ライフサイエンスコーパス: termination codon

1 enerated and characterized ("Term" indicates termination codon).

2 orescent protein, which contains a premature termination codon.

3 ethionine codons downstream of the premature termination codon.

4 s function of stalling ribosomes at the uORF termination codon.

5 ation, leading to a frameshift and premature termination codon.

6 mma3 gene, leading to an immediate premature termination codon.

7 n of the final intron leading to a premature termination codon.

8 d the location of the stem-loop close to the termination codon.

9 eplaces an arginine codon with a translation termination codon.

10 disrupted by the insertion of a translation termination codon.

11 mRNA, resulting in each case in a premature termination codon.

12 nine (Arg) by stalling ribosomes at the uORF termination codon.

13 by increased ribosomal occupancy of the uORF termination codon.

14 70 nucleotides downstream of the translation termination codon.

15 ntronic fragments with an in-frame premature termination codon.

16 t involves Stau1, the NMD factor Upf1, and a termination codon.

17 y changing the distance from the translation termination codon.

18 its mRNA decay when tethered downstream of a termination codon.

19 t regulators of readthrough at the premature termination codon.

20 pen reading frame and results in a premature termination codon.

21 that lacks the exon containing the premature termination codon.

22 erate and present epitopes downstream of the termination codon.

23 in read through of the normal translational termination codon.

24 f, resulting in a frameshift and a premature termination codon.

25 splicing to a cryptic exon with a premature termination codon.

26 ing of Lmod1 to generate a similar premature termination codon.

27 mination and ribosome release at a premature termination codon.

28 ulted in frame-shift mutations and premature termination codons.

29 ipts with pseudoexon inclusion and premature termination codons.

30 vely degrade transcripts harboring premature termination codons.

31 gnition of only the conventional UAA and UAG termination codons.

32 romotes readthrough of premature translation termination codons.

33 the ability of ribosomes to properly decode termination codons.

34 are nonsense mutations leading to premature termination codons.

35 transcripts containing premature translation termination codons.

36 omal readthrough of premature but not normal termination codons.

37 t can be decoded as either selenocysteine or termination codons.

38 0% of the LQT2 mutations result in premature termination codons.

39 ids eukaryotic cells of mRNAs with premature termination codons.

40 ecognizing and degrading mRNAs with aberrant termination codons.

41 the others were predicted to have premature termination codons.

42 f transcripts carrying premature translation termination codons.

43 degrades mRNAs with premature translational termination codons.

44 re are limited interactions with translation termination codons.

45 at degrades mRNAs with premature translation-termination codons.

46 hat rids cells of mRNAs containing premature termination codons.

47 mutations predict the formation of premature termination codons.

48 (NMD) eliminates transcripts with premature termination codons.

49 rades transcripts with premature translation-termination codons.

50 exons compared to other exons with premature termination codons.

51 otation of open reading frames and premature termination codons.

52 rades mRNAs containing premature translation termination codons.

53 all these mutations created nonsense (chain termination) codons.

54 ons (Leu127X; Lys292X) resulted in premature termination codons, 2 (Pro190LeufsX47; Arg319GlufsX34) i

55 gene resulting in a frameshift and premature termination codon 7 bp downstream from the site of the d

56 tron at least 50 nucleotides downstream of a termination codon, a context sufficient to initiate NMD.

57 tion, but only if they are within 15 nt of a termination codon; a spacing of 16 nt has no effect, sug

58 C terminus and the adjacent inefficient UGA termination codon act to recruit the SsrA-tagging system

59 rmal mRNA splicing, resulting in a premature termination codon after exon 17.

60 This editing generates a premature termination codon and a truncated open reading frame.

61 ion of aberrant mRNAs containing a premature termination codon and also controls the levels of endoge

62 gging correspond to ribosome stalling at the termination codon and at rare AGG codons encoding Arg-30

63 ncrease in PRF was independent of a proximal termination codon and did not result from increased ribo

64 reversion system is based on mutations in a termination codon and involves positive selection for re

65 Consequently, ribosomes stall at the uORF2 termination codon and obstruct downstream translation.

66 that leads to aberrant splicing, a premature termination codon and partial deficiency of the canonica

67 n non-neuronal tissues generates a premature termination codon and results in the truncation of the o

68 ions lead to the introduction of a premature termination codon and subsequent NMD of mutant UPF3B mRN

69 s-of-function mutations creating a premature termination codon and the degradation of the mutated mes

70 Neither the distance in space between the termination codon and the poly(A) tail nor the binding o

71 ), which is predicted to lead to a premature termination codon and thus to haploinsufficiency of RUNX

72 destabilized by introduction of a premature termination codon and, importantly, that this mRNA is a

73 present full-length coding sequences without termination codons and are Gateway(R) compatible.

74 Whereas eRF1 recognizes all three termination codons and induces hydrolysis of peptidyl tR

75 ll proband LEPRE1 mutations led to premature termination codons and minimal mRNA and protein.

76 pseudoexon, leading to mRNAs with premature termination codons and nonsense-mediated decay, decrease

77 he surveillance of mRNAs to define premature termination codons and possibly also in modulating the t

78 transcripts containing premature translation termination codons and regulates the levels of a number

79 nd rapid degradation of mRNAs with premature termination codons and, importantly, some wild-type mRNA

80 nus of the coding region and obliterated the termination codon, and del2 also altered the polyadenyla

81 or sites, creation of a downstream premature termination codon, and extremely unstable mRNA.

82 ative transcripts examined contain premature termination codons, and most persist even after rigorous

83 ch as those mediated by microRNAs, premature termination codons, and mRNA deadenylation.

84 uman beta-globin mRNAs harboring a premature termination codon are degraded in the erythroid tissues

85 demonstrate in yeast that mRNAs lacking all termination codons are as labile as nonsense transcripts

86 cannot be tested at codon sites, where only termination codons are inferred at any interior node or

87 ryotic mRNAs harboring premature translation termination codons are recognized and rapidly degraded b

88 Eukaryotic mRNAs containing premature termination codons are subjected to accelerated turnover

89 results show that mRNAs without translation termination codons are unstable in eukaryotic cells.

90 ly in the G319S cell line included premature termination codons as a result of the inclusion of 7 nuc

91 ly in the G319S cell line included premature termination codons as a result of the inclusion of seven

92 c to the 129S6/SvEv strain that introduces a termination codon at exon 7, abolishes production of the

93 containing a mutated initiation codon and a termination codon at internal position 27.

94 del from Igh (Ter5H) mice having a premature termination codon at position +5 in leader exon of Igh (

95 le novel mutation in CCDC65, which created a termination codon at position 293, was identified in a s

96 from the target epitopes, by introduction of termination codons at 519Y and 521Y.

97 nce, and type III, the most abundant, lacked termination codons at their 3' ends.

98 transcript that bears the unusual premature termination codon besides the canonically spliced OsPCS2

99 duced when translation terminates at an opal termination codon between nsP3 and nsP4.

100 lectively degrades mRNAs harboring premature termination codons but also regulates the abundance of c

101 s transcripts carrying premature translation termination codons, but the role of NMD on yeast unsplic

102 ted translation termination at the premature termination codon, by controlling PABP activity.

103 Termination codons can be ignored to obtain larger read-

104 mtDNA mutation that results in the loss of a termination codon causes enhanced mt-mRNA decay by trans

105 Degradation of premature termination codon-containing mRNA transcripts by nonsens

106 tion and subsequent termination at premature termination codons, culminating in NMD of the transcript

107 directs translating ribosomes to a premature termination codon, destabilizing it through the nonsense

108 es, but a child homozygous for the premature termination codon displayed symptoms consistent with MMI

109 -to-exon 5 junction and creating a premature termination codon downstream.

110 amma, retains intron I and has two premature termination codons far from the 3'-most exon-exon juncti

111 o disruption of Ig-domain 2D and a premature termination codon following the first amino acid in the

112 Here, a T116G point mutation, substituting a termination codon for Leu-39 (L39stop), was identified i

113 Loss of these two residues removes the termination codon for MTATP6 and sets MTCO3 immediately

114 the HIV-1 gp41 glycoprotein that substituted termination codons for amino acids 682 to 708, we show t

115 nslational readthrough or frameshifting past termination codons for the synthesis of extension produc

116 enable ribosomes to extend translation past termination codons for the synthesis of longer products.

117 lational readthrough occurs or when the opal termination codon has been replaced by a sense codon in

118 This frameshift mutation creates a premature termination codon immediately downstream, thereby nullif

119 lts in a frameshift and subsequent premature termination codon in each.

120 olated family was found to carry a premature termination codon in Leiomodin1 (LMOD1), a gene preferen

121 f principle in vitro, we correct a premature termination codon in mRNAs encoding the cystic fibrosis

122 However, introducing a premature termination codon in ORF1 or a thermostable hairpin in t

123 cleotides causing a frameshift and premature termination codon in RNA.

124 stability studies revealed the newly created termination codon in the elongated transcript activates

125 A premature termination codon in the human histidine decarboxylase (

126 a gammaHV68 mutant containing a translation termination codon in the LANA ORF (73.STOP).

127 the loss-of-function allele with an earlier termination codon in the precursor CTSK polypeptide.

128 that PKP2 mutations introducing a premature termination codon in the reading frame were associated w

129 t skipping of an exon introduces a premature termination codon in the transcript that downregulates M

130 ant virus containing a premature translation termination codon in the UL83 open reading frame (ORF) (

131 esignated c.442delAG, leading to a premature termination codon in the V1 domain of the K5 polypeptide

132 The discovery of premature termination codons in 38% of expressed genes was consist

133 These errors created premature termination codons in 4 and 42% of cDNA sequences in the

134 ation to concomitantly suppress two or three termination codons in an mRNA.

135 s the accurate identification of translation termination codons in eukaryotic cells.

136 Owing to the prevalence of premature termination codons in human disease, readthrough has eme

137 gulated suppression of amber, ochre and opal termination codons in mammalian cells.

138 rk progression, the recognition of premature termination codons in mRNAs, and inadequate nutrient ava

139 However, premature termination codons in pol, particularly in the integrase

140 mutant alleles are associated with premature termination codons in the disp1 coding sequence.

141 e from AME via the introduction of premature termination codons in the gp41 cytoplasmic tail coding r

142 , the majority of which arise from premature termination codons in the mRNA coding region.

143 variant (in which arginine is replaced by a termination codon) in the gene TBC1D4 with an allele fre

144 6), in the 3'-UTR, 1485 bp downstream of the termination codon, in a conserved region, with the A-all

145 mutations in hemojuvelin (HJV), including a termination codon, in a patient with juvenile hemochroma

146 ein-altering variants, including a premature termination codon, in CRKL.

147 Premature termination codons induce rapid transcript degradation i

148 oduced by using transformants with premature termination codon insertions in the corresponding pgp ge

149 p deletion that introduces a premature amber termination codon into the open reading frame of a putat

150 be highly conserved and introduced premature termination codons into coding regions.

151 Nonsense SNPs introduce premature termination codons into genes and can result in the abse

152 ng switches introduces premature translation termination codons into selected transcripts in a differ

153 rus (45STOP) by the insertion of translation termination codons into the portion of the gene encoding

154 Downstream from the termination codon is an insertion sequence that was homo

155 Element (RSE), located downstream of the p33 termination codon, is a large hairpin with two asymmetri

156 nslational enhancer (TED), located 3' to the termination codon, is necessary for efficient cap-indepe

157 The selectivity of PTC124 for premature termination codons, its well characterized activity prof

158 sequences by introduction of a translational termination codon just downstream from the initiator AUG

159 t a region of KRT10, upstream of a premature termination codon known to induce a genetic knockout.

160 ve, producing an 3'-truncated mRNA lacking a termination codon (known as nonstop mRNA) due to alterna

161 The duplication introduces a premature termination codon leading to nonsense-mediated mRNA deca

162 and 97% of these SNVs generated a premature termination codon, leading to loss of function through n

163 A 3'-UTR variants position the translational termination codon more than 50 nucleotides upstream of a

164 mRNAs containing premature translation termination codons (nonsense mRNAs) are targeted for dea

165 from translation of aberrant mRNAs lacking a termination codon (NonStop) or containing a sequence tha

166 RNA degradation pathway for messages lacking termination codons, northern blot analysis was performed

167 noglycosides stimulate readthrough of normal termination codons (NTCs) genome-wide.

168 lation in vivo, only the CITE closest to the termination codon of a reporter open reading frame is ac

169 The termination codon of uORF1 was mutated and the uORF was

170 Remarkably, the rare leucine codon, the termination codon of uORF1, uAUG2 and uAUG3 all improved

171 ral genes was substituted by a translational termination codon or a termination codon was inserted in

172 se; the remainder either introduce premature termination codons or create frameshifts both of which r

173 or F.IX variants with premature translation termination codons, or missense mutations, under the con

174 All three translation termination codons, or nonsense codons, contain a uridin

175 The initiation and termination codons overlap UGAUGA (underline highlights

176 In addition to premature termination codons, plant microRNAs can also direct the

177 These exon deletions introduce premature termination codons predicted to truncate the proteins ne

178 retain intron 2 during splicing; a premature termination codon present at the 5' end of intron 2 lead

179 ition, two modulators of NMD-translation and termination codon-proximal poly(A) binding protein-depen

180 splicing factor mutants comprise a premature termination codon (PTC) and are therefore potential targ

181 They introduce a premature termination codon (PTC) and prevent the formation of ful

182 ssential communication between the premature termination codon (PTC) and the exon-junction complex (E

183 ite, causing the introduction of a premature termination codon (PTC) and the reduction of steady-stat

184 rally occurs upon recognition of a premature termination codon (PTC) during a pioneer round of transl

185 9 is achieved by installation of a premature termination codon (PTC) from a frameshift-inducing INDEL

186 cally stabilizes mRNA containing a premature termination codon (PTC) in a VCS-dependent manner.

187 d by the presence of a premature translation termination codon (PTC) in an atypical sequence context.

188 A premature termination codon (PTC) in the ORF of an mRNA generally

189 e therapeutically desirable when a premature termination codon (PTC) is found in a critical gene.

190 ents with RDEB harbor at least one premature termination codon (PTC) mutation in COL7A1, and previous

191 Premature termination codon (PTC) mutations are due to insertion o

192 ERG, KCNH2) transcripts containing premature termination codon (PTC) mutations by nonsense-mediated m

193 Premature termination codon (PTC) mutations can have dramatic effe

194 100 ALS-associated SOD1 mutations, premature termination codon (PTC) mutations exclusively occur in e

195 oratory showed that C-terminal Gag premature termination codon (PTC) mutations in the 3' shared exon

196 ations particularly for those with premature termination codon (PTC) mutations who usually display lo

197 btype of fibrillinopathy caused by premature termination codon (PTC) mutations, we integrate genotype

198 ous effects of the position of the premature termination codon (PTC) on the CFTR protein function.

199 ukaryotic cells, an mRNA bearing a premature termination codon (PTC) or an abnormally long 3' untrans

200 des a frame-shifted protein with a premature termination codon (PTC) predicted to elicit degradation

201 genes, we show that mRNA bearing a premature termination codon (PTC) promptly triggers a GCR that inv

202 with a mutation that introduces a premature termination codon (PTC) that prevents synthesis of the f

203 efficiency of converting a U A: G premature termination codon (PTC) to tryptophan (U G: G) was impro

204 h degrades transcripts harboring a premature termination codon (PTC), depends on the helicase up-fram

205 trate that its inclusion creates a premature termination codon (PTC), that leads to a 65kDa truncated

206 se progranulin mutations contain a premature termination codon (PTC), thus progranulin haploinsuffici

207 s of both endogenous and exogenous Premature Termination Codon (PTC)-containing mRNA isoforms and its

208 onstrate that NMD in yeast targets premature termination codon (PTC)-containing mRNA to P-bodies.

209 (NMD) directs rapid degradation of premature termination codon (PTC)-containing mRNAs, e.g. those con

210 nt exon skipping and generation of premature termination codon (PTC)-containing mRNAs.

211 f cellular NMD targets, unlike for premature termination codon (PTC)-containing reporter mRNAs when c

212 diseases are caused by premature translation-termination codon (PTC)-generating mutations.

213 and degrading those that harbor a premature termination codon (PTC).

214 errant mRNAs containing a specific premature termination codon (PTC).

215 exon 7 that created a premature translation termination codon (PTC).

216 agging of transcripts containing a premature termination codon (PTC).

217 CHM gene resulting in an in-frame premature termination codon (PTC).

218 rotein C3 ( MYBPC3) resulting in a premature termination codon (PTC).

219 (NMD) degrades mRNAs containing a premature termination codon (PTC).

220 ation of translation by creating a premature termination codon (PTC); however, pseudouridylation at t

221 ation predicts a frameshift with a premature termination codon (PTC+32aa) in the eleventh transmembra

222 rders, including cancer, result in premature termination codons (PTC) and the rapid degradation of th

223 that would be predicted to produce premature termination codons (PTC) in ABCC4.

224 MD gene leading to the presence of premature termination codons (PTC).

225 ectively degrades transcripts with premature termination codons (PTC).

226 way that degrades mRNAs containing premature termination codons (PTC).

227 In-frame premature termination codons (PTCs) account for approximately 11%

228 ough agent, capable of suppressing premature termination codons (PTCs) and restoring functional prote

229 e show that transcripts containing premature termination codons (PTCs) are not always degraded effici

230 yotic mRNAs containing premature translation termination codons (PTCs) are rapidly degraded by a proc

231 mRNAs containing premature termination codons (PTCs) are rapidly degraded through n

232 Premature termination codons (PTCs) are responsible for 10-15% of

233 ugh which mRNA transcripts bearing premature termination codons (PTCs) are selectively degraded to ma

234 s (mRNAs) that contain premature translation termination codons (PTCs) are targeted for rapid degrada

235 (TCRbeta) genes naturally acquire premature termination codons (PTCs) as a result of programmed gene

236 lectively degrades mRNAs harboring premature termination codons (PTCs) but also regulates the abundan

237 gradation of transcripts harboring premature termination codons (PTCs) by the nonsense-mediated mRNA

238 delity, but the mechanism by which premature termination codons (PTCs) can apparently affect splice-s

239 Alternative isoforms with premature termination codons (PTCs) comprised the majority of alte

240 Aberrant mRNAs containing premature termination codons (PTCs) have the potential to be trans

241 rrant mRNAs containing nonsense or premature termination codons (PTCs) in a translation-dependent man

242 Premature termination codons (PTCs) in an mRNA ORF inactivate gene

243 ch compound-induced readthrough of premature termination codons (PTCs) might be exploited as a potent

244 tion of mRNA harboring premature translation termination codons (PTCs) serves to protect cells from a

245 e to identify sequences containing premature termination codons (PTCs) that are likely targets of mRN

246 ntergenic transcripts that contain premature termination codons (PTCs), but chimeric mRNAs of genes t

247 ide changes that result in primary premature termination codons (PTCs), either UAA, UAG, or UGA.

248 Nonsense mutations create premature termination codons (PTCs), leading to the generation of

249 ance translational read-through of premature termination codons (PTCs), thereby permitting expression

250 lternative transcripts often carry premature termination codons (PTCs), which trigger nonsense-mediat

251 des some but not all mRNAs bearing premature termination codons (PTCs).

252 are caused by the introduction of premature termination codons (PTCs).

253 of human genetic disorders involve premature termination codons (PTCs).

254 ctively degrading mRNAs harbouring premature termination codons (PTCs).

255 at destroys mRNAs with premature translation termination codons (PTCs).

256 exonization events that introduced premature termination codons (PTCs).

257 angements that frequently generate premature termination codons (PTCs).

258 ctive destruction of mRNAs bearing premature termination codons (PTCs).

259 ects and degrades mRNAs containing premature termination codons (PTCs).

260 cripts that have skipped offending premature termination codons (PTCs).

261 recognizes and degrades mRNAs with premature termination codons (PTCs).

262 in human diseases associated with premature termination codons (PTCs).

263 ciated with alternative exons with premature termination codons (PTCs).

264 electively degrades mRNAs carrying premature termination codons (PTCs).

265 ng frame, separated by a UAG stop codon, and termination codon readthrough is required for expression

266 may express a protein if its initiation and termination codons reside in the same reading frame, but

267 the reading frame or introducing a premature termination codon, respectively.

268 li glutamine tRNA, suppress UAG, UAA and UGA termination codons, respectively, in a reporter mRNA in

269 induce read-through of mRNA around premature termination codons, restore ATM activity and improve the

270 the kl-H and 3'TSS proximal to the reporter termination codon restores translation to near wild-type

271 The introduced premature termination codon results in deletion of the carboxyl te

272 Analysis of splice variants for premature termination codons reveals approximately 50% of identifi

273 on bias in the two codon positions 5' of the termination codon showed no correlation with known effec

274 signals would direct ribosomes to premature termination codons, suggest two possible mRNA destabiliz

275 romotes readthrough of premature translation termination codons, suggesting that it may have the pote

276 programmed ribosomal frameshifting, hopping, termination codon suppression, and the incorporation of

277 ntified 191 bp downstream of the translation termination codon (TGA).

278 g in a -1 frameshift allele with a premature termination codon that escapes nonsense-mediated decay.

279 nt downstream of the gag natural translation termination codon that prevents degradation of the unspl

280 This exon contains a premature termination codon that triggers nonsense-mediated mRNA d

281 ons, with an intervening sequence containing termination codons, then the expression of the second ac

282 ple organisms indicate that proximity of the termination codon to the 3' poly(A) tail and the poly(A)

283 One cDNA contained a premature termination codon, two contained splice variants, and fo

284 rare amino acid, pyrrolysine, encoded by the termination codon UAG.

285 ate A3H sequences were compared, a premature termination codon was identified on the fifth exon of th

286 ed by a translational termination codon or a termination codon was inserted into the open reading fra

287 actor 1, which works specifically at the UAG termination codon, we constructed Escherichia coli strai

288 slational fidelity to promote readthrough of termination codons, were shown to increase SMN levels in

289 ad terminal in-frame thymidines that created termination codons when polyadenylated, type II had down

290 cript variant with a frame-shifted premature termination codon which is subjected to nonsense-mediate

291 Drugs targeting F508del CFTR and premature termination codons, which would be applicable to 90% of

292 substitutions and introduction of premature termination codons, while most mutations disrupt one of

293 a U12-type intron downstream of a premature termination codon within an open reading frame (ORF) ind

294 a 0.51 kb length transcript (AT5) that has a termination codon within intron 8-9.

295 gene family, but also to contain a premature termination codon within the first exon.

296 leles are predicted to result in a premature termination codon within the last exon, escape nonsense-

297 onstructs were designed containing premature termination codons within the coiled-coil neck domain.

298 when polyadenylated, type II had downstream termination codons within the elongated alpha-GalA seque

299 of peripheral neuropathy result in premature termination codons within the terminal or penultimate ex

300 Intron 2 contains a premature termination codon, yet the K8beta mRNA is insensitive to