ライフサイエンスコーパス: terminally

1 tylase (Nt-acetylase) and therefore cannot N-terminally acetylate a majority of normally N-terminally

2 Here, we report fibril structures of three N-terminally acetylated (Ac) alpha-syn constructs, Ac1-140

3 alphaS in humans is constitutively N-terminally acetylated (alphaSacetyl), although the impac

4 We obtained curated N-terminally acetylated and unacetylated sequences from th

5 n deacylase CobB long isoform (CobB(L)) is N-terminally acetylated by the YiaC protein of this bacter

6 R) spectroscopy to probe the nature of the N-terminally acetylated form of alphaS (NTAc-alphaS) bound

7 erminally acetylate a majority of normally N-terminally acetylated proteins, including Hsp90 and most

8 s, only ribosomal proteins are known to be N-terminally acetylated, and the acetyltransferases respon

9 ought to form extended homodimers that are C-terminally anchored to Golgi membranes, whereas their N

10 Complexes containing a series of N-terminally and C-terminally truncated Swr1 subunits reve

11 8(+) T cells and altered the balance between terminally and progenitor-exhausted T cells favoring the

12 oneurons in the cervical enlargement of four terminally anesthetized female macaque monkeys, and reco

13 PilD and (iii) that pilin subunits with a C-terminally appended hexa-histidine (6His) tag are still

14 er conditions in which Drosophila larvae are terminally arrested, we have characterized synaptic grow

15 When terminally attached to double-stranded nucleic acids via

16 Vitamin D(3) is terminally bioactivated in the kidney to 1alpha,25-dihyd

17 Using C-terminally biotinylated dCas9, endogenous biotin ligases

18 the human telomerase RNA component and the N-terminally biotinylated human telomerase reverse transcr

19 ensities of a promising backbone change of a terminally blocked delta-amino acid residue, a dipeptide

20 cyclononane-based pentadentate ligand, and a terminally bound azide ligand has been prepared and spec

21 4S]H(+) coupled to a diferrous [2Fe]H with a terminally bound Fe-hydride.

22 e show that low-temperature protonation of a terminally bound Fe-N(2)(-) species, supported by a bulk

23 ntify a heretofore unknown modification-an N-terminally bound glyoxylyl group-in the poorly character

24 tion with mesityl azide in benzene affords a terminally bound imido complex ((tbs) L)Cr(3) (mu(1) -NM

25 rein, we report the synthesis of an S = 1/2, terminally bound thiolate-Ni(III)-H complex.

26 ide ligand is either displaced toward Fe, or terminally bound to Fe.

27 athway, the N-terminally palmitoylated and C-terminally cholesterylated HH ligand is secreted into th

28 Patch-clamp experiments indicated that the C-terminally cleaved CaValpha2delta1 proteins up-regulate

29 We previously discovered that an N-terminally-cleaved form of RXRalpha (tRXRalpha), produce

30 An N-terminally deleted HA-TPD52 mutant (residues 40-184) alm

31 ionine is used to produce an undetectable, N terminally deleted ORC5, the protein would lack 80% of t

32 t the impaired RNA synthesis associated with terminally deleted viruses could be due to destabilizati

33 ristems that proliferate for a time and then terminally differentiate into a sharp tip.

34 grate to their final destination, where they terminally differentiate into mature oligodendrocytes an

35 ion of the vegetative cells in each filament terminally differentiate to nongrowing heterocysts.

36 However, they do not terminally differentiate, maintain expression of CCND2,

37 is gradually downregulated as committed SCs terminally differentiate.

38 s of unique transcriptional states to become terminally differentiated acinar, ductal and myoepitheli

39 e mainly naive and CD26(high) T cells appear terminally differentiated and exhausted.

40 had a higher level of TCR signaling and were terminally differentiated and exhausted.

41 Resting CMV-specific CD8 T cells were terminally differentiated and expressed high levels of t

42 Mature neutrophils are terminally differentiated and short-lived with a high tu

43 n tumours consist of distinct populations of terminally differentiated and stem-like cells.

44 originate from plasma cells (PCs), which are terminally differentiated B cells.

45 marrow are heterogeneous, consisting of (a) terminally differentiated B-1-derived plasma cells expre

46 erials, which is difficult for unculturable, terminally differentiated bacteroids.

47 Genome-wide mapping of H4K16ac in terminally differentiated blood cells, along with functi

48 cancer regression and TIL persistence and a terminally differentiated CD39-positive state (CD39(+)CD

49 ained significantly increased frequencies of terminally differentiated CD57+KLRG1+ cells in CMV serop

50 ncluding expanded effector and post-effector terminally differentiated CD8(+) T cells.

51 Osteocytes are the terminally differentiated cell type of the osteoblastic

52 Cell-identity switches, in which terminally differentiated cells are converted into diffe

53 Moreover, terminally differentiated cells can be experimentally pr

54 Deregulation of mitochondrial network in terminally differentiated cells contributes to a broad s

55 In contrast to quiescent cells, terminally differentiated cells fail to maintain CENP-A

56 Labeled SP cells give rise to terminally differentiated cells in bone marrow and intes

57 of efficient and stable splicing patterns in terminally differentiated cells is critical to maintenan

58 portant role in oxidative phosphorylation in terminally differentiated cells such as cardiomyocytes.

59 f self-renewal and differentiation into more terminally differentiated cells that downregulate Tcf-1

60 By converting terminally differentiated cells that harbor even a singl

61 Human corneal endothelial cells (HCEnCs) are terminally differentiated cells that have limited regene

62 caused reductions in cell numbers only among terminally differentiated cells while proliferation-comp

63 We hypothesize that resident AMs are terminally differentiated cells with low responsiveness

64 omyocytes are traditionally considered to be terminally differentiated cells, unable to proliferate.

65 spectrum of cell states, from stem cells to terminally differentiated cells.

66 Podocytes are non-proliferative, terminally differentiated cells.

67 l differentiation increases from ES cells to terminally differentiated cells.

68 alpha5 localizes to the lateral membrane of terminally differentiated colonocytes and that integrin

69 their clonal relationships and characterize terminally differentiated dysfunctional UC CD8(+) T cell

70 nity while other effector cells develop into terminally differentiated effector (TE) cells with limit

71 These data indicate that terminally differentiated effector CD8 T cells acquire e

72 cell subsets along with unique modulation of terminally differentiated effector CD8 T cells by combin

73 but not combination therapy, while activated terminally differentiated effector CD8 T cells expand on

74 fection, an activated CD4(+) T cell produces terminally differentiated effector cells and renews itse

75 ifferentiated CD8 T-cell effector memory and terminally differentiated effector cells.

76 Lower pre-treatment terminally differentiated effector memory (TEMRA) cell f

77 ild disease along with a strong expansion of terminally differentiated effector memory CD4+T-cells ,

78 Notably, this terminally differentiated effector memory CD8 T cell pop

79 eiling in both subsets an unattended pool of terminally differentiated effector memory cells with pre

80 l memory T cell, effector memory T cell, and terminally differentiated effector T cell populations to

81 l subsets-including effector memory (EM) and terminally differentiated EM (TEMRA) CD8(+) T cells-in b

82 profiles in naive, effector memory (EM), and terminally differentiated EM (TEMRA) cells.

83 Many terminally differentiated endocrine cell types, however,

84 d cancer stem cells and is also expressed in terminally differentiated epithelial and photoreceptor c

85 ase Thousand and One Kinase 3 (TAOK3) lacked terminally differentiated ESAM(+) CD4(+) cDC2s in the sp

86 ike CD8 T cell subset that gives rise to the terminally differentiated exhausted CD8 T cells.

87 ir responses highlight the dichotomy between terminally differentiated exhausted T cells that are TCF

88 nds molecular transition from the nascent to terminally differentiated fiber cells in the developing

89 c remodeling facilitate this transition from terminally differentiated gametes to totipotent blastome

90 eted beta cells revealed the collapse of the terminally differentiated gene program, indicated by a l

91 he key cell that prevents albuminuria is the terminally differentiated glomerular podocyte.

92 c YAP1) was mainly detected in luteal cells (terminally differentiated granulosa cells).

93 onic stem cells (hESCs) from endoderm toward terminally differentiated hepatocytes, thus mimicking th

94 at the cardiac precursors stage, but not in terminally differentiated hPSC-cardiomyocytes, by transi

95 cell-derived hepatocyte-like cells to their terminally differentiated human counterparts using defin

96 compartments within conidia, but not within terminally differentiated infection cells, and thus spat

97 The daily losses of terminally differentiated intestinal, skin, and blood ce

98 cancer cells that have undergone EMT can be terminally differentiated into adipocytes using the PPAR

99 lted from accumulation of greater numbers of terminally differentiated KLRG1(hi) effector CD8 T cell

100 nitors and hence the extent of production of terminally differentiated lineages.

101 sion of cell cycle-associated proteins, with terminally differentiated macrophages becoming highly su

102 how HIV-1 achieves efficient replication in terminally differentiated macrophages despite the restri

103 rance and new loop formation are observed in terminally differentiated macrophages, but not TNFalpha-

104 nsduce nondividing cells is key to infecting terminally differentiated macrophages, which can serve a

105 Reconstitution of effector, central and terminally differentiated memory cell population and inc

106 central memory T cell subsets at onset and 5 terminally differentiated memory T (TEMRA) cell subsets

107 , CD8CD28, CD4CD57PD1, and CD8CD28 end-stage terminally differentiated memory T cells were measured p

108 on of CD8(+)CD28(-) T cells, a population of terminally differentiated memory T cells, is one of the

109 with greater than 35 cells CD8CD28 end-stage terminally differentiated memory T cells/muL rejected, m

110 the earliest premyogenic progenitor stage to terminally differentiated myofibers, and discuss how thi

111 to complement-mediated injury owing to their terminally differentiated nature.

112 s strongly hindered by their short-lived and terminally differentiated nature.

113 ts suggest that telomeres are dispensable in terminally differentiated neurons and provide mechanisti

114 s surprisingly no detectable consequences on terminally differentiated neurons.

115 Mature and terminally differentiated NK cells with enhanced effecto

116 larly the CD56(bright) subset, and a lack of terminally differentiated NK cells.

117 ression of inhibitory receptor NKG2A/CD94 on terminally differentiated NK cells.

118 e effects reduced the number and function of terminally differentiated NKT and gammadelta T cells in

119 ifferent stages of erythropoiesis, including terminally differentiated nucleated RBCs that we term "j

120 titative PCR for gene expression analysis in terminally differentiated osteoclasts.

121 r5(+) stem cells are intermingled with their terminally differentiated Paneth cell daughters at crypt

122 for Musashi proteins in the morphogenesis of terminally differentiated photoreceptor neurons.

123 r of the transition from progenitor cells to terminally differentiated photoreceptors.

124 not revert back to the parent isotype, and a terminally differentiated plasma cell cannot contribute

125 ssion of the glycoprotein CD101 divides this terminally differentiated population into two subsets.

126 thymus TPA(lo)MHCII(lo) pre-Aire rather than terminally differentiated post-Aire TPA(hi)MHCII(lo) mTE

127 Long-lived cells such as terminally differentiated postmitotic neurons and glia m

128 Vdelta2 T cells presented a terminally differentiated profile, expressed granzyme B

129 ajor cell fates, CD57(+) CD127(-)-resembling terminally differentiated senescent memory cells and CD1

130 specification of other identity aspects of a terminally differentiated sensory neuron.

131 We demonstrate that terminally differentiated SH-SY5Y cells have neuronal mo

132 y in the adult maintains mature DCTs in this terminally differentiated state and prevents renal fibro

133 Thus, LDB1 maintains the terminally differentiated state of beta cells and is a c

134 ese cells does not represent conversion to a terminally differentiated state, but rather represents t

135 ed a requirement for LDB1 in maintaining the terminally differentiated status of pancreatic beta cell

136 CX3CR1, HAVCR2 (TIM-3), and ZEB2 represents terminally differentiated status with the unique transcr

137 , after: 16.5 +/- 2.3%) and 2) a decrease in terminally differentiated subsets (CD4(+): before: 47.3

138 tissue-resident populations, whereas mature, terminally differentiated subsets mediate immunosurveill

139 T-cell responses in the CD4 compartment and terminally differentiated T cells in the CD8 compartment

140 known properties of highly differentiated or terminally differentiated T cells.

141 sistant rejection (CoBRR) is associated with terminally differentiated T cells.

142 content and synthesis in MPEC compared with terminally differentiated Teff.

143 unchanged "educated" (CD11b(+)CD27(+)) and "terminally differentiated" (CD11b(+)CD27(-)) NK cell fre

144 ranscriptionally distinct from conventional, terminally differentiated, antigen-induced peripheral bl

145 ion, stem-like CD8 T cells give rise to more terminally differentiated, effector-molecule-expressing

146 However, terminally differentiated, neuronal SH-SY5Y cells releas

147 tal Cell, Amulic et al. (2017) show that the terminally differentiated, non-cycling neutrophils repur

148 e HBoV1 genome, and HBoV1 replicates only in terminally differentiated, nondividing cells.

149 Additionally, terminally differentiated, postmitotic myofiber nuclei f

150 not only during differentiation but also in terminally differentiated-macrophages and immature dendr

151 exhibited a skewing of CD8+ T cells toward a terminally differentiated/senescent phenotype.

152 ng skeletal muscle precursors (myoblasts) to terminally-differentiated myocytes is a critical step in

153 an ex vivo culture system that enriches for terminally differentiating cells.

154 rostate cancer cells functions to oppose the terminally differentiating effects of AR.

155 Terminally differentiating epidermal keratinocytes expre

156 n maintained at the surface of expanding and terminally differentiating erythroblasts.

157 ythroleukaemic K562 cell line, expanding and terminally differentiating primary erythroblasts and mat

158 s preferentially and abundantly expressed in terminally differentiating sensory epithelia.

159 mitogenic signaling and aberrant cycling in terminally differentiating tissues.

160 oding of specific mRNAs that are depleted in terminally differentiating/enucleating cells with decrea

161 tes, and phosphodegrons to empower an N-to-C terminally directed phosphorylation process.

162 Terminally diseased mice with severe neurological sympto

163 n with a target organism was discharged were terminally disinfected with one of four strategies: refe

164 nstrate that Arabidopsis and Medicago CEP (C-TERMINALLY ENCODED PEPTIDE)-CEP RECEPTOR signalling cont

165 The interaction of C-TERMINALLY ENCODED PEPTIDES (CEPs) with CEP RECEPTOR1 (C

166 and is required for the activity of carboxyl-terminally encoded peptides (CEPs).

167 Several N-terminally engineered analogs of C-C chemokine ligand 5

168 xpression signatures that shared features of terminally exhausted and progenitor-exhausted T cells, r

169 lf-renewal and also differentiating into the terminally exhausted CD8 T cells.

170 rity of tumor-infiltrating T cells exhibit a terminally exhausted phenotype, marked by a loss of self

171 new regulator of the differentiation of the terminally exhausted subpopulation that functions by att

172 Slamf6(+) progenitor exhausted and Tim-3(+) terminally exhausted subpopulations through unknown mech

173 kade but ultimately converted into a fourth, terminally exhausted subset.

174 pecific CD8 TCR repertoires of stem-like and terminally exhausted subsets generated during chronic LC

175 f Gal-9 with PD-1 was associated with a more terminally exhausted T cell phenotype in HIV-1 patients.

176 better able to control tumor growth than are terminally exhausted T cells.

177 scriptomic and epigenetic characteristics of terminally exhausted T cells.

178 d TILs can respond to anti-PD-1 therapy, but terminally exhausted TILs cannot.

179 y, persist long term and differentiate into 'terminally exhausted' TILs.

180 Moreover, enzymatic cleavage of terminally exposed sialic acids reduces macrophage surfa

181 helps explain how dopamine somatic, but not terminally expressed, KORs are inactivated by norBNI.

182 cessing, here we generated a nested set of N-terminally extended 10-20-mer peptides (RA) (n) AAKKKYCL

183 Peptide 1 was N-terminally extended as well as truncated and subjected t

184 C-terminally extended C-I30 is toxic when assembled into C

185 mRNA 5' cap4 structure, the trypanosomatid N-terminally extended form of eIF4E acts as the core molec

186 RAP1 and ERAP2 heterodimers (ERAP1/2), and N-terminally extended model and natural peptides in their

187 reports the NMR solution structures of two N-terminally extended mycolactone mACP constructs, mH0ACPa

188 y examined the structure and biophysics of N-terminally extended peptides in complex with MHC-I, reve

189 The N-terminally extended peptides N+1, N+2, N+4, N+6, N+8, N+

190 ing that MHC class I molecules can present N-terminally extended peptides on the cell surface that ca

191 al "untranslated regions" (UTRs) to create N-terminally extended viral proteins or entirely novel pol

192 eveal that Leishmania has a unique type of N-terminally-extended cap-binding protein (eIF4E4) that bi

193 igen-specific CD8 T cell population that was terminally fated with potent effector function but maint

194 TT expression clones comprised both N- and C-terminally FLAG-tagged HTT constructs with polyQ lengths

195 for DNA contacts to the residues extending C-terminally from the globular core, which are lacking in

196 electivity to chain-lengthened paraffins and terminally functionalized products (aldehydes, alcohols,

197 New stilbenoid and thiophenic compounds terminally functionalized with donor-donor, acceptor-acc

198 d as preproteins, carrying signal peptides N-terminally fused to their mature domains.

199 nd break repair of a 3'-phosphate-containing terminally gapped, linearized reporter plasmid.

200 annii strains ACICU and BIDMC57, which are C-terminally glycosylated.

201 Results Patients who reported a terminally ill health status had worse QOL (unstandardiz

202 .78; P < .001) among patients who reported a terminally ill health status.

203 Human AML cells from terminally ill mice treated with chemotherapy (chemoAML)

204 cribe medications to be self-administered by terminally ill patients to hasten their death.

205 enter a research study (eg, known dementia, terminally ill, or recently bereaved).

206 to ventilator withdrawal currently and 67.5% terminally in anticipation of death.

207 We hybridized a library of short, terminally labeled probes to Ebola virus RNA followed by

208 alpha-l-arabinofuranosidase, removing single terminally-linked arabinose residues, decreased the exte

209 beta-strands, whereas in mammalian cells, C-terminally located alpha-helical domains are sufficient

210 g A1 domain of VWF is connected to the VWF N-terminally located D'D3 domain through a relatively unst

211 matory actions of GIV are mediated via its C-terminally located TIR-like BB-loop (TILL) motif which b

212 with NKD, requirements for the generation of terminally mature functional innate effector cells can b

213 nal deletion of A2AR enhanced proportions of terminally mature NK cells at homeostasis, following rec

214 Notably, A2AR-deficient, terminally mature NK cells retained proliferative capaci

215 rate the glycan signal required for flagging terminally misfolded glycoproteins for ERAD.

216 n (ERAD) pathway facilitates the disposal of terminally misfolded proteins in the early secretory pat

217 The lifetime of POLRMT on terminally mismatched elongation substrate is increased

218 the skin secretion of arboreal frogs, was N-terminally modified (MsrA2) and evaluated in vitro for a

219 ranslated region, generating an oncogenic, C-terminally modified isoform (PACE4-altCT).

220 tion from 3' exonuclease in the context of a terminally modified oligonucleotide.

221 A C-terminally NHR3 + 4 truncated RUNX1/ETO containing a het

222 unknown beta-CN A hexa-phosphorylated and N-terminally-nicked beta-CN A phosphorylated forms present

223 In this signaling pathway, the N-terminally palmitoylated and C-terminally cholesterylate

224 nt studies are the first to explore KIFC1 in terminally postmitotic neurons.

225 s that are circularly permuted and about 13% terminally redundant.

226 etic resonance experiments that a similar, C-terminally retracted (Ub-CR) conformation also exists at

227 poris (Ph)PINK1 bound to ubiquitin in the 'C-terminally retracted' (Ub-CR) conformation.

228 Thus, IDPR acts on NUDT9H rather than N-terminally, revealing a regulatory function of NUDT9H in

229 o-ligand frequency in the same sequences and terminally sequenced nano-ligands at the same frequency

230 MyBP-C isoforms (1 fast-type MyBP-C and 3 N-terminally spliced slow-type MyBP-C) were expressed in E

231 n ligase ZNF598 is required for ribosomes to terminally stall during translation of poly(A) sequences

232 ular traps (NETs) consist of DNA released by terminally stimulated neutrophils.

233 The hydroboration of a series of terminally substituted alkenes with BH3 was examined exp

234 gT was N-terminally tagged with 3xFLAG and C-terminally tagged with 18xHis, we isolated SigT-interact

235 Moreover, after SigT was N-terminally tagged with 3xFLAG and C-terminally tagged wi

236 n the NanoBRET-based binding assay, SMO is N terminally tagged with nanoluciferase (Nluc) and binding

237 n is used to generate recombinant proteins C-terminally tethered to gels through environmentally sens

238 ified from Akkermansia muciniphila cleaves N-terminally to serine and threonine residues that are mod

239 ich untemplated Ala/Thr residues are added C terminally to stalled peptide, as shown during C-termina

240 Whereas almost stable helices are formed C terminally to the oligomerization domain, extremely tran

241 s between basic (Arg/Lys) residues located N-terminally to the phosphorylated Ser/Thr residues in the

242 s dropped below -4 degrees C, the specific N-terminally triply phosphorylated LHCB1 isoform (3p-LHCII

243 N-terminally truncated (96-585) GAD65 (tGAD65) autoantibod

244 hallmarks of Parkinson's disease, contain C-terminally truncated (DeltaC) alpha-synuclein (alpha-syn

245 0R) in the context of both full-length and N-terminally truncated (DeltaNT) G1.

246 As a consequence, N-terminally truncated Abeta will accelerate fiber formati

247 N-terminally truncated Abeta(11-40) and Abeta(11-42) make

248 Thus, we compared the accumulation of N-terminally truncated amyloid-beta and full-length amyloi

249 ross disease stages and brain areas, while N-terminally truncated amyloid-beta40 and full-length amyl

250 N-terminally truncated amyloid-beta42 accumulation showed

251 y APOE) were more strongly correlated with N-terminally truncated amyloid-beta42 accumulation than th

252 Cortical N-terminally truncated amyloid-beta42 accumulation was inc

253 We observed that N-terminally truncated amyloid-beta42 and full-length amyl

254 inical records showed that accumulation of N-terminally truncated amyloid-beta42 in cortical areas wa

255 Collectively, N-terminally truncated amyloid-beta42 species have spatiot

256 spectrometry analysis showed that several N-terminally truncated amyloid-beta42 species, represented

257 Moreover, N-terminally truncated amyloid-beta42 were more likely to

258 V(2)R agonists, we synthesized a series of C-terminally truncated analogues of [Val(4)]dDAVP, 2, modi

259 The resultant eIF4A protein is N-terminally truncated and acts as eIF4A inhibitor.

260 cterized full-length murine Trbeta2 and an N-terminally truncated and exclusively cytoplasmic 46-kDa

261 ptides, including full-length p19(Arf) and N-terminally truncated and unstable p15(smArf) ("small mit

262 bination and in vitro nuclease assays with C-terminally truncated ARTEMIS showing DNA-PKcs-independen

263 is mutation leads to reduced expression of C-terminally truncated BCOR (BCOR(DeltaE9-10)).

264 MP2B gene lead to the generation of mutant C-terminally truncated CHMP2B.

265 We found here that C-terminally truncated Drosophila TnT (TpnT-CD70) retains

266 determined the crystal structure of an amino-terminally truncated EHD4 dimer.

267 icroscopy studies have been performed with C-terminally truncated Env of the HIV-1(JR-FL) strain in c

268 on results in expression of full-length or N-terminally truncated ERG protein in prostate epithelia.

269 Importantly, the resulting C-terminally truncated fibrils acted as superior seeds in

270 econstituted human P-protein complexes and C-terminally truncated forms with ricin A chain (RTA), whi

271 In the absence of N-terminally truncated forms, blocking Nix-mediated mitoph

272 The mutations result in the expression of C-terminally truncated G-CSFRs that promote strong cell pr

273 both full-length/glycosylated beta1ARs and N-terminally truncated glycosylation-defective beta1ARs co

274 The C-terminally truncated IN (residues 1-269) produced an int

275 of p73 and reduced levels of the oncogenic N-terminally truncated isoform DeltaNp73 in Aldefluor(+) c

276 this IRES drives expression of a shorter, N-terminally truncated isoform of TDP2, DeltaN-TDP2, which

277 We show that in contrast to C-terminally truncated isoforms, which do not co-fibrilliz

278 More importantly, we identify a new C-terminally truncated Matr3 isoform that is likely to be

279 rather is the result of dominantly acting C-terminally truncated MN1 protein.

280 lation is posttranslational and identify a C-terminally truncated MRE11, which is formed after HDAC i

281 cient (mdx; N=3) mice, and mice expressing C-terminally truncated Na(v)1.5 (DeltaSIV; N=3).

282 ANAP was incorporated in full-length and C-terminally truncated Na(v)1.5 channels using mammalian c

283 mbryogenesis, nkap mutant zebrafish with a C-terminally truncated NKAP demonstrate severe development

284 C in 1991, all subsequent studies utilized N-terminally truncated open reading frames.

285 hal OXA2b T-DNA insertional mutants with a C-terminally truncated OXA2b lacking the TPR domain.

286 al ORFs within existing ORFs, resulting in N-terminally truncated products, as well as internal out-o

287 The susceptibility allele encodes a C-terminally truncated protein (Oas1b-tr).

288 ed that the Cvi-1 FtsZ2-2 allele encodes a C-terminally truncated protein lacking a region required f

289 ways degraded efficiently and can generate C-terminally truncated proteins which might have residual

290 position both in vitro and in vivo Because N-terminally truncated pyroglutamate (pE)-modified Abeta s

291 es containing a series of N-terminally and C-terminally truncated Swr1 subunits reveal further detail

292 nisms, translation reinitiation leading to N-terminally truncated target proteins or skipping of the

293 shorter transcript (Tet1(S) ) encoding an N-terminally truncated TET1 protein and a full-length Tet1

294 ptor potential melastatin-8 (TRPM8) and an N-terminally truncated TRPM8 variant (TRPM8-Delta801) are

295 cross-seeded with fibrils formed from the N-terminally truncated variant DeltaN6-hbeta(2)m.

296 A C terminally truncated variant of HjLPMO9A containing 21 r

297 the Galpha portion, but not Gsalpha or an N-terminally truncated XLalphas mutant unable to interact

298 translationally regulates expression of an N-terminally truncated, cytoplasmic isoform of TDP2.

299 Deltatau314, the C-terminally-truncated cleavage products, are soluble and

300 re able to target oligomers assembled from N-terminally ubiquitinated proteins.