ライフサイエンスコーパス: temperature-sensitive mutation

1 se activity, and can complement a yeast ctf7 temperature-sensitive mutation.

2 g of OTC cDNA and the ablation of E2a with a temperature-sensitive mutation.

3 e selected for genomic suppressors of a mot1 temperature-sensitive mutation.

4 c suppressors of the A. nidulans nimX2(cdc2) temperature-sensitive mutation.

5 n also suppress aurora protein kinase, ipl1, temperature-sensitive mutations.

6 verse metastable proteins with destabilizing temperature-sensitive mutations.

7 V40 large T antigen containing the tsA58/U19 temperature-sensitive mutations.

8 been isolated following a genetic screen for temperature-sensitive mutations.

9 parate screen for high copy suppression of a temperature-sensitive mutation (A79V) of the yeast trans

10 Here, we isolated a temperature-sensitive mutation affecting CPN60alpha2, wh

11 ased temperature imposed selection against a temperature-sensitive mutation affecting cytochrome oxid

12 l, to that observed previously for pol3-t, a temperature-sensitive mutation affecting DNA polymerase

13 Temperature-sensitive mutations affecting FACT and Cdc28

14 rm cells differentiate first in animals with temperature-sensitive mutations affecting germ cell stat

15 Temperature-sensitive mutations affecting the kinase dom

16 insights into the molecular basis of several temperature sensitive mutations and, in combination with

17 kc1p function was eliminated by the use of a temperature-sensitive mutation and beta(1-->3)glucan syn

18 mplement the defect associated with a cdc5-1 temperature-sensitive mutation and to localize to these

19 Viruses carrying temperature-sensitive mutations are good candidates for

20 roles because the imp1delta and the cut15-85 temperature-sensitive mutations are synthetically lethal

21 Here, temperature-sensitive mutations are used to characterize

22 otypes, multiple cold-adaptive mutations and temperature-sensitive mutations arose.

23 Two temperature-sensitive mutations at this interface have b

24 tion of NIMA using either the nimA1 or nimA5 temperature-sensitive mutations blocked cells in G2, NIM

25 Rescue of a parE temperature-sensitive mutation by overproduction of DnaX

26 This suggests that temperature-sensitive mutations can be created for time-

27 Both the nimA5 and nimT23 temperature-sensitive mutations cause an arrest in G2 at

28 The temperature-sensitive mutation cdc25-22 is synthetic let

29 The temperature-sensitive mutation ctf13-30, which confers r

30 We used a temperature-sensitive mutation, dbf4, to examine the req

31 mutation of CER1 in combination with a kar2 temperature-sensitive mutation displays synthetic growth

32 ypomorphic mutations that behave as apparent temperature-sensitive mutations due to the additive effe

33 concepts as dominance, incomplete dominance, temperature-sensitive mutations, epistatic interactions,

34 Temperature sensitive mutations fall into two general cl

35 Mapping temperature-sensitive mutations found in yeast fibrillar

36 y the function of the Z ring the effect of a temperature-sensitive mutation, ftsZ84(Ts), on ring dyna

37 d for high-copy-number suppressors of a bur1 temperature-sensitive mutation, identifying a single gen

38 expressed in Escherichia coli complemented a temperature sensitive mutation in E. coli rpoA, demonstr

39 A temperature sensitive mutation in one of the core comple

40 ion by testing their ability to complement a temperature sensitive mutation in the E. coli groEL gene

41 results provide a second example in which a temperature sensitive mutation in the ubiquitin conjugat

42 In Escherichia coli, temperature sensitive mutations in either its protein (r

43 Temperature sensitive mutations in host cell factor 1 (H

44 t was abrogated in orc2-1 cells containing a temperature-sensitive mutation in a component of the ori

45 store growth to an E. coli strain carrying a temperature-sensitive mutation in acpP, the gene that en

46 t by comparing a yeast strain that harbors a temperature-sensitive mutation in an essential Mediator

47 d characterization of an EMS-generated, cold-temperature-sensitive mutation in Arabidopsis thaliana,

48 Using PCR mutagenesis, we generated a temperature-sensitive mutation in BET5 (bet5-1) that blo

49 evel of RNase P at 43 degrees C because of a temperature-sensitive mutation in C5 protein, the protei

50 We have isolated a temperature-sensitive mutation in Caenorhabditis elegans

51 A temperature-sensitive mutation in CAK1 confers a G2 dela

52 Using a reversible temperature-sensitive mutation in capsid assembly, we ha

53 source of cytosolic Hsp70/SSA function or a temperature-sensitive mutation in CCT4, a subunit of the

54 This regulation was first identified using a temperature-sensitive mutation in dnaB.

55 v2Lu has a deletion in E1 and also carries a temperature-sensitive mutation in E2a.

56 ression of mDEAH9 in S. cerevisiae bearing a temperature-sensitive mutation in prp43 was sufficient t

57 A temperature-sensitive mutation in Sec16 causes tER fragm

58 activator, we reasoned that suppressors of a temperature-sensitive mutation in Srb4 would identify ot

59 n for gene dosage suppressors of sth1-3ts, a temperature-sensitive mutation in STH1, which encodes th

60 gp37 peptides into a P37 trimer; however, a temperature-sensitive mutation in T4 (ts3813) that suppr

61 Using a temperature-sensitive mutation in tax-2, we find that ta

62 A temperature-sensitive mutation in TFC3 that weakens DNA

63 the flagella of fla10-1 cells, which carry a temperature-sensitive mutation in the anterograde motor

64 Cells carrying a temperature-sensitive mutation in the CTD, rfc1-44, arre

65 , we identified eta1/axr6-3, a recessive and temperature-sensitive mutation in the CUL1 core componen

66 A derivative of Rap1p that has a temperature-sensitive mutation in the DNA-binding domain

67 A repressor with a temperature-sensitive mutation in the DNA-binding domain

68 Expression of HPV16 E7 in a cell line with a temperature-sensitive mutation in the E1 enzyme of the u

69 he availability of a yeast strain containing temperature-sensitive mutation in the eIF5 gene allowed

70 g a mannosyltransferase, as suppressors of a temperature-sensitive mutation in the gene encoding the

71 cond SH3 domain of the sem-5/Grb2 adaptor, a temperature-sensitive mutation in the helical hairpin of

72 li complements the growth defect caused by a temperature-sensitive mutation in the host pol I.

73 INH treatment of mycobacteria, we isolated a temperature-sensitive mutation in the inhA gene of Mycob

74 y in Caenorhabditis elegans has identified a temperature-sensitive mutation in the mTORC1 component R

75 oreover, the myo2-66 mutant, which carries a temperature-sensitive mutation in the Myo2p motor domain

76 A temperature-sensitive mutation in the N-terminal kelch d

77 By using a cell line (TS-41) with a temperature-sensitive mutation in the NEDD8 conjugation

78 encoding a component of the RNase MRP, and a temperature-sensitive mutation in the NME1 gene, coding

79 Yeast cells containing a temperature-sensitive mutation in the PRT1 gene were fou

80 As expected, a temperature-sensitive mutation in the region most highly

81 A temperature-sensitive mutation in the RNT1 gene encoding

82 pecifically stabilized in a strain bearing a temperature-sensitive mutation in the SSA1 gene.

83 AhR is inhibited in ts20 cells, which bear a temperature-sensitive mutation in the ubiquitin-activati

84 ed in cells infected with a virus carrying a temperature-sensitive mutation in the UL15 gene at nonpe

85 In a screen for suppressors of a temperature-sensitive mutation in the yeast SNAP-25 homo

86 Moreover, a temperature-sensitive mutation in U(L)15 precluded coimm

87 Utilizing a newly isolated temperature-sensitive mutation in zipA we have more full

88 Temperature-sensitive mutations in APC subunits increase

89 Temperature-sensitive mutations in ARP7 and ARP9 were is

90 f the UTRs together with the introduction of temperature-sensitive mutations in both the nucleocapsid

91 synthetic lethality at room temperature with temperature-sensitive mutations in cyclin B (cdc13-117)

92 Moreover, animals bearing weak or temperature-sensitive mutations in daf-2 and age-1 can d

93 omoter, its processing became insensitive to temperature-sensitive mutations in DIM1 or to depletion

94 profiling analyses of yeast strains bearing temperature-sensitive mutations in each of the 13 essent

95 We have isolated new temperature-sensitive mutations in five complementation

96 Temperature-sensitive mutations in FLA15 and FLA17 show

97 In addition to suppressing temperature-sensitive mutations in ftsA, ftsK, ftsQ, and

98 he replication of four HSV mutants harboring temperature-sensitive mutations in genes essential for v

99 ng a budding yeast minichromosome system and temperature-sensitive mutations in kinetochore proteins.

100 The characterization of temperature-sensitive mutations in model proteins, such

101 strategies could be used to generate useful temperature-sensitive mutations in other EGF motif-conta

102 , mutations in the E. coli lon gene suppress temperature-sensitive mutations in other genes.

103 Temperature-sensitive mutations in proteins produced at

104 3p led to allele-specific suppression of the temperature-sensitive mutations in region I, suggesting

105 Furthermore, temperature-sensitive mutations in RFC4 result in precoc

106 Temperature-sensitive mutations in SKP1 define two disti

107 ations and the molecular characterization of temperature-sensitive mutations in Spn1 indicate that th

108 Temperature-sensitive mutations in subunits of the Caeno

109 Two temperature-sensitive mutations in the 3' end of the dna

110 AB viruses containing temperature-sensitive mutations in the A2 background exh

111 y the SAC6 gene, mutations of which suppress temperature-sensitive mutations in the actin gene (ACT1)

112 dissect the functions of Spc110p, we created temperature-sensitive mutations in the amino and carboxy

113 subgenic M polypeptides, by incorporation of temperature-sensitive mutations in the N and L genes, an

114 his study, we introduced by reverse genetics temperature-sensitive mutations in the PB1 and PB2 genes

115 Yeast strains harboring temperature-sensitive mutations in the pescadillo gene w

116 mutants of the phage, and (iii) introducing temperature-sensitive mutations in the phage such that i

117 Temperature-sensitive mutations in the RNA recognition m

118 Two recessive, temperature-sensitive mutations in the Schizosaccharomyc

119 Temperature-sensitive mutations in the sepA gene prevent

120 hing suit ichthyosis is caused by recessive, temperature-sensitive mutations in the transglutaminase-

121 ient P. aeruginosa strains, we have isolated temperature-sensitive mutations in the xcpT gene and ext

122 earched for multicopy suppressors of various temperature-sensitive mutations in the yeast Hsp90 gene,

123 its N terminus functions in DNA binding, and temperature-sensitive mutations in this domain can be su

124 membrane traffic to the vacuole we generated temperature-sensitive mutations in YKT6.

125 encoding the NSs protein and introduction of temperature-sensitive mutations, in the design of attenu

126 forts of my students and I to understand how temperature-sensitive mutations interfered with assembly

127 iously demonstrated that the introduction of temperature-sensitive mutations into the PB2 and PB1 gen

128 onditional loss-of-function reagents such as temperature-sensitive mutations is that the resulting ph

129 o residues previously identified as sites of temperature-sensitive mutations lie buried directly bene

130 Three sth1 temperature-sensitive mutations map to the highly conser

131 Temperature-sensitive mutations mapping in WD-repeat dom

132 In contrast, a temperature-sensitive mutation near the C terminus of Se

133 The tsBN462 cell line, with a temperature-sensitive mutation of TAF(II)250, grows norm

134 plication and growth of H5ts36, an Ad with a temperature-sensitive mutation of the Ad polymerase prot

135 s confirmed by its ability to complement the temperature-sensitive mutation of the bacterial pantothe

136 shibire(ts1), a temperature-sensitive mutation of the Drosophila gene en

137 on of TLK1B in a yeast strain that harbors a temperature-sensitive mutation of the major H3 kinase, I

138 58 transgenic mice (immortomice) that have a temperature-sensitive mutation of the SV40 large tumor a

139 nes occurred in cells harboring a defective, temperature-sensitive mutation of the ubiquitin-activati

140 Temperature-sensitive mutations of BRN1 can be suppresse

141 ES1 and CES4 act as high copy suppressors of temperature-sensitive mutations of Ceg1p, the yeast mRNA

142 Functional inactivation of yTAFII17 by temperature-sensitive mutation or depletion results in l

143 ncreasing the ovarian ecdysone titer using a temperature-sensitive mutation or exogenous ecdysone res

144 that functional inactivation of yTAFII90 by temperature-sensitive mutations or depletion leads to ar

145 However, temperature-sensitive mutations or depletion of Swd2 cau

146 The dominant temperature-sensitive mutation RNA12-1 prevents growth o

147 Escherichia coli strain 397c carries a temperature-sensitive mutation, rpoC397, that removes th

148 multicopy suppressors of an mga2Delta spt23 temperature-sensitive mutation (spt23-ts).

149 DeltaF508 CFTR has been described as a temperature-sensitive mutation that can be rescued follo

150 e was examined in four yeast strains bearing temperature-sensitive mutations that arrest cells in dif

151 The SEC13 gene was originally identified by temperature-sensitive mutations that block all protein t

152 Temperature-sensitive mutations that block either the la

153 istem function we have designed a screen for temperature-sensitive mutations that cause a conditional

154 Temperature-sensitive mutations that suppress the Ca2+ s

155 To take full advantage of fast-acting temperature-sensitive mutations, thermal control must be

156 mplement the defect associated with a cdc5-1 temperature-sensitive mutation, to localize to the spind

157 Temperature-sensitive mutations (ts10, ts18, and ts39) o

158 of our understanding of yeast has relied on temperature-sensitive mutations which, when available, a

159 tein response (UPR(mt)), we first isolated a temperature-sensitive mutation (zc32) that conditionally