ライフサイエンスコーパス: terminal domain

1 hich interacts with XPB mainly through its N-terminal domain.

2 ct with positively charged residues in the C-terminal domain.

3 nopened dsDNA portion will bind to another C-terminal domain.

4 a conserved tyrosine (Y382) in the carboxyl-terminal domain.

5 nding to a nonoverlapping site on the CD73 N-terminal domain.

6 th a beta-sandwich structure and a diverse N-terminal domain.

7 ability to interact with Mhf1-Mhf2 via its C-terminal domain.

8 c-di-AMP-dependent regulation requires the C-terminal domain.

9 Thr231) in the proline-rich region of the N-terminal domain.

10 rylation of either Ser396 or Ser404 in the C-terminal domain.

11 : 1 from the palm subdomain and 2 from the N-terminal domain.

12 domain remains active independently of the N-terminal domain.

13 3, which leads to the demethylation of its C-terminal domain.

14 transient interactions with the structured C-terminal domain.

15 the GSDMD C-terminal domain distal to its N-terminal domain.

16 omoting eviction of histone H1 through its N-terminal domain.

17 roteins that lack the characteristic nexin C terminal domain.

18 zinc finger domain, as well as an extended C-terminal domain.

19 ular C-terminal domain and an unstructured N-terminal domain.

20 etitive protein strands, flanked by globular terminal domains.

21 g RNA, which is held in place by auxiliary C-terminal domains.

22 s bind ligands either within the N- or the C-terminal domains.

23 by these factors is dependent on divergent N-terminal domains.

24 s bound in opposite polarity to the N- and C-terminal domains.

25 oted interaction between the PrP(C) N- and C-terminal domains.

26 1 likely interacts with Pso2 through their N-terminal domains.

27 he protein's toxic N-terminal and globular C-terminal domains.

28 t flanked by serine residues between their N-terminal domains.

29 th glutamic acid/aspartic acid-rich carboxyl-terminal domain 2 (CITED2) as a critical intrinsic negat

30 A deletion mutant of EZH2, lacking its N-terminal domain, abrogates both TGF-beta-stimulated EZH2

31 ntractile tail phages, such as T4, and its C-terminal domain adopt an Ig-like fold of unknown functio

32 TET2 has a large N-terminal domain and a catalytic C-terminal region.

33 ameshift mutations, including those in the C-terminal domain and a large number of patient-associated

34 YRKs included an absence of the regulatory N-terminal domain and a unique conformation of the CMGC-in

35 Mechanistically, both the Ecm29 N-terminal domain and an intact AIS structure are required

36 (PrP(C)) comprises two domains: a globular C-terminal domain and an unstructured N-terminal domain.

37 Sixteen Ca ions are present in the LH1 C-terminal domain and are coordinated by residues from the

38 PCF11, which directly binds to the Pol II C-terminal domain and dismantles elongating Pol II from DN

39 bound PP2A dephosphorylates the RNA Pol II C-terminal domain and Spt5, preventing the transition to p

40 l oligomerization domain, while the folded N-terminal domain and the C-terminal IDR are not required.

41 we have solved the crystal structures of its terminal domains and functionally characterized them.

42 ction of a range of mini-spidroins with both terminal domains, and characterize their response to a n

43 red N-terminal domain (NTD) and structured C-terminal domain are essential for silencing.

44 onserved aromatic residues within the CCS1 C-terminal domain are integral in these processes.

45 ndows an additional function for the GSDMD C-terminal domain as a caspase-recruitment module besides

46 ndent O-GlcNAcylation of SIRT1, within its N-terminal domain, as a crucial determinant of hepatic fun

47 CesA's N-terminal domains assemble into a cytosolic stalk that in

48 ive N-glycosylation sites within the large N-terminal domain at N65 and N82.

49 nal extension that positions the conserved C-terminal domain at the ribosomal tunnel exit for an effi

50 erically inhibited clustering much less than terminal domains because the latter effectively restrict

51 rt failure, focusing on the bromo- and extra-terminal domain (BET) family of chromatin co-activator p

52 ibitors against BRDs of the bromo- and extra-terminal domain (BET) family proteins, non-BET family BR

53 Inhibitors for the bromo- and extra-terminal domain (BET) family were of particular interest

54 Pan-bromodomain and extra terminal domain (BET) inhibitors interact equipotently w

55 protein levels of the Bromodomain and extra-terminal domain (BET) protein BRD4 are significantly inc

56 A (CoA) homeostasis to Bromodomain and Extra-Terminal domain (BET) protein recruitment to chromatin.

57 , utilizing a PSTS motif matching the USP7 N-terminal domain-binding A/PxxS consensus, but uniquely r

58 During transposition, an array of N-terminal domains binds a single transposon end while the

59 3 C-terminal domain complex and the Nup133 N-terminal domain, both from S. cerevisiae.

60 al activation activity, due to a divergent C-terminal domain, but retains the ability to interact wit

61 DNA and tethers H2A-H2B through its carboxy-terminal domain by acting as a placeholder for DNA.

62 igation of rC0C7 (exogenous [recombinant] N'-terminal domains C0 to C7 of cardiac myosin binding prot

63 mmaC0C7 (endogenous [genetically encoded] N'-terminal domains C0 to C7 of cardiac myosin binding prot

64 ch for removal and replacement of cMyBP-C N'-terminal domains (C0-C7) in detergent-permeabilized card

65 We demonstrate that the CX3CL1 C-terminal domain can upregulate neurogenesis, which may a

66 tosis via the pore-forming activity of its N-terminal domain, cleaved by activated caspases associate

67 Nascent C-terminal domain clusters at primed genomic loci lower th

68 d structures: the full-length Nup84-Nup133 C-terminal domain complex and the Nup133 N-terminal domain

69 ugh a modular structural architecture: the N-terminal domain comprises a DNA binding/tetramerization

70 Furthermore, we identified a C-terminal domain conserved in all tonoplast-localized ALM

71 as delayed specifically in the presence of N-terminal domain containing TDP-43 variants, while C-term

72 amino acid-long N-terminal extension and a C-terminal domain containing two heme regulatory motifs (H

73 cal oligomers which, when aligned with the N-terminal domain crystal structure, suggest an N-terminal

74 ic N-terminal domain (NTD) and a catalytic C-terminal domain (CTD) connected by a short linker.

75 nal modifications of the RNA polymerase II C-terminal domain (CTD) coordinate the transcription cycle

76 n and negative imprinting, a region in the C-terminal domain (CTD) exhibits a differential behavior,

77 ealed that multiple genes related to carboxy-terminal domain (CTD) family proteins, including the gin

78 though it is now established that the long C-terminal domain (CTD) of H1 remains disordered upon nucl

79 e methyltransferase (MTase) domain and the C-terminal domain (CTD) of L adopt a unique conformation,

80 to the conserved elongation factor binding C-terminal domain (CTD) of ribosomal P stalk proteins to i

81 inase 12 (CDK12) phosphorylates the carboxyl-terminal domain (CTD) of RNA polymerase II (pol II) but

82 lates transcription by phosphorylating the C-terminal domain (CTD) of RNA polymerase II (RNAPII).

83 The C-terminal domain (CTD) of RNA polymerase II contains a re

84 its the phosphorylation of serine-2 in the C-terminal domain (CTD) of RNA-polymerase II (Pol II), and

85 n this work, we tested the function of the C-terminal domain (CTD) of Rpf2 during these anchoring ste

86 asmic reticulum (ER) membranes, the carboxyl-terminal domain (CTD) of SREBPs binds to the CTD of Scap

87 We tested the proposal that the C-terminal domain (CTD) of the AMPAR subunit GluA1 is requ

88 -TEFb) phosphorylates Ser2 residues of the C-terminal domain (CTD) of the largest subunit (RPB1) of R

89 Interest in the C-terminal domain (CTD) of the RPB1 subunit of the RNA pol

90 enabled measurement of RDCs in the mobile C-terminal domain (CTD) of the stalk protein bL12.

91 with CPL2, a plant-specific Pol II carboxyl terminal domain (CTD) phosphatase, to form the BAH-PHD-C

92 trate; an interfacial site between TMD and C-terminal domain (CTD) that modulates the Zn(2+) transpor

93 arginine residue in the RNA polymerase II C-terminal domain (CTD) to citrulline, uncovering a potent

94 PASS associates with the RNA polymerase II C-terminal domain (CTD) to establish proper levels and dis

95 rase II (RNA Pol II) contains a disordered C-terminal domain (CTD) whose length enigmatically correla

96 esidues for DNAJB6b oligomerization in its C-terminal domain (CTD).

97 point, leads to SUMOylation of the Topo II C-terminal domain (CTD).

98 lymerase II by hyperphosphorylation of its C-terminal domain (CTD).

99 rted through, and a regulatory cytoplasmic C-terminal domain (CTD).

100 cognize different DNA motifs, via diverged C-terminal domains (CTDs).

101 jects away from the crescent-shaped FIP200 N-terminal domain dimer.

102 ound a hydrophobic pocket within the GSDMD C-terminal domain distal to its N-terminal domain.

103 for DNA binding, and two YefM dimers with N-terminal domains dock into the adjacent major grooves of

104 e contributions for the spectrin and carboxy-terminal domains during different phases of spindle elon

105 protein micelles due to the addition of both terminal domains exhibit shear-thinning, a property whic

106 The C-terminal domain facilitates ER export of proSP-B.

107 e A (PKA), which phosphorylates SK2 in its C-terminal domain, facilitating its endocytosis.

108 1, an inhibitor of the bromodomain and extra terminal domain family that includes BRD2, BRD3, BRD4, a

109 rying a TRPV1 construct lacking the distal C-terminal domain features an enhanced response to capsaic

110 ription start site and phosphorylating the C-terminal domain for RNA polymerase II (RNAPII) for activ

111 central domains synapse the ends while two C-terminal domains form a separate dimer that contacts onl

112 taNPylRS/(DeltaNPyl)tRNA pairs (which lack N-terminal domains) form two distinct classes.

113 ies the site of LC3 lipidation, includes a C-terminal domain formed by 7 WD40-type repeats (WD40 doma

114 C-terminal fragments of TDP-43 CTD (TDP-43 C-terminal domain), formed upon proteolytic cleavage of fu

115 hase when ATP binding prevents the epsilon C-terminal domain from entering the inhibitory 'up' state.

116 t by S1P and then by S2P, liberating their N-terminal domains from membranes and enabling them to act

117 rinsically disordered linker histone carboxy-terminal domain (H1 CTD) influences chromatin structure

118 The N-terminal domain had a pentameric nucleoplasmin-fold; mak

119 Its N-terminal domain has the same fold as proteins that form

120 ence microscopy to demonstrate that both a C-terminal domain histidine residue and the 2-amino group

121 AcrIIA1 binds and inhibits Cas9 with its C-terminal domain; however, the function of its highly con

122 ion, not circular or twisted, in which the N-terminal domain I (DI) and the C-terminal domain V (DV)

123 hat both DDBH1 and DDBH2 interact with the N-terminal domain I of DnaA and studied the DDBH2 interact

124 g Gle1 function, Gle1 oligomerizes via its N-terminal domain in a phosphorylation-dependent manner.

125 ese data reveal novel roles for the ANGPT2 N-terminal domain in blood vessel remodeling, tumor growth

126 IV-1 particles, and we identify a distinct C-terminal domain in CLASP2 that promotes both MT stabiliz

127 t to a critical importance of the cationic N-terminal domain in mediating antibacterial, antiparasiti

128 sizing an important role for this variable N-terminal domain in regulating actomyosin crossbridge kin

129 etailed insights into the role of the TET2 N-terminal domain in TET2 regulation.

130 surface charge of the hinge region of the N-terminal domain in the GluN1 subunit of the NMDAR is req

131 an N-terminal domain that wraps around the C-terminal domain in the oligomer.

132 We used cMyBP-C's regulatory N-terminal domains in defined phosphorylation states for p

133 lts underscore the critical roles of SNARE N-terminal domains in mediating interactions with other el

134 clade G6, an ancestral exCNL has lost its N-terminal domains in the course of evolution.

135 nfirmed that phosphorylation of SK2 in the C-terminal domain increases its ubiquitination and endocyt

136 ylinositol (PtdIns) transfer proteins PYK2 N-terminal domain-interacting receptor 2 (Nir2) and Nir3 s

137 VP40 dimers assemble extended chains via C-terminal domain interactions.

138 We find that the PRPH2 C-terminal domain interacts with STX3 as well as other pho

139 We find that the carboxy-terminal domain interacts with the plus-end tracking pro

140 to RNA polymerase binding site within the N-terminal domain, into an unbound beta-barrel that intera

141 , indicating that the activity of the BcsG C-terminal domain is essential for integrity of the pellic

142 nositide lipid content is reduced, and the C-terminal domain is key to determining agonist response i

143 We also find that the hyperphosphorylated C-terminal domain is preferentially incorporated into cond

144 The C-terminal domain is smaller in overall size than in the m

145 from S. aureus strain RN6390 indicates its C-terminal domain is toxic when targeted to the Escherichi

146 transport function by removing a conserved C-terminal domain, leading to low fruit acidity in apple.

147 mily of proteins, homologs to the CTD, the C-terminal domain-like carotenoid proteins (CCPs).

148 rated a mutant p53(KQ) mouse where all the C-terminal domain lysine residues were mutated to glutamin

149 The MCM binding region in the N-terminal domain mapped to the chromatin binding domain (

150 Upon heme binding to the N-terminal domain, MFSD7C dissociates from ETC components

151 multimerization and explained why several C-terminal domain mutations are remarkably resistant to th

152 ng N53I substitution, which resides in the N-terminal domain (N-domain).

153 l cholesterol efflux, we found that NPC1's N-terminal domain need not release from the rest of the pr

154 mode of binding to non-bromodomain and extra terminal domain (non-BET) bromodomains through displacem

155 The other is the NP C-terminal domain (NP-Ct), whose function has not previous

156 A3G consists of a non-catalytic N-terminal domain (NTD) and a catalytic C-terminal domain

157 ies to decipher the contributions of Nbr's N-terminal domain (NTD) and exonucleolytic domain (EXO) in

158 orescence to investigate the role of Tau's N-terminal domain (NTD) and proline-rich region (PRR) in r

159 A disordered N-terminal domain (NTD) and structured C-terminal domain a

160 A tunnel connecting the N-terminal domain (NTD) and the transmembrane sterol-sensi

161 ever, the function of its highly conserved N-terminal domain (NTD) is unknown.

162 Here, we report that the N-terminal domain (NTD) of RAD52 devoid of the potential m

163 re we present the crystal structure of the N-terminal domain (NTD) of the A subunit of the Bacillus m

164 The N-terminal domain (NTD) of the GluN1 subunit (GluN1-NTD) i

165 Mouse hepatitis virus (MHV) uses its N-terminal domain (NTD) of the viral spike (S) protein to

166 BILBO1's N-terminal domain (NTD) plays an essential role in T. bruc

167 They also differ substantially at N-terminal domain (NTD) surfaces involved in dimerization

168 Interactions of the Ded1 N-terminal domain (NTD) with eIF4A, and Ded1-CTD with eIF4

169 viour and thereby the role/function of the N-terminal domain (NTD) within chromatin is yet unresolved

170 omain (RBD) and those directed against the N-terminal domain (NTD), indicating that both of these reg

171 We pinpointed critical N-terminal domain (NTD), NTD-nucleotide-binding domain 1 (

172 Using the NFAT5 N-terminal domain (NTD), which contains AD1, as a model, w

173 its ligand-independent AF-1 located in its N-terminal domain (NTD).

174 ectural diversity involving additional amino-terminal domains (NTDs).

175 We also find that the conserved N-terminal domain of AcrIIA13-AcrIIA15 binds to an inverte

176 alyzes isomerization of proline 128 in the C-terminal domain of alpha-synuclein.

177 iability in the dynamics of the disordered N-terminal domain of amyloid-beta fibrils (Abeta), compris

178 tion but can fold and bind in trans to the N-terminal domain of another M1 monomer, thus polymerizing

179 geneity in determining the activity of the C-terminal domain of bacterial Enzyme I (EIC).

180 Here we present evidence that the C-terminal domain of BcsG from E. coli (EcBcsG(DeltaN)) fu

181 hway-driven hemolysis, suggesting that the C-terminal domain of C3b has an important function in clas

182 ied arrhythmogenic mutations reside in the C-terminal domain of CaM and mostly affect Ca(2+)-coordina

183 alpha-helix and develops contacts with the C-terminal domain of CaM in about 2 ms.

184 pha-helical and develops contacts with the N-terminal domain of CaM more slowly, in about 8 ms.

185 ystal structure of MOR in complex with the N-terminal domain of CI, revealing the structural basis of

186 heterodimer formed by human MCT-1 and the N-terminal domain of DENR at 2.0- angstrom resolution.

187 a highly conserved arginine residue in the C-terminal domain of diverse HPV E7 mediates the interacti

188 c repair intermediates and the presence of N-terminal domain of DNA ligase I in a coupled reaction go

189 ing nucleotide and a template base and the N-terminal domain of DNA ligase I mediates its interaction

190 ffinity, and that antibodies targeting the N-terminal domain of ERFE that prevent ERFE-BMP6 interacti

191 We found that BMP6 binds the N-terminal domain of ERFE, and a polypeptide derived from

192 show how a small alpha-helical domain, the N-terminal domain of HemK, folds cotranslationally.

193 a deletion of either the N-terminal or the C-terminal domain of HflX abrogates ribosome splitting and

194 on of intragenic tandem repeats within the N-terminal domain of HPF1 was sufficient to cause pronounc

195 nd, the NS5 RdRP domain also binds the amino-terminal domain of hSTAT2.

196 nthamiana that transient expression of the N-terminal domain of JIP60, from which the inhibitor domai

197 e conserved residues (ELEFN(50-54)) in the N-terminal domain of KSHV gH that are critical for Eph bin

198 The N-terminal domain of LiaX binds daptomycin and AMPs (such

199 Domain swapping in the alpha-helical C-terminal domain of M(pro) (M(pro)C) locks M(pro) into a

200 We find that the C-terminal domain of M1 is disordered in solution but can

201 ed and solved the crystal structure of the C-terminal domain of NP (NP-Ct), but its role in virus rep

202 four conserved cysteine-rich motifs in the C-terminal domain of ORF66.

203 methyltransferase (MT) domain of L and the N-terminal domain of P (P(NTD)) is missing.

204 erminus, the antibody response against the N-terminal domain of PfCSP (N-CSP) remains obscure.

205 ical surface of epithelial cells where the N-terminal domain of pIgR, termed secretory component (SC)

206 We find that the hypophosphorylated C-terminal domain of Pol II is incorporated into mediator

207 We show that the N-terminal domain of proSP-B is a phospholipid-binding and

208 hat two highly conserved histidines in the C-terminal domain of PrP(C) are essential for the protein'

209 The C-terminal domain of RecA binds to dsDNA and directs it to

210 Upon recruitment, the C-terminal domain of RfaH refolds from an alpha-hairpin, w

211 ase in serine-2 phosphorylation within the C-terminal domain of RNA polymerase II (RNAP II) and in th

212 hosphorylates serine 2 (Ser2) of the carboxy-terminal domain of RNA polymerase II (RNAPII), which is

213 on elongation by phosphorylating the carboxy-terminal domain of RNA polymerase II and selectively aff

214 rs that enhances its interactions with the C-terminal domain of RNA polymerase II.

215 SSUP-72 would normally remodel the C-terminal domain of RNA polymerase in anticipation of ter

216 nd the biochemical characterization of the C-terminal domain of S. aureus OatA.

217 e remodeling of PriA requires a functional C-terminal domain of SSB.

218 The carboxyl-terminal domain of STN1 interacts with CTC1 at two separ

219 We show that the carboxyl-terminal domain of TaiP exposes a mimic of an eukaryotic

220 ied hemi- and heterozygous variants in the N-terminal domain of the A isoform of FHF2 (FHF2A).

221 ation; however, molecular details like the C-terminal domain of the alpha-chain, the heparin-binding

222 structural and biophysical analyses of the C-terminal domain of the bacteriophage phi29 ATPase (CTD)

223 one of the three PCNA monomers through the C-terminal domain of the catalytic subunit.

224 Phosphorylation of the N-terminal domain of the huntingtin (HTT) protein has emer

225 de bond, during the catalytic cycle of the N-terminal domain of the key bacterial oxidoreductase DsbD

226 ine 5 of heptapeptide repeats on the carboxy-terminal domain of the largest Pol II subunit Rpb1.

227 lpha-MoRE) of the intrinsically disordered C-terminal domain of the measles virus nucleoprotein (N(TA

228 three-dimensional dimeric structure of the N-terminal domain of the MERS-CoV nucleocapsid protein (ME

229 rect interaction between mLST8 and the NH(2)-terminal domain of the mTORC2 cofactor SIN1.

230 First, we show that the N-terminal domain of the Nse4 kleisin molecule binds to th

231 amphipathic alpha-helices clustered in the N-terminal domain of the protein; biochemical analyses dem

232 er-bound (holo-) WhiB1 in complex with the C-terminal domain of the sigma70-family primary sigma fact

233 procal "tyrosine clasp" formed between the N-terminal domain of TIMP-1 and proximal MMP-3 interface a

234 in the catalytic domain or truncating the C-terminal domain of TPS1 severely compromised growth.

235 ber of the superfamily, owing to its extra C-terminal domain of unknown function and the absence of t

236 The cytosolic C-terminal domains of both NMDA receptors (NMDARs) and AMP

237 FACT appears to be protected by the carboxy-terminal domains of both of its subunits, and this inhib

238 One potential mechanism for the N-terminal domains of cMyBP-C to achieve this is by bindin

239 que to this group of proteins, whereas the C-terminal domains of DivIVA and GpsB are radically differ

240 The Nidovirales order-specific N-terminal domains of each nsp13 interact with the N-termi

241 functional interactions between the C- and N-terminal domains of MukF with the MukB head and neck, re

242 usly shown that one likely function of the C-terminal domains of OPG is to bind cell surface heparan

243 he exact biological functions of the three C-terminal domains of OPG remain uncertain.

244 le much is known about the function of the N-terminal domains of OPG, which is responsible for bindin

245 trinsically disordered region (IDR) at the N-terminal domains of OsDGAT1 proteins.

246 e actions of two proteases release the amino-terminal domains of SREBPs that travel to the nucleus to

247 that are encoded in the structured N- and C-terminal domains of the complex.

248 the hydrolysis (HD) domain and regulatory C-terminal domains of the long RSHs such as Rel, RelA, and

249 We identified N- and C-terminal domains on TRPV1 responsible for TRPA1-TRPV1 (A

250 ith the oligomerization domain (P(OD)) and C-terminal domain (P(CTD)) of a tetramer of P.

251 earlier studies, the presence of the p261 C-terminal domain (p261C) and the three small subunits inc

252 3, or with an acetylation mimicking carboxyl-terminal domain p53 mutant.

253 Signals from the N-terminal domain persist, indicating that this segment re

254 by nutritional stress, affect the RNAP II C-terminal domain phosphorylation at Ser2, and control rec

255 Young and coworkers now establish that C-terminal domain phosphorylation regulates Pol II partiti

256 ly, we reveal that the N, C, and zinc finger terminal domains play unique roles in targeting each par

257 tic, and antiinvasive activities, with the C-terminal domain potentiating the 2 latter activities.

258 Anti-ERFE antibodies targeting the N-terminal domain prevented hepcidin suppression in ERFE-t

259 horylation of threonine in the cytoplasmic C-terminal domain, providing the first direct evidence of

260 ip of the alpha-hairpin and on neighboring N-terminal domain residues.

261 ructured hydrophobic core and a disordered N-terminal domain (residues 1-16).

262 lated at Ser2 in heptad repeats within the C-terminal domain (RNAP2 Ser2ph), and miR-430 transcripts

263 The RNA polymerase II carboxyl terminal domain (RNAPII CTD) kinase complex (CTK complex

264 The C-terminal domain showed strong PPIase activity, no role i

265 showed that deletion of the 1B domain and C-terminal domain significantly reduced the helicase activ

266 d that Arg259, which is located within the N-terminal domain, specifically interacts with UDP-GlcUA,

267 ee primary tumor-associated mutants in the N-terminal domain strongly destabilize the coiled-coil str

268 used to a degenerate polymerase fold and a C-terminal domain structurally similar to Cas11.

269 Moreover, we report a unique C-terminal domain structure that participates in stabilizi

270 adopts a novel open state and has a unique C-terminal domain structure, which plays a crucial role in

271 8 of the 11 tyrosines are conserved in the N-terminal domain, suggesting that phosphorylation of tyro

272 s (TULPs) are characterized by a conserved C-terminal domain that binds phosphoinositides.

273 Inp1 mediates peroxisome retention via an N-terminal domain that binds PI(4,5)P2 and a C-terminal Pe

274 disordered regions followed by a globular C-terminal domain that binds the template.

275 s in the receptor-binding domain (RBD) and N-terminal domain that confer resistance to monoclonal ant

276 ith TNFalpha treatment, generating a GSDMC N-terminal domain that forms pores on the cell membrane an

277 ol II contains an intrinsically disordered C-terminal domain that is phosphorylated by cyclin-depende

278 s in secondary structure within the TIMP-1 C-terminal domain that stabilize interdomain interactions

279 minal domain crystal structure, suggest an N-terminal domain that wraps around the C-terminal domain

280 he catalytic core to the flexibly attached C-terminal domains, thereby fixing a conformation that is

281 "sense" pathogen effectors differ in their N-terminal domains: these are Toll/interleukin-1 receptor

282 directly interacts with Nup98-Rae1 via its C-terminal domain to impair docking of cargo-receptor (kar

283 oiled DNA substrate first and position the N-terminal domains to bind and cleave the opposite strand

284 This allows the C-terminal domains to capture one strand of underwound neg

285 method revealed a novel role for cMyBP-C N'-terminal domains to damp sarcomere-driven contractile wa

286 TRADD (TRADD-N), which interacts with the C-terminal domain (TRADD-C) and TRAF2 to modulate the ubiq

287 In contrast, we found two residues in the C-terminal domain, tyrosine 351 and glutamate 355, that in

288 er bound to promoter DNA reveals that YefM C-terminal domain undergoes disorder to order transition u

289 which the N-terminal domain I (DI) and the C-terminal domain V (DV) are exposed to the solvent.

290 The regulatory role of the N-terminal domain was dissected.

291 tion was localized solely to the protein's N-terminal domain, we find that both domains contribute eq

292 OS cells, the YXY motif and the L-tetherin N-terminal domain were not required for either robust teth

293 inclusion in the complex depends upon its C-terminal domain, which contains highly conserved cystein

294 teractions between the AP2 complex and its N-terminal domain, which in turn recruits endocytic access

295 WT CLASP2 and a CLASP2 mutant lacking its C-terminal domain, which mediates its interaction with sev

296 The RIM-BP N-terminal domain, while dispensable for SV release site o

297 ions of the M1 sequence, especially in the C-terminal domain, whose structure is undetermined, were f

298 Here we show that overexpression of the N-terminal domain with (TDD) or without (TD) the distal le

299 In full-length enzymes, a C-terminal domain with a previously unknown fold has no im

300 n, thus influencing the interaction of the C-terminal domain with different components of the initiat