ライフサイエンスコーパス: telomeric

1 MCHD1 and the shelterin subunit TRF2 reduced telomeric 3'-overhang removal in time-course experiments

2 g base damage to the telomeres, we show that telomeric 8-oxoG accumulation directly drives telomere c

3 Acute telomeric 8-oxoG formation increased telomere fragility

4 Accumulation of telomeric 8-oxoG in chronically exposed OGG1-deficient c

5 However, chronic telomeric 8-oxoG induction over time shortens telomeres

6 to and cluster telomeric ends together with telomeric and DNA damage factors, which led to the propo

7 In cells, CST is recruited to telomeric and non-telomeric chromatin upon G4 stabilizat

8 ysical studies were performed employing both telomeric and oncogene promoter G-quadruplex-forming seq

9 elevated level, telomere R-loops cause more telomeric and subtelomeric double-strand breaks (DSBs) a

10 mes, mostly at centromeric, pericentromeric, telomeric and subtelomeric regions(1).

11 binding by RAP1 and, thus, RAP1 silencing of telomeric and subtelomeric VSG genes.

12 two enantiomers binds specifically to human telomeric antiparallel G-quadruplex.

13 We observed extra-telomeric binding of the telomere repeat binding factor

14 otential molecular connections between extra-telomeric biology and pluripotency.

15 d decay and defluorination, the reactions of telomeric C (n)F(2 n+1)-CH(2)CH(2)-COO(-) and C (n)F(2 n

16 Consistent with shortening of the telomeric C strand, metaphase chromosomes showed loss of

17 y that can explain the incremental nature of telomeric C-strand synthesis following telomerase action

18 lterin subunits TRF1, TRF2, and TIN2 mediate telomeric chromatin compaction, which was proposed to mi

19 investigated the structural organization of telomeric chromatin in human cells using super-resolutio

20 strate that shelterin-mediated compaction of telomeric chromatin provides robust protection of chromo

21 cells, CST is recruited to telomeric and non-telomeric chromatin upon G4 stabilization, even when ATR

22 Recompaction of telomeric chromatin using an orthogonal method displaces

23 1 has also been identified as a component of telomeric chromatin.

24 is in close proximity to NUP-1, the NPCs and telomeric chromosomal regions.

25 Removal of telomeric cohesion in combination with DAXX deficiency r

26 20A elicits global DNA damage but not telomeric damage and activates the ATM and autophagy pat

27 The ANK domain of TNKS1 is essential for the telomeric damage response and TRF1 interaction.

28 1/2 inhibitor only has such an effect at non-telomeric damage sites.

29 WRN responds to site-specific telomeric damage via its RQC domain, interacting at Lysi

30 and-break repair nuclease MRE11A, leading to telomeric damage, juxtacentromeric heterochromatin unrav

31 on, WRN depleted cells are also sensitive to telomeric damage.

32 elomeres (ALT) cells, which have spontaneous telomeric damage.

33 hed new light on the molecular mechanisms of telomeric DDR and CD4 T-cell homeostasis during HIV infe

34 eds new light on the molecular mechanisms of telomeric DDR and its role in CD4 T-cell homeostasis dur

35 We demonstrated that HIV-induced telomeric DDR plays a critical role in inducing telomere

36 on in vivo We demonstrated that HIV-induced, telomeric DDR plays a pivotal role in triggering telomer

37 ere dysfunction induces the transcription of telomeric DDRNAs (tDDRNAs) and their longer precursors f

38 Here, we measured loss of telomeric DNA and accumulation of replication errors in

39 tificial nucleases that degrade G-quadruplex telomeric DNA and exhibit selective DNA binding affinity

40 (Tg), regulate the structural properties of telomeric DNA and telomerase extension activity.

41 Phe, AtPOT1bOB1 gained the capacity to bind telomeric DNA and to stimulate telomerase repeat additio

42 Increases in telomeric DNA are suppressed by loss of BLM but not RAD5

43 , binding directly and with high affinity to telomeric DNA as well as to UPF1 and Ku70/Ku80 proteins

44 Telomeric DNA consists of tandem repeats of the sequence

45 omere shortening and the consequent onset of telomeric DNA damage and cellular senescence are a gener

46 Telomeric DNA damage generates cytosolic DNA species wit

47 gs identify a biomarker of resistance to the telomeric DNA damage mediator 6-thio-2'-deoxyguanosine.

48 ying CD4 T-cell destruction by analyzing the telomeric DNA damage response (DDR) and cellular apoptos

49 evoid of TRF2 instead activate an attenuated telomeric DNA damage response that lacks accompanying te

50 This leads to accumulation of RPA and telomeric DNA damage signaling.

51 oci, and augmented cell death upon oxidative telomeric DNA damage.

52 1 complex, which affects its ability to bind telomeric DNA efficiently.

53 At telomeres, TERRA competes with telomeric DNA for ATRX binding, suppresses ATRX localiza

54 s exhibit telomere dysfunction and cytosolic telomeric DNA fragments that are sensed by cGAS.

55 he most abundant sequence motif in irregular telomeric DNA from Saccharomyces cerevisiae (yeast), is

56 ed space on the property of individual human telomeric DNA G-quadruplexes.

57 simulations to study two bimolecular GQs, a telomeric DNA GQ and the analogous telomeric repeat-cont

58 that the TERRA GQ is more sensitive than the telomeric DNA GQ to water-mediated modulation of ion-ind

59 stone gamma-H2AX foci and a striking loss of telomeric DNA in mus81 send1 further support this interp

60 TRF1 facilitates the replication of telomeric DNA in part by recruiting the BLM helicase, wh

61 We found that the levels of estimated telomeric DNA methylation varied among studies.

62 nteractions of the gold complex with various telomeric DNA models have been analyzed by a combined ES

63 result of conventional DNA replication, new telomeric DNA must be added onto the chromosome end.

64 and cleavage reactivity toward G-quadruplex telomeric DNA over duplex DNA.

65 indicate that subtelomeric CTCF facilitates telomeric DNA replication by promoting TERRA transcripti

66 e structure of TRF1 and its interaction with telomeric DNA sequence.

67 nfold G-quadruplex (G4) structures formed by telomeric DNA sequences, a function important for telome

68 ral motif of G-quadruplexes formed by, e.g., telomeric DNA sequences, but are also interesting target

69 In contrast to 8oxoG which disrupts the telomeric DNA structure, Tg exhibits substantially reduc

70 d POT1 has the strongest binding affinity to telomeric DNA substrates comprised of double-stranded DN

71 RAD52 deficiency reduced spontaneous telomeric DNA synthesis and replication stress-associate

72 Telomerase catalyzes telomeric DNA synthesis at chromosome ends to allow for

73 We propose that TRF1 facilitates S-phase telomeric DNA synthesis to prevent illegitimate mitotic

74 rase RNA (TR) that provides the template for telomeric DNA synthesis.

75 The human shelterin proteins associate with telomeric DNA to confer telomere protection and length r

76 ALT relies on exchanges of telomeric DNA to maintain telomeres, a process that we s

77 terins but rather on the unique character of telomeric DNA when it is opened for transcription.

78 r resolution of stalled replication forks in telomeric DNA while BLM facilitates their resection and

79 With the exception of the single-stranded telomeric DNA, all genomic G-rich sequences will always

80 lude that a distinctive topological state of telomeric DNA, controlled by the TRF2-dependent DNA wrap

81 POT1 OB-fold fail to bind to single-stranded telomeric DNA, eliciting a DNA damage response at telome

82 stabilization in the potassium form of human telomeric DNA, it causes the unfolding of the same G4 se

83 embly of proteins that binds to and protects telomeric DNA, which composes the ends of all linear chr

84 telomere proteins bind, extend, and protect telomeric DNA, which itself evolves slowly in most syste

85 array of bound Rap1 molecules that mimics a telomeric DNA-protein assembly.

86 integrations of telomeric sequences into non-telomeric DNA.

87 the generation of circular, extrachromosomal telomeric DNA.

88 vation of telomerase, an enzyme that extends telomeric DNA.

89 d conformational alterations and dynamics in telomeric DNA.

90 but not POT1b, has an intrinsic affinity for telomeric DNA.

91 e (F65) that in human POT1 directly contacts telomeric DNA.

92 ich forms RNA:DNA hybrids (R-loops) with the telomeric DNA.

93 n enhance folding of the i-motif sequence of telomeric DNA.

94 to activate genes in otherwise repressed sub-telomeric domains.

95 etion from mouse cells altered the repair of telomeric double-strand breaks (DSBs) and induced ALT-li

96 nalysis together with experimentally induced telomeric double-stranded DNA breaks.

97 The data reveal that ATRX has an effect on telomeric DSB repair and that this role involves both te

98 Mechanistically, we show that ATRX affects telomeric DSB repair by promoting cohesion of sister tel

99 ation with DAXX deficiency recapitulates all telomeric DSB repair phenotypes associated with ATRX los

100 elomere formation in cells with FokI-induced telomeric DSBs and in alternative lengthening of telomer

101 BIR of telomeric DSBs competed with PARP1-, LIG3-, and XPF-depe

102 -induced telomeric R-loops promote repair of telomeric DSBs through CSB-RAD52-POLD3-mediated BIR, a p

103 omeres can arise from BIR-mediated repair of telomeric DSBs.

104 ired for the efficient repair of ROS-induced telomeric DSBs.

105 we document a role for DAXX in the repair of telomeric DSBs.

106 intenance leads to gradual shortening of the telomeric dsDNA, similar to that observed in cells lacki

107 CST first aids in duplication of the telomeric dsDNA.

108 -forming scaffolds linked at the 3' end to a telomeric duplex sequence and annealed to a complementar

109 lomeric hybrids that, in turn, can result in telomeric dysfunction.

110 enetic analysis mapped the vic2 locus to the telomeric end of chromosome 15.

111 scriptase inhibitors ddITP and AZT-TP to the telomeric end, causing chain termination.

112 APBs localize to and cluster telomeric ends together with telomeric and DNA damage fa

113 PIP5Pase and RAP1 bind to telomeric ESs, especially at 70-bp repeats and telomeres

114 he active VSG gene is in a Pol I-transcribed telomeric expression site (ES).

115 simultaneous transcription of VSGs from all telomeric expression sites (ESs) and from silent subtelo

116 meres using CAPTURE identifies known and new telomeric factors.

117 which can be subdivided into centromeric and telomeric fragments.

118 ized subtelomeric methylation and associated telomeric functions in cells derived from ICF1 model mic

119 vations suggest a role of telomeres in extra-telomeric functions.

120 ole chromosomes containing massive arrays of telomeric fusions indicative of multiple breakage-fusion

121 nd bound to any conformational form of human telomeric G-quadruplex (antiparallel, hybrid, parallel m

122 whereas Tg retains limited accessibility, of telomeric G-quadruplex DNA to complementary single stran

123 ies show that Delta1a can discriminate human telomeric G-quadruplex from other telomeric G-quadruplex

124 ne core ligand, BMPQ-1, which bound to human telomeric G-quadruplex multimers over monomeric G-quadru

125 T1 (Protection of Telomeres 1) unfolds human telomeric G-quadruplex structures is not fully understoo

126 the mechanical property of individual human telomeric G-quadruplexes bound to telomestatin, using op

127 nate human telomeric G-quadruplex from other telomeric G-quadruplexes.

128 the resolution of, and replication through, telomeric G-quadruplexes.

129 ates DNA polymerase delta progression across telomeric G-rich repeats, only WRN promotes sequential s

130 e anticancer alkaloid berberine to the human telomeric G4 (d[AG3(T2AG3)3]), computing also the bindin

131 -rich region that is also located within the telomeric gene desert but has no impact on Hoxd8 transcr

132 insertion and deletion mutations in the peri-telomeric genes, which is also a characteristic of other

133 s and alleviates repression of some polycomb telomeric genes.

134 sands of TRF2-binding sites within the extra-telomeric genome.

135 M) ligands have been used to stabilize human telomeric GQ (hGQ) to inhibit telomerase activity, or no

136 (hGQ) to inhibit telomerase activity, or non-telomeric GQs to manipulate gene expression at transcrip

137 span and induced senescence, associated with telomeric H3K9 (histone H3 lysine 9) hyperacetylation an

138 e telomere lengths linked to distinguishable telomeric haplotypes; this single-telomere genotyping me

139 tion and Swi6 recruitment to centromeric and telomeric heterochromatic loci.

140 origin licensing within both euchromatin and telomeric heterochromatin established the normal spatial

141 We find that telomeric heterochromatin is dynamic and remodelled upon

142 ithin both early-replicating euchromatin and telomeric heterochromatin, and replication activity with

143 tion, can enantioselectively stabilize human telomeric hybrid G-quadruplex and strongly inhibit telom

144 omers with contrasting selectivity for human telomeric hybrid G-quadruplex.

145 Telomeric hybrids are associated with high levels of DNA

146 vels in ICF syndrome lead to accumulation of telomeric hybrids that, in turn, can result in telomeric

147 Herein the human telomeric i-motif sequence was used to examine how these

148 on, which we term [ESI(+)] for expressed sub-telomeric information, is triggered by transient Snt1 ph

149 hat the ALT pathway preferentially occurs at telomeric lagging strands leading to heterogeneous telom

150 lls exhibited preferential elongation of the telomeric lagging strands, whereas telomerase positive c

151 ization abrogates nuclear foci formation and telomeric localization of not only SLX4 but also of its

152 These include a telomeric location of the vlsE gene, an inverse orientat

153 ced from a gene 60 kb upstream of its normal telomeric location.

154 RENT complex, as MET3pr-GFP expression in a telomeric locus does not have the same cell cycle depend

155 Telomeric macroH2A1.2 is re-deposited in a DNA damage re

156 s at telomeres, leading to the engagement of telomeric MiDAS (spontaneous mitotic telomere synthesis)

157 Telomeric MiDAS is a conservative DNA synthesis process,

158 N complex suppresses telomere clustering and telomeric MiDAS, whereas the SMC5/6 complex promotes the

159 this model, initial damage to DNA (genomic, telomeric, mitochondrial and epigenetic changes) results

160 ent types of large structural mosaic events: telomeric neutral events and interstitial losses.

161 ically probed guanine positions in the human telomeric oligonucleotide sequence (hTel) by substitutio

162 Whereas short telomeric oligonucleotides form a G-hairpin, their longe

163 We conclude that telomeric origin firing does not cause telomere elongati

164 rotein Phosphatase 1 (PP1) binding activated telomeric origins but did not elongate telomeres.

165 of telomere chromatin structure (telosomes), telomeric origins of replications, telomere length homeo

166 telomere length, we tested whether firing of telomeric origins would cause telomere lengthening.

167 nd Cdc7 increased DDK activity and activated telomeric origins, yet telomere length was unchanged.

168 -Delta1322 nor rif1(HOOK) affected firing of telomeric origins.

169 ne-rich oligonucleotide homologous to the 3'-telomeric overhang of telomeres, elicits potent DNA-dama

170 rved that ALT cells possess excessively long telomeric overhangs derived from telomere elongation pro

171 RA increases telomerase activity and induces telomeric pathologies, including formation of telomere-i

172 l DNA methylation and, accordingly, the ICF1 telomeric phenotype persists.

173 PF1) and Plasmodium Helical Interspersed Sub-Telomeric (PHIST) gene families.

174 Negative regulation by VEX1 also affected telomeric pol-I-transcribed reporter constructs, but onl

175 ture of the interacting portion of the human telomeric POT1-TPP1 complex and suggest how several of t

176 Naturally occurring mutations of the telomeric POT1-TPP1 complex are implicated in familial g

177 Typical nematode telomeres and telomeric protection-encoding genes are lacking.

178 propensity to form secondary structures and telomeric protein binding, pose a challenge to BIR and i

179 The telomeric protein TPP1 is essential for enhancing the pr

180 ty, while others, such as those found in the telomeric protein TPP1, reduce the recruitment of telome

181 uch as LMO2, LMO4, LHX2, LHX3, LDB1, and the telomeric protein TRF1.

182 interactions with telomerase RNA (TLC1) and telomeric proteins Sir4 and Cdc13, respectively.

183 ting proteins, including epigenetic factors, telomeric proteins, and the RNA helicase, ATRX.

184 while the stoichiometry was more complex for telomeric quadruplex DNA and a double-stranded DNA contr

185 Thus, ROS-induced telomeric R-loops promote repair of telomeric DSBs throu

186 RAD52 is recruited to telomeric R-loops through its interactions with both CSB

187 Telomeric recombination increases in asy1/+ occur in dis

188 a major malting QTL, QTL2, located near the telomeric region that accounts, respectively, for 28.9%

189 s their human counterparts also populate the telomeric region.

190 We observed preferential recombination in telomeric regions and reduced recombination in pericentr

191 atin is associated with the rDNA locus while telomeric regions are assembled into a weak heterochroma

192 Telomeric regions contain prominent sites of heterochrom

193 Ccr2 and Rps4l are located close to the telomeric regions of chromosome 9 and 6, respectively.

194 property of being able to integrate into the telomeric regions of human chromosomes.

195 TRF1 tethers SA1 within telomeric regions that SA1 transiently interacts with.

196 ed TERRA levels, are enriched for hybrids at telomeric regions throughout the cell cycle.

197 5hmU is enriched in strand switch regions, telomeric regions, and intergenic regions.

198 ssovers, with strongest reduction in the sub-telomeric regions.

199 NA:RNA hybrids form at many subtelomeric and telomeric regions.

200 ify high genome diversity, especially in sub-telomeric regions.

201 centromeres towards the less-polymorphic sub-telomeric regions.

202 Telomeric repeat binding factor 1 (TRF1) is essential to

203 c.752-2A>C) and another shelterin component, telomeric repeat binding factor 2, interacting protein (

204 eatment and hybridization with a Cy3-labeled telomeric repeat complementing (CCCTAA)3 peptide nucleic

205 t suppress the accumulation of DNA damage at telomeric repeat DNA.

206 utilizing the prototypical polymorphic human telomeric repeat sequence (H-Telo22, d[AG3(T2AG3)3]) tha

207 Consistent with their roles at telomeres, telomeric repeat sequence DNA also stimulated binding an

208 plex DNA sequence constructed from the human telomeric repeat sequence TTAGGG.

209 Notably, an azide-tailed sgRNA targeting the telomeric repeat served as a Trojan horse on the CRISPR-

210 and eight additional proteins, including the telomeric repeat single-stranded DNA-binding protein Teb

211 t eukaryotes, telomere maintenance relies on telomeric repeat synthesis by a reverse transcriptase na

212 odel binding partners: the PARylated partner telomeric repeat-binding factor 1 (TRF1) and the non-PAR

213 Repressor activator protein 1 (RAP1) and telomeric repeat-binding factor 2 (TRF2) are two subunit

214 ediated through the telomere-binding protein telomeric repeat-binding factor 2 (TRF2).

215 ar GQs, a telomeric DNA GQ and the analogous telomeric repeat-containing RNA (TERRA) GQ.

216 Functions of the telomeric repeat-containing RNA (TERRA), the long noncod

217 monstrated elongated telomeres and increased telomeric repeat-containing RNA (TERRA).

218 ion of shelterin complex, competing with the telomeric-repeat binding factors TRF1 and TRF2.

219 linking hinge, which bound to 12 bp in human telomeric repeats (5'-(TTAGGG)n-3') and could be used to

220 been reported for Q-quadruplexes formed from telomeric repeats depending on DNA length and ion soluti

221 ide probe confirmed its effective binding to telomeric repeats in the complex chromatinized genome.

222 The reverse transcriptase telomerase adds telomeric repeats to chromosome ends.

223 ich serves as a template for the addition of telomeric repeats to chromosome ends.

224 mosome ends; however, it may erroneously add telomeric repeats to DNA double-strand breaks.

225 lterin components, which allows CLRC to skip telomeric repeats to internal regions.

226 istinct activities of telomerase, which adds telomeric repeats to solve the end replication problem,

227 omerase maintains genome stability by adding telomeric repeats to the ends of linear chromosomes.

228 omere is by telomerase-catalyzed addition of telomeric repeats with homology-directed repair serving

229 /PK) which includes the template, for adding telomeric repeats, template boundary element (TBE), and

230 To synthesize telomeric repeats, the catalytic subunit telomerase reve

231 of four hairpin moieties, targeting 24 bp in telomeric repeats, the longest reported binding site for

232 ming, which results in the rapid deletion of telomeric repeats.

233 ked by upstream 70 bp repeats and downstream telomeric repeats.

234 estimate the unconverted rate (UCR) by using telomeric repetitive DNA as native spike-in control.

235 ALT cells, BRCA1 and BLM help to resolve the telomeric replication stress by stimulating DNA end rese

236 apping, and sequencing of parental and novel telomeric restriction fragments (TRFs), along with MinIO

237 s an essential, strictly conserved function: telomeric retrotransposon containment, not end-protectio

238 Telomeric retrotransposon diversification and disappeara

239 populations revealed that HOAP[yak] triggers telomeric retrotransposon proliferation, resulting in ab

240 HOAP function: silencing of the specialized telomeric retrotransposons that, instead of telomerase,

241 ence of retrotransposons (Magnaporthe oryzae Telomeric Retrotransposons-MoTeRs) inserted in the telom

242 it also needs to evolve quickly to restrict telomeric retrotransposons.

243 lohelices bind with a high affinity to human telomeric RNA G-quadruplex and that their binding select

244 molecular cationic metallohelices with human telomeric RNA G-quadruplex.

245 causes R-loop and DNA damage accumulation in telomeric RNA Pol I transcription sites, also leading to

246 P1-regulated appropriate levels of TERRA and telomeric RNA:DNA hybrid are fundamental to subtelomere/

247 Depletion of TbRAP1 also results in more telomeric RNA:DNA hybrids and more double strand breaks

248 he RNA strand of the RNA:DNA hybrid, brought telomeric RNA:DNA hybrids, telomeric/subtelomeric DSBs a

249 RNAs, including ribosomal, spliceosomal and telomeric RNAs, cisplatin binding sites in most RNA mole

250 of reactive oxygen species, suggesting a non-telomeric role for Pot1a in HSC maintenance.

251 seemingly distinct research areas: the extra-telomeric role of telomere-binding factors and the role

252 in the GGG triplet found in the G-rich human telomeric sequence (TTAGGG), making telomeres highly sus

253 emplate containing four repeats of the human telomeric sequence by stabilizing the RNA G-quadruplex s

254 nvolved in mismatch repair (MMR), suppresses telomeric sequence insertion (TSI) at intra-chromosomal

255 icity, we studied five and six repeats human telomeric sequence using a combination of single molecul

256 erin, fission yeast shelterin is composed of telomeric sequence-specific double- and single-stranded

257 G-quadruplex, and (iii) an i-motif of human telomeric sequence.

258 Aberrant formation of interstitial telomeric sequences (ITSs) promotes genome instabilities

259 demonstrated that TbPolIE is associated with telomeric sequences and here we show that RNAi-mediated

260 x known as shelterin prevents recognition of telomeric sequences as sites of DNA damage.

261 itically important for the proper capping of telomeric sequences by shelterin.

262 umor samples contain somatic integrations of telomeric sequences into non-telomeric DNA.

263 Hence, telomeric sequences may have evolved to facilitate their

264 Mb were assembled, including 4 contigs with telomeric sequences on both ends and an additional 8 con

265 n both ends and an additional 8 contigs with telomeric sequences on either the 5' or 3' end.

266 nsfer with optical tweezers to measure human telomeric sequences under tension.

267 d DNA damage foci and loss or duplication of telomeric sequences.

268 ation events between different DNAs at their telomeric sequences.

269 tid exchanges (T-SCEs), and extrachromosomal telomeric signals (ECTSs).

270 residue is required for Gdh1's functions in telomeric silencing and H3 clipping.

271 ic variation and demonstrated a link between telomeric silencing and subtelomere/telomere integrity t

272 is observed in GDH1 mutants, consistent with telomeric silencing defects.

273 Disruptor of telomeric silencing-1 like (DOT1L) protein specifically

274 nly a single methyltransferase, disruptor of telomeric silencing-1-like (DOT1L).

275 independent of the SIR-mediated pathway for telomeric silencing.

276 a key regulatory role for this metabolite in telomeric silencing.

277 n microscopy structure of human CST bound to telomeric single-stranded DNA (ssDNA), which assembles a

278 transcribed VSG expression site is the only telomeric site that is early replicating - a differentia

279 Analysis of telomeric SNPs indicated general agreement of allele fre

280 present in IL Holsteins based on the 10 most telomeric SNPs of the BovineSNP50 BeadChip.

281 ROS-induced telomeric SSBs may not only give rise to DSBs indirectly

282 g, suppresses ATRX localization, and ensures telomeric stability.

283 y replicate, resect, and/or form appropriate telomeric structures drives telomere shortening and, in

284 in the presence of modified dNTPs on various telomeric substrates.

285 A hybrid, brought telomeric RNA:DNA hybrids, telomeric/subtelomeric DSBs and VSG switching frequency

286 The telomeric TAD (T-DOM) contains several enhancers active

287 During limb development, the telomeric TAD controls the early transcription of Hoxd g

288 The telomeric (tel) part has an even balance of telA to telB

289 uncover a transition point in which 34 bp of telomeric (TG1-3)n repeat sequence renders a DNA end ins

290 Ts1Rhr mice harbor a duplication of the telomeric third of the Ts65Dn-duplicated sequence and de

291 nd near HEY2 and NCOA7), 8q24.21 (rs4733613, telomeric to MYC), 15q15.1 (rs937213, in EIF2AK4, near B

292 The telomeric transcript, TERRA, was detected in T. brucei p

293 ing RNAs, we investigate the function of the telomeric transcript, TERRA.

294 in vivo and is targeted to active genes and telomeric transposons via binding of the PWWP domain of

295 in H3K9me2 distribution at active genes and telomeric transposons.

296 Interestingly, we found that extra-telomeric TRF2 sites throughout the genome are enriched

297 t TbPolIE depletion leads to deregulation of telomeric variant surface glycoprotein genes, linking th

298 he VSG-exclusion-1 (VEX1) protein binds both telomeric VSG-associated chromatin and VEX2, an ortholog

299 the genome and repetitive regions: rDNA and telomeric Y' regions.

300 specific telomere-associated protein: TZAP (telomeric zinc finger-associated protein).