ライフサイエンスコーパス: tempol

1 e than a less targeted antioxidant approach (Tempol).

2 ydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL).

3 ydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPOL).

4 of EDD with the superoxide dismutase mimetic TEMPOL).

5 ydroxy-2,2,6,6-tetramethylpiperydine-1-oxyl (Tempol).

6 it is rescued by infusion of the SOD mimetic tempol.

7 NMDA and kainate, and during treatment with tempol.

8 ERK was abolished by treatment of rats with tempol.

9 pinephrine (NE) are normal and unaffected by tempol.

10 rsus -46 +/- 4%; P < 0.05) and normalized by tempol.

11 n of CGP-20,712A to NE but was normalized by tempol.

12 cessary for the chemopreventative effects of tempol.

13 of mice were coinfused with the antioxidant Tempol.

14 ated in SOD2+/-, and was acutely restored by Tempol.

15 arison with those on a KD diet alone without tempol.

16 e of p53 in the chemopreventative effects of tempol.

17 ng, which was abolished by the SOD1 mimetic, tempol.

18 hypothermia, except perhaps the antioxidant tempol.

19 groups and was unaffected by the addition of tempol.

20 ers citrate buffer containing 0 mM or 100 mM TEMPOL.

21 and hatching rate were observed in 10 uM of tempol.

22 when the extender was treated with 10 uM of tempol.

23 als originate from intramolecular protons on TEMPOL.

24 nal FXR mediates the anti-obesity effects of tempol.

25 t with the reactive oxygen species scavenger Tempol.

26 by pretreating animals with the antioxidant tempol.

27 dministered the superoxide dismutase mimetic tempol.

28 or by exposure to the free radical scavenger Tempol.

29 In some pigs, superoxide dismutase mimetic TEMPOL (1 mM) or vehicle (saline) was injected intravitr

30 l injection into the hindlimb circulation of tempol (10 mg), a superoxide dismutase mimetic (DeltaMAP

31 ins compared with equimolar concentration of tempol (10 mM).

32 The superoxide dismutase mimetic tempol (10(-4) M) moderated the AngII responses of Aff f

33 during inhibition of oxidative stress using tempol (100 microM).

34 atment with the superoxide dismutase mimetic Tempol (100 um) and Tempol plus the hydrogen peroxide (H

35 mpol before shock was induced (LTA/PepG plus tempol, 100 mg/kg i.v. bolus injection, 15 mins before L

36 5 mL/kg i.v., n = 6) or tempol (control plus tempol, 100 mg/kg i.v. bolus injection, followed by an i

37 Administration of Tempol (250 mg/kg, i.p.) 10 min prior to administration

38 tine diet (2 weeks prior to noise exposure), tempol (3 mM in drinking water 2 weeks prior to exposure

39 ed by the antioxidants ebselen (100 mum) and TEMPOL (3 mm).

40 droxy-2,2,6, 6-tetramethylpiperidine-N-oxyl (TEMPOL), 3-carboxy-proxyl, and 3-ethoxycarbonyl-proxyl,

41 ersus -34 +/- 3%; NS) and were unaffected by tempol (-32 +/- 4%; NS).

42 nd restored by coincubation of AA (37+/-2%), tempol (33+/-2%), losartan (34+/-2%), or apocynin (36+/-

43 gated to a triphenylphosphonium cation, Mito-Tempol (4) [Mito-T (4)].

44 ed hydroxytoluene, butylated hydroxyanisole, TEMPOL (4-hydroxy-2,2,6, 6-tetramethylpiperidine-N-oxyl)

45 addition of the superoxide scavenging agent tempol (4-hydroxy-2,2,6,6-tetramethyl piperidine-1-oxyl)

46 demonstrated that the nitroxide antioxidant tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl)

47 er the well-described nitroxide antioxidant, tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl),

48 id is oxidized to dehydroascorbic acid using Tempol (4-hydroxy-2,2,6,6-tetramethylpiperidinyloxy) and

49 nger, 4-hydroxytetramethylpiperidine-1-oxyl (tempol; 5 mM), was used in some experiments.

50 toTEMPO (mitochondria-targeted antioxidant), TEMPOL (a general antioxidant), apocynin (nicotinamide a

51 Intrathecal Mito-tempol (a mitochondria-targeted O2(.-)scavenger) reduced

52 Chronic administration of Tempol (a potent antioxidant) attenuated both SERCA oxid

53 f cells with Trolox (a soluble vitamin E) or Tempol (a radical scavenger).

54 e pyroptosis could be partially inhibited by Tempol (a superoxide dismutase-mimetic agent) and by gly

55 ongruently, the addition of 4-hydroxy-TEMPO (TEMPOL), a superoxide dismutase mimic that reacts with s

56 a model of FA, we examined the potential of tempol, a nitroxide antioxidant and a superoxide dismuta

57 xygen species, whereas preincubation of mito-TEMPOL, a superoxide dismutase mimetic, abolished statin

58 Coadministration of tempol, a superoxide dismutase mimetic, ameliorated the

59 Finally, treatment with Tempol, a superoxide dismutase mimetic, and insulin, bot

60 protein (P < 0.05), which were inhibited by Tempol, a superoxide dismutase.

61 Treatment with Tempol, a superoxide scavenger, attenuates the augmented

62 Chronic administration of tempol, a superoxide scavenger, reduced intraretinal oxi

63 ydroxy-2,2,6,6-tetramethylpiperidine-n-oxyl (TEMPOL,a superoxide dismutase-mimetic), N-omega-nitro-L-

64 cynin, or superoxide dismutase (SOD) mimetic tempol abolished O2- and restored BH4 levels.

65 mice with antioxidants (mitoTEMPO, apocynin, Tempol) abrogates the hypertensive, prothrombotic phenot

66 Thus, tempol acts as a novel chemopreventative agent in this m

67 ron spin resonance spectroscopy suggest that Tempol acts in this system by reacting directly with bot

68 icacy of 6OHDA, we have used the antioxidant Tempol adjunctively with 6OHDA.

69 on of 14 drugs in dogs, only the antioxidant tempol administered at the start of prolonged cardiac ar

70 Tempol administered continuously via the diet after wean

71 Finally, Tempol administration markedly attenuated impaired endot

72 ay 10 was equally attenuated by creatine and tempol alone or in combination.

73 OL for almost 5 h, whereas administration of TEMPOL alone results in clearance of blood redox activit

74 Tempol alone significantly reduced ABR threshold shifts

75 mor weights from mice administered saline or Tempol alone were 3.6 +/- 1.9 and 2.9 +/- 0.7 g, respect

76 enal superoxide levels more effectively than tempol alone.

77 TEMPOL also abrogated the inhibitory effect of 15-A2-Iso

78 Tempol also attenuated the RSNA response to 1 min interm

79 Tempol also normalized NF-kappaB translocation, PKC acti

80 Tempol also significantly decreased the AP-1-DNA binding

81 A broad antioxidant, Tempol, also reduced oxidant stress yet did not recouple

82 Here we show that tempol alters the gut microbiome by preferentially reduc

83 by oxidative stress, because treatment with Tempol, an superoxide dismutase mimetic, rescued kidney

84 The decay of Tempol and 3CP in tumor tissue was significantly faster

85 Tempol and Apocynin reversed the increased expression of

86 weeks prior to exposure), and creatine plus tempol and exposed to 120 dB SPL one-octave band noise c

87 Treatment with the antioxidants Tempol and MitoTEMPO reversed many proteomic signatures

88 sent study was to investigate the effects of tempol and straw size on rooster sperm post-thaw quality

89 Tempol and tempo are stable free radical nitroxides that

90 bsence of an environmental oxidative stress, tempol and tempo elicit distinct cellular signaling path

91 Both TEMPOL and TEMPOL/PNA give rise to prevention of apoptos

92 n vivo by treating mice with the antioxidant TEMPOL and the IsoLG scavenger 2-hydroxybenzylamine duri

93 ith phentolamine, antioxidant treatment with Tempol and thromboxane receptor antagonism with SQ-29548

94 roxy-2,2,6,6,-tetramethyl-1-piperidynyloxyl (Tempol) and 3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-1

95 inhibitor (L-NAME), a superoxide scavenger (Tempol), and an NADPH oxidase inhibitor (apocynin), as w

96 e restored in the presence of ascorbic acid, tempol, and apocynin, which inhibits NADPH oxidase assem

97 revented by the antioxidant agents Desferal, Tempol, and dimethylsulfoxide.

98 holine responses were improved (P<0.05) with Tempol, and histochemistry revealed oxidative stress in

99 a diet supplemented with a stable nitroxide, Tempol, and showed that the progression of neuromuscular

100 PNA enhances the therapeutic index of TEMPOL, and the recycling antioxidant that results from

101 apocynin, and the nonspecific ROS scavenger, tempol, are shown to reduce oxidative stress and improve

102 These results encourage further study of Tempol as a chemopreventive, to reduce the incidence of

103 ormed two types of adducts (LT and OLT) with TEMPOL as characterised by HPLC.

104 ubation with the antioxidants mito-TEMPO and TEMPOL, as well as inhibitors of xanthine oxidase and ar

105 and reactive oxygen species (ROS) scavenger tempol, as well as mitochondrial NCX (mNCX) blocker CGP-

106 n a frozen glycerol-water mixture doped with TEMPOL at ~1.4 K using spin diffusion enhanced saturatio

107 racellular application of the ROS scavenger, Tempol, attenuated the Ang II-induced increase in neuron

108 Pretreatment of rats with tempol augmented the hypotension but attenuated the rena

109 Another group of rats was pretreated with tempol before shock was induced (LTA/PepG plus tempol, 1

110 , polarity or partitioning of the spin probe TEMPOL-benzoate (TB), as proved by EPR measurements and

111 er (xestospongin C), or ROS scavengers (PBN, tempol), but not by an mGluR1 antagonist (LY367385) or N

112 The free radical scavenger Tempol, but not other classes of antioxidants, reduced o

113 tor of cAMP; -56 +/- 4%); were normalized by tempol; but were unaffected by ICI-118,551 (selective be

114 Agents such as the nitroxide Tempol can facilitate the oxidation of the semiquinone t

115 These results show that tempol can significantly delay tumor formation in Fancd2

116 Interestingly, however, only tempol caused increased extracellular signal-regulated k

117 tion of the clusters by the stable nitroxide TEMPOL caused their disassembly, potently inhibited the

118 ng and the reactive oxygen species inhibitor Tempol completely reversed the decline in Ser(P)(473)-AK

119 is inhibited by the antioxidants ebselen and TEMPOL, consistent with the concept that it requires an

120 metry of the adduct formation is two mole of TEMPOL consumed for one mole of LH and one mole of LOOH.

121 ydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL) consumption by using ESR allows to follow the an

122 by an infusion of 1.5 mL/kg i.v., n = 6) or tempol (control plus tempol, 100 mg/kg i.v. bolus inject

123 Tempol decreased ACh-mediated vasodilatation of medial c

124 However, tempol decreased basal production of superoxide anion in

125 In BSO-treated rats' supplementation of tempol decreased oxidative stress, normalized BP, and re

126 Tempol decreased the level of Ang II-induced aortic supe

127 More strikingly, tempol delayed the onset of epithelial tumors and increa

128 he animals that had first been injected with TEMPOL developed only stage 2 to stage 4 cataracts (the

129 Tempol did not affect the increase in nitrite/nitrate ca

130 ikewise, the antioxidants dithiothreitol and tempol did not reverse permeabilization.

131 Notably, delaying administration of the Tempol diet one month after TBI could also enhance survi

132 , and forebrain of animals maintained on the Tempol diet, IRP1 was converted from a cytosolic aconita

133 Oxypurinol and Tempol diminished the leak in NOS1(-/-) cardiomyocytes.

134 Here we show for the first time that tempol dramatically reduced STAT1 and 3 phosphorylation.

135 ted with the STAT1 activator, IFN-gamma, and tempol during I/R injury.

136 The antioxidants tempol, ebselen, and deferoxamine inhibited CO-induced O

137 Mice treated with antibiotics or tempol exhibited altered bile acid composition, with a n

138 In contrast, except for one antioxidant (Tempol), explorations of 14 different drugs added to the

139 olate-antioxidant conjugate 4-hydroxy-Tempo (tempol)-folate to target folate receptors, which are hig

140 nce revealed the successful targeting of the tempol-folate conjugate to the kidney and other tissues

141 Administration of tempol-folate protected the renal function of mice after

142 model of renal ischemia-reperfusion injury, tempol-folate reduced renal superoxide levels more effec

143 In contrast, mice administered Tempol followed by 6OHDA had an average tumor weight of

144 ine (BSO), an oxidant, with and without 1 mM tempol for 2 wk.

145 t of animals on a K-deficient (KD) diet with tempol for 7 days significantly decreased the production

146 L/PNA maintains redox-active blood levels of TEMPOL for almost 5 h, whereas administration of TEMPOL

147 oss (NIHL), we measured the effectiveness of tempol (free radical scavenger) and creatine (enhances c

148 motility, VAP and VSL increased in the 10 uM tempol group.

149 ,6,6-tetramethylpiperidine hydrochloride), a TEMPOL-H (OT-674) derivative, is a new catalytic antioxi

150 oxy-2,2,6,6-tetramethyl-1-hydroxypiperidine (TEMPOL-H) as a probe in conjunction with superoxide dism

151 Oxidized but not reduced TEMPOL (TEMPOL-H) was an effective radioprotector in cultured ra

152 enhancements as large as 50 are achieved on TEMPOL/H(2)O solutions at room temperature.

153 In the control rats, tempol had no effect on these responses.

154 aled oxidative stress in KW animals, whereas Tempol had no impact and reactive oxygen species stainin

155 the Lake cryopreservation medium with 10 uM tempol improved cryo-survival.

156 TEMPOL/PNA is also less toxic than TEMPOL in mice, allowing administration of higher doses

157 The level of total TEMPOL in the aqueous humor of rabbits at 15 minutes aft

158 t chronic supplementation of the antioxidant Tempol in the diet of mice can reduce body weight withou

159 containing 0 (control), 5, 10, 15 and 20 muM tempol (in two different straw size, 0.25 and 0.5).

160 y 6-OHDA than the non-recycling antioxidant, TEMPOL, in a murine model of catecholaminergic oxidative

161 Dietary tempol increased the mean tumor-free survival time of Fa

162 Both SOD and TEMPOL increased the signal intensity of the .OH adduct

163 Tempol inhibited the effects of IP(3) but not those of a

164 suggest that the chemopreventative effect of tempol is not solely due to the reduction of oxidative s

165 The free radical scavenger, tempol, is known to have cardioprotective properties, al

166 Moreover, 10 uM tempol led to lower ROS compared to other groups.

167 manner that was inhibited by bradykinin, AA, tempol, losartan, or apocynin.

168 ter incubation with the superoxide scavenger TEMPOL, maximal EDD improved by approximately 65% in Eln

169 Tempol may also find applications to reduce the risk of

170 l, suggesting that the protective effects of tempol may partly operate by decreasing the phosphorylat

171 suggested that SMG-1 was responsible for the tempol-mediated enhancement of p53 serine 18 phosphoryla

172 y in p53-deficient mice and the finding that tempol-mediated resistance to oxidative insult was p53-d

173 Administration of the superoxide scavenger TEMPOL, NAD(P)H oxidase inhibitor (apocynin), or anti-TN

174 ts, and administration of the O2*- scavenger TEMPOL, NAD(P)H oxidase inhibitor (apocynin), or anti-TN

175 In the presence of superoxide scavenger TEMPOL, NAD(P)H oxidase inhibitor apocynin, p38 kinase i

176 Tempol normalized basal VO2 and VCO2 and improved the wo

177 We also examined the effect of ICV Tempol on the RVLM of CHF rabbits.

178 s of a membrane-permeable radical scavenger (tempol) on the circulatory failure and MODS (kidney, liv

179 pyrroline N-oxide) or the O(2)(*-) scavenger Tempol or an SOD mimic (AEOL10113) resulted in a decreas

180 ations were inhibited by treatment with mito-tempol or apocynin or by inhibiting EGFR expression or a

181 ta with either superoxide dismutase (SOD) or tempol or apocynin significantly improved acetylcholine-

182 pletely restored by coincubation with tiron, tempol or apocynin.

183 ic arteries, which is rescued by SOD mimetic tempol or gene transfer of SOD3.

184 Treatment with the antioxidant TEMPOL or lung-specific overexpression of ecSOD prevente

185 tetramethylpiperidine1-oxyl (tempol) or Mito-tempol or MitoQ in the presence or absence of PEG-catala

186 Treatment with the superoxide scavenger tempol or the isoketal scavenger 2-hydroxybenzylamine (2

187 Administration of the SOD mimetic mito-tempol or the NADPH oxidase inhibitor apocynin attenuate

188 RPM2+/+ mice with the free radical scavenger Tempol or the PARP1 inhibitor 3-aminobenzamide attenuate

189 ion of L-arginine or a superoxide scavenger, tempol or tiron, attenuated sympathetic vasoconstriction

190 ydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL or TPL) in the ischemic isolated rat heart, allow

191 ydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL) or mice overexpressing lung-specific extracellul

192 ydroxyl-2,2,6,6-tetramethylpiperidine1-oxyl (tempol) or Mito-tempol or MitoQ in the presence or absen

193 blocked by the antioxidant 4-hydroxy-TEMPO (TEMPOL) or the mitochondrial uncoupler carbonyl cyanide

194 reduced by intracerebroventricular losartan, tempol, or apocynin in CHF rabbits but not in sham rabbi

195 restored by coincubation with ascorbic acid, Tempol, or apocynin.

196 olished by intracerebroventricular losartan, tempol, or apocynin.

197 ed by treatment of the superoxide scavenger, TEMPOL, or by overexpression of manganese superoxide dis

198 prevented by losartan, superoxide scavenger TEMPOL, or NADPH oxidase inhibitor apocynin.

199 asone, the reactive oxygen species scavenger tempol, or the glial inhibitor minocycline attenuated th

200 of ceramide levels in the ileum and serum in tempol- or antibiotic-treated mice fed a HFD resulted in

201 osure of the protein to the stable nitroxide TEMPOL oxidizes and degrades the cluster and drastically

202 Tempol, oxypurinol, or SB203850 decreased O2- in all gro

203 by preincubation with Tiron, ascorbic acid, Tempol, oxypurinol, or SB203850, an inhibitor of p38 kin

204 73 arbitrary units (a.u.); before vs. after tempol; P < 0.05).

205 4-hydroxy-2,2,6,6-tetramethylpiperidinyloxy (TEMPOL) partially recovered impaired endothelial functio

206 Tempol plus catalase further decreased ACh-mediated vaso

207 roxide dismutase mimetic Tempol (100 um) and Tempol plus the hydrogen peroxide (H(2)O(2)) scavenger c

208 Both TEMPOL and TEMPOL/PNA give rise to prevention of apoptosis and to t

209 TEMPOL/PNA is also less toxic than TEMPOL in mice, allow

210 TEMPOL/PNA is more effective against depression of activ

211 PC12 cells treated with 6-OHDA, but in vivo, TEMPOL/PNA maintains redox-active blood levels of TEMPOL

212 eridine-1-oxyl and polynitroxylated albumin (TEMPOL/PNA), an antioxidant complex that facilitates rec

213 On the other hand, tempo, but not tempol, potently activated stress-activated protein kina

214 Furthermore, TEMPOL pretreatment prevented nicotine effects on stimul

215 t with the reactive oxygen species scavenger Tempol prevented FRD-induced apoptosis in WT mice.

216 iredoxin-6 overexpression or the SOD mimetic tempol, prevented chromatin SUMO3 depletion, HDR loss of

217 We suggest that Tempol protected IRP2(-/-) mice by disassembling the cyt

218 Treatment with L-NAME or TEMPOL protected retinal neurons and confirmed the invol

219 we investigate the relaxation effects of the TEMPOL radicals used for the hyperpolarization process a

220 in modulating the cardioprotective effect of tempol, rats were injected with the STAT1 activator, IFN

221 O(2)(-) scavenging with Tempol reduced flow-induced vasodilatation from all grou

222 Tempol reduced oxidative stress and thereby restored D1

223 The permeant superoxide dismutase mimetic tempol reduced the effects of AngII400 on the SBP (-1.7

224 Tempol reduced the incidence of hematopoietic neoplasms

225 When combined with caspase inhibition, tempol reduced the production of ROS and provided an add

226 IKKbeta(-/-) cells, BCL10 silencing, but not Tempol, reduced the CGN-induced increases in KC, phospho

227 The antioxidant tempol reduces obesity in mice.

228 atment of the cerebral microcirculation with tempol restored impaired nNOS-dependent vasodilatation i

229 Infusion of the ROS scavenger tempol restored sympatholysis in these rats.

230 Addition of the superoxide radical scavenger tempol restored the ability of bradykinin, enalaprilat,

231 Intracameral injection of TEMPOL resulted in a decrease of nearly 70% in the level

232 ical, 2,2,6, 6-tetramethyl-1-piperidinyloxy (TEMPOL), resulted in protection of plasma Fe-TF against

233 f AMPKalpha1(-/-) mice with the antioxidant, tempol, resulted in decreased reticulocyte counts and im

234 chromatography demonstrated that conjugated tempol retained its efficacy to scavenge superoxide in p

235 Addition of tempol reversed the defects in responsiveness to enalapr

236 of MG132 or a superoxide dismutase mimetic, tempol, reversed the diabetes mellitus-induced reduction

237 ng showed that Ang II elicited losartan- and TEMPOL-sensitive superoxide production in arterioles.

238 DHE staining showed that CRP produced TEMPOL-sensitive superoxide production in the arteriolar

239 eeks after x-ray, rabbits irradiated without TEMPOL showed either stage 5 (complete posterior subcaps

240 r PBN and the superoxide-selective scavenger TEMPOL significantly attenuated nicotine-induced hyperlo

241 Compared to vehicle treated CHF rabbits, Tempol significantly decreased AT1R protein expression (

242 Finally, suppressing O(2)(-) production with tempol significantly increased renal K excretion measure

243 ravenous nicotine self-administration study, TEMPOL significantly reduced nicotine-taking behavior wi

244 Both valsartan and tempol substantially attenuated mitochondrial lipid pero

245 FN-gamma abrogated the protective effects of tempol, suggesting that the protective effects of tempol

246 contractions to AngII that are normalized by tempol (superoxide dismutase mimetic), whereas contracti

247 Furthermore, addition of tempol (superoxide dismutase-mimetic) which is a superox

248 Oxidized but not reduced TEMPOL (TEMPOL-H) was an effective radioprotector in cul

249 ydroxyl-2,2,6,6-tetramethylpiperidin-1-oxyl (tempol) throughout exposure to intermittent hypoxia impr

250 tion in HF-SED was normalized by apocynin or TEMPOL to LF-SED and HF-RUN.

251 effect may be associated with the ability of TEMPOL to protect against radiation-produced peroxides b

252 Moreover, with the treatment of antioxidant tempol to suppress RNS, not only are DNA lesions signifi

253 elin-1 that was normalized by ifetroban plus tempol together.

254 Addition of catalase to Tempol-treated arterioles eliminated flow-induced vasodi

255 In Tempol-treated arterioles, flow-induced vasodilatation w

256 The reduction in oxidative DNA damage in tempol-treated FA fibroblasts and mice suggests that its

257 ue-Dawley, untreated Ren2, and valsartan- or tempol-treated Ren2 rats.

258 show lower diet-induced obesity, similar to tempol-treated wild-type mice.

259 arp apical ROMK staining was observed in the tempol-treated WT or gp91(-/-) mice.

260 Furthermore, tempol treatment did not adversely affect the repopulati

261 Further, tempol treatment does not decrease weight gain in Fxr(De

262 tribution in WT, gp91(-/-), and WT mice with tempol treatment in response to K restriction.

263 In contrast, tempol treatment in WT mice abolished whereas deletion o

264 Its increased levels during tempol treatment inhibit FXR signalling in the intestine

265 In contrast, the tempol treatment not only increased channel activity to

266 Tempol treatment of cancer-prone p53-deficient mice resu

267 Tempol treatment reduced ROS, restored mitochondrial mem

268 Surprisingly, tempol treatment specifically increased serine 18 phosph

269 m gp91(-/-) mice and completely abolished by tempol treatment.

270 conditions that were improved by apocynin or tempol treatment.

271 tan or superoxide dismutase/catalase mimetic tempol treatment.

272 rylated STAT1 and STAT3 and examined whether tempol was able to affect STAT activation after in vivo

273 TEMPOL was effective in protecting against lens epitheli

274 Consistent with these data, tempol was found to be noncytotoxic, whereas tempo induc

275 Tempol was given to each mouse for 7 days by an intraper

276 adioprotector in cultured rabbit lenses, and TEMPOL was nearly completely bioreduced in the plasma an

277 nsion, whereas a similar dose of nontargeted TEMPOL was not effective.

278 In vitro studies showed that TEMPOL was reduced rapidly by ascorbic acid but not by r

279 The latter process was inhibited by tempol, which recombines with the hSOD1-derived tryptoph

280 binding to Brca1 promoter by the antioxidant Tempol, which reduces NADH levels, relieved CtBP1-mediat

281 Furthermore, Tempol, which restored SERCA activity and decreased oxid