ライフサイエンスコーパス: template

1 state functional magnetic resonance imaging template.

2 linear polymers prepared in the presence of template.

3 lective BRD7/9 inhibitor from a pyridazinone template.

4 he same RNA target strand, serving here as a template.

5 clinician communication using an information template.

6 int mutations without supplying a DNA-repair template.

7 resolve G-quadruplexes on the lagging-strand template.

8 mRNA output is higher when PQS is in the non-template.

9 ch in turn generates G4 structure in the non-template.

10 oparticles in the presence of glucose as the template.

11 the shape and chemical functionality to the template.

12 quinolinones, an underrepresented privileged template.

13 tly confirming the localized presence of the template.

14 the first RNA strand that is later used as a template.

15 n of both precursors (Ni and Ce) on the 3DOM template.

16 ing tetrabutylammonium perchlorate as a soft-template.

17 but not Pol II, could transcribe nucleosomal templates.

18 hout requiring double-strand breaks or donor templates.

19 tin and other bulky adducts in synthetic DNA templates.

20 cleotides does not impede the copying of RNA templates.

21 plication of both undamaged and base-damaged templates.

22 h affinity for supercoiled and catenated DNA templates.

23 s on both short (10-nt) and long (25-nt) RNA templates.

24 ition as the matching of patterns to learned templates.

25 line and some of its methylated analogues as templates.

26 provided different single-stranded donor DNA templates.

27 ein propagates via prion-like conformational templating.

28 der structures was complex and involved self-templating.

29 n of ventricular segment based on population templates, (2) population-based localization within a se

30 superheat of just 2.2 degrees C for the salt templated 3 wt% GNP draped 20 um diameter copper particl

31 Photothermal stimulation using NW-templated 3D fuzzy graphene (NT-3DFG) is flexible due to

32 First, niche cell wrapping templates a laminin-based basement membrane around the g

33 nal inferential method using potential donor templates absent from B cell genomes, we obtain estimate

34 MASQ counts variant templates accurately in the presence of millions of host

35 solvent evaporation, even in the presence of templating agents.

36 yeast mtRNAP that explain promoter melting, template alignment, DNA scrunching, abortive synthesis,

37 ntercellular transmission and the subsequent templated amplification of these misfolded proteins are

38 into the energetic determinants involved in templating amyloid assembly.

39 Template analysis methodology was employed to develop an

40 talytic system leveraging a remote directing template and a transient norbornene mediator to selectiv

41 1 RNA serves two functions, as a translation template and as a viral genome, individual RNA molecules

42 re biasing terms, the addition of homologous template and co-evolutionary restraints to AWSEM-Suite g

43 host genomes by using tags to identify each template and demanding consensus over multiple reads.

44 -especially the O helix-to engage the primer-template and dNTP triphosphate.

45 thesized using three C bases in the DNA as a template and extends RNA without displacement of the pro

46 To gain access to the N-RNA template and orchestrate the L(RdRP), L(PRNT), and L(MT)

47 mplexan cytoskeletons, illuminating how they template and orient critical processes during infection.

48 form an extensive interface with the primer-template and the triphosphate of the incoming dNTP.

49 ing double-cysteine-modified peptides as the templates and adsorbing the templates on a gold surface

50 d the knock-in of specific alleles using DNA templates and homology directed repair (HDR).

51 ions of folding-enhancing mutations into GFP templates and screening for brightness and expression ra

52 The server then searches for templates and uses them for docking, presenting the user

53 The assay was developed with synthetic DNA templates and validated with DNA from two breast cancer

54 l monomers, organic surface modifiers, dummy templates, and cross-linkers.

55 ral RdRp elongation traces on kilobases long templates, and this has shown that RdRp nucleotide addit

56 ty using a combination of ball milling, salt-templating, and sintering techniques.

57 prediction that gains the advantages of both template- and non-template-based methods.

58 (synthesized for the first time, via a soft-templating approach, with high phase-purity) can be used

59 CR is diminished at higher concentrations of template approaching 100 percent positive partitions, wi

60 However, their interactions with templates are not sufficiently strong.

61 bstituents forming stable complexes with the templates are used.

62 ows for accurate modeling of receptors using templates as low as 20% sequence identity, which account

63 human transferrin (HTR), were prepared via a template assisted synthesis.

64 en the Bayesian optimal observer weights the template at each pixel location by the estimated reliabi

65 the motile cilium to date and reveal how BBs template axonemes.

66 ferentiation of an incoming nucleotide and a template base and the N-terminal domain of DNA ligase I

67 basic ridge' domain of DnaG, but not the DNA template base at the -1 position.

68 es Prim-PolC to couple primer extension with template base dislocation, ensuring that the unpaired te

69 jacent Val-557 is in direct contact with the template base, and the V557L mutation is implicated in l

70 did not form a planar base pair with either templating base.

71 On template-based analyses, the sensitivity, specificity, a

72 the PET and the morphologic datasets using a template-based analysis on a 5-point scale.

73 The template-based approach has been essential for achieving

74 g this additional information in a so-called template-based method has the potential to significantly

75 Our core template-based method is an algorithmic approach that us

76 ins the advantages of both template- and non-template-based methods.

77 With this protein localization atlas and template-based protein structure modeling, we have assem

78 ology modeling is a critical step forward in template-based protein structure prediction.

79 base dislocation, ensuring that the unpaired templating bases in the gap are ushered into the active

80 m when RNA hybridizes with complementary DNA templates behind RNA polymerases.

81 a model in which the 3' terminus of the vRNA template binds in the mode B site during elongation.

82 y further sequence engineering of the set of template/blocker scaffolds and their coupling to a nicki

83 A set of four DNA template/blocker scaffolds coupled to the polymerase/dNT

84 Also, sequence-engineered template/blocker scaffolds, coupled to the polymerase/dN

85 uring transcription upon invasion of the DNA template by the nascent RNA.

86 Dicopper complexes templated by dinucleating, pacman dipyrrin ligand scaffo

87 Multilayered structures are templated by the morphology of the underlying layers.

88 is a strategy to prepare chiral AgNP arrays templated by two constitutionally isomeric aromatic pept

89 incorporation of chemical lesions into dsDNA templates by sequential PCR and translesion synthesis.

90 hese modifications enable the copying of RNA templates by the multistep ligation of tetranucleotide b

91 placement of the excised region with a donor template carrying the wild-type repeat size to maintain

92 he directed evolution of RT function for any template chemistry called compartmentalized bead labelli

93 The intrinsic collagen-like structure of templated CMP pairs helps to explain the success of stic

94 ncounters with R-loops on the leading-strand template (co-directional) resulted in gaps in the nascen

95 neuronal SNARE assembly through an obligate template complex intermediate containing Munc18-1 and 2

96 utational studies suggest that the MUN-bound template complex is functionally important for SNARE ass

97 Therefore a full range of template concentrations cannot be quantified accurately

98 as a bridge between concentrated and dilute template concentrations.

99 The (1)H NMR shifts of the bound templates confirm the disrupted aromaticity of the edge-

100 allohelices inhibit DNA synthesis on the RNA template containing four repeats of the human telomeric

101 rmed by untemplated polymerization, but that template copying chemistry favored RNA synthesis; multip

102 is problematic due to the low efficiency of template copying with mononucleotides.

103 Finally, facile integration of the bottom-up templated crystallization with emerging top-down techniq

104 tion with DNA substrates containing either a templating cytosine (nonmutagenic) or adenine (mutagenic

105 o-GTP adopts an anti conformation opposite a templating cytosine and a syn conformation opposite aden

106 metric-space nearest neighbor search over a template database of fixed-length amino acid words to de

107 on step of RT-qPCR with a rapid nucleic-acid-template-dependent DNA chemical ligation system, that al

108 ve data provide strong evidence to show that template-dependent inhibition of SARS-CoV-2 RdRp by RDV

109 In doing so, they relied predominantly on a template derived from the expression of REM sleep in the

110 Template-directed assembly has been shown to yield a bro

111 We show that template-directed ligation can assemble long RNAs from s

112 t isomer kick-starts replication through the template-directed pathway.

113 a wide range of transition-metal-catalyzed, template-directed remote C-H activation reactions of alc

114 This template-directed solid-state nucleation pathway is enab

115 he link between allosteric cooperativity and template-directed synthesis has been investigated by stu

116 Template-directed synthesis has been used to prepare a f

117 Our study revealed how RNA slips on template DNA and how RNA polymerase and template DNA det

118 s on template DNA and how RNA polymerase and template DNA determine length of reiterative RNA product

119 ing bidirectional transcription when the non-template DNA strand bonds with the hybrid duplex (collap

120 also performed biochemical assays to monitor template DNA translocation during RNA synthesis from the

121 encoding an intrinsic stall site within the template DNA, our chemical transcription roadblocking ap

122 synthesis requires a considerable amount of template DNA, the preparation of high-quality DNA "parts

123 e II (RNApII) transcribes messenger RNA from template DNA.

124 le binding of individual RNApII molecules to template DNA.

125 d for specimens containing highly fragmented template DNA.

126 RPA stimulates RNA-templated DNA repair in vitro and associates in vivo wit

127 tutions predominated including frequent A:A (template: dNMP) mispairings.

128 In yeast, transcript RNA was shown to template DSB repair of DNA.

129 ntly specified by a homology-directed repair template during editing with Cascade-Cas3, but not Cas9.

130 enhances the physical search for an ectopic template during homology-directed repair (HDR), we teste

131 B, deaminate cytosines in the lagging-strand template during replication.

132 1,5-naphthalene units, have been obtained by template effect in a thermodynamically controlled synthe

133 prisingly, the chloride anion had a negative template effect in opposition to the results obtained fo

134 ver, the bromide anion had a clear catalytic template effect in the macrocyclization reaction, and su

135 ix is directly correlated to the "reciprocal templating" effect, which modulates the interactions bet

136 tic resonance spectroscopy confirms that the templated electro-synthesis affords structural defects i

137 to a view- and orientation-independent face template encoded in a face-centered reference frame, tha

138 loop preceding the F motif, close to the RNA template entrance.

139 tes a potential structural basis for surface-templated fibril assembly.

140 disorder-to-order transition in IDPs termed "templated folding," whereby the binding partner dictates

141 l)methyl benzamide scaffold was studied as a template for (18)F-positron emission tomography ((18)F-P

142 This provides a template for adoption of a multidisciplinary telehealth

143 -like fashion by misfolded protein forming a template for aggregation of endogenous alphasyn.

144 gration, the CMOS imager makes an attractive template for an optoelectronic sensing platform.

145 ing to this class of molecules as a valuable template for boosting the antitumor immune system.

146 40), and the ligand is an effective Vernier template for directing the synthesis of the 12-porphyrin

147 nto one comparative model, the best possible template for every region of a target can be used expand

148 ield a new AAV variant that then serves as a template for evolving the next surface loop.

149 rocuticle during cell division and provide a template for further cutin deposition.

150 and pseudotime analysis that can serve as a template for future analyses.

151 This trial provides a template for future simultaneous testing of multiple dis

152 tral role in viral replication, serving as a template for Gag/Gag-Pol translation and as a genome for

153 We defined the minimal length of the RNA template for in vitro de novo RNA synthesis using the pu

154 This map will serve as a template for mapping using different strains of the path

155 The PSS provides both a soft-template for nanofibre formation and a poly-anionic char

156 ntial for replication and also serves as the template for new genome synthesis.

157 They may also provide a template for photopharmacology targeting the ubiquitous

158 ption initiation factor that engages the DNA template for RNA priming and growth and disengages when

159 uman telomerase RNA (hTR), which serves as a template for the addition of telomeric repeats to chromo

160 e tryptophan moiety as a solid pharmacophore template for the design of highly potent modulators of T

161 thin physiological complexes could provide a template for the design of safer and more effective ther

162 Our aim is to provide a template for the development of clinical recommendations

163 1T-MoS(2) platforms provided a novel template for the formation of C(60) nanosheets (NSs) wit

164 model suggests that RDV, when serving as the template for the incoming UTP, is not properly positione

165 of an infected hepatocyte and serves as the template for the transcription of viral mRNAs.

166 he target of neutralizing antibodies and the template for vaccine immunogen design.

167 hydrogels can be employed as precursors and templates for architecting three-dimensional frameworks

168 Sacrificial templates for patterning perfusable vascular networks in

169 eceived high-index Cu foils can serve as the templates for producing high-index single-crystal Cu-bas

170 res that can be used as optical microarrays, templates for soft lithography, and ordering matrices fo

171 Both were used as templates for synthesis of arrays of ~8 nm AgNPs to unde

172 alpha-synuclein peptides were synthesized as templates for the molecular imprinting of conductive pol

173 nd/or therapeutic potential and can serve as templates for vaccine design.

174 accumulation of ssDNA in the lagging-strand template fosters the formation of a triplex between the

175 phi29 polymerase used in MDA is sensitive to template fragmentation and presence of sites with DNA da

176 ng robust performance for decoy selection in template-free protein structure prediction.

177 ls by several known molecules, including the template gamma-tubulin and the polymerase XMAP215.

178 This atlas includes a population template generated from 30 neurologically and clinically

179 o rotaxanes via copper-mediated active metal template Glaser or Cadiot-Chodkiewicz coupling.

180 Here we report a templated growth mechanism of layered perovskites from 3

181 ligand, performs conformational sampling and template-guided energy refinement to produce a variety o

182 The sequence of the DNA template has long been thought to influence the rate of

183 We suggest a mechanism in which the JC templates IgA oligomerization and imparts asymmetry for

184 NNS) RNA viruses possess a ribonucleoprotein template in which the genomic RNA is sequestered within

185 en the recombinogenic filament and the donor template in yeast, limiting strand rejection by the Sgs1

186 cription assays indicate that PQS in the non-template increases mRNA production rate and yield.

187 ng the endogenous homologous transcript as a template, indicating ATXN3's role in PNKP-mediated error

188 The results suggest the formation of template induced 1-1 diad repeats in the polymer main ch

189 sequence that is identical to flanking DNA ("templated" insertions).

190 e ends of the homology-directed repair (HDR) template interact with Cas9 ribonucleoproteins (RNPs) to

191 offer catalytic activity and an ultrasmooth templating interface that promotes Frank-van der Merwe r

192 ts and a homologous recombination (HR) donor template into embryos to trigger homology directed repai

193 Pooled knockin of dozens of unique barcoded templates into the T cell receptor (TCR)-locus revealed

194 Transcription of a chromatin template involves the concerted interaction of many diff

195 ular prism-assemble in concert around Co(II) template ions.

196 The template is based on imine-linked frameworks and their (

197 hat is most useful when a suitable structure template is not available.

198 R) to develop the chimpanzee brain reference template Juna.Chimp for spatial registration and the mac

199 ocessivity factor, is loaded onto the primer-template junction by replication factor C (RFC).

200 by MOCVD on high and low hillock density GaN template layers.

201 d by assembling a functional ribozyme by the templated ligation of short oligonucleotides.

202 t tolerance factor rule), and they generally template low-dimensional structures.

203 s to predesigned hairpins H(E) and H(F), the templates M'/M and N'/N, the RNAp/NTPs machinery, and th

204 se that was constructed so that the standard template-matching (TM) observer performs equally well wh

205 nalytical difficulties, we developed a novel template-matching-based spike sorting method, which enab

206 mensional (1D) nanoscale pores of surfactant-templated mesoporous silica films.

207 lar strands within a discrete layer by anion-template metal-ion coordination opens the way for the sy

208 Fabrication of bio-templated metallic structures is limited by differences

209 egies, including biomaterial fabrication and templating, might be used to overcome existing challenge

210 anner, by passing to naive cells in which it templates misfolding and aggregation.

211 ted nested Laplace approximations (INLA) and Template Model Builder (TMB) for Bayesian and frequentis

212 ate-specific antigen (PSA) was selected as a template model.

213 CGLFold obtains template modeling score >= 0.5 models on 95 standard tes

214 aFold created high-accuracy structures (with template modelling (TM) scores(6) of 0.7 or higher) for

215 ization with poly-sialic acid (PolySia) as a template molecule and p-aminobenzeneboronic (p-ABA) acid

216 nylenediamine (o-PD) in the presence of PFOS template molecules on a glassy carbon macroelectrode.

217 y sensitive to small chemical changes to its template mRNA.

218 In each case the two template N atoms bind to a specific framework Al site to

219 ion fork DNA helicase, and 2) on the damaged template, nascent leading-strand gaps were generated by

220 to pure tones, similar to cortical "harmonic template neurons" (Feng and Wang, 2017), but to a lesser

221 base-specific interactions with flipped non-template (NT) nucleotides "AAGT" at -4 to -1 positions o

222 antly higher probability that the downstream template nucleotide coded for the incoming nucleotide.

223 If the first templating nucleotide was a cytidine, there was a signif

224 However, when the initial templating nucleotide was a pyrimidine, fidelity was dec

225 fined point following infection to clear the template of ribosomes to allow efficient replication.

226 By testing three templates of different origin and sequence identities, w

227 lating, the complete exchange of metals in a template, of group 11 clusters across the entire coinage

228 peptides as the templates and adsorbing the templates on a gold surface by means of forming self-ass

229 ted in samples with a high load of nontarget template or influenza B virus, demonstrating assay speci

230 Using DNA-templated parallel carbon nanotube (CNT) arrays as model

231 ds as diverse as bioinspired mineralization, templating, pharmaceuticals, colloidal crystallization,

232 ous covalent organic frameworks via topology-templated polymerization.

233 our results show that memory-guided identity templates proactively impact perception and are associat

234 are implicated in the control of diverse DNA-templated processes including gene expression.

235 2Bub1) has central functions in multiple DNA-templated processes, including gene transcription, DNA r

236 DNA-templated processes, including transcription, require ch

237 ind chromatin to execute and regulate genome-templated processes.

238 ures of the SARS-CoV-2 holo-RdRp with an RNA template product in complex with two molecules of the ns

239 tential model for how these interactions can template protein-protein interactions causative of cellu

240 Yeast prions provide self-templating protein-based mechanisms of inheritance whose

241 scent leading strand, whereas lagging-strand template R-loops (head-on) had little impact on replicat

242 The experimental parameters, such as monomer/template ratio, electropolymerization cycle and adsorpti

243 orporation of the complementary UTP opposite template RDV is compromised, providing a second opportun

244 xample of an electrochemical oligonucleotide-templated reaction (EOTR), whereby two PNA probes - func

245 hybridization architecture that enhances the templated reaction and enables the uncaging of a substra

246 tion factors and synthetic DNA transcription templates regulates the synthesis of a fluorescence-acti

247 circuit components beyond naturally-derived templates remains challenging due to poorly understood d

248 en grids, followed by the removal of the ion template, result in a wholly organic molecular material

249 Metal template Schiff base condensations have produced multinu

250 is not known what controls the formation and templated seeding of strain-specific structures associat

251 with AgNCs/PMAA (PMAA = polymethyl acrylate templating several AgNC) are also electroactive for H(2)

252 hese findings suggest that a chromatin donor template should be useful for a wide range of HDR applic

253 ngly high wicking rates compared to non-salt-templated sintered coatings.

254 n hurdles, including secondary structures in template, slowed helicase, or uncoupled helicase-polymer

255 r imaging or co-registration within a common template space.

256 coordination, triphosphate binding, and RNA template stabilization.

257 play a crucial role in RNA priming by aiding template strand alignment in the active site for high-af

258 replisomes easily bypassed R-loops on either template strand.

259 ires the recognition of a single strand by a templated strand dimer.

260 a triplex between the nascent and fold-back template strands of the repeat.

261 c IgG antibody to two antigen-conjugated DNA templating strands that triggers a chemical reaction tha

262 ntegrate organic and inorganic structures by templating strategies and electrodeposition to create ma

263 ls for bulk Ag(3) PO(4) , and offers a fresh template strategy for the synthesis of silver NCs with h

264 Herein, we report a templating strategy using sacrificial double cubic netwo

265 ion of the strengthening phase theta' onto a template structure in the aluminium-copper alloy system.

266 Secondly, by merging multiple template structures into one comparative model, the best

267 ot most, of these events are associated with template switching in postreplication gaps as opposed to

268 Some gap filling occurs via template switching, a process that generates recombinati

269 triggers a recombinogenic process involving template switching.

270 Here, we report on the metal-free active template synthesis of [2]rotaxanes in one step, up to 95

271 Therefore, the developed zinc-mediated template synthesis strategy for boosting the density and

272 DNA-templated synthesis takes advantage of the programmabili

273 CDN to two hairpins, H(A) and H(B), and two templates T(A) and T(B) and a nicking/replication machin

274 istic dissection of the Coriobacteriia and a template that can be applied to study other genetically

275 lates), which defines a suite of class-based templates that allows users to develop and implement hig

276 The templates that best predicted recognition were sequences

277 sit the strategies - including soft and hard templating - that have been developed for generating nan

278 process requires tetrafluoroborate anions to template the assembly of the interwoven grid by binding

279 We templated the current best available class 1b antiarrhyt

280 s sulfur to the scaffold protein IscU, which templates the Fe-S cluster assembly.

281 eaves 3D-like perovskites which surprisingly templates the growth of layered perovskites, enabled by

282 These aggregates were thought to act by templating the formation of an assembly-competent nuclea

283 g Ni by successive infiltration in the solid template, the CeO(2) crystal size is reduced, Ni dispers

284 enes, we report and rationalize the absolute templating, the complete exchange of metals in a templat

285 In this work, we provide a template to circumvent the tradeoff between cell viabili

286 rtan-bound human AT1R (PDB:4ZUD) served as a template to create an inactive apo-AT1R via molecular dy

287 sed vector was defined from the pyridazinone template to enable bifunctional molecule synthesis, and

288 as9 ribonucleoproteins (RNPs) to shuttle the template to the nucleus, enhancing HDR efficiency approx

289 n-loop amplification reaction using circular templates to generate intermediate amplicons, and an off

290 ility of combining synthetic gRNAs and dsDNA templates to perform homology directed repair and genome

291 ESI-MS was used to gauge the effect of each template upon library redistribution.

292 -3 can add long stretches of alternating non-templated uridine (U) and guanosine (G) ribonucleotides

293 ense genomic and negative-sense replicative, template viral RNA; essential viral replication proteins

294 elements with examples that can be used as a template when preparing and submitting ML-based manuscri

295 tive interphase layer will be formed outside templates when the redox potential exceeds the potential

296 ed struct (Statistics in R using Class-based Templates), which defines a suite of class-based templat

297 ng diodes (LEDs) grown on semi-polar (11-22) templates with a high crystal quality.

298 ine ecological responses as suitable habitat templates with enough usable surface area to support GRD

299 Two isomeric K-shaped tetrapyridyl templates with trifluoromethyl substituents at different

300 pically transcribed from random-sequence DNA templates, yielding a highly diverse set of RNAs that co