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1 1 419 bp (plus about 2000 bp of undetermined telomeric sequences).
2 G-quadruplex, and (iii) an i-motif of human telomeric sequence.
3 specificity to the hairpin form of the viral telomeric sequence.
4 e-stranded DNA as well as internal tracts of telomeric sequence.
5 flexibility of a model single-stranded long telomeric sequence.
6 nteractions and DNA repair within the GGTTAC telomeric sequence.
7 les stabilize the G4DNA derived from a human telomeric sequence.
8 brid G-quadruplex structures formed by human telomeric sequence.
9 fic manner, and discriminates against RNA of telomeric sequence.
10 er extent than the quadruplex DNA of a human telomeric sequence.
11 the interface between the duplex and the 3' telomeric sequence.
12 n]pyrrole, the more strongly it binds to the telomeric sequence.
13 ely without polymerase-mediated extension of telomeric sequence.
14 exchanges between often imperfectly matched telomeric sequences.
15 elomerase templating region in vivo with non-telomeric sequences.
16 forms of several oligonucleotides containing telomeric sequences.
17 d DNA damage foci and loss or duplication of telomeric sequences.
18 ation events between different DNAs at their telomeric sequences.
19 ity of telomerase to elongate completely non-telomeric sequences.
20 e non-replicative DNA rings containing yeast telomeric sequences.
21 of labile mRNAs, 5'- and 3'-splice sites and telomeric sequences.
22 vely binds to and protects otherwise exposed telomeric sequences.
23 s), ultimately leading to stochastic loss of telomeric sequences.
24 Sessea (family Solanaceae) lack known plant telomeric sequences.
25 a variety of DNA structures without or with telomeric sequences.
26 r Y. lipolytica telomeres but also for human telomeric sequences.
27 lytica (GGGTTAGTCA)(n) and human (TTAGGG)(n) telomeric sequences.
28 ion nor in vitro DNA replication through non-telomeric sequences.
29 rity of known naturally occurring eukaryotic telomeric sequences.
30 bility by repressing recombination involving telomeric sequences.
31 enome against recombination events involving telomeric sequences.
32 tion fork progression through the repetitive telomeric sequences.
33 a cells that lack telomerase or have altered telomeric sequences.
34 recombination events and accelerated loss of telomeric sequences.
35 ramolecular G-quadruplex formed by the human telomeric sequence 5'-(GGTTAG)(5)-3', and that inhibits
36 quence was removed on addition of Sch. pombe telomeric sequence, a process similar to that described
39 uplex formed by the 22-mer four-repeat human telomeric sequence AG3(TTAG3)3 and (ii) the intermolecul
40 ic effect on its affinity toward the cognate telomeric sequence, alleviating the need for homodimeriz
42 s that result in an increase in HR between a telomeric sequence and a more internal sequence, which n
43 uctures, including those formed in the human telomeric sequence and in the promoter regions of bcl-2
44 ormation with effective packing in the human telomeric sequence and provide important implications fo
45 replication fork pause was specific to yeast telomeric sequence and was independent of the Sir and Ri
46 demonstrated that TbPolIE is associated with telomeric sequences and here we show that RNAi-mediated
47 MECs emerge from senescence, exhibit eroding telomeric sequences and ultimately enter telomere-based
48 mpassing long tracts of alpha satellite DNA, telomeric sequences, and the human hypoxanthine phosphor
50 rom degradation in a CDC13-dependent manner, telomeric sequences are added efficiently, and addition
51 major conformations in K(+) solution, human telomeric sequences are always in equilibrium between Hy
52 have implications for current models of how telomeric sequences are lost in normal somatic cells and
56 uadruplex structures formed within the human telomeric sequence, as well as the effects of sequence a
57 ric DNA primers that carried one repeat of a telomeric sequence at various positions upstream of a no
58 overhangs, blunt ends or 3' termini with non-telomeric sequences at the junction are deficient in loo
59 ded DNA (ssDNA) containing the Chlamydomonas telomeric sequence but not the RNA containing the cognat
60 emplate containing four repeats of the human telomeric sequence by stabilizing the RNA G-quadruplex s
61 enzymes, efficiently extended completely non-telomeric sequences by positioning the 3' terminus at a
64 Formation of the G-quadruplex in the human telomeric sequence can inhibit the activity of telomeras
65 ll dividing cells are subject to the loss of telomeric sequences, cells with long proliferative lifes
66 ential lies in overcoming the steady loss of telomeric sequence commonly referred to as the 'end-repl
67 selectively target sequence variants of the telomeric sequences containing adenine-to-thymine mutati
70 ic G-quadruplex formed by the Oxytricha nova telomeric sequence d(G(4)T(4)G(4)) with a peptide nuclei
71 demonstrate by NMR that the two-repeat human telomeric sequence d(TAGGGTTAGGGT) can form both paralle
72 mplate consisting of 10 repeats of the human telomeric sequence d(TTAGGG) and deoxy- and ribonucleosi
75 of a misfolded G-quadruplex in a particular telomeric sequence decreases with an increase in the loo
76 the same assay, we differentiate 4q from 10q telomeric sequences, determine A/B haplotype, identify p
77 didates, we have targeted a 24-nt G4-forming telomeric sequence employing a receptor-based virtual sc
78 short region of the immediately adjacent non-telomeric sequence, exist in two distinct types of chrom
80 mobilization; mutant Rap1p binding sites and telomeric sequences from other organisms were not suffic
81 art because the perfect repetitive nature of telomeric sequence hampers in situ detection of telomere
82 ilization of DNA G-quadruplexes in the human telomeric sequence have been shown to inhibit the activi
85 his suggests that as hTRF2 recruits hRap1 to telomeric sequences, hRap1 alters the affinity of hTRF2
86 ring was diminished by addition of competing telomeric sequences, implicating a role for an as yet un
89 we report the folding structure of the human telomeric sequence in K+ solution determined by NMR.
90 rate constant was 2-fold lower for the same telomeric sequence in the duplex form ((3.0 +/- 1.3) x 1
91 stimulation is dependent on the presence of telomeric sequence in the duplex regions of the substrat
92 d serve to hold the genomic subtelomeric and telomeric sequences in a partially single-stranded confi
93 g that t-loops can also form at interstitial telomeric sequences in a TRF2-dependent manner, forming
95 erase adds telomeric repeats directly to non-telomeric sequences in Tetrahymena, forming de novo telo
96 retention of G.G pairing is specific to the telomeric sequence incorporating the 5' leading sequence
97 when it was adjacent to an internal tract of telomeric sequence, indicating that Cdc13p binding was t
98 nvolved in mismatch repair (MMR), suppresses telomeric sequence insertion (TSI) at intra-chromosomal
99 an also associate with a single-repeat human telomeric sequence into a structure with the same topolo
102 ecombination hotspot created by insertion of telomeric sequences into the region upstream of HIS4.
105 hRap1 are in a complex, its affinity for ds telomeric sequences is 2-fold higher than TRF2 alone and
106 rate that TRF2 association with interstitial telomeric sequences is stabilized by co-localization wit
107 cated reverse transcriptase that synthesizes telomeric sequences, is strongly associated with cancer,
108 telomere becomes dysfunctional, the terminal telomeric sequence itself determines the fate of that te
111 ylation extends 1 to 2 kbp from Interstitial Telomeric Sequences (ITSs) that abut or are very near to
113 ide, which base-pairs near the 5' end of the telomeric sequence, leaving a telomerase-extendable 3' t
116 summary of recent research performed on long telomeric sequences, nominally defined as those that can
117 inum drug cisplatin, which targets the human telomeric sequence nonspecifically, the platinum-interca
119 Mb were assembled, including 4 contigs with telomeric sequences on both ends and an additional 8 con
121 me integrity through synthesis of repetitive telomeric sequences on the ends of eukaryotic chromosome
122 e budding yeast Cdc13p binds single-stranded telomeric sequences, prevents lethal degradation of chro
127 rase is a ribonucleoprotein enzyme that adds telomeric sequence repeats to the ends of linear chromos
128 ized DNA and plasmids containing Histoplasma telomeric sequences showed the greatest transformation e
130 erin, fission yeast shelterin is composed of telomeric sequence-specific double- and single-stranded
134 single-stranded representative of the yeast telomeric sequence [Tel11, d(GTGTGGGTGTG)] with a 3 pM a
135 dominant conformation for the extended 26 nt telomeric sequence Tel26 in the presence of K+, regardle
136 cancer cells causes incorporation of mutant telomeric sequences, telomere uncapping, and initiation
139 h unprecedented transition dynamics in human telomeric sequences that contain four to eight TTAGGG re
140 tory sequences show striking similarities to telomeric sequences that form diverse G-quartet structur
141 iliense and L. carrikeri showed interstitial telomeric sequences that probably resulted from expansio
142 te folds back and hybridizes with downstream telomeric sequence to form a t loop that is stable in th
146 r containing two tandem repeats of the human telomeric sequence (TTAGGG) into di- and tetrameric G-qu
147 in the GGG triplet found in the G-rich human telomeric sequence (TTAGGG), making telomeres highly sus
148 in cancer and aging has made the repetitive telomeric sequences (TTAGGG repeats) and the G-quadruple
149 nce for the presence of the Arabidopsis-type telomeric sequence (TTTAGGG)n at the chromosome termini
151 mposed of a heterogeneous mixture of GT-rich telomeric sequence, unlike in higher eukaryotes which ha
152 icity, we studied five and six repeats human telomeric sequence using a combination of single molecul
156 trast, chromosomal end fusions that retained telomeric sequence were observed in nontransformed DNA-P
158 A fragments composed solely of mitochondrial telomeric sequences were detected and their properties w
160 f chromosomes in ALT cells contain canonical telomeric sequences with the same terminus bias (-ATC) o
161 mportantly, WRN's specificity for the G-rich telomeric sequence within this precise structural contex
163 ly be detected in the specifically truncated telomeric sequences without any 5'-flanking residues, ou
164 ng and both factors bind along their cognate telomeric sequences without showing strong cooperative i