ライフサイエンスコーパス: tertiary structure

1 shift, adopting higher average secondary and tertiary structure.

2 s proteins unfold with loss of secondary and tertiary structure.

3 unfolding to changes in protein primary and tertiary structure.

4 sible folding pathways leading to its native tertiary structure.

5 le and maintains a near-native secondary and tertiary structure.

6 of cation-pi interactions that stabilize the tertiary structure.

7 2 with the large-scale transformation of its tertiary structure.

8 mation in primary sequence and secondary and tertiary structure.

9 g its environmental change from secondary to tertiary structure.

10 theoretic approach when considering protein tertiary structure.

11 utational clusters while considering protein tertiary structure.

12 mation of hydrogen bonds associated with the tertiary structure.

13 rpoS leader, folding the RNA into a compact tertiary structure.

14 ond-to-microsecond movement of secondary and tertiary structure.

15 y applied to the characterization of protein tertiary structure.

16 ate NMR, which is important to study protein tertiary structure.

17 elices, it is not known how they disrupt RNA tertiary structure.

18 es native RNA folding for both secondary and tertiary structure.

19 ing of secondary structure at the expense of tertiary structure.

20 e 80% similar in sequence and show conserved tertiary structure.

21 ing protein folding in silico and predicting tertiary structure.

22 MAPK activation, substrate interaction, and tertiary structure.

23 roach to monitor the effect of pH on protein tertiary structure.

24 nvolving the formation of both secondary and tertiary structure.

25 disruption of the retinal-binding pocket and tertiary structure.

26 step towards accurate prediction of the full tertiary structure.

27 trategy to increase the stability of protein tertiary structures.

28 polymers that can self-assemble into complex tertiary structures.

29 l mechanisms of RNAs are determined by their tertiary structures.

30 re of a protein, separate from secondary and tertiary structures.

31 goal of extending the alpha/beta approach to tertiary structures.

32 ital for folding mt-tRNAs into their correct tertiary structures.

33 t the self-assembly of discrete thermostable tertiary structures.

34 , and rate of formation of the secondary and tertiary structures.

35 the highest rates and largest secondary and tertiary structures.

36 lding landscape of RNAs as they assume their tertiary structures.

37 omated tool for analyzing and annotating RNA tertiary structures.

38 e, proteins showed strong evidence of stable tertiary structures.

39 top-ranked bases clustered in secondary and tertiary structures.

40 the same thermal stability and very similar tertiary structures.

41 s are prevalent in DNA and RNA secondary and tertiary structures.

42 ated only minor alterations in secondary and tertiary structures.

43 on the assessment of blind prediction of RNA tertiary structures.

44 gues, with similar or functionally different tertiary structures.

45 functions of proteins are realized by their tertiary structures.

46 s" through the emergence of secondary and/or tertiary structures.

47 asmid, BTA121 can serve as a model for their tertiary structures.

48 have essentially identical active sites and tertiary structures.

49 le stranded regions to discrete secondary or tertiary structures.

50 tool for the analysis and annotation of RNA tertiary structures.

51 rface ((568)NGR) and the other buried in the tertiary structure ((962)NGR).

52 detergent prevents the loss of secondary and tertiary structures after thermal unfolding at 90 degree

53 nances were enhanced, enabling secondary and tertiary structure analysis of proteins with remarkable

54 In silico pre-mRNA secondary and tertiary structure analysis revealed that this substitut

55 rcaptoethanol caused significant loss in the tertiary structure and a drop in caspase 3 and 9 activat

56 activity and binding assays to dissect this tertiary structure and assess its functional role.

57 , which seem to be important to maintain its tertiary structure and compact fold.

58 terized by their lack of stable secondary or tertiary structure and comprise a large part of the euka

59 lations predicted a more relaxed NC1 hexamer tertiary structure and diminished assembly competence in

60 dentical in human Hsp90 but which differs by tertiary structure and dynamics.

61 requiring an interacting partner to acquire tertiary structure and function.

62 ot can be applied to any protein for which a tertiary structure and homologous sequences are availabl

63 by NMR and CD spectroscopy that LcrG lacks a tertiary structure and it consists of three partially fo

64 elength of r-betaLg suggested changes in its tertiary structure and more solvent-exposed tryptophan r

65 is predominantly alpha-helical with extended tertiary structure and oligomerizes in solution.

66 However, when the effects of tertiary structure and protein interactions were removed

67 Unlike DNA aptamers where a change in the tertiary structure and the folding of the polyanionic ba

68 ovide new insight into the interplay between tertiary structure and the inhibitory activity of a mult

69 The unique tertiary structures and ease of synthesis of CovCore pro

70 providing accurately predicted secondary and tertiary structures and featured sites annotations.

71 tion of allosteric networks from primary and tertiary structures and for quantitative descriptions of

72 pieces of preexisting proteins to create new tertiary structures and functions.

73 rough-space interaction networks that define tertiary structures and govern sampling of multiple conf

74 portant information to undefirstafinding the tertiary structures and thus the functions of ncRNAs.

75 single-stranded sequences, RNA secondary or tertiary structure, and a combination of these features.

76 c fluorescence of OCP reveals changes in its tertiary structure, and the fluorescence properties of N

77 ies, including the quaternary structure, the tertiary structure, and the ligand-binding site.

78 econdary structure, the HP model for protein tertiary structure, and the Polyomino model for protein

79 However, introducing specific sequences, tertiary structures, and chemical modifications into lam

80 actions and the resulting flexibility of the tertiary structure are essential for tRNA(Sec) function.

81 ions with RNAs of more complex secondary and tertiary structure are less understood.

82 that electrostatics, excluded volume, and NA tertiary structure are sufficient to predict assembly th

83 ns caused significant destabilization of the tertiary structure as measured by variable-temperature c

84 to extraordinarily complicated secondary and tertiary structures as a result of intramolecular base p

85 nucleic acids and specifically stabilize RNA tertiary structures as well as impact the folding landsc

86 ondary structure and three have well ordered tertiary structure, as demonstrated by circular dichrois

87 al domain that forms transient secondary and tertiary structures, as well as an equilibrium between a

88 Elucidation of four new GH74 tertiary structures, as well as one distantly related du

89 ra-C2 domain interactions forming a "closed" tertiary structure at low calcium that "opens" as calciu

90 econdary structural features, nor have their tertiary structures been characterized because solved st

91 ich in isolation do not adopt a well-defined tertiary structure but instead populate a structurally h

92 roteins and protein regions that lack stable tertiary structure, but nevertheless retain biological f

93 functional paradox because they lack stable tertiary structure, but nonetheless play a central role

94 roperties, one fragment adopted the expected tertiary structure, but the other failed to fold, despit

95 the "disulfide-locked" Rgg2Sd secondary and tertiary structures, but another displayed more extensiv

96 Stabilization of protein tertiary structure by disulfides can interfere with glyc

97 However, the nucleic acid secondary and tertiary structure can also act as a recognition site fo

98 ditions, aspects of the native secondary and tertiary structure can be conserved.

99 orts the conclusion that the oligonucleotide tertiary structure can significantly alter the chemical

100 ansition involving cooperative secondary and tertiary structure changes and a partially folded interm

101 early indicate that the bovine serum albumin tertiary structure changes as protein concentration and

102 ure preformed in the unbound state with only tertiary structure changes occurring during target bindi

103 erogeneous-backbone foldamer design to a new tertiary structure class and show that judiciously appli

104 and are in regions predicted to have altered tertiary structure compared with the receiver domains of

105 Chemokines are defined by a conserved tertiary structure composed of a three-stranded beta-she

106 ties such as binding affinity, secondary and tertiary structure, conformational dynamics, and thermal

107 etic resonance of Skint-1 DV revealed a core tertiary structure conserved across the Skint family, bu

108 hose members share a unique disulfide-bonded tertiary structure, conserved catalytic motifs, and the

109 cal significance of membrane proteins, their tertiary structures constitute less than 3% of known str

110 ces and oligourea 2.5-helices suggest that a tertiary structure could be retained when swapping the t

111 The stability of RNA tertiary structures depends heavily on Mg(2+).

112 Secondary and tertiary structure determined by circular dichroism and

113 ary structure, but the completely folded RNA tertiary structure develops small pockets of very negati

114 tional clustering by considering the protein tertiary structure directly in 3D space.

115 However, the interplay between tertiary structure dynamics and quaternary hierarchical

116 at is characterized by increased mobility of tertiary structure elements and solvent accessibility.

117 the importance of considering secondary and tertiary structure elements and their role in RNA-protei

118 te tetratricopeptide repeats, their distinct tertiary structures enable them to bind different partne

119 ods have generally failed to determine ncRNA tertiary structures, even at the 1-nm resolution that en

120 er design can be extended to reliably create tertiary structure features that mimic more complex biom

121 g dynamics of 10 ms or faster, likely due to tertiary structure fluctuations, and slow dynamics on th

122 nal folding revealed different secondary and tertiary structure folding pathways for GlpG and DsbB th

123 Exploring the tertiary structure folding processes of RNA enables us t

124 rough target mass loading coupled to aptamer tertiary structure folding.

125 ous modeling approaches to propose candidate tertiary structures for the apical region of domain 3, t

126 f the mechanism by which the ion facilitates tertiary structure formation is not fully known.

127 escence resonance energy transfer to monitor tertiary structure formation of the hairpin ribozyme as

128 scence experiments revealed that kinetics of tertiary structure formation upon addition of MgCl2 are

129 The three mutants report on tertiary structure formation via different fluorescent h

130 dy the influence of Mg(2+) and Ca(2+) on RNA tertiary structure formation.

131 ysical and chemical characteristics, such as tertiary structure, fractional solvent accessibility, pK

132 Prediction of RNA tertiary structure from sequence is an important problem

133 , whose goal is to predict monomeric protein tertiary structures from sequence is described.

134 by the removal of semi-stable secondary and tertiary structures from single polymer strands leading

135 by utilizing graph theory to account for the tertiary structure, GraphPAC discovers clusters in DPP4,

136 folding pathway from secondary structure to tertiary structure has not been previously observed, but

137 amide bond to the formation of protein-like tertiary structure, has and will continue to enable the

138 secondary structure but only loosely packed tertiary structure, has been suggested to be a ubiquitou

139 Here we carried out tertiary structure homology modelling of the peroxidases

140 ns exhibit high affinity to RNA G-quadruplex tertiary structures implicated in diverse cellular proce

141 ow that the DEAD-box protein CYT-19 disrupts tertiary structure in a group I intron using a helix cap

142 ubdomain folds to local native secondary and tertiary structure in a linked transition and assembles

143 in hydrophobicity indicated unfolding of the tertiary structure in all samples.

144 Secondary or tertiary structure in an mRNA, such as a pseudoknot, can

145 t a number of proteins do not adopt a unique tertiary structure in solution and that some degree of d

146 contribute specific interactions to the GAC tertiary structure in the cocrystals.

147 fic transient opening rates of secondary and tertiary structure in the protein provides a structural

148 Similar to the space of protein tertiary structures in which discrete patterns are clear

149 a novel test for enrichment of higher-order (tertiary) structure in disordered proteins; the size and

150 al information, but none of them use protein tertiary structure information in prediction.

151 This demonstrates that tertiary structure intactness of Cyt c was essential for

152 lysis indicates a decomposition of the RNase tertiary structure into spatially distributed yet physic

153 been subdivided-based on their secondary and tertiary structures-into two major groups (A and B), eac

154 the existence of a pH- and Mg(2+)-dependent tertiary structure involving pseudoknot formation within

155 A local and global folds, especially for RNA tertiary structures involving cross-linked base pairs.

156 trate that the Smc5/6 complex recognizes DNA tertiary structures involving juxtaposed helices and mig

157 rect folding of the active site and ribozyme tertiary structure is also regulated by metal ions in a

158 This complex tertiary structure is established during the regenerativ

159 The analysis of RNA tertiary structure is hindered by the fact that not too

160 ed RNAs have led to the perspective that RNA tertiary structure is modular, made of locally stable do

161 In solution, we find that this tertiary structure is not static, but rather is best des

162 ation with an aptamer forming a secondary or tertiary structure is still lacking.

163 Given that Concanavalin A's tertiary structure is thought to be relatively robust, t

164 Comparing protein tertiary structures is a fundamental procedure in struct

165 nts in a biomolecule, transition dynamics of tertiary structures is often too complex to profile usin

166 l radical cleavage is widely used to map RNA tertiary structure, lack of mechanistic understanding of

167 ant in the micromolar range and modifies its tertiary structure leading to a decrease of its thermost

168 ch can interact with a target mRNA to form a tertiary structure like a pre-tRNA and recruit intracell

169 thway, highlighting the potential of protein tertiary structure mimetics as an emerging class of PPI

170 tions, because often, specific cases require tertiary structure mimetics.

171 te a platform for the discovery of potential tertiary structure mimetics.

172 information extracted from predicted protein tertiary structure models, and are firstly used in methy

173 local quality assessment method for protein tertiary structure models.

174 ds to changes in the aptamer's secondary and tertiary structure; monitoring such changes has led to t

175 Despite their similar primary and tertiary structures, MTs show distinct binding selectivi

176 ind to the GAC until the RNA has adopted its tertiary structure, new experimental data show that L11

177 l changes in the nature of the secondary and tertiary structure of a larger assembly.

178 Finally, this server predicts tertiary structure of a sequence by feeding its predicte

179 alpha-helical fraction and marked change in tertiary structure of actomyosin.

180 mapped them on a homology-based model of the tertiary structure of Asp t 36.

181 From the FCS experiment, the tertiary structure of betaLG was observed to be stable i

182 560 nm, referring to the conservation of the tertiary structure of bR in nanodiscs of different lipid

183 Thus, it is the particular tertiary structure of epitope II, which is presented in

184 DESTINI successfully predicts the tertiary structure of four times the number of "hard" ta

185 These RNA-coat interactions stabilize the tertiary structure of gRNA within the virion, which coul

186 imary structure of single nucleosomes or the tertiary structure of long-range looping interactions.

187 led the structure of MxB using the published tertiary structure of MxA.

188 ondary structure and lack the tightly packed tertiary structure of natively folded globular proteins.

189 le protein scaffolds taking advantage of the tertiary structure of odorant binding proteins.

190 a compound, B02, that docks to the predicted tertiary structure of PfRad51 with high affinity.

191 luorescence spectra analysis showed that the tertiary structure of polygalacturonase was changed.

192 E-Symm, to detect pseudo-symmetry within the tertiary structure of protein chains.

193 We found a dramatic change of the overall tertiary structure of protein G'e when the pH was change

194 py was used to investigate the secondary and tertiary structure of proteins carefully transferred fro

195 nd features taken from the three-dimensional tertiary structure of proteins.

196 In the same way DNA was modeled, the tertiary structure of RNA is constrained using an elasti

197 oldRNA server that permits the prediction of tertiary structure of RNAs as long as a few hundred nucl

198 s between Rpg1b and Rpg1r onto the predicted tertiary structure of Rpg1b, which revealed highly polym

199 wered, such as a detailed description of the tertiary structure of SpA domains in complex with Fc and

200 h synthetic epitope targeting to exploit the tertiary structure of the BoNT protein as a landscape fo

201 First, calcium ions change the tertiary structure of the bound Abeta monomer by destabi

202 Here, we have determined the tertiary structure of the CUB module from human TSG-6, i

203 The tertiary structure of the GTPase center (GAC) of 23S rib

204 The disulfide bridges stabilize the tertiary structure of the peptides and often make them s

205 disordered PPIs, it is crucial to obtain the tertiary structure of the PPIs.

206 ted with folding and potential secondary and tertiary structure of the scaffold.

207 n sequence to interpreting the secondary and tertiary structure of their models, their domain composi

208 Despite the conserved tertiary structure of these regulators, structural analy

209 ine aminopeptidase can disrupt secondary and tertiary structure of this essential enzyme, thereby kil

210 The secondary and tertiary structure of this protein was determined, which

211 We also find that changes in the tertiary structure of transthyretin can be associated wi

212 The secondary and tertiary structures of 3A5 and 3A4 are similar, but the

213 ges were analyzed based on the secondary and tertiary structures of a previously crystallized protein

214 DB is becoming a fundamental resource of the tertiary structures of biological macromolecules.

215 ing a resolution sufficient to determine the tertiary structures of both gp7 and gp10 protein subunit

216 (2+) or Mg(2+), stabilized the secondary and tertiary structures of CML36, guiding a large structural

217 The prediction of tertiary structures of complex RNAs is still a challengi

218 has been used to elucidate the secondary and tertiary structures of peptides and small proteins that

219 approaches for determining the secondary and tertiary structures of proteins.

220 conformational changes in the secondary and tertiary structures of proteins.

221 The primary, secondary, and tertiary structures of spectrin are reasonably well defi

222 The code is realized by distinct dynamic tertiary structures of the anchor on the plasma membrane

223 We review here the tertiary structures of the domains that regulate c-di-AM

224 Overall, the unique secondary and tertiary structures of the N-terminal domains of apoB su

225 In this study, by comparing the primary and tertiary structures of two GH1 beta-glucosidases with di

226 conformational alterations in secondary and tertiary structures of whey proteins induced by safranal

227 ein crystallography to determine the folded (tertiary) structure of biologically active Ts3 toxin by

228 mera explored the effects of tail length and tertiary structure on sodium channel activity.

229 e studies give us a view of the formation of tertiary structure on the folding pathway, which complem

230 in interaction (PPI), gene ontology, protein tertiary structures, orthologous sequences, kinase/phosp

231 Further, by utilizing the tertiary structure, our algorithm also identifies cluste

232 tructure report on Watson-Crick pairing, but tertiary structure parameters such as solvent accessibil

233 high glycosylation levels caused some minor tertiary structure perturbations.

234 boosting our group's performance in the main tertiary structure prediction category.

235 Protein tertiary structure prediction methods have matured in re

236 Finally, tertiary structure prediction of E4 34K and its comparis

237 e ability is demonstrated in the large-scale tertiary structure prediction of over 1,200 single-domai

238 rises an integrated pipeline of methods for: tertiary structure prediction, global and local 3D model

239 d as one of the major challenges for protein tertiary structure prediction.

240 ones of similar category in both contact and tertiary structure prediction.

241 as restraints to improve the accuracy of RNA tertiary structure prediction.

242 traints according to their importance to RNA tertiary structure prediction.

243 have focused on performance improvements in tertiary structure predictions, in terms of global 3D mo

244 sis offers an efficient way for accurate RNA tertiary structure predictions.

245 on, Qprob makes contributions to our protein tertiary structure predictor MULTICOM, which is official

246 The tertiary structure promoted by Zn(2+) is thought to regu

247 ues leads to progressive disruption of HSP90 tertiary structure, promoting exposure of R502/R510 to P

248 utations that disrupt the stability of PMP22 tertiary structure reduce or eliminate this preference i

249 ount of beta-sheets) were observed while the tertiary structure remained unchanged.

250 system which sustains delicate secondary and tertiary structures, reminiscent of those present in nuc

251 nimal but fully active construct lacking the tertiary structure reveals a crucial role in PKR binding

252 ecognition of an RNA hairpin loop and an RNA tertiary structure, reveals the capacity of minimalist l

253 se-pair step, which accumulate to impact RNA tertiary structure stability.

254 rs and coaxial stacking interactions for the tertiary structure stabilization.

255 and final morphologies of the secondary and tertiary structures strongly depend on the cation employ

256 l regions, which are widely separated in the tertiary structure, suggest a higher order architecture

257 Comparisons of primary and tertiary structures supported that ePKs and ChKs evolved

258 NA interactions, it is important to know the tertiary structures surrounding the splice sites.

259 Predictions of RNA tertiary structure tend to be least accurate in loop reg

260 and characterization of a stabilized protein tertiary structure that acts as an inhibitor of the inte

261 th a complex and unprecedented secondary and tertiary structure that constructs itself highly selecti

262 of VA RNAI is proposed to contain a complex tertiary structure that contributes to its optimal inhib

263 sequences called DNAzymes that can fold into tertiary structures that display catalytic activity.

264 re but rather, with an ensemble of secondary/tertiary structures that interact with the capsid protei

265 werful tool for predicting monomeric protein tertiary structures that is most useful when a suitable

266 lead to the formation of secondary and even tertiary structures that transmit information, act as me

267 ne can then determine both its secondary and tertiary structures through structure prediction, which

268 btuB riboswitch modulates the formation of a tertiary structure to perform metabolite sensing and reg

269 A secondary structures translated from known tertiary structures to suggest which hypothetical large

270 sponse to dehydration and slightly amplified tertiary-structure transitions induced by ligand binding

271 ed proteins (IDPs) lack stable secondary and tertiary structure under physiological conditions in the

272 dered regions of proteins, which lack unique tertiary structure under physiological conditions, are e

273 DPs) are proteins that lack secondary and/or tertiary structure under physiological conditions.

274 iants investigated herein exhibit non-native tertiary structures under physiological conditions, lead

275 It folds into an intricate tertiary structure upon addition of Mg(2+) ions, which i

276 matical analysis from protein primary to its tertiary structure using the evolutionary couplings as a

277 milestone to the accurate prediction of RNA tertiary structure using unbiased all-atom molecular dyn

278 onal clusters by taking into account protein tertiary structure via a graph theoretical approach.

279 The resulting tertiary structure was investigated using intermolecular

280 ogical importance of this macromolecule, its tertiary structure was never determined.

281 X maintained its secondary structure but the tertiary structure was substantially affected and enzyme

282 preservation of the proteins' secondary and tertiary structures was evidenced using molecular dynami

283 In addition to secondary and tertiary structure, we consider generic structural prope

284 Both secondary and tertiary structures were affected severely by higher pre

285 phorylation and acetyl-Lys sites mapped onto tertiary structures were proximal in >50% of proteins in

286 celles (3HM), based on a coiled-coil protein tertiary structure, were evaluated as an alternative to

287 IDPs can acquire tertiary structure when bound to their partners; therefo

288 unction of an RNA molecule is encoded in its tertiary structure, which in turn is determined by the m

289 Our results demonstrate that complex RNA tertiary structures, which may be difficult to predict c

290 Protein domains can fold into stable tertiary structures while they are synthesized on the ri

291 ity with known PagP enzymes, the beta-barrel tertiary structure with an interior hydrocarbon ruler ap

292 e demonstrates that RNA alone folds into its tertiary structure with bound divalent ions.

293 Pseudoknots are a fundamental RNA tertiary structure with important roles in regulation of

294 quisite to specifically target the peptide's tertiary structure with the aim to promote the emergence

295 family, which is predicted to share similar tertiary structure with visual-/beta-arrestins and also

296 rce for the automated prediction of: protein tertiary structures with built-in estimates of model acc

297 ys residues in different regions of the FepA tertiary structure, with the potential to form disulfide

298 t depending on the amino acid properties and tertiary structure within the MBD.

299 employs -1 PRF directed by RNA secondary and tertiary structures within its viral genome (canonical P

300 onstrained peptides with precisely specified tertiary structures would enable the design of shape-com