ライフサイエンスコーパス: temper

1 ing diseases in which mTOR activity is to be tempered.

2 ther sampling techniques, including parallel tempering.

3 er failure during liver regeneration through tempering a strong innate inflammatory response mediated

4 oxytocin and estrogen receptor polymorphisms temper accelerated cellular aging in young females who t

5 Chronic inhibition of this protease may temper amyloid production and cure or prevent AD.

6 A new approach for non-isothermal tempering analysis utilizing dilatometry is proposed and

7 ing owing to the limited survival of organic temper and unreliability of visible residues(2-4).

8 l reports of donor deaths, interest has been tempered and more diligent evaluation of the ethics and

9 faster than ensemble methods using parallel tempering and appeared to provide a globally optimum sol

10 pace is sampled by a combination of parallel tempering and equi-energy Monte Carlo, we find that the

11 ilk allergens was differentially affected by tempering and extractant.

12 was sampled by replica exchange with solute tempering, and the free energy landscape was explored by

13 produced by ensemble methods using parallel tempering, and the resulting [Formula: see text] per dat

14 ular interactions within epithelial clusters temper anisotropic cell-substratum forces, resulting in

15 onment of hepatocellular carcinoma (HCC) and temper anticancer immune responses.

16 Thus, ODC in macrophages tempers antimicrobial, M1 macrophage responses during ba

17 ers were generated using a Bayesian parallel tempering approach to produce model fits that could recr

18 the formation of transition carbides by auto-tempering as well as the presence of retained austenite

19 y, these data suggest that AEA signaling can temper aspects of the stress response and that FAAH inhi

20 wever, several regulatory T cell subsets can temper autoaggressive T cells, although it remains undet

21 Dietary cyclocreatine tempered autophagy, restored microglial clustering aroun

22 Cryab plays a critical role in tempering AxD pathology and should be investigated as a

23 Npas4 tempers beta-cell function through a direct inhibitory i

24 To this end, we have used well-tempered bias exchange metadynamics simulations to deter

25 cal for full anabolism in cortical bone, but tempers bone gain in cancellous bone.

26 atment of respiratory and cardiac failure is tempered by a need for evidence to support many current

27 This disappointment is tempered by a potentially important observation suggesti

28 The effects of IL-22 can be tempered by a secreted natural antagonist, known as IL-2

29 its impact on treatment resistance could be tempered by altering the dosing schedule of systemic che

30 Nevertheless, this finding is tempered by an inability to prolong survival, a limitati

31 in ApoE(-/-) mice, anti-col(V) immunity was tempered by an interleukin (IL)-10-dependent mechanism.

32 inhibit hepatitis C virus replication can be tempered by baseline mutations that confer resistance.

33 s and feelings; however, such effects can be tempered by broader social network resources.

34 , the extent of complement activation may be tempered by complement inhibiting regulatory proteins th

35 nergized respiration in IBAT mitochondria is tempered by complex I-derived OAA in a manner dependent

36 however, efforts to increase production are tempered by concern over induced earthquakes.

37 e use of stents in smaller patients has been tempered by concerns about the potential for stent expan

38 nthusiasm for their use in patients has been tempered by concerns of a possible profibrotic role of e

39 However, enthusiasm for this approach is tempered by concerns that the therapeutic synergy of a c

40 Nevertheless, early enthusiasm was tempered by controlled studies showing that antibiotics

41 Because LC activation is tempered by endogenous opioid release during stress, the

42 r disorders, and vascular lesion severity is tempered by enhanced endothelial repair.

43 iPSCs) in cell replacement therapy have been tempered by evidence that undifferentiated, syngeneic mo

44 ews media and on the Internet, with optimism tempered by evidence to support the ethical translation

45 ogical impact of these observations might be tempered by extensive recombination of co-ingested strai

46 the authors' confidence in these results is tempered by factors related to study design that may hav

47 vation, advanced by thrombin generation, and tempered by fibrinolysis.

48 also reveal that immature GC excitability is tempered by functional synaptic inhibition and reduced e

49 stic criteria, although this effect could be tempered by future adaptation of diagnostic practices an

50 on stimulated by in vivo cocaine exposure is tempered by G protein-dependent inhibitory feedback mech

51 e human disease, the knockdown phenotype was tempered by genetic-modifier loci.

52 aroscopic adjustable banding (LAGB) has been tempered by high reoperation rates.

53 favorable route of Cr(VI) formation which is tempered by humic matter.

54 e reactivity of the key radical precursor is tempered by hybridization effects.

55 primarily due to water temperature increases tempered by increased nutrient levels resulting from cha

56 that the face validity of the system may be tempered by insufficient specificity in the indexing ter

57 the diagnosis of extracapsular extension is tempered by its low sensitivity.

58 The promise of biotechnology is tempered by its potential for accidental or deliberate m

59 sm for vanguard biologic therapies should be tempered by judicious monitoring for adverse events.

60 However, this possibility is tempered by limitations in interpreting the functional c

61 Success has been tempered by new challenges.

62 benefit for the organ transplant recipient, tempered by patient informed awareness of limited organ

63 lthough its predictive value is likely to be tempered by phylogenetic distance and genome duplication

64 n (LMWH) in anti-angiogenic therapy has been tempered by poor in vivo delivery to the tumor cell and

65 Activation of the Lmd protein is also tempered by posttranslational modifications of the prote

66 n) and APOBEC3G (retrovirus restriction) are tempered by probable contributions to carcinogenesis.

67 regenerative medicine in the heart has been tempered by realizations that reparative processes in th

68 initial enthusiasm for these agents has been tempered by recognition that JAK2 V617F may represent on

69 inotropic agents for heart failure has been tempered by reports of impaired relaxation.

70 otentiating influence of the Girk1 P-loop is tempered by residue F162 in the second membrane-spanning

71 However, this is tempered by results from several recent studies that sho

72 ion and exercise capacity but its benefit is tempered by significant morbidity.

73 omise of high rates of hematologic responses tempered by studies showing the inability to overcome po

74 are tempered by study heterogeneity and methodologic limitat

75 oncogenic activity of the mutant receptor is tempered by the activation of premature cellular senesce

76 quisition and how these negative effects are tempered by the AM colonization.

77 ased importance of capturing those elements, tempered by the challenges to collect them.

78 utic potential of endogenous neurogenesis is tempered by the demonstration that traumatic brain injur

79 This interest is tempered by the discovery of SMO mutations mediating res

80 y period of antimicrobial discovery has been tempered by the emergence of bacterial strains with resi

81 ncer with small molecule inhibitors has been tempered by the emergence of drug-resistant kinase domai

82 This enthusiasm should be tempered by the fact that the probability for life to or

83 The new genetics must be tempered by the findings that many epigenetic phenomena

84 Early optimism, however, was soon tempered by the hard realities of these new materials: b

85 ced CTA as more genetically distinct must be tempered by the inability to test the CTA lines beyond S

86 compromising physicochemical properties was tempered by the judicial use of ligand efficiency indice

87 SUD treatment via Medicaid expansion may be tempered by the local availability of facilities to prov

88 pretation of the BACH Survey results must be tempered by the low enrollment rate (less than 25% of el

89 enthusiasm for applying these techniques is tempered by the need to generate training data, an arduo

90 However, this conclusion is tempered by the nonadherence rate.

91 This enthusiasm has been tempered by the observations that the transition from da

92 This extraordinary achievement is tempered by the persistence of cognitive delays and cere

93 which this hypothesis can be held has to be tempered by the poor reproducibility between studies in

94 However, these inferences must be tempered by the potential for epistatic interactions bet

95 e, the benefit of carotid stenting should be tempered by the potential for increased perioperative ev

96 That optimism has been tempered by the potential risks of these therapies, such

97 l Endoscopic Surgery (NOTES) has been partly tempered by the reality that a NOTES procedure without l

98 Enthusiasm for tolerance induction has been tempered by the realization that it is more difficult to

99 the benefit of prospective clinical trials, tempered by the recognition of all of the possible medic

100 itial therapy, even for advanced disease, is tempered by the recognition of some important limitation

101 , and very-late-onset subtypes now should be tempered by the recognition that comorbid medical and ne

102 This realization is tempered by the relatively mild SMA phenotype in our mod

103 This is tempered by the reports of younger patients developing h

104 These results need to be tempered by the risk of bias of included studies.

105 ne-reactivation strategies, however, will be tempered by the stability that epsilon-globin mRNA exhib

106 randomized phase-I clinical trials, was then tempered by the subsequent disappointing results of rand

107 expression is abated in a wak2-null, but is tempered by the WAK-dominant allele that induces elevate

108 ition in treating neurological conditions is tempered by their toxicity toward a host of CNS cell typ

109 Although tempered by transmission risk factors, such as donor vir

110 the enthusiasm for these therapies has been tempered by tumor resistance and the paucity of informat

111 e unprecedented response rates, however, was tempered by tumor unresponsiveness through both intrinsi

112 ess of orthopedic implants has been recently tempered by unexpected pathologies and early failures of

113 Unfortunately, this success has been tempered by unintended and often devastating cardiac com

114 nergy surface that we obtain from a parallel tempering calculation.

115 n the eye to promote inflammation while also tempering cell responses to PGN akin to what has been re

116 iR-146a regulates cholesterol metabolism and tempers chronic inflammatory responses to atherogenic di

117 ckling in" a swarm of individual small tasks tempers competition for CPU time in the shared HPC envir

118 surgeon opinion and patient attitudes should temper concerns about the quality of treatment for women

119 ssor of cytokine signaling 3, a protein that tempers cytokine receptor signaling, they also suggest t

120 by which adaptive immunity, once triggered, tempers DC activation and prevents overreactive immune r

121 Tempering decreased antibody binding regardless of extra

122 hanced sampling approaches, such as Parallel Tempering, do not improve the situation, as the entropic

123 us, as with FGF and EGF receptors, Spry2-GFP tempers downstream Met signaling in addition to its pron

124 The tempered dynamics contrast sharply with the dynamics of

125 genous LO-generated effectors that assist in tempering EAE.

126 (BTLA) coinhibitory signaling is required to temper early inflammation.

127 e first time that chronic morphine treatment tempers endotoxin tolerance resulting in persistent infl

128 ferent approaches: a combination of the well-tempered ensemble (WTE) and parallel tempering (PT) sche

129 that publication of this viewpoint will help temper enthusiasm for overzealous conversion of guidelin

130 es due to the infused cells themselves, have tempered enthusiasm.

131 It localizes to acidic organelles, tempers evoked Ca(2+) signals, and regulates cell-matrix

132 AAT2 modulates cardiorespiratory control and tempers excitatory cardiorespiratory responses to activa

133 te data on some outcomes, these findings may temper expectations about the financial return on invest

134 gy perturbation with replica exchange solute tempering (FEP/REST).

135 after gastrulation in the forelimb field to temper Fgf8a signaling in the cardiac field, thus coordi

136 ied: 1) aggressive phenomena (e.g., kicking, temper fits, argumentativeness), 2) purely motor and pho

137 sis requires intrinsic sensing mechanisms to temper function in the face of prolonged activity.

138 n contrast, lower affinity interactions show tempered GCs, producing B(mem) and affinity-matured, lon

139 dogenous populations of human microflora and temper gut disorders provoked by bacterial pathogens.

140 Oral supplementation with Gln was shown to temper H. suis induced gastritis and epithelial (hyper)p

141 of FLD, we show that synthetic YLGA peptide tempers hepatocyte apoptosis and liver damage and theref

142 e has cast doubt on both these associations, tempering hopes of the feasibility of developing a vacci

143 otential neuroprotective therapeutic must be tempered, however, by the knowledge it also enlarges cir

144 ntitled "SSRIs, Adolescents, and Aggression: Tempering Human Implications Regarding SSRI-Induced Aggr

145 This reliance is tempered if adaptation is polygenic-does not depend on o

146 (CD25) on virus-specific CD4 T cells, which tempered IL-2 signaling and STAT5 and mammalian target o

147 critical function for Mvarphi HIF-1alpha in tempering IL-10 production following infection.

148 rucial role in tumor immune pathogenesis and temper immune therapeutic efficacy.

149 lular metabolism can beneficially enhance or temper immunity.

150 Immune responses are tempered in immunologically privileged sites including t

151 that sheds light on how its self-cleavage is tempered in the absence of RecA, as well as a framework

152 owth and how its predatory activities may be tempered in the wild, as well as suggestions for future

153 immunity is controlled by cDCs and actively tempered in vivo by migDCs.

154 on (AMI), enthusiasm for glucose lowering is tempered, in part, by concerns of inducing hypoglycemia.

155 eterogeneity and imprecision of some results temper inferences from this literature.

156 phagy accompanies inflammasome activation to temper inflammation by eliminating active inflammasomes.

157 T (Treg) cells inhibit immune responses and temper inflammation.

158 e data expand the roles of T-regs to include tempering inflammation during acute infection in additio

159 ting that C5a may play a significant role in tempering inflammation in Th2-driven diseases such as as

160 own pathway that allows the immune system to temper inflammatory responses.

161 events tissue invasion by microorganisms and tempers inflammatory responses to the myriad contents of

162 potential limitations of disclosure somewhat tempered interest.

163 gene excision became apparent that, in turn, tempered interpretation.

164 The goal of tempering is to obtain a sufficient amount of beta(V) po

165 e-dependent increases in adverse events have tempered its utility.

166 ssion of virulence factors, and by doing so, tempers its pathogenesis.

167 their ability to preserve phosphatases that temper kinase signaling and proinflammatory cytokine pro

168 ica exchange-like SWHAM)and ST-SWHAM (serial tempering-like SWHAM).

169 protein 3B [ARID3B]) that we show is able to temper lytic reactivation.

170 atalase restricts reactive oxygen species to temper macrophage TRPM2-mediated Ca(2+) signaling and li

171 eted immune modulation should be possible to temper maladaptive factors, enabling beneficial immune r

172 s Coarse-Grained molecular dynamics and well-tempered MetaDynamics (CG-MetaD), we characterize the la

173 ar dynamics simulations employing transition-tempered metadynamics and compare these results to those

174 onal metadynamics, and multiple-walkers well-tempered metadynamics calculations.

175 Simulations were performed using well-tempered metadynamics combined with a path collective va

176 olecular modeling study consisting of a well-tempered metadynamics simulation, which allowed one to i

177 thesis of MIL-101(Cr). Microsecond-long well-tempered metadynamics simulations uncover a rich structu

178 re are explored using microsecond-scale well-tempered metadynamics simulations.

179 ere we use atomistic level modeling and well-tempered metadynamics to calculate the configurational f

180 We use LDT-MD in combination with well-tempered metadynamics to reconstruct the tension-depende

181 sing molecular dynamics simulations and well-tempered metadynamics was also performed.

182 uated with advanced simulation methods (well-tempered metadynamics) allowing a microscopic understand

183 Taking advantage of well-tempered metadynamics, we compute the free-energy change

184 iltonian replica exchange combined with well-tempered metadynamics.

185 On the basis of microsecond-long parallel-tempering metadynamics and temperature-replica exchange

186 dynamics simulations together with parallel tempering, metadynamics, and one of the best force-field

187 we adapted the replica exchange with solute tempering method to sample the conformations of the beta

188 Using a single-trajectory-based tempering method with a high-temperature dihedral bias,

189 An innovative replica exchange (parallel tempering) method called replica exchange with solute te

190 We introduce a replica exchange (parallel tempering) method in which attempted configuration swaps

191 nd neurite dystrophy, impacted behavior, and tempered microglial inflammatory response.

192 s, Gal1-glycan interactions are essential in tempering microglial activation, brain inflammation, and

193 We use parallel tempering molecular dynamics simulations on the microsec

194 xplicit solvent replica exchange with solute tempering molecular dynamics simulations probing aggrega

195 We have performed simulated tempering molecular dynamics simulations to study the th

196 ced phase-space sampling algorithm, parallel-tempering molecular dynamics, we have explored the energ

197 A parallel tempering Monte Carlo algorithm with tempering over the

198 rly role in reducing CR cell neurogenesis by tempering Neurog2's proneural activity.

199 ow that the Serrate antagonist, fringe, must temper Notch activity to insure that the activation of t

200 ployed jagged-2 triggered Notch2/Hey1, while tempering Notch2/Hes1 signaling in HSPCs.

201 ate our planet's intermediate redox state by tempering O(2) production.

202 production of chocolate, which is defined as tempering of cocoa butter through primary and secondary

203 Slow cooling of such a melt or tempering of hP-Na2ZnSn5 (e.g., at 300 degrees C) leads

204 n of RssB provides a moderate and reversible tempering of its activity, followed by a specific and ro

205 and the sprawling cities show an exponential tempering of Pareto tail.

206 tingly, this occurs in resting MPhis through tempering of steady-state mitochondrial reactive oxygen

207 required for NPC renewal potential and that tempering of the differentiation program requires cooper

208 The findings offer cause for tempered optimism about the accuracy of strategic intell

209 results suggest that students' mindsets may temper or exacerbate the effects of economic disadvantag

210 which may be associated with the display of temper outbursts and repetitive questioning.

211 chronic nonepisodic irritability and severe temper outbursts.

212 arallel tempering Monte Carlo algorithm with tempering over the temperature domain is used to examine

213 f the BET proteins has a beneficial outcome, tempering oxidative stress and muscle damage.

214 nes, as a key circuit element that tunes and tempers P1 neuron activity.

215 Exponentially tempered Pareto node-degree distributions well described

216 as a treatment option has been appropriately tempered, particularly as the therapy is introduced beyo

217 development, survival, or homeostasis, while tempering peripheral NK cell activation.

218 Tempering platelet activation genetically reduced TGF-be

219 Strategies that temper postprandial reductions in glucose levels might r

220 can be used as alternatives to conventional tempering process.

221 stem growth rate represent a mechanism that tempers progression of early commitment to the light env

222 In vascular smooth muscles, HDL tempers proinflammatory, promigratory, and degradative p

223 he well-tempered ensemble (WTE) and parallel tempering (PT) schemes and metadynamics (MetaD) to chara

224 s the use of activity-based probes that show tempered rates of reactivity with enzymes, such that com

225 ression is mediated by poverty and that heat tempers rather than fuels poverty-induced aggression.

226 To temper recombination, cells have employed DNA helicases

227 19,857 square kilometers from protection and tempering regulations in an additional 1,659,972 square

228 may deplete vesicle availability and thereby temper release strengthening.

229 ) method called replica exchange with solute tempering (REST) for the efficient sampling of aqueous p

230 FEP/REST (i.e., replica exchange with solute tempering) sampling protocol, based on detail studies on

231 used to investigate the polymorphic forms of tempered SHSs and CBEs in the long term.

232 s well as the observed growth inhibition, is tempered significantly by coexpression of the CfPV2 E6 a

233 Our computational studies exploit parallel tempering simulations of coarse-grained model proteins t

234 pluralism in both its homeland and colonies tempers some of archaeology's global assumptions about t

235 at controlling the chronic phase disease is tempered somewhat by the persistence of the LSC pool in

236 ults in the alleviation of heme toxicity and tempered staphylococcal virulence.

237 e as glass in as-quenched or low-temperature-tempered state.

238 ng their optimal range requires both SKIP to temper synaptic potentials (incoherent feedforward loop)

239 theta and thereby targeted to lipid rafts to temper TCR signaling.

240 Such genetic changes would temper the alkali sensitivity and Na(+) sensitivity that

241 sence of mitotic inhibitors normally used to temper the astrocyte population.

242 oglobin (HbF) can blunt the pathophysiology, temper the clinical course, and offer prospects for cura

243 he release of glucocorticoids that, in turn, temper the ensuing immune/inflammatory response, and the

244 that one function of MeCP2 in neurons is to temper the expression of the longest genes in the genome

245 osis-competent VZV glycoprotein, was able to temper the fusogenicity of the gH endocytosis mutants by

246 n-induced D-type cyclin production serves to temper the mitogenic response to androgen.

247 reversibility of the intermediate steps, and temper the nature of the driving force of the reaction.

248 t the analog 7-aza-Trp, which is expected to temper the nucleophilicity of C2 in Trp, is a very poor

249 endogenous functions of immune AT1 receptors temper the pathogenic actions of renal and vascular AT1

250 cess in using bidentate phosphine ligands to temper the reactivities of in situ-generated gold carben

251 of a large number of protecting groups that temper the reactivity of nitrogen; however, the use of p

252 DA neurons by SNr GABAergic neurons and also temper the release of glutamate in the dorsal striatum.

253 nd, differently to animal cells, it does not temper the ribonuclease activity of inositol-requiring e

254 late ligand bioavailability and consequently temper the signaling of canonical G protein-coupled rece

255 t declining C, called dematerialization, can temper the sustainability challenge of growth (P x A), a

256 Negative checkpoint regulators (NCRs) temper the T cell immune response to self-antigens and l

257 These biases should temper the use of plots for extrapolations of forest dyn

258 aden, our understanding of complications has tempered the initial excitement.

259 Previous research has tempered the notion that sleepers are isolated from thei

260 Moreover, VLDLR deficiency tempered the synergistic inflammatory interactions betwe

261 cellular HCO(3) (-) flux becomes absorptive, tempering the alkaline pH generated by transcellular HCO

262 decreases the action of the cag PAI T4SS via tempering the bacterium's interaction with alpha5beta1 i

263 More broadly, a case can be made for tempering the empirical enthusiasm here with a little mo

264 Tempering the enthusiasm for their use, however-particul

265 suggest that TLR2 plays an important role in tempering the host response to pneumonic tularemia.

266 of the sympathetic fight-or-flight response, tempering the rise in [Na](i) and cellular Ca loading an

267 in both cancerous and normal cells, however, tempers the broad spectrum of activity of currently used

268 suggest that the sympathetic nervous system tempers the capacity of antigen-presenting cells to acti

269 tors by repressing the Ink4A-Ink4B locus and tempers the developmental rate of differentiation by pre

270 tested whether reduced nighttime temperature tempers the effect of ALAN.

271 d functions as a barrier to water vapor that tempers the effects of humidity changes and stabilizes t

272 ndamental mechanism by which the hippocampus tempers the forgetting of older memories as newer memori

273 uncovered an immune-regulatory pathway that tempers the intensity of the host response to influenza

274 eurons, mediated by GIRK channel activation, tempers the locomotor stimulatory effect of cocaine whil

275 uced miR-21, by silencing PTEN and GSK3beta, tempers the LPS-induced inflammatory response.

276 Myc, leading to the notion that organization tempers the sensitivity of individual cells to Myc activ

277 tting of primary immunodeficiencies but also temper their dysregulation in conditions of antibody-med

278 cquiring a hemophagocytic phenotype but also tempers their proinflammatory cytokine and ferritin secr

279 l responses to K(+) deprivation that seem to temper these negative effects.

280 e of scientists ( approximately 7,085), thus tempering these differences in propagule load.

281 a negative role of the morphogen TGF-beta in tempering these signals under physiological conditions,

282 Vertebrates temper this effect by catabolizing ATP to adenosine - a

283 level of autophagy for survival, caspase-10 tempers this response to avoid cell death.

284 the strength of insulin-generated signals is tempered through interactions with the IGF-1R.

285 uited to the mucosa, where responses must be tempered to prevent excessive inflammation.

286 echniques, such as metadynamics and parallel tempering, to characterize the oligomerization landscape

287 gy perturbation/replica exchange with solute tempering, to two modifications of protein-ligand comple

288 This tempers triglyceride availabiity for very low density li

289 e American Thyroid Association guidelines of tempering TSH suppression in patients with low risk of c

290 Improving tumor perfusion, thus tempering tumor-associated hypoxia, is known to impair c

291 ilitates tracking of actions and outcomes to temper urges for riskier rewards as they become less pro

292 e molecular dynamics simulations with solute tempering, we study the effect of methionine oxidation o

293 stigation of chiral ion-pairs using parallel tempering, were performed in order to probe the mode of

294 It would be prudent to temper widening the scope of practice of mid-level provi

295 epidemiologists have for population health, tempered with concerns for remaining true to epidemiolog

296 ers using solvophobic driving forces must be tempered with functionalities that promote solubility of

297 d interpret biomarkers with more confidence, tempered with necessary caution.

298 s on nontarget organisms, but theory must be tempered with pragmatism in the selection of volatiles a

299 The significance of these findings must be tempered with the limitations (possible underreporting)

300 el reduction approach that combines Parallel Tempering with Lasso regularization to identify minimal