ライフサイエンスコーパス: termination factor

1 form of Sup35p, a subunit of the translation termination factor.

2 mary site of action is the rho transcription termination factor.

3 of the Saccharomyces cerevisiae translation termination factor.

4 cled in the presence of the La transcription termination factor.

5 ve degradation of human GSPT1, a translation termination factor.

6 3, a 3'-end RNA-processing and transcription termination factor.

7 he prion form of the yeast Sup35 translation termination factor.

8 ltered conformation of the Sup35 translation termination factor.

9 olymerase, and the rho gene, which encodes a termination factor.

10 in the prion domain of Sup35, a translation-termination factor.

11 ides underlying the binding of transcription termination factors.

12 yces cerevisiae and that Gle1 interacts with termination factors.

13 elements and mRNA elongation, processing and termination factors.

14 mpeting for RNA binding with polyadenylation/termination factors.

15 on factors or with translation elongation or termination factors.

16 n exchange of elongation and polyadenylation/termination factors.

17 ination for recruiting beta turn-recognizing termination factors.

18 n Tyr1 and both transcription initiation and termination factors.

19 ue in the GGQ motif of ribosomal translation termination factors.

20 ng factors, 3'-end-processing complexes, and termination factors.

21 inity binding of mitochondrial transcription termination factor 1 (mTERF1) to the site.

22 ochondria is the mitochondrial transcription termination factor 1 (MTERF1, also denoted mTERF), which

23 -29% identical to mouse TTF-1 (transcription termination factor-1) and Saccharomyces cerevisiae REB1

24 cible 1 and 2 (DDI1/2), regulate Replication Termination Factor 2 (RTF2) levels at stalled replisomes

25 signaling pathway, we found that replication termination factor 2 (RTF2) restricts influenza virus at

26 hibit termination of Pol II by transcription termination factor 2 (TTF2) as well as block elongation

27 n to recruit proteins, such as transcription termination factor 2 (TTF2), to bind the YAP/TEAD/NSP13

28 Pol II termination activity of transcription termination factor 2 (TTF2).

29 latory proteins, such as TTF2 (transcription termination factor 2), TFIIS, and RPB9.

30 mined the structure of the Rho transcription termination factor, a hexameric RNA/DNA helicase, with s

31 n factors at the promoter and recruitment of termination factor aCPSF1 to the early TEC.

32 unctional analyses suggest that p, and other termination factors across life, may use analogous strat

33 ctional analyses suggest that rho, and other termination factors across life, may use analogous strat

34 The transcription termination factor activity of the D1-D12 capping enzyme

35 nitiation factor activity of La augments its termination factor activity to produce a novel mechanism

36 Evidence indicates that a required termination factor acts through binding to the UUUUUNU s

37 Finally, termination factors also contribute to genomic stability

38 at a stalled RNAP in the absence of vaccinia termination factor and U(5)NU when transcription elongat

39 codon nucleotide context, the activities of termination factors and the abundance of suppressor tRNA

40 cessing or translation, and (iii) recruiting termination factors and thereby silencing laterally tran

41 NELF interacts with Pcf11, a transcription termination factor, and diminishing Pcf11 in primary CD4

42 TP-dependent RNA polymerase II transcription termination factor, and discovered that it was identical

43 up35 protein is a subunit of the translation termination factor, and its conversion to the [PSI (+)]

44 with the discovery of the Rho transcription termination factor, and the regulatory mechanism of tran

45 osomal subunits; initiation, elongation, and termination factors; and aminoacyl tRNAs.

46 mination site by mitochondrial transcription termination factor (approximately 80%).

47 lso a subunit of the essential transcription termination factor APT (associated with Pta1).

48 und that the interactions with transcription termination factors are primarily governed by the C-term

49 Using the Escherichia coli Rho transcription termination factor as a model system, we have used solut

50 e structure of the E. coli Rho transcription termination factor bound to RNA and nucleotide.

51 otein, normally a subunit of the translation termination factor, but impaired in this vital function

52 rpedo model in which Rat1 is not a dedicated termination factor, but is an integrated component of th

53 Only select sequences or transcription termination factors can disrupt the otherwise extremely

54 rmination activity (Eta), the first archaeal termination factor capable of disrupting the transcripti

55 Vaccinia termination factor/capping enzyme is a multifunctional h

56 rase requires a termination factor (vaccinia termination factor/capping enzyme) and is coupled to the

57 ies are shared by the homologous translation termination factor complex eRF1:eRF3, suggesting a commo

58 We demonstrate that negative and positive termination factors control the efficiency of terminatio

59 bacterial morphogenesis, but polymerization termination factors controlling this process have yet to

60 RNA polymerase II CTD and the 3' processing/termination factors CPF and Rhn1, mutations of which res

61 ends on: (i) 3'-processing and transcription termination factors CPF, Pin1, and Rhn1; and (ii) Threon

62 PII and accumulated R-loops-and recruits the termination factor Dhp1 to ensure efficient RNAPII relea

63 endent ATPase that serves as a transcription termination factor during viral mRNA synthesis.

64 interaction of transcription initiation and termination factors during gene looping in budding yeast

65 Thus, the action of a eukaryotic termination factor entails recognition of the nucleotide

66 have shown that domain 1 of the translation termination factor eRF1 mediates stop codon recognition.

67 Downregulating the translation termination factor eRF1 produces defective virus particl

68 e termination is mediated by the translation termination factor eRF1, which recognizes ribosomes stal

69 translation factors, including eEF1A and the termination factor eRF1.

70 resses PTCs by reducing the abundance of the termination factor eRF1.

71 tRNA(Arg)(UCC), and depletion of translation termination factor eRF1.

72 lates Gln(185) of the eukaryotic translation termination factor eRF1.

73 s have proposed a direct role for eukaryotic termination factors eRF1 and eRF3 (and the related facto

74 34p and Hbs1p are similar to the translation termination factors eRF1 and eRF3, indicating that these

75 ed that Tpa1p interacts with the translation termination factors eRF1 and eRF3.

76 1p interact with both eukaryotic translation termination factors eRF1 and eRF3.

77 and self-propagating form of the translation termination factor eRF3 (Sup35), can be cured of its inf

78 Translation termination factor eRF3 enhances the activity of release

79 prion state of the S. cerevisiae translation termination factor eRF3, Rps23p hydroxylation can either

80 is caused by a prion form of the translation termination factor eRF3.

81 n elongation factor EF1A and the translation termination factor eRF3.

82 the second requires an 80S ribosome and the termination factors eRF3/Sup35 and eRF1/Sup45.

83 (Leu(UUR)) gene that binds the transcription termination factor failed to reveal any difference in oc

84 tion in the Sen1 helicase, which is a Pol II termination factor for noncoding RNA genes.

85 s from full-length readthrough, and we found termination factor FPA specifically promotes termination

86 Addition of rho termination factor from E. coli induces RNA pol II to re

87 itination and degradation of the translation termination factor GSPT1.

88 inase 1alpha (CK1alpha), and the translation termination factor GSPT1] whose ubiquitylation is induce

89 glue, inducing degradation of a translation termination factor, GSPT1 to achieve its potent anticanc

90 tmRNA(+) and DeltatmRNA cells, whereas other termination factors had little or no effect on recycling

91 racterized in each domain, but transcription termination factors have been identified only in bacteri

92 Although many eukaryotic termination factors have been identified to date, the de

93 Two termination factors have been identified.

94 binder of ARL 2, Paxillin, and transcription termination factor I have not been previously reported t

95 A genetic screen to identify termination factors identified an allele that separated

96 e NusA was known to function as an intrinsic termination factor in B. subtilis, the role of NusG in t

97 Rho is a general transcription termination factor in bacteria, but many aspects of its

98 el antibiotic that targets rho transcription termination factor in Escherichia coli.

99 present the first example of a transcription termination factor in Saccharomyces cerevisiae that affe

100 results suggest that the mechanisms used by termination factors in archaea, eukarya, and bacteria to

101 human TTF2, an RNA polymerase (Pol) I and II termination factor, in mitotic repression of transcripti

102 Two pathways of transcription termination, factor-independent and -dependent, exist in

103 To our knowledge, intended aggregation of a termination factor is a way to overcome the bacterial tr

104 Rho termination factor is an essential hexameric helicase re

105 consistent with a model in which a required termination factor is converted from an inactive to an a

106 The involvement of the termination factors is independent of a termination even

107 se that a critical function of transcription termination factors is to prevent TEC from blocking DNA

108 When Sup35, a yeast translation termination factor, is aggregated in its [PSI(+)] prion

109 ressor tRNAs, or the targeted degradation of termination factors, lack mRNA target selectivity and ma

110 reducing expression levels of the viral anti-termination factor M2-1.

111 is devoid of the mitochondrial transcription termination factor MOC1 and aberrantly expresses the mit

112 The human mitochondrial transcription termination factor mTERF plays a central role in the con

113 The human mitochondrial transcription termination factor (mTERF) cDNA has been cloned and expr

114 of the so-called mitochondrial transcription termination factor (mTERF) family are found in metazoans

115 a member of the mitochondrial transcription termination factor (MTERF) family of proteins, MTERF4, r

116 The human mitochondrial transcription termination factor (mTERF) is a nuclear-encoded 39-kDa p

117 The mitochondrial transcription termination factor (mTERF) proteins are nucleic acid bin

118 -4 1), encodes a mitochondrial transcription termination factor (mTERF)-related protein, one of 35 Ar

119 tch of the human mitochondrial transcription termination factor MTERF1, which has a modular, superhel

120 Rho transcription termination factor mutant, F355W, showed tryptophan fluo

121 -binding dynamics of the yeast transcription termination factor Nab3 in response to glucose starvatio

122 in the interaction of a single transcription termination factor (Nab3) with a specific RNA substrate

123 w that it is the translation initiation (not termination) factor, namely eIF3, which critically promo

124 ignal (UUUUUNU) in the nascent RNA, vaccinia termination factor, nucleoside triphosphate phosphohydro

125 titermination, was restored by the bacterial termination factor NusA.

126 , but still responsive to, the transcription termination factor NusG.

127 formed by the interaction of initiation and termination factors occupying the distal ends of a gene

128 Our data reveal that WNK1 phosphorylates the termination factor PCF11 on its RNA polymerase II (Pol I

129 We show that the termination factor, Pcf11, causes premature termination

130 a56 mutant allele by impeding recruitment of termination factors Pcf11p and Rna15p (subunits of cleav

131 Notably, termination factors play an additional promoter role by

132 Rho is a general transcription termination factor playing essential roles in RNA polyme

133 We also show that, like Mfd, the Rho termination factor promotes forward translocation of RNA

134 a protein related to the yeast transcription termination factor Rai1, is essential for piRNA producti

135 fic DNA bound proteins such as the RNA pol I termination factor, Reb1p, or lac repressor.

136 ity control (post PT QC) mechanism where the termination factors recognize mismatched (i.e. error-con

137 (2) A general transcription termination factor, recruited by transcribing Pol II at

138 Mitochondrial Transcription tERmination Factor-related (mTERF) proteins are involved

139 he function of two known E. coli translation termination factors, RF1 and RF2.

140 avage-polyadenylation factor (CPF) subunits, termination factor Rhn1, and the Thr4 letter of the CTD

141 efects absent CPF subunits Ctf1 and Dis2 and termination factor Rhn1.

142 nd polyadenylation factor (CPF) subunits and termination factor Rhn1; 4) synthetic lethality of seb1-

143 homohexameric Escherichia coli transcription termination factor Rho along RNA, rates for association

144 hat a major function of the Escherichia coli termination factor Rho and its cofactor, NusG, is suppre

145 The expression and activity of transcription termination factor Rho and the requirement for transcrip

146 The transcription termination factor Rho associates with most nascent bact

147 However, the termination factor Rho can remove the nonantiterminated

148 mutations in Escherichia coli transcription termination factor Rho enhance in vitro transcription te

149 Escherichia coli transcription termination factor Rho exhibits the phenomenon of cataly

150 The active form of transcription termination factor rho from Escherichia coli is a homohe

151 Transcription termination factor Rho from Escherichia coli is a protei

152 The function of transcription termination factor Rho from Escherichia coli is dependen

153 Transcription termination factor Rho from Micrococcus luteus, a high G

154 The gene which encodes transcription termination factor Rho from Rhodobacter sphaeroides 2.4.

155 se activity of Escherichia colitranscription termination factor rho have been analyzed.

156 vities of the Escherichia coli transcription termination factor rho have been investigated using natu

157 ons M219K, S266A, and G337S in transcription termination factor Rho have been shown to confer resista

158 k, we describe the role of the transcription termination factor Rho in prophage maintenance through c

159 The transcription termination factor Rho is a global regulator of RNA poly

160 Escherichia coli transcription termination factor rho is a hexamer with three catalytic

161 Transcription termination factor rho is a hexameric, RNA-dependent NTP

162 Escherichia coli transcription termination factor Rho is a ring-shaped hexameric protei

163 Transcription termination factor Rho is also likely not involved, beca

164 e broadly and highly conserved transcription termination factor Rho is necessary and sufficient for p

165 The Escherichia coli transcription termination factor Rho is structurally and functionally

166 Inhibition of the transcription termination factor Rho is used to treat some bacterial i

167 Like dksA mutations, transcription termination factor Rho mutations also confer sensitivity

168 The transcription termination factor Rho preferentially inhibits swimming

169 pe and mutant Escherichia coli transcription termination factor Rho provides a model for the enzyme-R

170 Escherichia coli transcription termination factor Rho shows a 30-fold faster rate of AT

171 scherichia coli genome require transcription termination factor rho to function.

172 Escherichia coli transcription termination factor Rho uses the energy of ATP hydrolysis

173 the essential Escherichia coli transcription termination factor rho utilizes Mg(2+) and ATP as a subs

174 HEH domains from the bacterial transcription termination factor Rho, bacterial and eukaryotic lysyl-t

175 roles in the Escherichia coli transcription termination factor Rho, E211, R366, R212, and D265, and

176 Termination factor Rho, responsible for the main factor-

177 Mutants in Escherichia coli transcription termination factor Rho, termed rho(nusD), were previousl

178 mutations in rho, the gene for transcription termination factor Rho, that block the growth of phages

179 he transcription elongation Nus proteins and termination factor Rho, which are involved in rRNA antit

180 tural product inhibitor of the transcription termination factor rho.

181 script containing RNA residues recognized by termination factor Rho.

182 ion in Escherichia coli is the transcription termination factor rho.

183 ion in Escherichia coli is the transcription termination factor rho.

184 the activity of the M. luteus transcription termination factor Rho.

185 o a hexameric helicase, the Escherichia coli termination factor Rho.

186 plary homohexameric motor, the transcription termination factor Rho.

187 either in the RNA polymerase complex or the termination factor rho.

188 CM), a potent inhibitor of the transcription termination factor Rho.

189 A transcription termination factor (Rho) was purified from the Gram-posi

190 hape-determining protein (mreB), and the rho termination factor (rho).

191 ral capsid, inhibits hexameric transcription termination factor, rho, by presently unknown mechanisms

192 les: initiation factors, elongation factors, termination factors, ribosomes, mRNA, amino-acylsyntheta

193 , which are subsequently disassembled by the termination factor Rli1, an ATPase.

194 We show that the key transcription termination factor, RNA exonuclease Xrn2 engages with Po

195 Ser5-P while that bound to the transcription termination factor Rtt103 had higher levels of Ser2-P.

196 the human homolog of the yeast transcription termination factor Rtt103, remain undefined.

197 S, in the RNA-binding domain of an essential termination factor, Seb1.

198 Also, depletion of termination factors substantially reduces Pol II pausing

199 on [PSI(+)], a prion form of the translation termination factor Sup35 (eRF3).

200 When the translation termination factor Sup35 adopts the prion state, [PSI(+)

201 roteins are, respectively, the translational termination factor Sup35 and the yet poorly characterize

202 Pin3) promotes conversion of the translation termination factor Sup35 into its prion form, [PSI(+)].

203 rom the prion domain NM of yeast translation termination factor Sup35 persistently propagate and inva

204 rains, weak and strong, of yeast translation termination factor Sup35 with respect to angular orienta

205 prion [PSI(+)] (prion form of translational termination factor Sup35).

206 ing amyloidogenic isoform of the translation termination factor Sup35.

207 uating amyloid conformers of the translation termination factor Sup35.

208 self-perpetuating isoform of the translation termination factor Sup35.

209 t prion [PSI (+)], formed by the translation termination factor Sup35.

210 SI(+)] is a prion isoform of the translation termination factor Sup35.

211 lf-perpetuating amyloid of the translational termination factor Sup35.

212 as a mimic of a normal 3'-UTR, recruits the termination factor Sup35p (eRF3) and stabilizes nonsense

213 The prion [PSI+] forms when the translation termination factor Sup35p adopts a self-propagating conf

214 hange in the conformation of the translation termination factor Sup35p is the basis for the prion [PS

215 tional, ordered aggregate of the translation termination factor Sup35p that influences new Sup35 prot

216 conformation and function of the translation termination factor Sup35p, and is transmitted from mothe

217 (+)] is a prion of the essential translation termination factor Sup35p.

218 self-propagating amyloid of the translation termination factor, Sup35p, of Saccharomyces cerevisiae.

219 self-propagating amyloid of the translation termination factor, Sup35p.

220 The Escherichia coli rho transcription termination factor terminates select transcripts and rho

221 La RNA-binding protein is a transcription termination factor that facilitates recycling of templat

222 results, we suggest Grs1p is a transcription termination factor that may interact with the 3'-end of

223 by Rho, a conserved bacterial transcription termination factor that rapidly terminates untranslated

224 termined that NusG functions as an intrinsic termination factor that works alone and cooperatively wi

225 tify many core spliceosome and transcription termination factors that control the RNA outputs of repo

226 competition between RNA polymerases and the termination factors that pursue them.

227 The susceptibility of TECs to disruption by termination factors that target the upstream surface of

228 what leads to their regression and eventual termination, factors that ultimately limit the extent to

229 The active termination factor then interacts with the ternary compl

230 Although Rho was the first termination factor to be discovered, the actual mechanis

231 MD machinery interfaces with the translation termination factors to initiate NMD.

232 differences in the abundance or activity of termination factors to modulate the balance of terminati

233 case DDX5 and RNA polymerase I transcription termination factor (TTF-I), it has been speculated that

234 pping proteins Edc3, Dcp1a, and Dcp2 and the termination factor TTF2 coimmunoprecipitate with Xrn2, t

235 gnal to the elongating polymerase requires a termination factor (vaccinia termination factor/capping

236 e of the nascent RNA depends on the vaccinia termination factor (VTF) and an ATP cofactor.

237 nscription termination requires the vaccinia termination factor (VTF), NPH I, a single stranded DNA-d

238 ing polymerase requires a trans-acting viral termination factor (VTF/capping enzyme), and is coupled

239 ongating polymerase requires a virus-encoded termination factor, VTF.

240 The existence of a second termination factor was suggested by the finding that tra

241 her demonstrate that HUSH interacts with the termination factor WDR82 and-via its component MPP8-with

242 reen for protein-coding gene transcriptional termination factors, we identified ZC3H4.

243 Suppression was efficient when the termination factors were present at physiological levels

244 sult of aggregation of the Sup35 translation termination factor, which increases stop codon read-thro

245 e yeast prion protein Sup35 is a translation termination factor, whose activity is modulated by seque

246 of paused pol II, knockdown of decapping or termination factors Xrn2 and TTF2 shifted polymerase awa