeric DNA in vit

98 Rap1p, the major yeast telomere binding protein, recognizes a 13 bp duplex site

99 east and humans that encodes a single-strand telomere binding protein required for chromosome end pro

100 Therefore, Cdc13p is a telomere-binding protein required to protect the telomer

101 the solution conformations of the Oxytricha telomere binding protein subunits and serve as the basis

102 rticle are also capable of colocalizing with telomere binding proteins, suggesting that the C protein

103 We show that telomere-binding protein sumoylation nucleates APB conde

104 caused by the absence of the double-stranded telomere-binding protein Taz1 demonstrates that the circ

105 In contrast, when the telomere-binding protein Taz1 is also deleted, taz1Delta

106 In the absence of the telomere-binding protein Taz1, fission yeast undergo let

107 d17, Rad26, Hus1, Crb2, Chk1, Cds1), Tel1, a telomere-binding protein (Taz1), and DNA repair proteins

108 nfluence telomere length regulation, such as telomere binding proteins, telomere capping proteins, te

109 ments revealed that cRap1 interacts with the telomere-binding protein telomeric repeat binding factor

110 This regulation is mediated through the telomere-binding protein telomeric repeat-binding factor

111 We find that expression of just one telomere-binding protein, telomeric repeat-binding facto

112 n genes encoding components of telomerase or telomere-binding protein (TERT, TERC, DKC1, NOP10, or TI

113 y demonstrated that hTRF2 is a double strand telomere binding protein that forms t-loops in vitro and

114 tection of telomeres 1) is a single-stranded telomere binding protein that is essential for chromosom

115 omeres 1 (POT1) protein is a single-stranded telomere binding protein that is essential for proper ma

116 HOAP is a telomere-binding protein that has a conserved role in Dr

117 The biological implications of a telomere-binding protein that is regulated by dimerizati

118 CDC13 encodes a telomere-binding protein that prevents degradation of te

119 When tethered away from telomeres and other telomere-binding proteins, the TPP1 OB-fold domain is su

120 Here, we show that the OB-fold domain of the telomere-binding protein TPP1 recruits telomerase to tel

121 The telomere binding proteins TRF1 and TRF2 limit digestion

122 the telobox that is also found in the human telomere binding proteins TRF1 and TRF2, and Tbf1p, a pr

123 ADP-ribose) polymerase (PARP) that binds the telomere-binding protein TRF1 and increases telomere len

124 compared with the bulk genome in cells, and telomere-binding protein TRF1 significantly reduces phot

125 nteraction with the resident double-stranded telomere-binding protein TRF1.

126 In mammalian cells, telomere-binding proteins TRF1 and TRF2 play crucial rol

127 Instead, this role is replaced by SA1 and telomere binding proteins (TRF1 and TIN2).

128 d52 along with replication factors (RPA) and telomere binding proteins (TRF1 and TRF2), are associate

129 ically interacts with the TRFH domain of the telomere binding protein TRF2.

130 P1, which disrupted its interaction with the telomere-binding protein TRF2 and facilitated its nucleo

131 ve recently been revealed: these involve the telomere-binding protein TRF2 and the ubiquitin E3 ligas

132 be localized to telomeres via binding to the telomere-binding protein TRF2.

133 ere via interaction with the double-stranded telomere-binding protein TRF2.

134 Rap1 and were additive with knockdown of the telomere-binding protein TRF2.

135 mage was suppressed by overexpression of the telomere-binding protein TRF2.

136 o interact with the Werner protein (WRN) and telomere-binding protein (TRF2) were required for FEN1 a

137 current model for telomere protection by the telomere-binding protein, TRF2, involves the formation o

138 ns of a myb/SANT DNA-binding domain from the telomere-binding protein, TRF2, with reconstituted telom

139 ayed marked upregulation (10-15 fold) of the telomere-binding protein, TRF2.

140 n fall within the DNA-binding domains of the telomere-binding proteins, when rTP was first identified

141 mining regions and sequences from Myb family telomere binding proteins, which are hypothesized to con

142 These repeats are bound by telomere binding proteins, which are thought to interact

143 ct physical interactions between Blm and two telomere-binding proteins, which may thus recruit or reg

144 ns of the beta subunit of the Oxytricha nova telomere binding protein with the telomeric DNA sequence

145 In the absence of the DSB and telomere-binding protein yKu70, the bleomycin sensitivit

146 Recently we identified a novel type of telomere-binding protein YlTay1p from the yeast Yarrowia