ライフサイエンスコーパス: telomeric repeat

1 lomere homology that is longer than the unit telomeric repeat.

2 ppress corresponding sequence changes in the telomeric repeat.

3 nucleotides of perfect homology to the 25-bp telomeric repeat.

4 a specific permutation of the guanosine-rich telomeric repeat.

5 referred termination points within the 25-bp telomeric repeat.

6 anslocation step after the synthesis of each telomeric repeat.

7 n being the central guanine residues in each telomeric repeat.

8 t lasted only 1-2 h from a DSB adjacent to a telomeric repeat.

9 ene family are located within 10 kb from the telomeric repeat.

10 s specifically with the G-rich strand of the telomeric repeat.

11 ruitment--binding and extension of the first telomeric repeat.

12 N-terminal OB domain of each monomer to each telomeric repeat.

13 red for a high affinity of YlTay1p to either telomeric repeat.

14 PA, Teb1 binds DNA with high specificity for telomeric repeats.

15 subunit to elongate chromosome ends with new telomeric repeats.

16 unit binds sequence specifically to multiple telomeric repeats.

17 ming, which results in the rapid deletion of telomeric repeats.

18 than those seen in cells with only wild-type telomeric repeats.

19 odified base, J is located mainly within the telomeric repeats.

20 ted and typically capped by species-specific telomeric repeats.

21 omere, which contains degenerate and variant telomeric repeats.

22 wed by several kilobases of TTAGG or variant telomeric repeats.

23 has adapted mechanisms to maintain terminal telomeric repeats.

24 multiple 8-oxo-guanine lesions in the tandem telomeric repeats.

25 a Pot1 monomer is extended into two adjacent telomeric repeats.

26 ked by upstream 70 bp repeats and downstream telomeric repeats.

27 lomere length and the sequence of newly made telomeric repeats.

28 t observed above background along the duplex telomeric repeats.

29 rm within guanine-rich DNA sequences such as telomeric repeats.

30 e alterations appearing in newly synthesized telomeric repeats.

31 l as the synthesis of aberrant, 5-nucleotide telomeric repeats.

32 ataxia telangiectasia, have short but stable telomeric repeats.

33 constant to 24 bp sequences made up of four telomeric repeats.

34 ntains at least three G-rich single-stranded telomeric repeats.

35 s of eukaryotic chromosomes by adding tandem telomeric repeats.

36 ell lineages by restricting the reservoir of telomeric repeats.

37 on ablated RPA1 and RPA2 binding to the cell telomeric repeats.

38 cules bind an oligonucleotide containing two telomeric repeats.

39 b-like domains conferring specificity toward telomeric repeats.

40 of an RNA subunit as template to synthesize telomeric repeats.

41 erase RNA subunit templates the synthesis of telomeric repeats.

42 some ends by the addition of single-stranded telomeric repeats.

43 linking hinge, which bound to 12 bp in human telomeric repeats (5'-(TTAGGG)n-3') and could be used to

44 n the Leishmania genome and is only found in telomeric repeats (99%) and in regions where transcripti

45 ose that after formation of the DSB near the telomeric repeat, a mature telomere forms in 1-2 h, and

46 es composed of either of two types of mutant telomeric repeats, Acc and SnaB, that each alter the bin

47 r DNA also resembles the situation found for telomeric repeat addition to macronuclear-destined seque

48 geneity could be observed in the position of telomeric repeat addition.

49 I), and the other possesses amplification of telomeric repeats alone (type II), similar to previously

50 The telomeric repeat amplification protocol (TRAP assay) has

51 We develop a real-time quantitative PCR telomeric repeat amplification protocol (TRAP) assay tha

52 Typical assay for telomerase activity is the telomeric repeat amplification protocol (TRAP) based on

53 The telomeric repeat amplification protocol (TRAP) is a two-

54 The sensitive telomeric repeat amplification protocol (TRAP) permits t

55 Telomerase activity was measured using the telomeric repeat amplification protocol (TRAP).

56 Additional evidence from Telomeric Repeat Amplification Protocol (TRAP-LIG) assay

57 nhibited telomerase activity, as measured by telomeric repeat amplification protocol assay and human

58 Telomerase activity was evaluated by a telomeric repeat amplification protocol assay based on e

59 and it can be regarded as an alternative to telomeric repeat amplification protocol assay, having th

60 uantitative real-time quantitative-PCR-based telomeric repeat amplification protocol assay, with telo

61 el of telomerase activity as measured by the telomeric repeat amplification protocol assay.

62 se activity was determined using a PCR-based telomeric repeat amplification protocol coupled with ELI

63 invasive breast cancers by the quantitative telomeric repeat amplification protocol method.

64 erase activity at 24 h as detected using the telomeric repeat amplification protocol, and this inhibi

65 ive telomerase, as assessed according to the Telomeric Repeat Amplification Protocol.

66 Telomeric-repeat amplification protocol assays and telom

67 which rules out quadruplex formation by the telomeric repeat and confirms an ordered secondary struc

68 We designed TALEs for the human telomeric repeat and fused them with any of numerous flu

69 ese complexes also fold much faster than the telomeric repeat and there is little or no hysteresis be

70 ions many kilobases internal to the terminal telomeric repeats and correlates strongly with the previ

71 TRF2 binds to DNA substrates containing telomeric repeats and facilitates their degradation spec

72 l senescence and ageing, due to attrition of telomeric repeats and insufficient retention of the telo

73 its RNA subunit as a template to synthesize telomeric repeats and maintain telomere tracts on chromo

74 Telomerase catalyzes conservation of telomeric repeats and may promote cell immortality and h

75 lencing is initiated by Rap1p binding to the telomeric repeats and subsequent recruitment of the Sir

76 The bridges required telomeric repeats and were dependent on meiotic recombin

77 ogeneous spacers that occur between S. pombe telomeric repeats, and it also has implications for telo

78 The telomeric repeats are maintained by telomerase, which so

79 We further discovered that telomeric repeats are refractory to heterochromatin spre

80 ase levels--and extension of as few as three telomeric repeats are sufficient to maintain functional

81 Telomeric repeats are synthesized and maintained by a sp

82 of the 3' telomeric overhang into the duplex telomeric repeat array.

83 nity in vitro correlates with the ability of telomeric repeat arrays to regulate telomere length in v

84 The shortening of telomeric repeats as a cell replicates has long been imp

85 Mammalian POT1 binds two telomeric repeats as a monomer in a sequence-specific ma

86 ble as part of a holoenzyme that synthesizes telomeric repeats at chromosome ends.

87 RNA, which can explain the heterogeneity of telomeric repeats at de novo and native telomeres in S.

88 them also carry several shorter stretches of telomeric repeats at or near their 3' ends, which could

89 chromosomal segmental duplications capped by telomeric repeats at the ends of chromosomes.

90 ase recognizes, and compensates for, partial telomeric repeats at the ends of fragmentation intermedi

91 The total number of telomeric repeats at the terminal end of a chromosome de

92 8-oxoG in telomeric repeats attenuates the binding of the telomere

93 hand, when hPOT1 is bound at a position one telomeric repeat before the 3'-end, leaving an 8-nucleot

94 ADP-ribosylate TRF1 and to down-regulate the telomeric repeat binding activity of TRF1, resulting in

95 interacts with the telomere-binding protein telomeric repeat binding factor (TRF)2 and localizes to

96 Here we report the identification of telomeric repeat binding factor 1 (Tbf1), a second TRF1/

97 Telomeric repeat binding factor 1 (TRF1) is a component

98 Telomeric repeat binding factor 1 (TRF1) is essential to

99 igh-mobility group AT-hook 1 (HMGA1), HMGB1, telomeric repeat binding factor 1 (TRF1), xeroderma pigm

100 nd in telomerase and the shelterin component telomeric repeat binding factor 1 (TRF1)-interacting nuc

101 re maintained by three DNA-binding proteins (telomeric repeat binding factor 1 [TRF1], TRF2, and prot

102 CSNK2A2 phosphorylates telomeric repeat binding factor 1 and plays an important

103 teraction proteins, we have identified TRF1 (telomeric repeat binding factor 1) as a potential Plk1 t

104 teins suppressed the ADP-ribosylation of the telomeric repeat binding factor 1, another tankyrase 1-i

105 Human telomeric repeat binding factor 2 (hTRF2) is a protein t

106 of either or both of the shelterin proteins telomeric repeat binding factor 2 (TRF2) and protection

107 (SSRP1), a subunit of the FACT complex, and telomeric repeat binding factor 2 (TRF2) formed complexe

108 t cells lacking MRN do not activate ATM when telomeric repeat binding factor 2 (TRF2) is removed from

109 TRF2 (telomeric repeat binding factor 2) is an essential compo

110 c.752-2A>C) and another shelterin component, telomeric repeat binding factor 2, interacting protein (

111 ctional interactions between WRN and TRF2, a telomeric repeat binding factor essential for proper tel

112 In mammalian cells, abrogation of telomeric repeat binding factor TRF2 or DNA-dependent pr

113 xpression of a dominant negative form of the telomeric repeat binding factor, TRF2(DN).

114 eas mammalian cells harbor two double strand telomeric repeat binding factors, TRF1 and TRF2, the fis

115 t this suppression of apoptosis involves the telomeric-repeat binding factor 2 (TRF2).

116 ion of shelterin complex, competing with the telomeric-repeat binding factors TRF1 and TRF2.

117 We demonstrated that NS could interact with telomeric repeat-binding factor 1 (TRF1) and enhance the

118 odel binding partners: the PARylated partner telomeric repeat-binding factor 1 (TRF1) and the non-PAR

119 Here we establish that telomeric repeat-binding factor 1 (TRF1), a core compone

120 Repressor activator protein 1 (RAP1) and telomeric repeat-binding factor 2 (TRF2) are two subunit

121 To examine the role of telomeric repeat-binding factor 2 (TRF2) in epithelial t

122 ediated through the telomere-binding protein telomeric repeat-binding factor 2 (TRF2).

123 ditional deletion of the shelterin component telomeric repeat-binding factor 2, cells survived but re

124 SIRT1 but abolished its association with the telomeric repeat-binding factor 2-interacting protein 1.

125 d reduced expression and telomere binding of telomeric repeat-binding factor-2 (TRF2), associated wit

126 plex array of telomeric repeats bound to the telomeric repeat-binding factors TRF1 and TRF2.

127 ammalian telomeres contain a duplex array of telomeric repeats bound to the telomeric repeat-binding

128 g from DNA breaks up to 0.6 kb away from the telomeric repeat but not from a DSB present on a separat

129 contains a template for the synthesis of the telomeric repeats by the telomerase reverse transcriptas

130 Rif1 function is weaker at short telomeric repeats compared with Rif2 function and is par

131 eatment and hybridization with a Cy3-labeled telomeric repeat complementing (CCCTAA)3 peptide nucleic

132 The literature seems to agree that the human telomeric repeat containing four stretches of three guan

133 ar GQs, a telomeric DNA GQ and the analogous telomeric repeat-containing RNA (TERRA) GQ.

134 Telomeric repeat-containing RNA (TERRA) has been identif

135 RPA displacing activity is inhibited by the telomeric repeat-containing RNA (TERRA) in early S phase

136 Telomeric repeat-containing RNA (TERRA) is important for

137 Functions of the telomeric repeat-containing RNA (TERRA), the long noncod

138 monstrated elongated telomeres and increased telomeric repeat-containing RNA (TERRA).

139 cised) plus a template sequence encoding the telomeric repeat d(GGT TAG).

140 ith G-quadruplex DNA (G4DNA) formed by human telomeric repeat d[(G(3)T(2)A)(3)G(3)].

141 been reported for Q-quadruplexes formed from telomeric repeats depending on DNA length and ion soluti

142 ng studies that a single deoxythymidine in a telomeric repeat dictates the DNA versus RNA discriminat

143 Pin2 directly bound the human telomeric repeat DNA in vitro, and was localized to all

144 t suppress the accumulation of DNA damage at telomeric repeat DNA.

145 and the structural basis and significance of telomeric-repeat DNA recognition by Teb1, we solved crys

146 elease of all of the subunits, including the telomeric-repeat DNA-binding subunit Teb1.

147 e, including an increase in extrachromosomal telomeric repeat DNAs, putative recombinational byproduc

148 omerase, as well as disperse and amplify sub-telomeric repeat elements.

149 on of several kilobase pairs compared to the telomeric repeat, even though both silencers recruited s

150 stablish a convenient way to make long human telomeric repeats for in vitro study of their folding an

151 cially constructed circles of DNA containing telomeric repeats form long tandem arrays at telomeres w

152 TRF1 and TRF2, which preferentially bind the telomeric repeat found at chromosome ends, effectively b

153 chromosomes separating the relatively stable telomeric repeats from the recombinationaly active regio

154 De novo telomeric repeats from transformants indicate that the p

155 Telomeric repeats >>1000 nt in length could be synthesiz

156 he 5' thymidine tail preceding the Oxytricha telomeric repeat has no apparent effect on the hairpin s

157 adruplex d(TTAGGGT)(4), containing the human telomeric repeat, has been determined in solution in com

158 ng of the DNA quadruplex formed by the human telomeric repeat have been investigated using real-time

159 -stranded nucleic acids, including the human telomeric repeat (hTR) d(TTAGGG)n.

160 ochromatin that silences pericentromeric and telomeric repeats in a cell cycle- and differentiation-i

161 e useful for probing structures of Oxytricha telomeric repeats in complexes with telomere end-binding

162 WRN helicase strand displacement of HJs with telomeric repeats in duplex arms, but unwinding of HJs w

163 DNA telomeric repeats in mammalian cells are transcribed to

164 ining a duplex region at the 5' end and four telomeric repeats in the 3' overhang.

165 ide probe confirmed its effective binding to telomeric repeats in the complex chromatinized genome.

166 non-coding bases immediately internal to the telomeric repeats in the two 5' ends of macronuclear DNA

167 ADP-ribosylation inhibits binding of TRF1 to telomeric repeats in vitro [5], suggesting that tankyras

168 ce in normal human cells, demonstrating that telomeric repeats indeed are hypersensitive to DNA repli

169 ity of telomerase to processively synthesize telomeric repeats, indicating a role for the T motif in

170 ld observe the direct folding of long, human telomeric repeats induced by the small analyte potassium

171 We found that an internal tract of telomeric repeats inhibited DNA damage checkpoint signal

172 lication efficiency of guanine-rich (G-rich) telomeric repeats is decreased significantly in cells la

173 g that exogenous DNA exclusively composed of telomeric repeats is recognized by shelterin components.

174 Instead, a tandem array of 12 telomeric repeats is sufficient to impede illegitimate r

175 DNA repair intermediates when the number of telomeric repeats is too small to completely inhibit DNA

176 Without TRF1, replication forks stall in the telomeric repeats, leading to ATR kinase signaling upon

177 The observation of spacer DNAs with telomeric repeats makes it unlikely that differential te

178 The replication of long tracts of telomeric repeats may require specific factors to avoid

179 he human genome, this study has examined the telomeric repeat, necessary for the protection of chromo

180 f the IGH gene is located within 8 kb of the telomeric repeats of 14q.

181 ptase that directs RNA-templated addition of telomeric repeats on to chromosomal termini.

182 Telomerase adds telomeric repeats onto chromosome ends and is almost uni

183 s an RNA subunit to template the addition of telomeric repeats onto chromosome ends.

184 its integral RNA as a template to synthesize telomeric repeats onto chromosome ends.

185 Incorporation of incorrect telomeric repeats onto the ends of chromosomes has been

186 scriptase (RT) and catalyses the addition of telomeric repeats onto the ends of chromosomes using the

187 emplate, acting processively to add multiple telomeric repeats onto the same substrate.

188 ining the capacity to add short stretches of telomeric repeats onto the shortest telomeres, sole expr

189 telomerase reconstitution in vivo and direct telomeric-repeat primer extension activity assays to com

190 affects telomerase activity and synthesis of telomeric repeat products.

191 1B, achieve high affinity and selectivity of telomeric-repeat recognition by principles similar to th

192 ins that retained the ability to localize to telomeric repeats revealed that FEN1's nuclease activity

193 utilizing the prototypical polymorphic human telomeric repeat sequence (H-Telo22, d[AG3(T2AG3)3]) tha

194 In contrast, the human telomeric repeat sequence and a complex containing two h

195 alian TRF1 and TRF2 bind the double-stranded telomeric repeat sequence and in turn are bound by TIN2,

196 plex C3 was highly specific for the G-strand telomeric repeat sequence and shares biochemical charact

197 n vivo, de novo synthesis of one strand of a telomeric repeat sequence by telomerase balances the seq

198 The interactions of the Tetrahymena telomeric repeat sequence d(TG4T) and the polyguanylic a

199 The Tetrahymena telomeric repeat sequence d(TG4T) contains only guanine

200 y for both single-stranded RNA and the human telomeric repeat sequence d(TTAGGG)(n).

201 Consistent with their roles at telomeres, telomeric repeat sequence DNA also stimulated binding an

202 d to an oligonucleotide containing the human telomeric repeat sequence folded in the G-quadruplex con

203 the TER sequence, we used the unusually long telomeric repeat sequence of Aspergillus oryzae together

204 elomerase that adds a well-tolerated variant telomeric repeat sequence to telomere ends.

205 plex DNA sequence constructed from the human telomeric repeat sequence TTAGGG.

206 ins each bind the G-rich strand of their own telomeric repeat sequence, consistent with a direct role

207 ics as native cytosine residues in the human telomeric repeat sequence, where it causes little or no

208 without added potassium, in contrast to the telomeric repeat sequence.

209 glycol, replacing the TTA loops in the human telomeric repeat sequence.

210 t, possibly concomitant with a change in the telomeric repeat sequence.

211 NA, and another DHBV integrant occurred in a telomeric repeat sequence.

212 ease results in terminal deletions involving telomeric repeat sequences added directly onto the end o

213 ns revealed one deletion to be stabilized by telomeric repeat sequences and two to have terminal dele

214 Analysis of J and telomeric repeat sequences by J immunoblots and Southern

215 ations were tested for the ability to detect telomeric repeat sequences in FISH assays.

216 scriptase responsible for the maintenance of telomeric repeat sequences in most species that have bee

217 were found that could effectively stain the telomeric repeat sequences of either cytidine- or guanos

218 Telomerase adds telomeric repeat sequences to chromosome ends using a sh

219 somes at metaphase showed frequent losses of telomeric repeat sequences, enhanced frequencies of chro

220 , reveals approximately 25% of J outside the telomeric repeat sequences.

221 contain short regions of complementarity to telomeric repeat sequences.

222 otein complex that binds specifically to the telomeric-repeat sequences, regulates telomere length, a

223 Notably, an azide-tailed sgRNA targeting the telomeric repeat served as a Trojan horse on the CRISPR-

224 ures of quadruplexes with two and four human telomeric repeats show an all-parallel-stranded topology

225 and eight additional proteins, including the telomeric repeat single-stranded DNA-binding protein Teb

226 l components: an RNA molecule that templates telomeric repeat synthesis and a catalytic protein compo

227 t eukaryotes, telomere maintenance relies on telomeric repeat synthesis by a reverse transcriptase na

228 other species, the predominant pause during telomeric repeat synthesis by P. tetraurelia telomerase

229 Eukaryotic chromosome maintenance requires telomeric repeat synthesis by telomerase.

230 The template for telomeric repeat synthesis is carried within the RNA com

231 d of the template prior to a second round of telomeric repeat synthesis.

232 P catalytic activity, or loss in fidelity of telomeric repeat synthesis.

233 RNA molecule that provides the template for telomeric repeat synthesis.

234 RNA molecule that provides the template for telomeric repeat synthesis.

235 se of adjacent 5' residues as a template for telomeric repeat synthesis.

236 nent of telomerase provides the template for telomeric repeat synthesis.

237 function to these interactions in processive telomeric repeat synthesis.

238 y short primer-template hybrid necessary for telomeric-repeat synthesis.

239 mechanisms of telomerase specialization for telomeric-repeat synthesis.

240 Duplex DNA containing either human telomeric repeats (T(2)AG(3))(4) or the Tetrahymena telo

241 ic repeats (T(2)AG(3))(4) or the Tetrahymena telomeric repeats (T(2)G(4))(4) are readily photooxidize

242 /PK) which includes the template, for adding telomeric repeats, template boundary element (TBE), and

243 Telomerase replenishes the telomeric repeats that cap eukaryotic chromosome ends.

244 e DNA structures, forked duplexes containing telomeric repeats, that are substrates for the simultane

245 romyces lactis cells containing two types of telomeric repeats, that recombinational telomere elongat

246 To synthesize telomeric repeats, the catalytic subunit telomerase reve

247 of four hairpin moieties, targeting 24 bp in telomeric repeats, the longest reported binding site for

248 ssion of mutant telomerases that add mutated telomeric repeats, thereby compromising shelterin bindin

249 ly, a small minority survives by maintaining telomeric repeats through recombination among telomeres.

250 this terminal sequence loss by synthesizing telomeric repeats through repeated cycles of reverse tra

251 and HHV-6, among other herpesviruses, harbor telomeric repeats (TMRs) identical to host telomeres at

252 MDV, and several other herpesviruses harbors telomeric repeats (TMRs) that are identical to host telo

253 This allows a newly synthesized telomeric repeat to translocate back to the 3' end of th

254 The telomerase is responsible for adding telomeric repeats to chromosomal ends and consists of th

255 omerase is a reverse transcriptase that adds telomeric repeats to chromosomal ends.

256 Telomerase adds telomeric repeats to chromosome 3' ends, forestalling th

257 elomerase, a reverse transcriptase that adds telomeric repeats to chromosome ends [1,2].

258 The addition of telomeric repeats to chromosome ends by the enzyme telom

259 verse transcriptase, telomerase, adds tandem telomeric repeats to chromosome ends to promote genome s

260 Telomerase adds telomeric repeats to chromosome ends using an internal R

261 omerase, the reverse transcriptase that adds telomeric repeats to chromosome ends, was sufficient to

262 ich serves as a template for the addition of telomeric repeats to chromosome ends.

263 The reverse transcriptase telomerase adds telomeric repeats to chromosome ends.

264 mosome ends; however, it may erroneously add telomeric repeats to DNA double-strand breaks.

265 lterin components, which allows CLRC to skip telomeric repeats to internal regions.

266 f telomerase, a specialized enzyme that adds telomeric repeats to pre-existing telomeres.

267 istinct activities of telomerase, which adds telomeric repeats to solve the end replication problem,

268 anscriptase, which catalyzes the addition of telomeric repeats to the 3' ends of linear chromosomes u

269 Telomerase activity, the ability to add telomeric repeats to the ends of chromosomes, has been d

270 The ribonucleoprotein enzyme telomerase adds telomeric repeats to the ends of linear chromosomes.

271 omerase maintains genome stability by adding telomeric repeats to the ends of linear chromosomes.

272 fully annotate the region extending from the telomeric repeats to the previously published tuberous s

273 ddition of only a few functionally wild-type telomeric repeats to their ends, after which the frequen

274 ties of two different silencers, HMR-E and a telomeric repeat, to promote silencing and found that th

275 t telomeres serves to maintain the length of telomeric repeats, to suppress recombination, and to aid

276 s a strong sequence preference for the human telomeric repeat tract and predict that POT1 can bind bo

277 begins approximately 100 bp upstream of the telomeric repeat tract sequence.

278 on results in replication stalling in duplex telomeric repeat tracts and the subsequent formation of

279 Stabilization of telomeric repeat tracts may also be achieved through a t

280 ls demonstrated that the outer halves of the telomeric repeat tracts turn over within a few hundred c

281 of telomeric RNA molecules containing G-rich telomeric repeats transcribed from the subtelomere to th

282 r fluorescent polyamide probes for the human telomeric repeat TTAGGG, and we examined the binding aff

283 s are bound to a significant fraction of the telomeric repeat (TTAGGG) (n).

284 ion directly affect the length of individual telomeric repeat units.

285 Telomerase synthesizes chromosome-capping telomeric repeats using an active site in telomerase rev

286 T-stumps contained arrangements of telomeric repeat variants and a minimal run of seven can

287 bind telomeric DNA directly but localizes to telomeric repeats via its interaction with TRF1.

288 Hybridization to a probe extended from telomeric repeats was used to anchor the ends of the map

289 a BclI restriction site in newly synthesized telomeric repeats, was indistinguishable from wild type

290 xpected from the presence of canonical TTAGG telomeric repeats, we identified a candidate telomerase

291 all genes telomeric to HIS1 were deleted and telomeric repeats were added to a 9 nt sequence within t

292 These telomeric repeats were incorporated into duplex/quadrupl

293 Nine complexes of UP1 bound to modified telomeric repeats were investigated using equilibrium fl

294 less TOTA photocleavage of these quadruplex telomeric repeats when compared to the duplex repeats.

295 They have 1-2 kb of TTAGGG telomeric repeats, which are preceded by a subtelomeric

296 Replacing the TTA loops of the human telomeric repeat with AAA causes a large decrease in qua

297 Human telomeres contain duplex telomeric repeats with 3' single-stranded G-overhangs, a

298 ere predicted to lead to synthesis of mutant telomeric repeats with disrupted binding of the telomeri

299 omere is by telomerase-catalyzed addition of telomeric repeats with homology-directed repair serving

300 t chromosome ends through the interaction of telomeric repeats with shelterin, a protein complex that