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1 t majority of symbionts has been regarded as terminally differentiated.
2 rapidly than adult cells and quickly became terminally differentiated.
3 sts, withdraw from the cell cycle and become terminally differentiated.
4 tinued proliferation and clonal expansion of terminally differentiated acinar cells in all major sali
5 mia efficiently stimulates the conversion of terminally differentiated acinar cells to beta-like cell
7 s of unique transcriptional states to become terminally differentiated acinar, ductal and myoepitheli
8 Conversion of mesenchymal stem cells into terminally differentiated adipocytes progresses sequenti
9 Here, we identified a subset of lincRNAs in terminally differentiated adult human retinal neurons ba
10 ficantly elevated frequencies of circulating terminally differentiated alpha-NAC-specific CD8(+) T ce
15 3 (-)2B4(+) cells; in turn, these cells were terminally differentiated and highly susceptible to cell
16 chynomene spp. and that these bacteroids are terminally differentiated and polyploid, similar to bact
17 osphohydrolase, down-regulates dNTP pools in terminally differentiated and quiescent cells, thereby i
20 monstrating that this tolerized state is not terminally differentiated and that tolerized DCs can rec
22 at mammalian adult cardiomyocytes (ACMs) are terminally-differentiated and are unable to proliferate.
23 t neuronal populations that are postmitotic, terminally differentiated, and non-regenerating, depend
24 ranscriptionally distinct from conventional, terminally differentiated, antigen-induced peripheral bl
25 or the T-box transcription factor T-bet lack terminally differentiated antitumor CD27(low)KLRG1(+) NK
28 tudied multiple myeloma (MM) as a model of a terminally differentiated B cell malignancy that selecti
32 marrow are heterogeneous, consisting of (a) terminally differentiated B-1-derived plasma cells expre
35 ossible to deliver safely stem cell-derived, terminally differentiated, biologically and genetically
38 at coordinate the final mitotic divisions of terminally differentiated bone marrow (BM) erythroid cel
39 in infarcted hearts and emerged de novo into terminally differentiated cardiac myocytes, smooth muscl
40 unchanged "educated" (CD11b(+)CD27(+)) and "terminally differentiated" (CD11b(+)CD27(-)) NK cell fre
41 production--are specifically associated with terminally differentiated (CD27(-)) allergen-specific CD
42 s thematuration of NK cells from CD27high to terminally differentiated CD27low NK cells, we used Rag-
43 cancer regression and TIL persistence and a terminally differentiated CD39-positive state (CD39(+)CD
45 ained significantly increased frequencies of terminally differentiated CD57+KLRG1+ cells in CMV serop
46 rated a greater fall in the concentration of terminally differentiated CD8 effector memory T cells (T
48 ion leads to acute loss of antigen-specific, terminally differentiated CD8 T cells, possibly through
49 at is associated with a relative increase of terminally differentiated CD8 Temra cells protects again
50 vere disease stage had a higher frequency of terminally differentiated CD8(+) T cells than patients a
51 d that an increased proportion of senescent, terminally differentiated CD8(+) T cells would identify
57 nd mouse genomes in embryonic stem cells and terminally differentiated cell types at unprecedented re
58 Progress has also been made in converting terminally differentiated cell types into beta-cells usi
60 sor effector cells; MPEC) and those that are terminally differentiated cells (short-lived effector ce
61 mechanisms of protection, poor protection by terminally differentiated cells and the importance of T
62 of replicating muscle progenitor cells into terminally differentiated cells and to develop new strat
65 Deregulation of mitochondrial network in terminally differentiated cells contributes to a broad s
68 method of generating iMS cells from primary terminally differentiated cells has significant scope fo
70 ition from lineage-restricted progenitors to terminally differentiated cells is a central aspect of n
71 of efficient and stable splicing patterns in terminally differentiated cells is critical to maintenan
72 the long-held belief that DNA methylation of terminally differentiated cells is permanent and essenti
76 portant role in oxidative phosphorylation in terminally differentiated cells such as cardiomyocytes.
77 Glomerular podocytes are highly specialized terminally differentiated cells that act as a filtration
78 f self-renewal and differentiation into more terminally differentiated cells that downregulate Tcf-1
81 Cardiomyocytes in adult mammalian hearts are terminally differentiated cells that have exited from th
82 Human corneal endothelial cells (HCEnCs) are terminally differentiated cells that have limited regene
84 eostasis of multicellular organisms requires terminally differentiated cells to preserve their lineag
86 The prospect of changing the plasticity of terminally differentiated cells toward pluripotency has
87 caused reductions in cell numbers only among terminally differentiated cells while proliferation-comp
88 ically considered a homogenous population of terminally differentiated cells with a well-defined and
90 H3 from centromeres is a general property of terminally differentiated cells, and the persistence of
91 immune system, were previously thought to be terminally differentiated cells, incapable of altering t
92 to acquire KIRs when maturing from naive to terminally differentiated cells, little information is a
93 te PPARgamma cistrome and show that, even in terminally differentiated cells, PU.1 can remodel the ci
96 omyocytes are traditionally considered to be terminally differentiated cells, unable to proliferate.
99 ression loss also resulted in the decline of terminally differentiated cells, which was supplanted by
109 alpha5 localizes to the lateral membrane of terminally differentiated colonocytes and that integrin
110 lanted nucleus (ES cell, fetal fibroblast or terminally differentiated cumulus cell) and the recipien
112 their clonal relationships and characterize terminally differentiated dysfunctional UC CD8(+) T cell
113 nity while other effector cells develop into terminally differentiated effector (TE) cells with limit
115 cell subsets along with unique modulation of terminally differentiated effector CD8 T cells by combin
116 but not combination therapy, while activated terminally differentiated effector CD8 T cells expand on
117 fection, an activated CD4(+) T cell produces terminally differentiated effector cells and renews itse
118 s, the Vbeta5(+) subset expressed markers of terminally differentiated effector cells, and their expa
121 etected and associated with the expansion of terminally differentiated effector memory (TEMRA; CD45RA
122 ild disease along with a strong expansion of terminally differentiated effector memory CD4+T-cells ,
124 eiling in both subsets an unattended pool of terminally differentiated effector memory cells with pre
125 ustion-/suppression-associated PD1, CD57 and terminally differentiated effector memory cells, with mo
126 ld, which were proliferative and exhibited a terminally differentiated effector memory phenotype.
128 we show that human ALPS DNT have features of terminally differentiated effector memory T cells reexpr
129 daughter cells with a propensity towards the terminally differentiated effector or self-renewing memo
130 ve mTORC1 activation, these cells retained a terminally differentiated effector phenotype and were in
131 nce, most CMV-specific CD8(+) T cells become terminally differentiated effector phenotype CD8(+) T ce
132 l memory T cell, effector memory T cell, and terminally differentiated effector T cell populations to
133 ion, stem-like CD8 T cells give rise to more terminally differentiated, effector-molecule-expressing
134 n the generation of more cytolyticly potent, terminally differentiated effectors that possess limited
135 l subsets-including effector memory (EM) and terminally differentiated EM (TEMRA) CD8(+) T cells-in b
137 confined within the effector memory (EM) or terminally differentiated EM CD45RA(+) cell subsets expr
139 the adult Drosophila posterior midgut, both terminally differentiated enterocyte (EC) and enteroendo
140 em-cell population, but rather indicate that terminally differentiated epithelia reexpress apparent s
141 d cancer stem cells and is also expressed in terminally differentiated epithelial and photoreceptor c
145 ase Thousand and One Kinase 3 (TAOK3) lacked terminally differentiated ESAM(+) CD4(+) cDC2s in the sp
147 ir responses highlight the dichotomy between terminally differentiated exhausted T cells that are TCF
148 nds molecular transition from the nascent to terminally differentiated fiber cells in the developing
149 c remodeling facilitate this transition from terminally differentiated gametes to totipotent blastome
150 eted beta cells revealed the collapse of the terminally differentiated gene program, indicated by a l
154 onic stem cells (hESCs) from endoderm toward terminally differentiated hepatocytes, thus mimicking th
156 at the cardiac precursors stage, but not in terminally differentiated hPSC-cardiomyocytes, by transi
157 cell-derived hepatocyte-like cells to their terminally differentiated human counterparts using defin
158 draining lymph nodes became replenished with terminally differentiated human follicular Th cells, pla
159 nvasion, which is crucial for replacement of terminally differentiated hypertrophic chondrocytes by b
160 compartments within conidia, but not within terminally differentiated infection cells, and thus spat
161 d that ventricular endocardial cells are not terminally differentiated; instead, they are angiogenic
163 cancer cells that have undergone EMT can be terminally differentiated into adipocytes using the PPAR
164 ymocytes maintained high PLZF expression and terminally differentiated into interleukin 4 (IL-4)-prod
165 lls generated from somatic cells; (2) can be terminally differentiated into mature connective tissue
166 o critically dependent on normal shedding of terminally differentiated keratinocytes, a process terme
167 cells lacking Id2 did not generate a robust terminally differentiated killer cell lectin-like recept
168 as established memory CD8(+) T cells toward terminally differentiated KLRG-1(hi)IL-7Ralpha(lo)GzmB(h
169 tory cytokine IL-12 drives the generation of terminally differentiated KLRG1(+) effector CD8(+) T cel
170 lted from accumulation of greater numbers of terminally differentiated KLRG1(hi) effector CD8 T cell
172 allenging the classic view of neutrophils as terminally differentiated leukocytes destined to die or
174 er CD4(+) T cell subsets have been viewed as terminally differentiated lineages with limited flexibil
176 tein LL (hnRNPLL) is specifically induced in terminally differentiated lymphocytes, including effecto
177 idence that loss of CD28 cells is typical of terminally differentiated lymphocytes, the aim of this s
178 sion of cell cycle-associated proteins, with terminally differentiated macrophages becoming highly su
179 how HIV-1 achieves efficient replication in terminally differentiated macrophages despite the restri
180 rance and new loop formation are observed in terminally differentiated macrophages, but not TNFalpha-
181 nsduce nondividing cells is key to infecting terminally differentiated macrophages, which can serve a
182 hyltransferase Dnmt3a has high expression in terminally differentiated macrophages; however, its role
183 not only during differentiation but also in terminally differentiated-macrophages and immature dendr
185 expression is substantially downregulated in terminally differentiated mast cells as compared with th
186 The adult heart is composed primarily of terminally differentiated, mature cardiomyocytes that ex
187 Reconstitution of effector, central and terminally differentiated memory cell population and inc
188 central memory T cell subsets at onset and 5 terminally differentiated memory T (TEMRA) cell subsets
189 , CD8CD28, CD4CD57PD1, and CD8CD28 end-stage terminally differentiated memory T cells were measured p
190 on of CD8(+)CD28(-) T cells, a population of terminally differentiated memory T cells, is one of the
191 with greater than 35 cells CD8CD28 end-stage terminally differentiated memory T cells/muL rejected, m
192 prisingly DNA replication takes place in the terminally differentiated mother cell as offspring grow.
194 cycling neural progenitor cells but also in terminally differentiated, myelinating oligodendrocytes.
195 view, until now based on in vitro data, that terminally differentiated myeloid cells in vivo are site
198 derived suppressor cells into protumorigenic terminally differentiated myeloid mononuclear cells (TDM
199 nificant downregulation of TFIID subunits in terminally differentiated myocytes, hepatocytes and adip
200 ng skeletal muscle precursors (myoblasts) to terminally-differentiated myocytes is a critical step in
201 the earliest premyogenic progenitor stage to terminally differentiated myofibers, and discuss how thi
206 ts suggest that telomeres are dispensable in terminally differentiated neurons and provide mechanisti
208 rated acute murine knock-out models of Rb in terminally differentiated neurons in vitro and in vivo.
209 taining the survival and normal functions of terminally differentiated neurons is also crucial for li
214 NK cells, naive T cells, and accumulation of terminally differentiated NK and CD8(+) memory T cells.
222 rm (4-day) murine cytomegalovirus infection, terminally differentiated NKs accumulate in the livers o
223 e effects reduced the number and function of terminally differentiated NKT and gammadelta T cells in
225 tal Cell, Amulic et al. (2017) show that the terminally differentiated, non-cycling neutrophils repur
228 rating de novo cardiomyocyte-like cells from terminally differentiated nonmyocytes in the heart in si
229 ifferent stages of erythropoiesis, including terminally differentiated nucleated RBCs that we term "j
231 Although their phenotype resembles that of terminally differentiated or exhausted T cells, lack of
233 the differentiation of human macrophages to terminally differentiated osteoclasts are dependent on s
235 r5(+) stem cells are intermingled with their terminally differentiated Paneth cell daughters at crypt
241 not revert back to the parent isotype, and a terminally differentiated plasma cell cannot contribute
242 d a high number of activated CD8(+) T cells, terminally differentiated plasma cells, and activated ep
244 versial, and has gained interest because the terminally differentiated pollen vegetative nurse cell s
245 ssion of the glycoprotein CD101 divides this terminally differentiated population into two subsets.
246 thymus TPA(lo)MHCII(lo) pre-Aire rather than terminally differentiated post-Aire TPA(hi)MHCII(lo) mTE
255 define paracellular transport properties of terminally differentiated renal proximal tubule epitheli
257 ajor cell fates, CD57(+) CD127(-)-resembling terminally differentiated senescent memory cells and CD1
261 These and other properties are analogous to terminally differentiated short-lived CD8(+) T effector
263 monstrate plasticity in the reprogramming of terminally differentiated sperm nuclei and suggest that
264 y in the adult maintains mature DCTs in this terminally differentiated state and prevents renal fibro
265 own about how gene batteries that define the terminally differentiated state of a neuron type are mai
267 reveal a novel mechanism for maintaining the terminally differentiated state of Drosophila photorecep
268 ese cells does not represent conversion to a terminally differentiated state, but rather represents t
269 glycolytic flux drives CD8+ T cells toward a terminally differentiated state, while its inhibition pr
271 ed a requirement for LDB1 in maintaining the terminally differentiated status of pancreatic beta cell
272 CX3CR1, HAVCR2 (TIM-3), and ZEB2 represents terminally differentiated status with the unique transcr
273 d, the specific accumulation of oocytes, the terminally differentiated stem cell progeny, triggers a
274 oid male gametophyte, the pollen grain, is a terminally differentiated structure whose function ends
275 In the thymus, DOCK8-deficient mice lack a terminally differentiated subset of NK1.1(+) NKT cells e
276 , after: 16.5 +/- 2.3%) and 2) a decrease in terminally differentiated subsets (CD4(+): before: 47.3
277 tissue-resident populations, whereas mature, terminally differentiated subsets mediate immunosurveill
278 in the bladder whereas K20, a marker of the terminally differentiated superficial urothelial cells w
279 erative cytotrophoblast (CTB), precursors to terminally differentiated syncytiotrophoblast (STB) in c
280 T-cell responses in the CD4 compartment and terminally differentiated T cells in the CD8 compartment
281 eline naive T cells and lower percentages of terminally differentiated T cells, compared with nonresp
282 ell response deficiency, a high frequency of terminally differentiated T cells, the presence of monof
287 of CD4 effector memory T cells (TEM) and CD8 terminally differentiated TEM (TEMRA), with greater CD4
288 nfirmed an acute and persistent depletion of terminally differentiated TEMRA and cytomegalovirus-spec
289 otection to Mtb rechallenge when compared to terminally differentiated Th1 cells that reside preferen
290 PA:LFn-GAL4:ASO transfection of non- or terminally-differentiated THP-1 cells and Vero cells res
291 subset of RD-histone genes are expressed in terminally differentiated tissues as polyadenylated mRNA
292 ting for myelination studies, or they can be terminally differentiated to myelin basic protein-positi
293 udy, we show that Klrg1(+) Tregs represent a terminally differentiated Treg subset derived from Klrg1
295 ity is caused by an accumulation of the most terminally differentiated type of chondrocytes that prod
296 In galegoid plants, the endosymbionts are terminally differentiated, uncultivable polyploid cells,
299 postnatal cochlea, the sensory epithelium is terminally differentiated, whereas tympanic border cells
300 n be similarly reprogrammed and subsequently terminally differentiated with abrogation of tumorigenic