ライフサイエンスコーパス: terminus

1 fications to the hydrophobic moiety at the N-terminus.

2 h Vac14 in a manner that requires the Fig4 C-terminus.

3 BXO44 through a stretch of residues in its N terminus.

4 d with a double (V5-HA) epitope tag at the C-terminus.

5 which was alleviated upon deletion of its N terminus.

6 ted the X position reorients the chemokine N terminus.

7 ential folding pathway initiating from the C-terminus.

8 c residues are introduced into its soluble N terminus.

9 Kv1.5 communicates with the intracellular N terminus.

10 s that have been fused onto the receptor's C terminus.

11 ne targeting depended on the intracellular C-terminus.

12 t against neurotoxicity carried out by its N terminus.

13 terminal regulation of its otherwise toxic N terminus.

14 g to truncation of ~300 amino acids in the C terminus.

15 or due to residues that interacts with the N-terminus.

16 in a position shifted toward the peptide's N terminus.

17 labeled acetyl-cysteine at the maleylated N-terminus.

18 s via a nuclear localization signal in its N terminus.

19 om S. coelicolor WhiD (ScWhiD) only at the C terminus.

20 ing a 2',3'-cyclic phosphate group at its 3' terminus.

21 e-shifted protein product with an extended C terminus.

22 evolutionarily conserved sequences in its C-terminus.

23 iffer only by the sequence position of the N terminus.

24 as a novel Art v 3-specific epitope at the C terminus.

25 tor major subpocket by the CXCL12 proximal N terminus.

26 existence of the phenyl group on the alkyne terminus.

27 on and reveal a dimer mediated by the Ku80 C terminus.

28 ies a novel KLTF peptide motif in the Cik1 N-terminus.

29 ge of isoseramox produced a native peptide N-terminus.

30 ted N terminus and cytoplasmically located C terminus.

31 n N-terminus with P and V but has a unique C-terminus.

32 additional microtubule binding site in the N terminus [1-4].

33 ve steps: (1) selective maleylation at the N-terminus; (2) labeling at the epsilon-NH(2) group of the

34 We engineered within its N terminus a motif conserved among natural peptides with p

35 ttle effect on CXCL12 binding to the CXCR4 N terminus, a major component of the chemokine-GPCR interf

36 e mutation at position 53 of the Kv7.5 amino terminus abrogated its ability to confer forskolin sensi

37 2-(diphenylphosphanyl)phenyl)methanol as a C-terminus activator has been demonstrated at simple and s

38 suggest that overexpression of the Spc110 C terminus acts as a dominant-negative mutant that titrate

39 d amphipathic alpha-helix in the prodomain N terminus adopt helical structure in a membrane-mimetic e

40 II) nor fusing hCA II to the NBCe1-A carboxy terminus affects background-subtracted NBCe1 slope condu

41 ctivates the gamma-tubulin complex via its N terminus, allowing nuclear microtubule polymerization to

42 We find that the Fig4 C-terminus alone interacts with Vac14 in vivo and retains

43 proximately 18 domains further towards the C terminus along titin.

44 nd 4R isoforms, underrepresentation of the C terminus, an increase in negative charge in the proline-

45 C(H)2s has a 7-residue deletion at the N-terminus and a 16-residue C-terminal extension containin

46 of the tail-tube protein are braced by the N-terminus and a beta-hairpin loop, and interconnected alo

47 It has a conserved PPIase domain at the C-terminus and a highly charged N-terminal stretch, which

48 which cleaves the Arg5,6 precursor at its N-terminus and at an internal site.

49 e cell, proteins are synthesized from N to C terminus and begin to fold during translation.

50 wo different catcher domains at the N- and C-terminus and by combining two corresponding Tag-fused an

51 enesis, we map phosphorylation to the Env7 C terminus and confirm that Ser-331 is a primary and prefe

52 lices with an extracytoplasmically located N terminus and cytoplasmically located C terminus.

53 Alternative splicing of Shtn1 at the C terminus and downstream of the WH2-PRR domain produces a

54 to the non-neutralizing epitopes on the E1 N-terminus and E2 hypervariable region 1 did not differ si

55 y a scanning mechanism initiated from the 3' terminus and favoring bidirectional progression into fla

56 se-causing mutations are restricted to the N terminus and how they cause human disease has been uncle

57 bilized by a helix-loop-helix motif at the C terminus and interactions between the beta-sheets of the

58 FA4-L phosphorylation occurs on the distal C terminus and is directly responsible for recruitment and

59 to contributions from glycosylation of the N terminus and palmitoylation of the C terminus of CB(2).

60 translated into a protein that shares the N terminus and potentially some functions with the full-le

61 We observe that the more exposed the N-terminus and the beginning of the NAC region of aSyn are

62 delta'-residues associated with the alpha2 C-terminus and the clamp-binding loop.

63 located within flexible regions of the gH N terminus and the gL C terminus, while the fifth was plac

64 tational sensitivity of the fusion peptide N terminus and the length sensitivity of the transmembrane

65 LI forms specific interactions between the N-terminus and the transmembrane domain.

66 ated variants cluster in the extracellular N-terminus and transmembrane domains 1-3, with more severe

67 cytoplasmic kinase phosphorylates RBOHD's C-terminus and two phosphorylated residues (S862 and T912)

68 LAPTM4B-24 lacks the extreme N-terminus and, contrary to LAPTM4B-35, failed to promote

69 agments indicated unfolding started at the N-terminus, and the charge states of UVPD fragments enable

70 R spectroscopy showed that residues of the N terminus are involved in binding to CCL5.

71 the Ku-binding motif (KBM) at the extreme C-terminus are required for end joining.

72 that specific residues within the tatM2NX C terminus are required to confer antagonism on TRPM2.

73 ed the site of fragmentation to the NOTCH3 N terminus at the peptide bond joining Asp(80) and Pro(81)

74 NuMA's C terminus binds DNA in vitro and chromosomes in interphas

75 epends on the extent to which the receptor N terminus binds the chemokine.

76 ure of a short motif in the disordered XPA N-terminus bound to the RPA32C domain.

77 Meanwhile, MKT1L resembles MKT1 at the C terminus but additionally features an N-terminal extensi

78 uncated AtPRMT3 protein bearing the entire N-terminus but lacking an intact enzymatic activity domain

79 by proteolytic cleavage of their receptor N terminus by enzymes such as thrombin, trypsin, and cathe

80 initiated by phosphorylation of its carboxyl terminus by G protein-coupled receptor kinase 1 (GRK1).

81 ze released N-glycans at their free reducing terminus by reductive amination.

82 tations in a PEST-like domain near the LLO N terminus cause enhanced LLO translation during intracell

83 eceptor-chemokine interaction in which the N terminus contributes only to binding affinity.

84 esidues (S325/S328/S330) in the regulatory C-terminus contributes to multiple features of the cardiom

85 6 enzyme with a CBM35 module linked to its N terminus (CrMan26) from a cattle rumen metatranscriptome

86 8-interacting motifs (AIMs) located at the C-terminus, cytoplasmic loop, and within the transmembrane

87 nslate into proteins with a cationic carboxy terminus depleted in hydrophobic residues.

88 We progressively deleted the distal carboxyl terminus domain (CTD) of the cold-activated melastatin r

89 ature and feature Kondo fingerprints at each terminus due to the unpaired spin.

90 ns multiple PCNA-interaction motifs in its N terminus, each of which is essential to its ability to e

91 in negatively charged residues near their C-terminus eject the fastest, while nascent chains enriche

92 The 3D(pol) N terminus encodes a nuclear localization signal (NLS) seq

93 onventional fashion with the myristoylated N-terminus facing the lumen of the micronemes.

94 eceptors (GPHR) have a large extracellular N-terminus for hormone binding.

95 vealed two 8-base target sequences at the 3' terminus for hsa-miR-34a and hsa-miR-449a.

96 inding/tetramerization element whereas the C-terminus forms an intrinsically disordered linker (IDL)

97 changes leading to release of the flexible N-terminus from the docking interface.

98 f MPST, differing by 20 amino acids at the N terminus, give rise to the cytosolic MPST1 and mitochond

99 Our approach, implemented in the tool terminus, groups together transcripts in a data-driven m

100 , phosphorylation of multiple sites on the C-terminus has been recognized as a critical step underlyi

101 specifically, a 0.58 kbp deletion, at the C-terminus has been reported in high frequencies in Senega

102 t the binding of calcium-calmodulin to the C-terminus has long-range allosteric effects on the extrac

103 ases NEIL1 and NEIL2, Xenopus laevis NEIL3 C terminus has two highly conserved zinc finger motifs con

104 eatures are a catalytic homologous to E6AP C terminus (HECT) domain and 3 central WW domains that bin

105 revealed that the residues at the HIV-1 MA C terminus help stabilize protein-protein interactions wit

106 helicase DDX43 contains a KH domain in its N-terminus; however, its function remains unknown.

107 enzyme complex, suggesting a role for the N-terminus in autoinhibition.

108 data also suggest the participation of the C terminus in membrane localization, which is generally ov

109 Deletion of 25 amino acids (aa) from the C terminus inactivated MGAT4D-L, but deletion of 20 aa did

110 that BIK1-mediated phosphorylation on its N terminus increases this channel activity.

111 Overexpression of the Spc110 C terminus induces SPB defects and disrupts microtubule or

112 eveals that PACAP27 engages VIP1R with its N-terminus inserting into the ligand binding pocket at the

113 was partly mediated by an increase in the N terminus insertion and, as shown by X-ray crystallograph

114 n and the other pathway terminating at the N terminus insertion site.

115 ere we show that a segment within the CTCF N terminus interacts with the SA2-SCC1 subunits of human c

116 Combined with recent evidence that the N terminus is a toxic effector regulated by the C terminus

117 pendent phosphorylation of the Kv7.5 carboxy terminus is associated with a reduction in PIP(2) affini

118 Terminus is implemented in Rust, and is freely available

119 of truncated Inp1 variants showed that the C terminus is important for association to the peroxisome,

120 migration is clearly defined when the alkyne terminus is phenylated.

121 We therefore propose that melanopsin's C-terminus is proximal to intracellular loop 3, and C-term

122 We showed that a free N-terminus is required for 3B to function as a primer and

123 Rit2 surface dissociation and that the DAT N terminus is required for both PKC-mediated DAT-Rit2 diss

124 Farnesylation at the C-terminus is required for hGBP1's activity against microb

125 ssion of the cytosolic, positively charged N terminus is sufficient to block TA protein insertion in

126 Expressing the Epe1 C-terminus is sufficient to disrupt heterochromatin by out

127 One role of the multifunctional KCNQ C terminus is to mediate subtype-specific assembly of hete

128 gh-affinity binding of InsP(8) to the XPR1 N-terminus (K (d) = 180 nM) was demonstrated by isothermal

129 annels is a highly conserved domain on the N terminus, known as the eag domain, consisting of a Per-A

130 Deletion of this N terminus leads to functionally non-inactivating channels

131 s throughout the protein's sequence on the N terminus (Lys-118 and Lys-129), helicase domain (Lys-525

132 omain (Lys-525, Lys-639, and Lys-725), and C terminus (Lys-800).

133 where a conserved, flexible region in the N-terminus masks the [4Fe-4S] cluster at the docking inter

134 Furthermore, interactions at the peptide C terminus modulated DM-binding affinity, suggesting dista

135 e tryptophan residues are located near the N terminus, near the middle, and near the inserting C-term

136 The unreactivity of the alkyne terminus not bearing a phenyl ring is because the cycliz

137 Here we show that the N-terminus (NT) of ASIC1a interacts with its CT to form an

138 entical 3' terminus of (-)strand DNA, the 3' terminus of (+)strand DNA on DP-rcDNA is further elongat

139 hile rcDNA and DP-rcDNA have an identical 3' terminus of (-)strand DNA, the 3' terminus of (+)strand

140 oncanonical amino acid either at the N- or C-terminus of a protein or microprotein of interest for su

141 e central and C-terminal regions, with the N-terminus of Abeta accommodated by the oligomers as an un

142 idence has accumulated that implicates the N-terminus of Abeta as a region that may initiate the form

143 Abeta, which bear "tails" derived from the N-terminus of Abeta.

144 dicated that the charge at the "unfolding" N-terminus of ADH decreased at high in-source activation e

145 rom radical a-ions produced by UVPD at the N-terminus of ADH.

146 end-to-end bonds formed between the N- and C-terminus of adjacent Tpm molecules define Tpm continuity

147 Sas4 interacts with a short region in the N terminus of Ana2/STIL.

148 (DBD) of AR, and its autoinhibition by the N terminus of AR.

149 hannels reveal a reentrant loop at the amino terminus of ASIC1 that includes the highly conserved 'Hi

150 tides change the local conformation of the N terminus of beta-ENaC, and two sites of gamma-ENaC adjac

151 we show in vitro that UBE2W can modify the N-terminus of both alpha-synuclein and a tau tetra-repeat

152 102E are similar in that neither binds the C terminus of Brd4, but in all other aspects the mutant be

153 f the N terminus and palmitoylation of the C terminus of CB(2).

154 specific inhibitory phosphorylation in the N-terminus of CDC20.

155 of W1282X-CFTR, whose PTC is closer to the C-terminus of CFTR, suggest the presence of both C-terminu

156 Here, we show that Qtip interacts with the N terminus of cI(VP882), inhibiting both cI(VP882) DNA bin

157 onstrate this utility, we fused TTR to the C terminus of conatumumab, an antibody that targets tumor

158 rnative interface comprising beta6 and the C terminus of CRD and beta2 of RBD.

159 S alpha4-alpha5 while state B involved the C terminus of CRD, beta3-5 of RBD, and part of KRAS alpha5

160 d) cassette was inserted in-frame with the C terminus of CSF1R, separated by a T2A-cleavable linker.

161 emonstrate that Rubisco interacts with the N terminus of CsoS2, a multivalent, intrinsically disorder

162 We demonstrate that the N terminus of CTCF interacts with cohesin which explains t

163 The N terminus of DGAT1 interacts with the neighbouring protom

164 In this study, we tagged mEGFP to C terminus of dishevelled2 gene using CRISPR/Cas9-induced

165 stem cells, we show that a mutation at the C terminus of eIF2gamma impairs CDC123 promotion of eIF2 c

166 Multiple residues in the C terminus of eIF6 are phosphorylated by GSK3 in a sequent

167 The C-terminus of Epe1 directly interacts with Swi6(HP1), and

168 that backbone interactions between the amino terminus of ExsD and the ExsA beta barrel constitute a p

169 The discovered role of the amino terminus of ExsD in ExsA binding explains how ExsC might

170 rmational rearrangements must occur in the N terminus of FepA during FeEnt transport.

171 is study, a highly conserved region in the N terminus of FMDV capsid protein VP2 (VP2N) was character

172 The C-terminus of Galpha is ejected from its beta sheet core,

173 s reveal that the engagement of the distal C-terminus of Galphai/o with the receptor differentiates p

174 weaker interaction site within the carboxyl terminus of gamma-ENaC (K(d) ~800 mum) was also observed

175 electively conjugates to the unique reducing terminus of glycans in which a localized nascent free ra

176 The carboxy terminus of hepcidin directly contacts the divalent meta

177 domain of ZZEF1 (ZZEF1(ZZ2)) binds to the N-terminus of histone H3 and is capable of accommodating c

178 Carboxyl terminus of Hsc70-interacting protein (CHIP) is an impor

179 The ubiquitin ligase CHIP (C terminus of HSC70-interacting protein) promoted SIRT6 st

180 tination by the Hsp70-associated E3 ligase c-terminus of Hsp70-interacting protein (CHIP) and subsequ

181 aneously to H3S10ph and the phosphorylated C-terminus of Hst2.

182 The amino terminus of influenza A virus matrix 2 ectodomain (M2e)

183 Replacing the amino terminus of Kv7.4 with the amino terminus of Kv7.5 confe

184 g the amino terminus of Kv7.4 with the amino terminus of Kv7.5 conferred partial responsiveness to fo

185 nt phosphorylation of serine 53 on the amino terminus of Kv7.5 increases its affinity for PIP(2), whe

186 Thus, the processed C-terminus of lacritin that is deficient or absent in dry

187 r of MEILB2 by binding to an alpha-helical N-terminus of MEILB2 and preventing MEILB2 self-associatio

188 BRCA2 binds to the C-terminus of MEILB2, resulting in the formation of the BR

189 that reveal ligand-induced ordering of the N terminus of Mycobacterium tuberculosis ATR, which organi

190 troscopy, show that the interaction of the C terminus of Neuroligin-2 with Collybistin-2 induces a co

191 Mutations that truncate the C terminus of neuronal Kv7/KCNQ channels are linked to a s

192 The N terminus of NOCT is necessary and sufficient to confer i

193 mations displaying open channel pores, the N terminus of one subunit of the channel tetramer sticks i

194 ts with both subunits, especially near the C-terminus of p51.

195 ive splicing and show that the full-length C terminus of p73 is essential for hippocampal development

196 ons, Lgmn cleaved within the extracellular N terminus of PAR(2) at Asn(30) Arg(31), proximal to the c

197 opose that autoproteolytic cleavage of the N-terminus of PC-1, a hotspot for ADPKD mutations, produce

198 backbone-extended monomers at the N- and C- terminus of peptides using wild-type and engineered ribo

199 allowed cryo-EM tomography mapping of the C terminus of protein A to the apical lobe, which correlat

200 studies on the role of the H2 alpha-helix C terminus of PrP, we found that deletion of the highly co

201 e, Dcp2, participates in repression by the N-terminus of Pumilio.

202 69-residue (Asn(81)-Asn(149)) fragment at C terminus of Rhi o 2 was identified as crucial for IgE-re

203 Here, we show that the C terminus of RRS1-R but not RRS1-S is phosphorylated.

204 sphosites within the acidic and disordered N-terminus of Set2p affect H3K36 methylation levels in viv

205 tion with Cys-18, a residue present at the N terminus of SIRT6 but absent from other isoforms, induce

206 ns are located in the extended cytoplasmic C-terminus of Slack channels and result in increased Slack

207 Previous experiments have shown that the C-terminus of Slack channels binds a number of cytoplasmic

208 native structure in a peptide model of the C-terminus of SOD1, a sequence that might serve as a poten

209 al binding site was identified between the C-terminus of SOST and the LRP6 E2 domain.

210 Here, we show that overexpression of the C terminus of Spc110 is toxic to cells and correlates with

211 We propose the extreme C terminus of Sss1p/Sec61gamma is an essential component o

212 -binding site of cardiac leiomodin and the N-terminus of striated muscle tropomyosin.

213 inding peptide (DSARGFKKPGKR) fused to the C-terminus of superfolder green fluorescent protein (sfGFP

214 e, we present the crystal structure of the N-terminus of TBC1D23 (D23N), which consists of both the T

215 in/TonB, short N-terminal subdomain at the C terminus of the CCSSD, a previously unobserved topologic

216 sed to attach an EGFP coding module to the C-terminus of the endogenous NME1 gene in melanoma cell li

217 somes pause in the sequence coding for the N-terminus of the envelope protein, immediately downstream

218 cing (GAIN) domain that is proximal to the N terminus of the G protein-coupling seven-transmembrane-s

219 cloned viruses revealed mutations near the N terminus of the G9 open reading frame but none in A16 or

220 e BC-loop) and a potential paratope at the N-terminus of the heavy chain.

221 omes and adds an ssrA tag or degron to the C-terminus of the incomplete protein, which directs degrad

222 frame deletion to contain an HA tag at the N terminus of the large UNC-89 isoforms.

223 ng Program (IODP) Site U1421 that tracks the terminus of the largest Alaskan Cordilleran Ice Sheet ou

224 h the exception of a 1 aa extension at the C terminus of the longer peptide.

225 Mounting the CRX-527 ligand at the N-terminus of the model peptide antigen delivered a vaccin

226 ved phosphorylated Ser/Thr residues at the C-terminus of the nucleolar phosphoprotein Treacle.

227 t where early interactions between the far N-terminus of the peptide and SecR ECL2 likely occur follo

228 pitope within vancomycin was mapped to the N-terminus of the peptide chain, distinct from the binding

229 site of the enzyme that normally binds the C-terminus of the peptide substrate.

230 An AfsA-like domain at the C-terminus of the PKS was shown to catalyze condensation o

231 uster of threonine residues located in the N-terminus of the protein, which can be phosphorylated by

232 HBR), located near the myristoylated (Myr) N-terminus of the protein.

233 tion (p.Arg21Cys) has been reported in the N terminus of the protein.

234 ng is terminated by phosphorylation of the C terminus of the receptor by GPCR kinases (GRKs) and by c

235 truncations and mutations in the conserved N terminus of the Rubisco large subunit.

236 onstrated that the AH motif located at the N-terminus of the sequence is involved in cell-Ambn adhesi

237 most of the pore-forming domain (PFD) and C terminus of the Serum Resistance Associated-interacting

238 us on the mechanism by which the cytosolic C terminus of the synaptic cell adhesion protein Neuroligi

239 n the exposure of a cryptic epitope on the C terminus of the transmembrane portion of pro-TNF on clea

240 s is consistent with a model in which the 3' terminus of the vRNA template binds in the mode B site d

241 s to the intermediate state, the hand-like C-terminus of the VSD-pore linker (S4-S5L) interacts with

242 target the two adjacent PPXY motifs at the C-terminus of the Warts polypeptide and additional WW doma

243 eby an individual can navigate-first, to the terminus of their migration, and second, back to a suita

244 As such, the function of the N terminus of this large protein remains poorly characteri

245 runcation of the putatively autoregulatory N terminus of TMEM165.

246 taining a tetrazole-derived warhead at the C-terminus of ubiquitin and employed a cyclic polyarginine

247 trating peptide (cR(10)) conjugated to the N-terminus of ubiquitin via a disulfide linkage to deliver

248 strate that the first 19 residues from the N-terminus of UmuD (Sug(1-19) ) fused to a reporter protei

249 The C-terminus of UNC80 contains a domain that interacts with

250 ditional stretch of ~919 amino acid at the N-terminus of unknown function.

251 ion between LvgA and a linear motif in the C-terminus of VpdB.

252 The location of this interaction on the C terminus overlaps with the sites of human pathogenic mut

253 Abeta peptides with a pyroglutamate at the N-terminus (pGlu3, pE3), are attractive antibody targets,

254 RNA motif was bound by the ZC3H12B's PilT N terminus (PIN) RNase domain, revealing a potential mecha

255 ests sediment dynamics can control tidewater terminus position on an open shelf under temperate condi

256 nent is two tandem stop codons at the G gene terminus, preceding the gene end transcription terminati

257 Segregated charged regions within the RNF4 N-terminus promote compaction, juxtaposing RING domain and

258 nd that the intrinsically disordered SIRT6 C-terminus promotes binding at the higher affinity site th

259 ctly with CypD via its acidic proline-rich C-terminus region and binding at the putative ligand bindi

260 aggard replication fork progression near the terminus region of the right replichore, resulting in SO

261 se frameshifts often create cationic carboxy-terminus residues that replace hydrophobic amino acids a

262 a conformational change that dislodges the C terminus, resulting in a cis-to-trans switch that is lik

263 Docking of the tetraspanin 33 C terminus revealed that it fits into the hydrophobic hot

264 ination between chromosome (and specifically terminus) segregation and cell division may result in as

265 a short stretch of ribonucleotides at the 5' terminus stimulates resection by EXO1.

266 TMIE point mutations in the C terminus that are linked to deafness disrupt phospholipi

267 ains four methionine residues close to the N terminus that can act as alternative translation initiat

268 PA) is an RNA-processing mechanism on the 3' terminus that generates distinct isoforms of mRNAs and/o

269 atenin with a preserved hypophosphorylated N-terminus that interacted with nuclear TCF-4 resulting in

270 uorescent protein attached directly to the C-terminus that is similar to fusions used in previous stu

271 both the third intracellular loop and the C terminus that may promote this interaction.

272 ied responses to the repeat region and the C-terminus, the antibody response against the N-terminal d

273 minus is a toxic effector regulated by the C terminus, there is an emerging consensus that this cis i

274 tween EZH2, the nucleosomal DNA and the H3 N-terminus therefore creates the geometry that permits all

275 nsiently threads the Rubisco large subunit N terminus through the axial pore of the AAA+ hexamer.

276 LCCBs act on the STIM N terminus to cause STIM relocalization to junctions and s

277 an unexpected contribution of the receptor N terminus to chemokine signaling.

278 PAR4 is activated by proteolysis of the N terminus to expose a tethered ligand.

279 hanistically, Pak1 phosphorylates the Mid1 N-terminus to promote its association with cortical nodes

280 The binding of troponin T's N terminus to the actin-mutant tropomyosin complex was als

281 ed across the Dio family anchor the loop's N-terminus to the active site Ser-Cys-Thr-Sec sequence.

282 r following initial binding of the peptide C-terminus to the ECD.

283 he orientation of CTCF motifs presents the N-terminus towards cohesin as it translocates from the int

284 inus of CFTR, suggest the presence of both C-terminus truncated CFTR proteins that are poorly functio

285 th E60X- and G542X-CFTR, although abundant N-terminus truncated proteins due to reinitiation of trans

286 of melanopsin mutants including a proximal C-terminus truncation (at residue 365) and proline mutatio

287 cytoplasmic loop, which is increased upon C-terminus truncation, supporting the idea that these two

288 nit EZH2 to nucleosomal DNA orients the H3 N-terminus via an extended network of interactions to plac

289 te (PIP(2)) binding domains, or the entire C terminus, was without effect on the forskolin response,

290 osed on the cytoplasmic face of the folded C terminus, where it might interact with other channel par

291 ease also required an intact intracellular N terminus, which contains the binding motif for endogenou

292 ends on a discrete domain within its carboxy terminus, which targets the enzyme to the bacterial pole

293 le regions of the gH N terminus and the gL C terminus, while the fifth was placed around gL residue 7

294 and facilitates the interaction of RRS1's C terminus with its TIR domain.

295 ne through mRNA editing, W shares a common N-terminus with P and V but has a unique C-terminus.

296 f three tyrosine residues in the alpha-dbn C terminus with phenylalanine compromising the alphakap-al

297 by the viral protein Gag and tagged at its C-terminus with the fluorescent protein Dendra2 have the s

298 although the interaction of the chemokine N terminus with the receptor-binding pocket is the key dri

299 the diacylglycerol moiety to the alpha-amino terminus without forming a covalent thioester intermedia

300 -glycopeptides modified exclusively at the N-terminus would enable O-glycoproteomic methods to rely s