ライフサイエンスコーパス: terminal part

1 s peptide, we have raised mAbs against its C-terminal part.

2 n its backbone that enables bending of its C-terminal part.

3 inal region and a rubredoxin domain in the C-terminal part.

4 domain and between Cys49 and Thr50 in the C-terminal part.

5 a long hydrophilic cytoplasmic tail in the C-terminal part.

6 ge ( approximately 250-residue) disordered C-terminal part.

7 al binding site(s) probably exist in their C-terminal parts.

8 in the extracellular space, and a residual C-terminal part (130 kDa, p130) that remains integrated at

9 e of trifluoroethanol, CsTx-1 and the long C-terminal part alone (CT1-long; Gly-45-Lys-74) exhibit an

10 Indeed, the N-terminal part alone confers receptor binding and activit

11 otein with 12 transmembrane domains in the N-terminal part and a long hydrophilic cytoplasmic tail in

12 sylated on 2 neighboring threonines in the C-terminal part and this modification is important for its

13 utation and a covalent modification in the C-terminal part, and the assignment of a sequence of a pre

14 cycle via its C-terminal part, whereas its N-terminal part appears necessary for recruitment of some

15 Nevertheless, the C- and N-terminal parts are rich in basic amino acids, and these

16 We found that both LEAP2 and its N-terminal part behave as inverse agonists of GHSR and as

17 of SelB recognizes this hairpin, while the N-terminal part binds GTP and tRNA in analogy with elongat

18 lucose cotransporter rbSGLT1 and its carboxy-terminal part, C5, which contains transmembrane helices

19 es a helix to strand conversion when N and C-terminal parts come together.

20 ated by its C-terminal sequence, while the N-terminal part comprises structural information and contr

21 ults of this investigation showed that the C-terminal part contains three thioether bridges connectin

22 a fourth site, K364, was identified in the C-terminal part exclusive of LEDGF/p75.

23 2 possesses protease activity, whereas the N-terminal part exhibits NTPase and RNA triphosphatase act

24 helix truncated, but not the form with the C-terminal part extended, bound ligands.

25 repair proteins (domains 1-3, MfdN), and a C-terminal part harboring motor activity (domains 4-7, Mfd

26 The posttranslationally modified N-terminal part has three domains that function to attach

27 The other, situated in the C-terminal part, has sequence similarity to the luciferin-

28 eading frame, adding a common proline rich C-terminal part instead of the last KH RNA binding domain.

29 Mfd can be functionally dissected into an N-terminal part instrumental in recruiting DNA repair prot

30 in five different crystal structures, the C-terminal part is able to adopt two alternative conformat

31 Thus the N-terminal part is apparently required for CENH3 loading d

32 The larger, constitutively expressed C-terminal part is bound to the thick filament.

33 on and live-cell imaging, we show that the C-terminal part is crucial for Brd2 association with chrom

34 of Tim10 is a substrate sensor whilst its C-terminal part is essential for complex formation.

35 d that the F2 subdomain, in particular its C-terminal part, is crucial for the differential functiona

36 -arresting activity, bound directly to the C-terminal part of 14-3-3, outside of its phosphopeptide-b

37 Most remarkably, the terminal part of a phospholipid acyl chain is directly i

38 ORF1 (675 bp) encodes the C-terminal part of a Soj-like protein.

39 These studies indicate that the C-terminal part of AhpF and bacterial TrR have very simila

40 smaller (35 kDa) TrR protein occurs in the C-terminal part of AhpF; a stretch of about 200 amino acid

41 Different from mammalian homologs, the amino-terminal part of almost all AtTLPs has nucleocytosolic a

42 gnal peptide and pro-region of PC2 and the N-terminal part of alpha1-antitrypsin, called pro2alpha1.

43 We found that mutations within the amino-terminal part of alphaM1 had effects on activity and sel

44 observed that mutations within the carboxyl-terminal part of alphaM1 had effects on activity and sel

45 Rcd4 interacts with the C-terminal part of Ana3, which loads onto the procentriole

46 reading frame (ORF) which encodes the amino-terminal part of antizyme and overlaps the +1 frame (ORF

47 stence of a novel inhibitory domain in the N-terminal part of AR, which might play important roles in

48 l as a chimeric protein containing the amino-terminal part of AtCGL160 and Synechocystis sp. PCC6803

49 Our data indicate that the C-terminal part of Avo3, a subunit unique to TORC2, is clo

50 These findings indicate that the N-terminal part of BDV p56 is sufficient for receptor reco

51 d that a type I beta-turn structure at the C-terminal part of both ligands plays an important role in

52 ding dimerization domain indicate that the N-terminal part of C/EBPbeta prevents it from binding to t

53 etate inhibits C/EBPbeta by binding to the N-terminal part of C/EBPbeta, thereby disrupting the coope

54 l and central domains of Hipk2 and the amino-terminal part of C/EBPbeta.

55 The C-terminal part of CALM binds clathrin heavy chain, althou

56 inding of the Ca2+-pump domain to only the C-terminal part of CaM (b) dimer formation with fragments

57 gion has no known activity at present, the C-terminal part of CARM1 contains an autonomous activation

58 In both cases, the C-terminal part of Cdc37 is relevant for kinase binding, w

59 ealed that they shared a 14 cM region in the terminal part of chromosome 13q that included the locus

60 identified a 125 amino acid domain in the C-terminal part of Ci that mediates response to Cos2 inhib

61 imer that noncovalently interacts with the N-terminal part of CLCA1, which further interacts to form

62 lexes (27 kBT), and is concentrated at the C-terminal part of CTD zippering.

63 d that CyoA-N-P2 (a construct with the amino-terminal part of CyoA fused to the Lep P2 soluble domain

64 ion of psbDI (coding for a 96-residue-long C-terminal part of D2) with sodium bisulfite.

65 g binding to the membrane focus in D1; the C-terminal part of D4; and strands beta1, beta4, and beta5

66 e mediated by the evolutionarily conserved N-terminal part of DBT.

67 on, and the 57K fragments were from the COOH-terminal part of DMP1.

68 Thus, the N-terminal part of Drosophila CENP-C is sufficient to recr

69 and the Ndc80 complex) network bind to the N-terminal part of Drosophila CENP-C.

70 er in the binding-site crevice than is the N-terminal part of E2.

71 nslational mechanism on the folding of the C-terminal part of EF-G.

72 etails of inter-domain interactions in the C-terminal part of eIF2D and sheds light on the possible r

73 roism spectroscopy indicated that the most C-terminal part of EMILIN-3 has a substantial alpha-helica

74 The N-terminal part of Era contains a conserved GTPase domain,

75 urin-dependent proteolytic cleavage of the N-terminal part of FcgRIIA, shifting neutrophils away from

76 other species, however, implying that the C-terminal part of FliG can function in conjunction with t

77 We show that the C-terminal part of FRQ, particularly the FRQ-FRH interacti

78 The N-terminal part of GEF115 contains a sequence motif that i

79 between Galpha13 and GEF115 depends on the N-terminal part of GEF115, and there was no synergistic ef

80 ng of the N-terminal part of GLUT7 and the C-terminal part of GLUT5.

81 ed a GLUT7-GLUT5 chimera consisting of the N-terminal part of GLUT7 and the C-terminal part of GLUT5.

82 n generates gp43, which corresponds to the C-terminal part of gp84.

83 ng that the highly conserved sequence of the terminal part of H2 is not critical for the conversion.

84 esses a nuclear export signal, whereas the C-terminal part of HDAC3 contributes to the protein's loca

85 fically hTSP-1; however, truncation in the N-terminal part of Hic decreases the binding activity, sug

86 end of the actin-binding domain 1 and the N-terminal part of hinge 1.

87 nt to a functional domain localized in the C-terminal part of histatin 5.

88 endosome interaction but dependent on the N-terminal part of HookA.

89 In contrast, the N-terminal part of Hot appears uniquely responsible for it

90 We present the crystal structure of a C-terminal part of HUWE1, including the catalytic domain,

91 dosomal sorting signal, secretion, and the C-terminal part of Ii were needed for the full adjuvant ef

92 F/SF2 from speckles by phosphorylating the C-terminal part of its RS domain.

93 Similar binding studies with the carboxy-terminal part of KCBP lacking the calmodulin-binding dom

94 e site in Kindlin-3 at tyrosine 373 in the N-terminal part of Kindlin-3 pleckstrin homology domain.

95 f KorB in vivo or in vitro showed that the C-terminal part of KorA between amino acid positions 68 an

96 A coiled-coil domain located in the N-terminal part of L-Sox5, and absent in Sox5, showed >90%

97 analyses, we identified two regions in the C-terminal part of L4 that contribute to an antiviral inte

98 , whereas A3H hapI-GKE associated with the C-terminal part of matrix and the N-terminal capsid domain

99 In contrast, Factor H, which binds to the N-terminal part of mature PspC molecules, did not interfer

100 analysis in S2 cells indicates that the COOH-terminal part of Megator without the coiled-coil region

101 with fusion proteins comprising either the N-terminal part of mesothelin/MPF (D1Ig), reported to be e

102 th defects in the MA (matrix), CA, and the N-terminal part of NC (nucleocapsid) sequences produced de

103 y the Gag nucleocapsid protein NC, and the N-terminal part of NC is most critical for this interactio

104 We found that the amino-terminal part of Net2p interacts with Fis1p, whereas the

105 ions, because point mutations in the carboxy-terminal part of nsP2 could make SIN and other alphaviru

106 The C-terminal part of nsP2 possesses protease activity, where

107 Modeling of the structure of the C-terminal part of Opi3 was consistent with the topology o

108 The C-terminal part of p300 containing the transactivating reg

109 nic liposomes at pH 5, full-length and the C-terminal part of PB1-F2 assemble into amyloid structures

110 At pH >/= 7, the C-terminal part of PB1-F2 spontaneously switches to amyloi

111 The N-terminal part of Pdc-ND is likely located outside the ce

112 PA63 (the 63-kDa, C-terminal part of protective antigen) forms heptameric ch

113 s and synthetic peptides revealed that the N-terminal part of protein F contains the host-interacting

114 Copeptin, the C-terminal part of provasopressin, has emerged as a novel

115 es a three-dimensional fold similar to the C-terminal part of PrP, is also harmful to neuronal and ot

116 on of amide hydrogens) was detected in the N-terminal part of PrP90-231 fibrils, arguing against the

117 enic peptide that was derived from the amino terminal part of rat alpha3(IV)NC1 domain, and serum and

118 sful after using hybrid receptors with the C-terminal part of ReMAX replaced by that of Eix2.

119 , we show that one conserved lysine in the N-terminal part of Rep is pivotal for nuclear localization

120 or the first time that it is precisely the N-terminal part of ribosomal protein L11 that is required

121 unique N-terminal sequence followed by the C-terminal part of RIM2.

122 SUMO interaction motifs (SIMs) in the N-terminal part of RNF4 tightly bind to SUMO polymers, and

123 at interact with the RNA and membrane, the C-terminal part of S. pneumoniae Era was systematically de

124 In bacteria, the C-terminal part of SelB recognizes this hairpin, while the

125 4 is important for granule initiation, the N-terminal part of SS4 serves to establish the correct gra

126 ion with fibrillins 1 were mediated by the N-terminal part of SS4.

127 our epitopes (epitopes 1-4) located in the N-terminal part of TG2.

128 site 282 and the surrounding region in the C-terminal part of the 31-kDa domain.

129 The 16-kDa fragment corresponded to the N-terminal part of the 37-kDa peptide.

130 Mutations in the C-terminal part of the a' domain have significant effects

131 question of whether these mutations in the C-terminal part of the a' domain, which affect P4H assembl

132 domain within vIL-6 site I, mapped to the C-terminal part of the AB-loop and the beginning of helix

133 hange results in stable positioning of the N-terminal part of the activation domain of PGC-1alpha, fa

134 The C-terminal part of the adhesin consists of the receptor-bi

135 tophan residues in the beta-barrel and the N-terminal part of the alpha-helical domain become partial

136 hanging key amino acids located within the C-terminal part of the alpha2 domain and the alpha3 domain

137 n is mainly posttranslational and that the C-terminal part of the alpha2 domain and the alpha3 domain

138 Thus, the C-terminal part of the AP-4epsilon subunit plays an import

139 Atg16L1(153-210) comprises the C-terminal part of the Atg16L1 coiled-coil domain.

140 of the A, G, and H helix segments and the C-terminal part of the B helix are similar to those in nat

141 ontaining the TQQS-to-ETPV mutation in the N-terminal part of the betaG-betaH loop of VP1 showed not

142 Biophysical data have suggested that the N-terminal part of the C99 transmembrane domain (TMD) is s

143 or protein interaction using as a bait the N-terminal part of the CEA encoding the binding site.

144 These results indicate that the N-terminal part of the CFTR R domain is dispensable for in

145 eS binding domain, which overlaps with the N-terminal part of the CheY2 binding domain (CheA(174-316)

146 ation region and by increasing that of the C-terminal part of the cleavage region.

147 by introduction of silent mutations in the N-terminal part of the coding region.

148 fragment of M(r) 47,000 containing the NH(2)-terminal part of the cofactor (amino acid residues 1-348

149 the formation of HEXIM1 oligomers via the C-terminal part of the coiled-coil or basic regions is cri

150 Importantly, mutations of the N-terminal part of the coiled-coil region abrogate the abi

151 n between the two complexes resided at the N-terminal part of the complex, adjacent to peptide residu

152 of ventricular myocytes is controlled by the terminal part of the conduction system known as the Purk

153 ide chains were detected in the middle and N-terminal part of the core protein.

154 5'-UTR plus simultaneous truncation of the N-terminal part of the CP impaired SPMV spread in foxtail

155 the resultant EWS/ERG fusion protein, the N-terminal part of the ETS family protein ERG is replaced

156 the mutant yeast strains suggests that the N-terminal part of the eukaryotic and, in particular, yeas

157 Both interactions are localized to the N-terminal part of the EVI5 protein.

158 ) derived from a conserved sequence in the C-terminal part of the extracellular N terminus can activa

159 Sequence analysis of the C-terminal part of the F2 subdomain of K3 suggests that in

160 Hence, the C-terminal part of the first extracellular loop not only d

161 also a short segment of 3(10) helix at the N-terminal part of the folded domain.

162 third transmembrane segment (S3b) and the N-terminal part of the fourth segment ((NT)S4) that harbor

163 ization reaction, where the N-terminal and C-terminal part of the fragment are fused into a macrocycl

164 criptional transactivation function in the N-terminal part of the glucocorticoid receptor (GR) appear

165 ed upon PPACK-binding, but residues in the N-terminal part of the heavy chain, the gamma-loop, and an

166 stallin domain, and one mutation is in the C-terminal part of the HSP27 protein.

167 ovel site is completely different from the C-terminal part of the human UEV domain that binds to P(S/

168 The results show that the carboxy-terminal part of the KCBP, with or without calmodulin-bi

169 gene rearrangement t(8;21) that fuses the N-terminal part of the key hematopoietic regulatory factor

170 maintaining these alleles and identify the N-terminal part of the leucine-rich repeat region as a pro

171 m requiring the DNA-binding domain and the N-terminal part of the ligand-binding domain.

172 ) sequence in Kir channels, located in the N-terminal part of the linker between the two transmembran

173 sertion of a 16-residue spacer between the C-terminal part of the loop sequence (i.e. between residue

174 Initially, the Ca2+ binds to the N-terminal part of the loop, thus generating a rigid link

175 This involves the C-terminal part of the Ltr proteins, which control specifi

176 betaHis81 and two amino acids from the NH(2)-terminal part of the MHC bound peptide coordinate Ni(2+)

177 Phosphorylation of sites in the NH2-terminal part of the microtubule-binding domain by glyco

178 ed within a 140-residue-long region of the C-terminal part of the middle region of Leu3p.

179 deletion mutants of C/EBPbeta lacking the N-terminal part of the molecule are able to bind to the PP

180 2 monoclonal antibodies (mAbs) against the N-terminal part of the molecule but not by mAb 6H4, which

181 The isoform-dependent N-terminal part of the molecule forms an elastic connectio

182 e, likely in a transmembrane form with the C-terminal part of the molecule inserted into the cytoplas

183 hand, antibodies directed against the amino-terminal part of the molecule, including the fusion pept

184 cant variability in the orientation of the C-terminal part of the molecule, the region expected to be

185 l the epsin endocytic motifs reside in the C-terminal part of the molecule, these results suggest tha

186 oop located between beta7 and beta8 in the N-terminal part of the molecule.

187 n additional ubiquitin binding site in the C-terminal part of the molecule.

188 G(M1) gangliosidosis patients found in the C-terminal part of the molecule.

189 P results in a significant ordering of the N-terminal part of the molecule.

190 or C-S bonds also led to the release of the terminal part of the monolayer in a predictable manner.

191 ermore, we found that CLCA1 can cleave the N-terminal part of the mucus structural component MUC2.

192 the epitope for mAb 5F1 is created by the N-terminal part of the N domain, between residues 1 and 14

193 Thus, the amino-terminal part of the nucleocapsid protein is probably in

194 tion of a truncated CFTR protein lacking the terminal part of the nucleotide-binding domain 1 (NBD1)

195 recognized by the virus proteinase in the N-terminal part of the open reading frame 1 (ORF1) polypro

196 iophysical techniques and showing that the N-terminal part of the peptide may be modified without cha

197 Repositioning of the N-terminal part of the peptide on CyP.TS formation becomes

198 The structure of the N-terminal part of the peptides is variable and interacts

199 e periplasmic displacement of 3-4 A of the C-terminal part of the periplasmic ligand-binding domain u

200 how that a 49-mer peptide derived from the C-terminal part of the Phe521Leufs chain is deposited as f

201 nt upon configurational flexibility in the C-terminal part of the polypeptide chain to ensure passage

202 multiple virus passages suggests that the N-terminal part of the prM protein, a specific site in the

203 ionally relevant PC processing site in the N-terminal part of the pro-domain that is important for th

204 age, which requires a free cysteine in the C-terminal part of the protein and results in the producti

205 atment of P41 cleaves the same bond in the C-terminal part of the protein as is cleaved in the P46-->

206 osphate isomerase barrel is covered by the C-terminal part of the protein containing an additional [4

207 ins a conserved GTPase domain, whereas the C-terminal part of the protein contains an RNA- and membra

208 The C-terminal part of the protein does not associate with eit

209 The C-terminal part of the protein is best conserved and most

210 xtended variants of nsP2 revealed that the C-terminal part of the protein is indispensable for helica

211 Though the N-terminal part of the protein showed disorderness the C-t

212 ng DNA in the presence of ATP, and the NH(2)-terminal part of the protein was found to mediate its lo

213 cids with an ATPase-helicase domain in the N-terminal part of the protein, a central spacer domain, a

214 uncated allele of beta-catenin without the N-terminal part of the protein, give rise to embryos whose

215 sephosphate isomerase barrel formed by the N-terminal part of the protein, which contains the [4Fe-4S

216 ion comprising a 20-residue stretch in the C-terminal part of the protein.

217 ine esterase) activity is localized on the N-terminal part of the protein.

218 a dimer with a conserved interface in the N-terminal part of the protein.

219 the DNA-binding ETS domain of FLI1 in the C-terminal part of the protein.

220 and that the CSA-binding site lies in the N-terminal part of the protein.

221 The toxin-binding site is located in the C-terminal part of the PTPvarsigma ectodomain and includes

222 sistent with weak interactions between the N-terminal part of the RBD and the kinase.

223 re kinase activity and is conferred by the N-terminal part of the receptor.

224 he Galpha beta-sheet that wraps around the C-terminal part of the Ric8A armadillo domain, leading to

225 Mutations were clustered in the carboxy-terminal part of the rod domain, which is critical for f

226 e localization of the COU-1 epitope to the N-terminal part of the rod domains.

227 phosphorylation of ASF/SF2 by SRPK1 to the N-terminal part of the RS domain - a property essential fo

228 Rosetta modeling, we reveal that the carboxy-terminal part of the S4 helix exhibits an unexpected til

229 uncoupled FPR mutants were located in the N-terminal part of the second transmembrane domain (S63W a

230 ubiquitin is highly polarised towards the N-terminal part of the sequence and involves a nucleus of

231 irpin stabilises local interactions in the C-terminal part of the sequence, resulting largely in a de

232 The terminal part of the small intestine and large intestine

233 Transient helix I comprises the most N-terminal part of the SNARE motif, transient helix II ext

234 heterodimeric subunit Rpa34.5/Rpa49 or the C-terminal part of the specific subunit Rpa12.2 showed a l

235 NMR studies further revealed that the N-terminal part of the Spp2 G-patch, which is the most con

236 In the full-length molecule, the C-terminal part of the tail has an additional bend taking

237 n the N-terminal F3 FERM subdomain and the C-terminal part of the talin rod contributes to an autoinh

238 amino acid peptide located near the carboxyl-terminal part of the tenascin-C molecule.

239 are located adjacent to each other in the N-terminal part of the TG2 molecule.

240 ia a paddle-shaped motif that includes the C-terminal part of the third transmembrane segment (S3b) a

241 ion encompassing Cys-1448 derived from the N-terminal part of the triple-helical domain.

242 Copeptin, the C-terminal part of the vasopressin prohormone, is secreted

243 ely 40-amino acid residue D repeats in the C-terminal part of these proteins.

244 Importantly, the N-terminal part of this alpha-helix, from Phe(93) to Thr(9

245 t(12;16) translocation that fuses the amino-terminal part of TLS to the entire coding region of CHOP

246 Deletion of the C-terminal part of TRAM2 inhibits type I collagen synthesi

247 The C-terminal part of TRAM2 interacts with the Ca(2+) pump of

248 the UbiK protein forms a complex with the C-terminal part of UbiJ, another UQ biogenesis factor we p

249 it proton transport only when fused to the N-terminal part of UCP1 (chimera U1U2).

250 mbinant UIEF1 interacted with RNA, and the C-terminal part of UIEF1 mainly contributed to the RNA int

251 region around residue 224 and more of the C-terminal part of Ure2p restore prion-inducing ability.

252 n and factor H, and that it recognized the C-terminal part of Vn (aa 352-362).

253 Mutation analysis showed that the C-terminal part of Vpr binds to the C-terminal portion of

254 18 N-terminal domain can interact with the N-terminal part of Vps11 and also binds to lipids.

255 NtPEX5 fusion proteins, consisting of the N-terminal part of yeast Pex5p and the C-terminal region o

256 indicate that, instead of this domain, the N-terminal part of Yos9 including the mannose 6-phosphate

257 e domain is inserted in between the N- and C-terminal parts of a homologous domain.

258 ies of point mutants show that both N- and C-terminal parts of each protein are important for stabili

259 The C-terminal parts of Ent1 and Sla2 bind redundantly to acti

260 uence of F1 binds in an inhibitory mode to N-terminal parts of exogenous and endogenous fibronectin w

261 A crystal structure of the middle and C-terminal parts of FliG shows two globular domains connec

262 The crystal structure of the middle and C-terminal parts of FliG shows two globular domains joined

263 sent study using antibodies against N- and C-terminal parts of human melanopsin, confocal microscopy

264 Several mutations affecting the mid- to C-terminal parts of MinD led to a protein probably unable

265 ied multiple T cell epitopes hosted in the N-terminal parts of the alpha- and beta-chains and common

266 N- and C-terminal parts of the G. lamblia acetyl-CoA synthetase s

267 The N-terminal and C-terminal parts of the LRP-515 subunit are resistant and

268 maritima, which encompasses the middle and C-terminal parts of the protein (termed FliG-MC).

269 he interface of the core (DNA-binding) and N-terminal parts of the protein a slow conformational exch

270 Fragment ions derived from both N- and C-terminal parts of the protein are equally unaffected by

271 nal information between the N-terminal and C-terminal parts of the protein.

272 s of deletion mutants lacking either N- or C-terminal parts of the RGS9 molecule.

273 a2+-binding sites are located in the C and N-terminal parts of the S100P molecule, respectively.

274 essential for these activities, the N- and C-terminal parts of the Streptococcus pneumoniae Era - Era

275 n atypical FERM domain, whereas the N- and C-terminal parts of the talin rod include a series of alph

276 ixth transmembrane domains near the N- and C-terminal parts of the third cytoplasmic loop did not res

277 mains of 250-270 amino acids in the N- and C-terminal parts of their sequences.

278 The N-terminal parts of these multidomain proteins contain six

279 A helical tripod, the carboxy-terminal parts of three heavy chains, projects inward fr

280 g region (215-amino acids or 215aa), 103aa N-terminal part or a smaller N-terminal region (34aa), eac

281 of full-length syndapins, but not the NH(2)-terminal part or the SH3 domains alone, had a strong eff

282 the polalpha catalytic domain without the C-terminal part (p180DeltaN-core) possessed a much higher

283 -160) sequence with PCNA revealed that the N-terminal part (residues 141-152) of the above peptide is

284 P(C) (HuPrP) fold features an unstructured N-terminal part (residues 23-124) and a well-defined C-ter

285 d domain formed by two closely intertwined C-terminal parts (residues 33-76), and two highly mobile t

286 e Era was systematically deleted while the N-terminal part, responsible for the GTPase activity of th

287 cts as a ligand binding to the S6 gate (S6 C-terminal part, S6(T)) and stabilizes it in a closed stat

288 us, it is shown that a modification in the C-terminal part significantly reduces the adhesion of cell

289 However, the N-terminal part (Suc-Ala) becomes repositioned in the TS s

290 at links its N-terminal WD40 domain to the C-terminal part that contains the exonuclease, with a 2:1

291 to the helicase domain, RecQ4 has a unique N-terminal part that is essential for viability and is con

292 cmB), a middle P-loop GTPase domain, and a C-terminal part that is homologous to the large subunit of

293 Caspase-8 cleaves Bid, and the COOH-terminal part translocates to mitochondria where it trig

294 udokinase domain linker indicated that its N-terminal part was essential for interaction of JAK2 with

295 A "latch" region in the N-terminal part was observed to close over the topoisomera

296 To test whether CENP-C's N-terminal part was sufficient to recruit KMN proteins, we

297 tromeres throughout the cell cycle via its C-terminal part, whereas its N-terminal part appears neces

298 , they differ in the length of their carboxy terminal part, which in pCP-2 has the composition CUB1,

299 large insert in the RecA2 domain, and the C-terminal part, which includes winged-helix, ratchet, and

300 es E. coli switch protein FliN only in its C-terminal part, while an additional N-terminal domain is