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1 nefit, clinical importance, and feasibility (tertiary).
2 between phenols and primary, secondary, and tertiary 2-aminonaphthalene derivatives was investigated
5 We recruited patients with diabetes from a tertiary academic retina practice and obtained 3-mm x 3-
6 ors of up to 200 were achieved for the KR of tertiary alcohols bearing an adjacent ester substituent,
7 ective synthesis of alpha-fluorinated chiral tertiary alcohols from (hetero)aryl methyl ketones is de
9 be converted to an assortment of homoallylic tertiary alcohols in 70-96% yield and 92:8 to >98:2 dr-i
10 epoxides and oxetanes yielding secondary and tertiary alcohols in excellent yields and regioselectivi
11 owing the challenging kinetic resolutions of tertiary alcohols to be performed at 500 ppm catalyst lo
14 l) are the nucleophilic attack of a hindered tertiary alkoxide, a ring-closing metathesis reaction, a
15 product scope since primary, secondary, and tertiary alkyl amines are accessible and hydrogen is the
16 merically pure and enantiomerically enriched tertiary alkyl bromide, chloride, ester, and fluoride co
17 ted in a broad substrate scope that included tertiary alkyl halides and heteroaromatic boronic esters
19 source, alkyl peresters as the secondary and tertiary alkyl sources, and aryl diacyl peroxides as the
20 e Heck-type reactions involving unactivated (tertiary) alkyl halides remains an unmet challenge owing
21 o produce a range of multifaceted gamma-aryl tertiary alkylamines and can be rendered enantioselectiv
23 ment of robust catalytic methods to assemble tertiary alkylamines provides a continual challenge to c
24 present a practical and general synthesis of tertiary alkylamines through the addition of alkyl radic
25 ed protocol that appends arene feedstocks to tertiary alkylamines via C(sp(3))-H functionalization.
27 rol via a more reactive alpha,alpha-bisboryl tertiary allylcopper species to furnish products with hi
28 ith Thr599 in the pocket was achieved with a tertiary amide moiety, confirmed by the X-ray co-crystal
29 a pentynoyl traceless linker that features a tertiary amide protected MMAE was also decaged in the pr
30 these conditions, the decaging of pentynoyl tertiary amides and N-propargyls occurs rapidly in aqueo
31 on the efficient and controlled reduction of tertiary amides by a sodium hydride/sodium iodide compos
32 es, acidic protons alpha to carbonyl groups, tertiary amides, and aryl rings having common organic fu
34 ned syntheses of complex ether, sulfone, and tertiary amine products, some of which would be difficul
36 permits iterative alkyl group transfer from tertiary amines and demonstrates a deaminative strategy
37 ocyclic and aliphatic primary, secondary and tertiary amines as well as N-methylamines and more compl
38 recurring events: the in situ methylation of tertiary amines by PO(OMe)(3), Ni-catalyzed C-N bond cle
39 esters react with heteroaromatic and certain tertiary amines in the presence of an oxidant (I(2)) to
40 f linear and branched primary, secondary and tertiary amines including N-methylamines and molecules u
41 effective for the dehydrogenation of simple tertiary amines to give enamines than the previously rep
42 hydrogenation of several beta-functionalized tertiary amines to give the corresponding 1,2-difunction
44 talyst, provides a direct synthesis of alpha-tertiary amines, or their corresponding gamma-lactams.
45 metal-free and modular transformation forms tertiary amines, without structural constraint, via the
49 um ions led to six faceted nanocrystals, but tertiary ammonium ions obtained in this case stabilized
51 n otherwise difficult-to-access vicinal beta-tertiary and gamma-quaternary carbon stereogenic centers
53 These reactions result in the formation of tertiary and quaternary centers, and give products that
54 ) by cryo-electron microscopy, revealing the tertiary and quaternary structure at sufficient resoluti
55 catalyst for the deoxygenative reduction of tertiary and secondary amides with pinacolborane (HBpin)
56 ere highly efficient for primary, secondary, tertiary, and benzyl alcohols and tolerate a broad range
59 aging were classified as primary, secondary, tertiary, and quaternary, according to the injury type.
61 ly latent, late latent, or unknown duration; tertiary as well as neurosyphilis, ocular syphilis, and
64 fluorides, including primary, secondary, and tertiary benzylic fluorides as well as unactivated terti
67 deracemizative functionalization of racemic tertiary C-H bonds for stereoselective construction of c
69 ndency for inducing C-H functionalization at tertiary C-H bonds versus their triaryl counterparts but
70 mary alkyl bromides suggest a unique mode of tertiary C-radical generation through chain-walking foll
71 s of such reactions include the formation of tertiary-C(sp(3))-C bonds, presumably due to unfavorable
73 l survival (OS) of lung cancer patients of a tertiary cancer center in Yunnan to investigate screenin
75 ave a higher tendency of H/F exchange on the tertiary carbon and thus lower percentages of defluorina
76 ves a late-stage fragment coupling between a tertiary carbon radical and an electrophilic butenolide
80 d iodine(III)-catalyst allows the control of tertiary carbon-fluorine stereocenters with up to 96% ee
83 )phthalimide esters (primary, secondary, and tertiary carboxylic acid derived), several saturated and
85 having surgery during a one-year period at a tertiary care academic center in Boston, Massachusetts.
86 dentified in women at two hospitals (a large tertiary care academic hospital and a National Comprehen
87 ents who underwent lung transplantation at a tertiary care academic hospital from January 2007-Octobe
90 retrospective cohort of 220 admissions to a tertiary care center for invasive infections due to OUD,
91 th CCA who underwent EUS staging at a single tertiary care center from October 2014 to April 2018.
96 controlled study of 26 patients treated at a tertiary care center, with 13 eyes assigned to each trea
97 s descriptive formative evaluation describes tertiary care center-specific experiences rather than ai
99 ventricular unloading using an Impella at 16 tertiary care centers in 4 countries were collected.
100 ious studies have, however, been mainly from tertiary care centers, with risk for referral bias towar
104 validated the model in a second cohort of 14 tertiary care hepatology centers that prospectively enro
105 ncer therapy and follow-up visits in a large tertiary care hospital are feasible and safe after imple
107 rch 2020, 20 of 46 (43%) COVID-19 cases at a tertiary care hospital in San Francisco, California were
108 nated national outbreak screening center and tertiary care hospital in Singapore for SARS-CoV-2 testi
109 ram-negative bacteremia conducted in 3 Swiss tertiary care hospitals between April 2017 and May 2019,
110 al diagnosis of typhoid were enrolled from 4 tertiary care hospitals in Karachi, 2 pediatric hospital
113 4 and June 2018, attending physicians at one tertiary care institution reviewed all body CT studies i
114 e Liver Failure Study Group, comprised of 33 tertiary care liver centers, has enrolled consecutive pa
118 This prospective study was conducted in a tertiary-care center in Mexico between December 2016 and
119 rmed sensory polyneuropathy in subjects at a tertiary-care Children's Hospital from 2013 to 2019.
120 ens and antibiotic resistance cassettes in a tertiary-care hospital, from repeated sampling (up to 1.
121 were prospectively enrolled from primary and tertiary-care services providing care for 85% of GBM wit
122 days after the first cases were diagnosed, 1 tertiary case was detected in a symptomatic patient with
123 or technetium-99 m pyrophosphate at a single tertiary center from June 2015 through January 2019.
131 litis (ADEM) recruited from 40 secondary and tertiary centres in Spain were investigated for MOG anti
134 adolescents (5-17 years) presenting to three tertiary concussion clinics between April 2018 and March
136 del of Monod, Wyman, and Changeux to include tertiary conformational changes provides a better quanti
137 Recently, copper has been observed to drive tertiary contact in PrP(C), inducing a neuroprotective c
138 , the analysis indicates that (cross-linked) tertiary contacts can cause much stronger topological co
146 primary surgery from 1997 through 2000 at a tertiary eye center in India with minimum of 5 years of
147 ry benzylic fluorides as well as unactivated tertiary fluorides, that are typically inaccessible by n
149 .0 [35.8] months), and 76 (43%) were lost to tertiary follow-up (55% male; mean [SD] age: 58.9 [53.1]
150 ssified as adherent, nonadherent, or lost to tertiary follow-up if they followed up within 0-30 days,
151 protein secondary structure defines not only tertiary geometry, but also maintains control in functio
153 spective study of adults receiving care at a tertiary health care system from January 1, 2013, to Dec
158 ective method for the preparation of complex tertiary homoallylic alcohols containing a vicinal quate
159 tional case-control study was conducted at a tertiary hospital clinic (University of Calgary Liver Un
160 tomy for suspected acute appendicitis at our tertiary hospital during 2015 versus similar patients at
163 al anesthesia lasting more than 2 hours in a tertiary hospital in Melbourne, Australia, from February
165 d, open-label, crossover clinical trial in a tertiary hospital involving patients with history of ana
166 l study from February 2018 to July 2019 at a tertiary hospital of the 24-h/day, 7-day/week implementa
168 chest radiographs were reviewed for the main tertiary hospital to reclassify hospital admissions in c
173 OVID-19 were compared from three independent tertiary hospitals (one in Liechtenstein, two in Switzer
174 ious uveitis were recruited from 2 Victorian tertiary hospitals and 1 private ophthalmic practice.
179 , respiratory-, and cardiovascular-related), tertiary ICU status, and presence of limitations of medi
182 ical interactions-revealed that a long-range tertiary interaction guides native RNA folding for both
183 aling the catalytic consequences of specific tertiary interactions, and allowing us to infer structur
184 ling reveals cold-induced disruptions of key tertiary interactions, suggesting that a kinetic trap pr
187 Environmental stresses during the Cretaceous-Tertiary (KT) mass extinction caused range contraction,
188 d to the Infectious Diseases department of a tertiary level Swedish hospital, and sampled for SARS-Co
189 spital da Restauracao, a secondary-level and tertiary-level hospital, with suspected acute neurologic
190 d their 3070 fetuses) from 29 secondary- and tertiary-level hospitals across Bangladesh, India, Kenya
192 l for complex object recognition, contains a tertiary, longitudinal sulcus (mid-fusiform sulcus, MFS)
193 (C-C motif) ligand 21 in lung lymphatics and tertiary lymphoid organ formation, and then decreased as
195 merging evidence supports a crucial role for tertiary lymphoid organs (TLOs) in chronic obstructive p
198 splant tolerance, Foxp3+ cells accumulate in tertiary lymphoid organs that are induced within the pul
202 ng data, in which T cells in tumours without tertiary lymphoid structures had a dysfunctional molecul
204 ights into the potential role of B cells and tertiary lymphoid structures in the response to ICB trea
205 mbination with CD20 reveals the formation of tertiary lymphoid structures in these CD8(+)CD20(+) tumo
206 class E was characterized by the presence of tertiary lymphoid structures that contain T cells and fo
207 a, and unravels the potential of B-cell-rich tertiary lymphoid structures to guide clinical decision-
208 erapeutic option that combines prevention of tertiary lymphoid structures(1) and inhibition of apopto
209 s lymphoid neogenesis and the development of tertiary lymphoid structures(1,2), which are associated
210 imaging for prostate cancer at a single U.S. tertiary medical center, access to (68)Ga-PSMA-11 for Bl
215 scope (OPM) that uses a bespoke glass-tipped tertiary objective to improve the resolution, field of v
216 referred from the emergency department to a tertiary ophthalmology centre with bilateral exquisite e
220 pective study of children who presented to a tertiary pediatric hospital from December 2018 to Decemb
221 US, CT, and MRI in 35 children admitted to a tertiary pediatric hospital in April and May 2020 with a
223 ture research and programming should include tertiary prevention approaches to IPV, such as CETA, rat
226 y to alpha,alpha,alpha-trisubstituted (alpha-tertiary) primary amines by C-H functionalisation has lo
227 ed in the stabilization of the secondary and tertiary protein structures as well as the recognition o
228 at the obstetrics registration centers of 3 tertiary public hospitals in 3 major cities (Guangzhou,
229 e ligands lead directly to the corresponding tertiary radical cross-coupling products via an outer-sp
230 e of methyl radical via beta-scission from a tertiary radical generated upon chlorine-mediated hydrog
231 Hantzsch ester, which decomposes to afford a tertiary radical that is readily trapped by the enyne.
232 ere recruited and followed in a large German tertiary reference center with comprehensive microbiolog
233 study of PWID aged >=18 years admitted to a tertiary referral center between 01/2016 and 07/2019, wh
234 nts older than 10 years with ROP seen at our tertiary referral center from 2000 through 2018, 5 (3.6%
235 is is a retrospective analysis from a single tertiary referral center of all patients older than 18 y
238 y for ampullary adenocarcinoma in 9 European tertiary referral centers between February 2006 and Dece
239 these results were similar to those of other tertiary referral centers, it would be reasonable to per
241 2000, and Dec 31, 2012, at 37 collaborating tertiary referral centres across 18 European countries o
244 brimonidine-associated anterior uveitis in a tertiary referral glaucoma clinic presenting between 201
245 had undergone cardiac MRI at a single large tertiary referral hospital between March 2008 and Januar
247 352 IE episodes in 344 adult patients of our tertiary referral hospital were retrospectively investig
248 nts, from January 2009 to December 2013 at a tertiary referral hospital, who had available serum ioni
250 reaction confirmation who were treated at a tertiary referral, university-based academic practice.
251 nts treated for acute cholangitis in a large tertiary refferential center, use of carbapenems seems n
252 d global communication network comprising of tertiary (residue-residue contacts) and quaternary (rigi
253 serum all-trans-retinol (1) delivered via a tertiary retinol binding protein 4 (RBP4)-transthyretin
254 tions to TAR bulge variants and more complex tertiary RNAs support the generality of this approach an
255 H bond substrates was explored and benzylic, tertiary, secondary, and primary C-H bonds are successfu
256 drosilylation with the industrially relevant tertiary silane 1,1,1,3,5,5,5-heptamethyltrisiloxane (MD
258 opose that L11 stabilizes a specific GAC RNA tertiary state, corresponding to the crystal structure,
259 ped, enabling construction of two contiguous tertiary stereocenters in a single step with moderate to
261 n-hydrogen (C-H) bonds of a methylene group, tertiary stereocentres containing fluorine have not yet
267 thway, highlighting the potential of protein tertiary structure mimetics as an emerging class of PPI
268 information extracted from predicted protein tertiary structure models, and are firstly used in methy
273 utations that disrupt the stability of PMP22 tertiary structure reduce or eliminate this preference i
276 quisite to specifically target the peptide's tertiary structure with the aim to promote the emergence
277 ysical and chemical characteristics, such as tertiary structure, fractional solvent accessibility, pK
278 ind to the GAC until the RNA has adopted its tertiary structure, new experimental data show that L11
279 ys residues in different regions of the FepA tertiary structure, with the potential to form disulfide
283 tion of allosteric networks from primary and tertiary structures and for quantitative descriptions of
284 nucleic acids and specifically stabilize RNA tertiary structures as well as impact the folding landsc
286 ns exhibit high affinity to RNA G-quadruplex tertiary structures implicated in diverse cellular proce
287 A local and global folds, especially for RNA tertiary structures involving cross-linked base pairs.
288 re but rather, with an ensemble of secondary/tertiary structures that interact with the capsid protei
289 werful tool for predicting monomeric protein tertiary structures that is most useful when a suitable
290 employs -1 PRF directed by RNA secondary and tertiary structures within its viral genome (canonical P
296 secondary structure to predict corresponding tertiary topologies, (b) RAG Builder: builds three-dimen
298 ded all adults diagnosed with candidemia our tertiary university hospital from 2012-2017 who had at l