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1 and whether associated with VGLUT1 or VGLUT2 terminals.
2 es, and had enlarged mossy fiber presynaptic terminals.
3 rees C) suggested early involvement of the N-terminal (1-11) and central (12-19) fragments in interac
7 he modus operandi for NAA80-mediated actin N-terminal acetylation, a modification with a major impact
8 able interactor and regulator of the actin N-terminal acetyltransferase NAA80, and establish the modu
10 -dependent force transfer required talin's C-terminal actin binding site, ABS3, but not vinculin.
11 amate are released, Na(+) accumulated in the terminals, activated vesicular Na(+)/H(+) exchanger, and
13 portance of stereochemistry, the effect of N-terminal acylation, and homologation between the two est
14 proline II helix, while segment 2 of ArkA (C-terminal) adopts a 310 helix, but is far less structured
15 atom leads to a planar bicyclic frame with a terminal Al-O(*-) radical site, accompanied by a change
16 ave been limited to conjugated, strained, or terminal alkenes(2-4); only a few examples occur by the
17 (4) catalyze the cis haloalkynylation of the terminal alkyne, whereas introduction of a weakly basic
18 B acidic patch regions through the SMARCB1 C-terminal alpha-helix and the SMARCA4/2 C-terminal SnAc/p
19 tive cysteine pair at the groove (C55) and C-terminal alpha9 helix (C175) of BFL-1 operates as a redo
20 inhibitory activity, we propose that those C-terminal amino acid residues are a potentially targetabl
23 thin exons 1 and 9 produces four different N-terminal and three different C-terminal products (type I
24 ad greater spine density, larger presynaptic terminals, and more putative efferent filopodial contact
27 ic localization of TRPV1 to smooth muscle of terminal arterioles in the heart, adipose tissue and ske
28 d in VIP(+)/ChAT(+) interneuron pre-synaptic terminals, as quantitative molecular analysis shows that
33 This subpopulation formed clusters within terminal bronchioles and exhibited enriched clonogenic o
34 -43 from the axonal shaft to the presynaptic terminal but also its activation in the axonal bouton by
36 fects on the RNA-unwinding activity of the N-terminal cassette, with one configuration enhancing and
37 are emerging as new, important regulators of terminal cell differentiation, including neurons and gam
38 the superficial localization of itch neuron terminals, cells that dwell close to the skin contribute
39 is a 2ODH of plant origin and catalyzes the terminal chlorination step in the biosynthesis of (-)-ac
44 tructure of the periplasmic complex of the C-terminal CSS domain (CCSSD) of PupR, the sigma regulator
46 e condensation between CBT derivatives and N-terminal cysteine residues has been established as a bio
47 s of C-type lectin-like domains, where the N-terminal cysteine-rich and fibronectin domains reside at
49 ugation of 2-cyanobenzothiazole (CBT) with N-terminal cysteines (NCys) typically gives a luciferin pr
50 ense mutations that partially truncate its C-terminal cytoplasmic regulatory domain impair NHE6 activ
51 ropeptides with tripeptide stems lacking the terminal d-ala-d-ala and reduced peptidoglycan cross-lin
53 optotic cellular events as evidenced by both terminal deoxynucleotidyl transferase dUTP nick-end labe
54 and induced apoptosis, as determined by the terminal deoxynucleotidyl transferase mediated deoxyurid
55 decreased retinal apoptosis as shown by the terminal deoxynucleotidyl transferase-mediated dUTP nick
57 F2 is regulated by interaction between its N-terminal diaphanous inhibitory domain (DID) and its C-te
61 its downstream target KCTD1 is essential for terminal differentiation of early stage DCTs into mature
62 Ts into mature DCTs, and impairment of their terminal differentiation owing to lack of KCTD1 leads to
65 trate; an interfacial site between TMD and C-terminal domain (CTD) that modulates the Zn(2+) transpor
66 rase II (RNA Pol II) contains a disordered C-terminal domain (CTD) whose length enigmatically correla
68 mode of binding to non-bromodomain and extra terminal domain (non-BET) bromodomains through displacem
69 omain (RBD) and those directed against the N-terminal domain (NTD), indicating that both of these reg
70 TRADD (TRADD-N), which interacts with the C-terminal domain (TRADD-C) and TRAF2 to modulate the ubiq
71 th glutamic acid/aspartic acid-rich carboxyl-terminal domain 2 (CITED2) as a critical intrinsic negat
72 ameshift mutations, including those in the C-terminal domain and a large number of patient-associated
73 (PrP(C)) comprises two domains: a globular C-terminal domain and an unstructured N-terminal domain.
74 ription start site and phosphorylating the C-terminal domain for RNA polymerase II (RNAPII) for activ
75 t to a critical importance of the cationic N-terminal domain in mediating antibacterial, antiparasiti
78 ffinity, and that antibodies targeting the N-terminal domain of ERFE that prevent ERFE-BMP6 interacti
79 ed and solved the crystal structure of the C-terminal domain of NP (NP-Ct), but its role in virus rep
82 structural and biophysical analyses of the C-terminal domain of the bacteriophage phi29 ATPase (CTD)
84 lpha-MoRE) of the intrinsically disordered C-terminal domain of the measles virus nucleoprotein (N(TA
85 three-dimensional dimeric structure of the N-terminal domain of the MERS-CoV nucleocapsid protein (ME
86 tic, and antiinvasive activities, with the C-terminal domain potentiating the 2 latter activities.
87 In contrast, we found two residues in the C-terminal domain, tyrosine 351 and glutamate 355, that in
90 igation of rC0C7 (exogenous [recombinant] N'-terminal domains C0 to C7 of cardiac myosin binding prot
91 central domains synapse the ends while two C-terminal domains form a separate dimer that contacts onl
92 FACT appears to be protected by the carboxy-terminal domains of both of its subunits, and this inhib
93 usly shown that one likely function of the C-terminal domains of OPG is to bind cell surface heparan
95 le much is known about the function of the N-terminal domains of OPG, which is responsible for bindin
96 ction of a range of mini-spidroins with both terminal domains, and characterize their response to a n
99 and functionally modular, consisting of an N-terminal effector domain (NTD) and a C-terminal regulato
100 CE STATEMENT Noxious stimuli are detected by terminal endings of primary nociceptive neurons, which a
102 clusters of acetylcholine receptors and axon terminals exhibited numerous terminal varicosities.
104 that a soluble fragment generated from the N-terminal extracellular domain of PC-1 functions as an in
105 he synovium of 28 of 30 rhesus macaques with terminal filovirus disease had evidence of infection (64
106 axons in the corpus callosum and that their terminals form excitatory, glutamatergic synapses on hos
107 synthetic binding proteins, that bind the N-terminal four-helix bundle (4HB) "killer" domain and nei
109 interactions during the lag phase, whereas C-terminal fragments (20-32 and 26-32) showed limited invo
111 t and other tumors characterized by PIK3CA C-terminal frameshift mutations may derive benefit from p1
112 urface:intracellular distribution in DAergic terminals from female ventral, but not dorsal, striatum.
114 e N-terminal myristoylation signal and the C-terminal FXXF motif in PKAc regulate its thermal stabili
115 c dissection experiments revealed that the N-terminal G domain of GBP2 mediates these anti-MNV effect
120 the LegK7-MOB1A complex revealed that the N-terminal half of LegK7 is structurally similar to eukary
123 disordered region that connects the N- and C-terminal halves in many eukaryotic ABC transporters, all
125 We show here that the strongly amphipathic N-terminal helix of CPn0678 mediates binding to phospholip
129 pots were identified within the A-band and N-terminal I-band that closely correlated with regions of
130 nfirmed enteric fever or with a nontraumatic terminal ileal perforation, with a median cost of illnes
131 e the microbial communities' compositions of terminal ileum and large intestine in 5 healthy individu
132 ally colocalized with thalamic over cortical terminals in both the striosome and matrix compartments.
137 f As terminals outnumbered that of S1 and S2 terminals in VApc and CM of control and parkinsonian ani
138 ves S1 inputs, and activation of the S1 axon terminals increases the response to noxious stimuli in A
139 in sensory thalamic systems, large amygdalar terminals innervated excitatory relay and inhibitory neu
140 oid receptor, CB1R, is expressed on afferent terminals instead of output neuron Purkinje cell synapse
142 ese toxins to target and bind to motor nerve terminals is a key factor determining their potency and
143 ntegrity of dopaminergic nigrostriatal nerve terminals is associated with nigrostriatal axonal dysfun
145 colocalized with the post-synaptic afferent terminals is likely to increase, indicating the presence
146 analysis indicated that ICP22 contains an N-terminal J domain and a C-terminal substrate binding dom
147 NEMO in the activation of oncogenic c-Jun N-terminal kinase (JNK) signaling, induced by the latent m
148 gen-activated protein kinase (MAPK), Jun NH2-terminal kinase (JNK), and nuclear factor kappa-light-ch
149 lated kinase 1/2 (ERK1/2), p38 and Jun amino-terminal kinase (JNK), which consequently potentiates Pi
152 ular signal-regulated kinase 1/2 and c-Jun N-terminal kinase activation, which contributed to CXL146-
154 the protein originating in the peripheral C-terminal ligand binding site and culminating in pore ope
155 ich derives from a hairpin with a suboptimal terminal loop and a suboptimal stem length, accumulates
156 three RNA recognition motifs (RRMs) and a C-terminal low-complexity domain, sometimes referred to as
158 ntion through a mechanism dependent on its C-terminal lysine residue; its deletion led to modest redu
160 onstrated that MCM10 is required for NK cell terminal maturation and acquisition of immunological sys
161 ajmaline-induced BrS, CineECG localized the terminal mean temporospatial isochrone forces in the RVO
164 ly more potent than the S diastereomer and N-terminal modification generally lowers TLR2 activity.
165 ottom cells, we achieved a PCE of 27% in two-terminal monolithic tandems with an area of 1 square cen
167 hat the [4Fe-4S](2+) cluster formed at the N-terminal motif of NUBP1 is tightly bound, while the [4Fe
169 tructural modeling have suggested that the N-terminal myristoylation signal and the C-terminal FXXF m
171 reveals a crystalline intermediate wherein N-terminal nucleation domains exhibit motional dynamics wi
172 thyl substituents attached to the 5'- and 3'-terminal nucleotides, respectively, provided insight int
173 bstantially accumulated in the calyx of Held terminals of juvenile mice of either sex during high-fre
175 el of density functional theory show how the terminal OH groups on node vacancies act as Bronsted bas
176 process is compatible with both internal and terminal olefins and tolerates a diverse array of functi
178 arctica expressed a complete pathway for the terminal oxidation of n-alkanes including two alkane mon
179 on of which occurs via the cis form when the terminal oxygen atom of the NOO moiety reacts with the o
181 itor of both the alternative pathway and the terminal pathway, with possible applications in compleme
183 training classification deepnets involves a terminal phase of training (TPT), which begins at the ep
187 ifically, we show that substitution of the N-terminal plug His-221 disrupts both signaling and transp
188 Pol2 is a fusion of two B-family Pols; the N-terminal Pol module is catalytic and the C-terminal Pol
191 ween mixing and freezing, we find that the N-terminal portion of M13 converts from a conformationally
192 g (ChIP-seq) was used to assess a range of N-terminal posttranscriptional modifications (marks) to hi
193 the Rab Ypt7, bound to membranes by either C-terminal prenyl groups (Ypt7-pr) or a recombinant transm
194 tracellular glutamate density in presynaptic terminals, presynaptic mitochondria, and in dendritic sp
196 ulating IL6 (interleukin-6) and NT-proBNP (N terminal pro B-type natriuretic peptide) levels were exa
197 m >11 mm) and elevated cardiac biomarkers (N-terminal pro-B-type natriuretic peptide [>40 pg/mL] or t
198 <=40% and a modest elevation of NT-proBNP (N-terminal pro-B-type natriuretic peptide) were eligible.
200 ybrid peptide-thiourea catalyst features a N-terminal proline moiety for aldehyde activation and a th
201 2 by 4% (95% CI: 1% to 7%; p = 0.002), and N-terminal propeptide of collagen III by 3% (95% CI: 0% to
202 ic and nonphotosynthetic bacteria lack the C-terminal prosequence, suggesting it is a recent function
203 n immune responses by activating the c-Jun N-terminal protein kinase (JNK) and NF-kappaB pathways; ho
204 dings indicate that there are lower synaptic terminal protein levels in schizophrenia in vivo and tha
205 -termini relies on the generation of single, terminal proteotypic peptides followed by chemical enric
206 preferential manner and with larger synaptic terminals, providing a putative explanation for function
207 blished receptors, an extended loop in the C-terminal receptor-binding domain (HC) of BoNT/B (HC/B) h
208 ion systems, carbon monoxide was used as the terminal reductant, preventing difficult postreaction se
210 yotic replisome, Timeless, harbours in its C-terminal region a previously unappreciated DNA-binding d
211 roteins from chromatin, bound to the Stat3 C-terminal region and antagonized its transcriptional and
212 ng of the [4Fe-4S] cluster by the flexible N-terminal region and the associated inhibition of the act
213 n homology (PH) domains interacts with the N-terminal region comprising ARL8- and kinesin-1-binding s
214 -function analyses of SKIP reveal that the C-terminal region comprising three pleckstrin homology (PH
215 missense mutations in the RING domain and N-terminal region compromise its activity, and therefore p
216 th a C-terminal RING domain and disordered N-terminal region containing SUMO Interactions Motifs (SIM
219 bine the CsgG nanopore with the 35-residue N-terminal region of its extracellular interaction partner
220 elic variants, antibodies elicited against C-terminal region of protein did not correlate with epidem
223 healthy donors responded similarly to the C-terminal region of the spike proteins of the human endem
225 re-forming alpha1 subunit and, through its C-terminal region, scaffolds the beta subunit of VGCC and
228 of UPF1 occurs in its unstructured N- and C-terminal regions at Serine/Threonine-Glutamine (SQ) moti
229 rpin peptides derived from the central and C-terminal regions of Abeta, which bear "tails" derived fr
230 topological stress require distinct N and C terminal regions of the protein, whereas the other funct
233 an N-terminal effector domain (NTD) and a C-terminal regulatory domain (CTD); a carotenoid spans the
234 unction analysis indicates that several long-terminal-repeat bursts that occurred from 5.7 million ye
236 adation of target mRNAs, mediated by three N-terminal Repression Domains (RDs), which are unique to P
238 N and C termini, and deletion of up to 11 C-terminal residues had little impact on the agonist-induc
239 the core interactions between SUN and the C-terminal residues of the KASH peptide are similar in all
241 vidence for correction of mis-annotated 28 C-terminal residues within the NADH dehydrogenase subunit
242 ipin membrane domains via a patch of basic C-terminal residues, and this membrane sequestration is di
245 nctional domains: a catalytic domain and a C-terminal ricin-like lectin domain comprised of three pot
247 ery large extracellular domain, was found in terminal Schwann cells within Meissner's corpuscles.
248 show that structural rearrangements in the N-terminal segment (NTS) can stabilize this Pfr-like state
250 at CDR3beta reaches the peptide's featured C-terminal segment for pMHC sampling, establishing the sub
251 dent calmodulin bound to the intracellular C-terminal segment of the GluN1 subunit of the receptor.
254 d appeared to have a mutated transposase and terminal sequences, while a second 3131 bp element, hopp
255 onorNet data, including admission, peak, and terminal serum creatinine, and biopsy data when availabl
256 eudobactin BN7/8 transport system, and the N-terminal signaling domain (NTSD) of PupB, an outer-membr
257 as been difficult, leading to focus on the C-terminal six cysteine domain (6C) with the use of fusion
258 1 C-terminal alpha-helix and the SMARCA4/2 C-terminal SnAc/post-SnAc regions, with disease-associated
259 in containing an N-terminal cutinase and a C-terminal SnapTag domain react with an ethyl p-nitropheny
261 ins in a proline-rich region between their N-terminal Src homology and Bcr homology domains disrupts
262 an be combined with two different types of C-terminal ssDNA binding domains to form diverse bacterial
264 e tuned depending on the stress and that its terminal subcellular address influences the decision bet
265 a-fold, followed by a secretin/TonB, short N-terminal subdomain at the C terminus of the CCSSD, a pre
266 CP22 contains an N-terminal J domain and a C-terminal substrate binding domain, similar to type II ce
268 inding to incoming monomers, and flatten the terminal subunit, which likely promotes ATP hydrolysis a
269 unique contacts between the penultimate and terminal subunits are consistent with existing cryogenic
270 iding cells and binds directly to both the N-terminal tail and the histone fold domain of non-nucleos
271 Finally, we provided evidence that the C-terminal tail of DHHC5 can be palmitoylated in response
274 egulated by a conformational change in the C-terminal tail that leads to creation of an enlarged bind
276 : 0% to 6%; p = 0.04) and increased carboxyl-terminal telopeptide of collagen type I by 4% (95% CI: 1
277 ging from the presence of fine versus beaded terminals, the vast majority of these neurons provide in
278 s-Alder cycloaddition through their inherent terminal thiocarbonylthio moiety with a diene-modified m
281 specifically, we show that acidic residues N-terminal to the substrate pTyr in EGFR and HER2 mediate
282 that a conserved transesterification unit (N-terminal toroid structure) for cutting and rejoining of
283 ICCB-19 and Apt-1 bind to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N), which
284 sm by which the intrinsically unstructured N-terminal translocation domain (IUTD) of the endonuclease
286 vealed that the structure of the nociceptive terminal tree determines the output of nociceptive neuro
287 m multiple terminals is integrated along the terminal tree, computing the neuronal output, which prop
289 -Phe binding and mutation of the conserved N-terminal Trp8 to Ala both promote an inward-facing state
290 isease-linked and experimentally generated C-terminal truncated KCNQ3 mutants retain the ability to a
291 ing the Src-binding motif of Kv1.5 through N-terminal truncation or mutagenesis abolished the mechani
292 racellularly applied proteinase K (PK), an N-terminal truncation up to amino acid residue 209 altered
293 ent-derived xenografts and cell lines with C-terminal truncations showed increased cell surface Frizz
297 er a decades-old question on the function of terminal web myosin and hold broad implications for unde
298 operant self-stimulation of thalamostriatal terminals when ChR2 expression was virally targeted to t
299 ity and Ca(2+) transients in the presynaptic terminals, where Kv1.2 potassium channels are downregula
300 among innate immune sensors because of its N-terminal Zalpha1 and Zalpha2 domains, which bind to nucl