ライフサイエンスコーパス: termini

1 l) or O(4)O(4) (4-oxazolyl) linkages on both termini).

2 the presence of two unpaired spins at their termini.

3 at both presynaptic termini and postsynaptic termini.

4 neuronal apoptosis with loss of postsynaptic termini.

5 s RNA breaks with 2',3'-cyclic-PO4 and 5'-OH termini.

6 sting sequence-dependent dynamics of the DNA termini.

7 148 GPCRs and all 11 unique Galpha subunit C termini.

8 tes with epitaxial crystallization from seed termini.

9 in no other protein, one each in the N and C termini.

10 are tagged for degradation at both N- and C-termini.

11 ed with low proportions of intact 5' genomic termini.

12 re is no requirement for DNA double-stranded termini.

13 along with partially structured cytoplasmic termini.

14 (2+)-free structures of KRAS with flexible N-termini.

15 s a Pol III transcript generated with mature termini.

16 of a plant legumain capable of linking free termini.

17 ), principally by receptors binding Galpha C termini.

18 isiae, identifying 2190 N-termini and 1562 C-termini.

19 nd locations of unreliable/flexible loops or termini.

20 nly to the hydrophobic residues near peptide termini.

21 late stage functionalization of spiroligomer termini.

22 y depends on the substitution at the C and N termini.

23 H3.1-containing nucleosomes with wrapped DNA termini.

24 ith Fc-C identical withC-Fc (Fc, ferrocenyl) termini.

25 ing NAD(+) caps can be added to 5'-processed termini.

26 d in DAT chimeras encoding both SERT N and C termini.

27 fold with degraded kinase motifs at their C termini.

28 rands and shorter more labile strands at the termini.

29 s, and chemoproteomic analysis of cellular N termini.

30 virus 1 (HSV-1) to enter neurons via axonal termini.

31 nabling enzymatic modification of the glycan termini.

32 nyl and methyl groups at their free N- and C-termini.

33 te the effect of modulating the C- and the N-termini.

34 atricopeptide repeat (TPR) domain at their C termini.

35 red proximity between their TIR domain and C termini.

36 conserved promoter elements at the 5' and 3' termini.

37 biased ladder sequencing of protein N- and C-termini.

38 in intrinsically disordered regions at their termini.

39 th a few nucleotides different at 5 and/or 3 termini.

40 omes from the interaction of VP4C and VP4B N-termini.

41 omains to interact with their respective DNA termini.

42 omeric DNA preferentially over the uncharged termini.

43 ed Pro-Glu and Pro-Pro-Glu motifs in their N termini.

44 ular nucleotide or can be placed only at the termini.

45 ouble-stranded breaks (DSBs) with hairpinned termini.

46 n-coupled receptor (GPCR), fused via their C-termini.

47 over the chiral bridge to the final (A2)/(R) termini.

48 eins recruit and anchor Ca(V)2s via Ca(V)2 C-termini.

49 or large truncations are made at the N or C termini.

50 eceptor is composed of intracellular N and C termini, a large extracellular domain containing the ATP

51 The N termini also promote nuclear localization of CLKs, but t

52 otations of proteomes, while proteome-wide C termini analysis still poses substantial challenges.

53 rminome of S. cerevisiae, identifying 2190 N-termini and 1562 C-termini.

54 conformationally dynamic double-[4]helicene termini and a rigid [6]helicene-based core within their

55 show that a few amino acid changes at the C-termini and active sites of Nasonia vitripennis SDRs lea

56 no acid side chains as well as nucleic acids termini and bases, it can adopt.

57 ffectively and selectively isolate protein C termini and contributes to the global annotation of C te

58 5-day mouse estrous cycle, with ~3-fold more termini and functional connections during estrus.

59 conformational dynamics and hydration at the termini and interior of the DNA in a sequence-dependent

60 f a wide assortment of molecules on both the termini and internal sites of Cas9, creating a platform

61 uctures of the unique portal vertex, genomic termini and ordered dsDNA coils in the capsid spooled ar

62 ry synaptic transmission at both presynaptic termini and postsynaptic termini and suggest that presyn

63 ry synaptic transmission at both presynaptic termini and postsynaptic termini.

64 that were quantitatively labeled at their N-termini and retained their binding characteristics.

65 at both presynaptic termini and postsynaptic termini and suggest that presynaptic and postsynaptic dy

66 oval of the intrinsically disordered N and C termini and the hook region of beta1a prevented oligomer

67 n of a monolayered epithelium at egg chamber termini and the morphogenesis of the stalk between adjac

68 t and site-selective way to modify protein N-termini and the unnatural amino acid p-aminophenylalanin

69 NHEJ relies on Ku to thread onto DNA termini and thereby improve the affinity of the NHEJ enz

70 autoinhibitory contacts between the N- and C-termini and unmask UvrA recognition determinants.

71 lar interactions between its charged N and C termini, and between its hydrophobic region and the C te

72 natural templates, extend mismatched primer termini, and bypass secondary DNA structures.

73 h siloxy or alkoxy functional groups at both termini, and can also be applied to polymeric vinyl- and

74 usters of polar residues at both the N and C termini, and deletion of up to 11 C-terminal residues ha

75 ated transcriptome, identify 40,000 novel 3' termini, and reveal that two-thirds of Drosophila genes

76 onine near acidic residues, near the protein termini, and within membrane associated proteins.

77 ), and highly acidic environments in which C-termini are also protonated.

78 te processive cleavage, while 3' overhanging termini are cleaved distributively.

79 At the same time, the termini are disordered and phase separated, reminiscent

80 nkers connecting the dimer components to the termini are engineered so that the dimer forms over the

81 ccurs via a concerted mechanism if the diene termini are held in close proximity, as in cyclopentadie

82 plitude anisotropic motions, whereas the two termini are nearly isotropically flexible.

83 Notably, Ub E2 N termini are serine/threonine rich in many other Ub E2s,

84 tide binding cleft, upon which the peptide C termini are tested for their capacity to dislodge the ta

85 conserved with the sequence ACAGG-5', the 3' termini are variable and are typically 3'-GCCUGU, ACCUGU

86 has a cis-configuration between the C- and N-termini around the cyclopentane core.

87 lymers by chain-growth process from the seed termini as confirmed by UV/vis spectroscopy and atomic f

88 r spokes radiate, placing the Sas-6 carboxyl termini at the outer edge of the approximately 60 nm rad

89 strategy for specific isolation of protein C termini based on LysC digestion and site-selective dimet

90 e cleavage, degenerate conservation of the C-termini between classes precludes pinpointing the analog

91 ss, likely due to differences in the N-and C-termini between the catenins.

92 nal glycine degrons are depleted at native N-termini but strongly enriched at caspase cleavage sites,

93 ans, [Pyr(1)]apelin-13 was cleaved from both termini but the C-terminal was more susceptible to cleav

94 F are isoforms that are identical in their N termini but unique in their C termini due to a -1 riboso

95 rupts epithelial organisation at egg chamber termini, but the cause of this phenotype remains unclear

96 We discovered that it was not the N termini, but the loop2 regions connecting TM2 and TM3 of

97 ther enzymatic modification of various neo-N termini by arginylation that generates potentially neofu

98 regarding the repeating units, lengths, and termini can be obtained directly from the surface sample

99 stematic interrogation, we find that protein termini can be positioned adjacent to bound DNA, offerin

100 sults indicate that modulations of the Abeta termini can determine the fate of a salt bridge far away

101 RE ) for proteins with fluorescently labeled termini, can be estimated using single-molecule Forster

102 ule which we show is sensitive to poly(A) 3'-termini, consistent with protection from deadenylation.

103 These peptides have atypically diverse C termini consisting of residues not recognized by either

104 The SSB C-termini contain a 9 residue acidic tip and a 56 residue

105 benzenoid nanographene with triangulene-like termini, contains a high proportion of zigzag edges whic

106 roteins to test whether DAT and SERT N and C termini contribute to transporter substrate and inhibito

107 allosteric sites located at the PKAc N and C termini coordinately regulate the phosphatase sensitivit

108 Numerous termini correlated with the extremities of small RNA foo

109 hment of long-range interactions between the termini coupled with compaction of the microtubule bindi

110 rotein where the intersection of two helix N-termini creates a region with a strong, localized positi

111 cation efficiency by obtaining the largest C termini data set of the human proteome with the least sa

112 Quantitative mapping of N-termini demonstrated perturbation of protease action dur

113 reaction generating replicated genomes with termini derived from the long-arm component of the herpe

114 lack information about the receptor distal N-termini, despite the importance of the latter in signali

115 iety next to the galactoside ligands on both termini did indeed lead to a higher enthalpy of binding,

116 cal in their N termini but unique in their C termini due to a -1 ribosomal frameshift during translat

117 from WNV infection, mice showed presynaptic termini elimination with lack of repair, while for ZIKV,

118 l rapidly inactivates when one of its four N-termini enters and occludes the channel pore.

119 by a cytosolic loop, and has both N- and C- termini exposed to the endoplasmic reticulum (ER) lumen.

120 anchored to Golgi membranes, whereas their N termini extend into the cytoplasm to initiate vesicle ca

121 nlike in the known rhodopsins, in HeRs the N termini face the cytoplasm.

122 Pairing is mediated by the septin N-termini face, and may occur symmetrically or staggered,

123 The septin C-termini face, namely the C-terminal extension of Cdc12,

124 In MTBP the conserved termini flank the metazoa-specific Cdk8/19-cyclin C bind

125 Blue-light illumination at the embryonic termini for 90 min was sufficient to rescue normal devel

126 d chromatin that protects natural chromosome termini from being recognized as DNA double-strand break

127 The bronchial termini had robust neutrophil infiltration, and depletio

128 So far, sequencing of protein N- and C-termini has been limited to single purified protein spec

129 with the same chemical constitution on both termini (i.e., O(5)O(5) (5-oxazolyl) or O(4)O(4) (4-oxaz

130 rated 3 mutant mouse models with truncated C termini in 2 different mouse strains, C57BL/6J (B6) and

131 hese mice revealed divergent roles for the C termini in morphine-induced behaviors, highlighting the

132 s by localised nucleolytic processing of DNA termini in preparation for longer range resection.

133 tability, which is exacerbated at chromosome termini in the form of dysfunction and telomere loss.

134 ed interaction between the amino to carboxyl termini in the functional tagged murine TRPC6 tetramer (

135 on generates DNA molecules with a variety of termini, including blunt ends and single-stranded overha

136 xpressed a gp41 construct that contains both termini, including the FP, the fusion peptide-proximal r

137 beta(2)-AR-Galpha C termini interactions alter receptor conformation, which

138 Therefore, the knowledge of protein termini is an indispensable prerequisite to understand p

139 Formation of the Drosophila embryonic termini is controlled by the localized activation of the

140 presence of, at least, one of these extended termini is required for IL-37 suppressive activity.

141 Analysis of protein C termini is very important for functional annotations of

142 Isobaric peptide termini labeling (IPTL) is an attractive protein quantif

143 ective maleylation-directed isobaric peptide termini labeling (SMD-IPTL) approach for quantitative pr

144 acking the intrinsically disordered N- and C-termini, loses specificity for DNA lesions and shows les

145 lectron microscopy, we show that the GroEL C-termini make physical contact with the PepQ folding inte

146 The C termini may function as homodimerisation domains.

147 stable proteoforms with undocumented N- or C-termini, meaning these proteoforms are stable functional

148 lator decorated with azide and alkyne at its termini, N3-Ala-Val-NHCH2-C identical withCH, which is d

149 e identification and enrichment of protein N-termini not accessible in GluC- or trypsin-digested samp

150 The amino and carboxyl termini, not resolved in the density map, appeared to be

151 endoribonuclease with activity on 3' and 5' termini of 16S and 23S rRNAs, and the capacity to suppre

152 ted the five Cys residues in the identical N termini of 6K and TF, the four additional Cys residues i

153 ted that by fusing each half of the dimer to termini of a protein that it is possible to selectively

154 e with this approach and modify the N- and C-termini of a single substrate protein in a sequential, s

155 in male meiosis, they are restricted to the termini of all four chromosomes studied, including chrom

156 ction is regulated by gates derived from the termini of alpha-rings and through binding of regulatory

157 This strategy was used to modify the C-termini of an antibody scFv construct and of Protein L,

158 to show that AtVAP27-1 interacts with the N termini of AtSEIPIN2 and AtSEIPIN3 and likely supports t

159 is elaborated PIP(2) interactions with the N termini of beta- (K(d) ~5.2 mum) and gamma-ENaC (K(d) ~1

160 sequons except for the site closest to the N termini of both proteins.

161 invariant residues that bind to the N and C termini of bound peptide found in most vertebrae classic

162 The N termini of bound peptides most probably bind first in th

163 a-helical bundles formed from the extended C-termini of capsid protein VP4B and VP4C protrude from th

164 ons with the unwrapped DNA duplex at the two termini of Cenp-A(Nuc) are mediated predominantly by a D

165 well-separated protein interfaces at the two termini of CRY2.

166 Surprisingly, both the N and C termini of csGRP78 were necessary for this profibrotic r

167 In this study, we characterized the four termini of cytoplasmic DP-rcDNA and compared them to its

168 dy, we systematically characterized the four termini of cytoplasmic HBV DP-rcDNA by 5'/3' rapid ampli

169 In accord, the respective termini of DeltaC-alpha-syn exhibited increased protease

170 bind to BRIL fused either into the loops or termini of different GPCRs, ion channels, receptors and

171 acted, and sequences corresponding to the 5' termini of enterovirus RNAs were identified.

172 C), which co-translationally acetylate the N-termini of eukaryotic proteins.

173 hat DHX34 induces extensive changes in the N-termini of every RUVBL2 subunit in the complex, stabiliz

174 During pre-RNA splicing, the 5' and 3' termini of exon(s) can be covalently ligated to form cir

175 denature proteins by pulling on the peptide termini of folded substrates, but it is not well-underst

176 cing (NGS) assay, XACTLY, to interrogate the termini of fragmented DNA, information traditionally los

177 gs will provide evidence for targeting the N-termini of FSGS ACTN4 mutants to downregulate their acti

178 We show that STEP(61) binds to the C termini of GluA2 and GluA3 as well as endogenous AMPARs

179 applied to the characterization of protein C termini of HeLa cells.

180 riant residue pairs within the DNA binding N-termini of helices alpha2 and alpha3; and gamma/delta'-r

181 ers of the IL-1 family, both the N and the C termini of IL-37 are extended, and we show they are diso

182 th of crystallizable block copolymers at the termini of immobilized, surface-confined crystallite see

183 We have documented new detached pits at the termini of linear gullies on Martian dunes.

184 ion strategy wherein the lacto-N-neotetraose termini of lipooligosaccharide (LOS) are "capped" by a s

185 between fluorescent proteins fused to the C-termini of LRRC8 subunits.

186 The N termini of MTBP and Sld7 share an essential origin firin

187 nt protein, and revealed that the flexible N-termini of mTXNPx form a well-resolved central belt that

188 The amino termini of nine Sas-6 dimers form a central hub of appro

189 hat R2TP interacts largely with the unfolded termini of Nop58p.

190 We find that B9D1, AHI1, and the N termini of NPHP4 and NPHP5 interact with the transmembra

191 xxEx (MADA motif) that is conserved at the N-termini of NRC family proteins and ~20% of coiled-coil (

192 Moreover, the N and C termini of one Hsp90 molecule simultaneously bound to tw

193 bind to negatively charged residues at the C-termini of P-proteins.

194 f a fuzzy complex in which both the N- and C-termini of p27 interact with Cdk2/cyclin A in multiple,

195 s that project into solution from the N or C-termini of peptide and protein substrates.

196 a strategy specifically designed to enrich N termini of proteins, we demonstrate that many human prot

197 induced conformational change bringing the N-termini of RAR and RXR closer together.

198 d between SpyCatcher (-sc; encoded at the C'-termini of recombinant proteins) and SpyTag.

199 Specifically, the N- and C-termini of Rev contribute to protein stability; mutation

200 N-termini of several proteases were downregulated in prt6,

201 move extraneous nucleotides at the 5' and 3' termini of sgRNAs.

202 nds between the 5'-phosphate and 3'-hydroxyl termini of single-stranded RNAs.

203 ve previously demonstrated that the C- and N-termini of SK2 channels interact with the actin-binding

204 eracting mainly with the disordered N- and C-termini of specific CCT subunits of both rings.

205 Thus, CAT tails functionalize the carboxy termini of stalled polypeptides to drive their degradati

206 n distances of neighboring residues at the C-termini of the alpha1 and alpha2 helices are consistent

207 es Tyr(240) and Tyr(274) binding the C and N termini of the B and C helices of IFN-beta, respectively

208 uding two highly flexible regions) and the N termini of the beta-chain, confirm these models with kno

209 otting can only be identified by closing the termini of the chain somehow.

210 All termini of the components are hidden from nuclease attac

211 e modification of numerous residues in the C termini of the D1 and D2 proteins on the donor side of t

212 rial enzyme, OpeRATOR, and released at the N-termini of the Gal((13)C(6))-Tn-occupied Ser/Thr residue

213 raction with Manalpha1-2Man on two different termini of the glycan, with the reducing-end mannose res

214 capsid shell via 5 asymmetrically arranged N termini of the inner capsid shell protein VP3A around th

215 Interestingly, genomic termini of the large (L) and small (S) components were d

216 firm that conserved sequences in the N and C termini of the Mfa1 fimbrial subunit protein perform cri

217 ring has been applied: the original N- and C-termini of the minichaperone were linked together by a p

218 We find that the nucleoporin Nup62 and the C termini of the nephronophthisis (NPHP) proteins NPHP4 an

219 es for pS319 and pY359+pS362 at the N- and C-termini of the P-domain, respectively.

220 cation, is coupled with the rotation of the termini of the pentadienyl cation, favoring a particular

221 munodominant antigenic sites in the N- and C-termini of the RSV-G protein, that were boosted >10-fold

222 of capturing the sequences of both 5' and 3' termini of the same transcript remain scarce.

223 y structural remodeling of the dorsal medial termini of the small ventral lateral neurons has long be

224 juxtaposition of 3 hydroxyl and 5 phosphate termini of the strand breaks for catalysis.

225 th a phosphoserine/phosphothreonine at the C-termini of the target protein.

226 atus, and has a preference for acetylating N termini of the transmembrane proteins.

227 rmation of non-native contacts between the C-termini of the two helices.

228 N-terminal helices positioned to match the C termini of the viral glycoproteins.

229 f complementary nucleotides at the 5' and 3' termini of the vRNA genome.

230 alysis with antibodies targeting the N and C termini of the VZV SCP indicates that the hexon-capping

231 g of their progenitor mRNAs joined the amino termini of these proteins to the NP1 open reading frame,

232 and guanosine (G) ribonucleotides to the 3' termini of these RNAs (designated poly(UG) or pUG tails)

233 Using peptides derived from the N- or C-termini of this sequence, as well as Ambn variants that

234 attaching isotopic tags to both the N- and C-termini of tryptic peptides, and second, a search engine

235 cturally distinct, representing the N- and C-termini of TSC1; a "pincer" is formed by the highly flex

236 Finally, intertwining of the N-termini of two-fold symmetry-related VP4A capsid protein

237 These RNAs correspond to 3' termini of uncharged tRNAs, which are not targeted by Rr

238 protein building blocks which present either termini on a single face of an oligomer.

239 , which generates the Ler-type extra ccmB 5' termini only after the introduction of the RPF4 allele f

240 peptides, which are cyclized from one of the termini onto a side chain, have received little attentio

241 tions for cyclizing peptides by either their termini or side chains provides a key advantage over tho

242 ation of non-B DNA structures at chromosomal termini participates in telomere maintenance.

243 es of VP2, arranged with their hydrophobic N termini pointing away from the virion surface.

244 P-CENH3 and CENH3-YFP, the fused tags at the termini probably affect the structure of CENH3 and reduc

245 Blunt termini promote processive cleavage, while 3' overhangin

246 toreceptor axons, we show that DRA R7 and R8 termini reach layer M6 sequentially, thus separating the

247 rrangements that facilitate their flexible C-termini refolding to engage distinct interfaces.

248 the proteome-wide identification of N- and C-termini relies on the generation of single, terminal pro

249 Extension from DNA damage at primer termini remains poorly understood.

250 ends to generate the 3'-OH,2'-PO4 and 5'-PO4 termini required for sealing by an N-terminal ATP-depend

251 s, we determined that the amino and carboxyl termini reside in the extracellular space and are initia

252 rginine(R)-phenylalanine(F) motif at their C-termini (RFamide peptides).

253 with APA events using a Whole Transcriptome Termini Sequencing (WTTS-Seq) approach as well as functi

254 ysis of the tailing and trimming of miRNA 3' termini showed that the flux was typically greatest thro

255 conformational dynamics of residues near the termini slow significantly more than central residues, i

256 Furthermore, the peculiarities on rcDNA 5' termini, specifically the RNA primer on the (+)strand an

257 and found good coverage of the peptide chain termini starting from c'2 and z'2 fragment ions.

258 NatB was seen to preferentially acetylate N termini starting with the initiator Met followed by acid

259 roteins with buried or sterically hindered N termini, such as virus-like particles (VLPs) composed of

260 th the prevailing description of discrete 5' termini, suggesting an imprecision of the transcription

261 methylase (AcCYP51)] formed a dimer via an N-termini swap, whereas drug-bound AcCYP51 was monomeric.

262 AcCYP51 dimerized head-to-head via N-termini swapping, resulting in formation of a nonplanar

263 lling experimental evidence that DAT N and C termini synergistically contribute to substrate and inhi

264 , which generates 5-phosphate/3-hydroxyl DNA termini that are critical for ligation by the NHEJ DNA l

265 idly undergo autocatalytic cleavage, leaving termini that are ligated by the ubiquitous endogenous RN

266 DNA cleavage inhibition and have divergent C termini that are required in each case for inhibition of

267 The CLKs have disordered N termini that bind tightly to RS domains, enhancing SR pr

268 ive opportunities within the ebolavirus NP C-termini that might be leveraged for diagnostics and nove

269 arrestins bound to phosphorylated receptor C-termini, the functional role of each phosphorylation sit

270 s of DNA oligomers modulates dynamics at the termini, the results suggest both short- and long-range

271 exCNLs have substantially elongated their N-termini through tandem duplications of exon segments.

272 se with circularly permuted repeats at their termini, thus providing new insight into native virus re

273 naEN and Ssp DnaEC) were attached to the two termini to be fused.

274 single-molecule junctions, using the organic termini to chemically "solder" a single cluster to two n

275 on, mapping, and quantification of protein N-termini to comprehensively characterize cleaved podocyte

276 y to two helical regions at the GRK5 N and C termini to inhibit GPCR phosphorylation, though only the

277 eals that Apn2/APE2 resolves such blocked 3'-termini to suppress Top1-induced mutations at rNMP sites

278 poration of a Ca(2+) cation, attaching the N termini under the icosahedral fivefold symmetry axis, an

279 a one-step enzymatic method to modify RNA 3' termini using recombinant human polymerase theta (Polthe

280 d into peptides with sterically accessible N-termini using specially adapted conditions of solid-phas

281 -ribose monomers and polymers at their 2'-OH termini using the enzyme OAS1 and dATP.

282 n potential phosphorylation sites at their C termini, we propose that preventing phosphorylation at t

283 isrupt intramolecular interactions of STIM C termini, we show that the increased flexibility of the S

284 und in intergenic regions, numerous abundant termini were also found within coding regions and intron

285 Nearly 2000 termini were altered in pnp1-1, revealing a dominant rol

286 While most termini were found in intergenic regions, numerous abund

287 A total of 781 protein C termini were identified with a 300 mug digest in our stu

288 her by a polypeptide linker and new N- and C-termini were made at desired parts of the protein surfac

289 By contrast, the termini were not detected by NMR and are unlikely to be

290 inding motifs, known as IQ motifs in their C termini, which associate with calmodulin (CaM), a univer

291 se was first introduced to analyze protein C termini, which effectively improved the accuracy and spe

292 ed to natural polypeptide chains at the Cas9 termini, which excludes a diverse array of molecules use

293 ctrometry, reveals the mass ladder from both termini, which is used to determine the sequence.

294 adthrough generates proteins with extended C-termini, which often possess distinct properties.

295 its tRNA(Ala(UGC)) to modify nascent-chain C termini with a polyalanine degron.

296 us lengths and sequences, and extends RNA 3' termini with an assortment of 2'-deoxy and 2',3'-dideoxy

297 for the selective modification of protein N-termini with mass boosters.

298 at interactions of the Galphas and Galphaq C termini with the beta(2)-adrenergic receptor (beta(2)-AR

299 Interaction of Galphas or Galphaq C termini with the GPCR increases signaling potency, sugge

300 sults in two isoforms that differ at their C termini: ZAPL (long) encodes a poly(ADP-ribose) polymera