ライフサイエンスコーパス: testes

1 an immunologically privileged tissues (i.e., testes).

2 at the Stra8 promoter in beta-TrCP-deficient testes.

3 long-term cultured xenogeneic reconstituted testes.

4 ified TRIM28 as a new SOX9 partner in foetal testes.

5 s of the basement membrane (BM) in adult rat testes.

6 1 that associate with chromatin in embryonic testes.

7 dymis-specific genes were upregulated in the testes.

8 d reduce malignancy in boys with undescended testes.

9 rectly and significantly to RA production in testes.

10 ptosis markers annexin V and p53 in knockout testes.

11 relatively higher expression of PRL2 in the testes.

12 tly within the seminiferous tubules of human testes.

13 f spermiogenesis and spermatogenesis in male testes.

14 or supernumerary testis means more than two testes.

15 hybrid males using mRNA-sequencing of whole testes.

16 germ cells and occur most frequently in the testes.

17 to mice, where expression is limited to the testes.

18 productive processes, expressed primarily in testes.

19 ough the latter occurred rarely in the human testes.

20 postnatal piRNAs in human juvenile and adult testes.

21 e seminiferous epithelium of adult mammalian testes.

22 h, including the development of eggs in male testes.

23 o-siRNA class with predominant expression in testes.

24 nfluenced the homing of these cells in mouse testes.

25 e primary self-renewal pathway in Drosophila testes.

26 nd and elongated spermatids, in normal human testes.

27 pupal development, opposes EGF signaling in testes.

28 was also evident in ALC stem cells in fetal testes.

29 lysis of testosterone-suppressed transfemale testes.

30 d uniquely in a rare subset of SSCs in mouse testes.

31 leen, liver, brain, lung, heart, kidney, and testes.

32 to HSP70 stabilization in tissues other than testes.

33 ntains germline identity in Drosophila adult testes.

34 ifference depends on the ovaries but not the testes.

35 ion and reduced crossover formation in mouse testes.

36 glycans were significantly reduced in Bsg KO testes.

37 ferous tubules in the Arid4a(-/-)Arid4b(+/-) testes.

38 anscript of Gudu is highly enriched in adult testes.

39 recapitulating those observed with TRF2(-/-) testes.

40 ies allowing reduced investment in expensive testes.

41 spermatogonia in prepubertal and adult mouse testes.

42 ty to promote regeneration in LC-ablated rat testes.

43 ysine 27 (H3K27ac) are elevated in Brg1(cKO) testes.

44 he maintenance of early germ cells in larval testes.

45 all of which are preferentially expressed in testes.

46 ed high uptake in kidney, spleen, liver, and testes.

47 cations and RNA methylation in adult F1 male testes.

48 lved in piRNA biogenesis in both ovaries and testes.

49 only present at very low levels in the fetal testes.

50 tly hypoechoic, round-to-oval masses in both testes.

51 ght loss and ZIKV infection in the brain and testes.

52 dative stress and cell junction signaling in testes.

53 ith this defect, we have identified in mouse testes 1,551 differentially expressed genes that cover b

54 %, followed by neck mass (4.2%), undescended testes (1.9%), breast mass (1.2%), club foot (1%), hypos

55 10-12 GW, or in second trimester xenografted testes (14-17 GW).

56 and penile size, which contrasted with small testes (4.5 mL).

57 rmatogonia were present at normal density in testes 5 d after birth, but they lacked the capacity for

58 To investigate this, we exposed human fetal testes (7-17 gestational weeks (GW)) to ibuprofen using

59 absence of Sertoli cell adenomas in 19 of 23 testes (83%).

60 cells and found that mutant mice had smaller testes, a delay in differentiation of pre-meiotic germ c

61 y lineage-tracing experiments in E(z) mutant testes, a portion of excessive early-stage somatic gonad

62 ased complement C3 protein deposition in the testes, accompanied by severe histological degeneration.

63 Moreover, we find Orco localization in testes across distinct insect taxa and posit that OR-med

64 Finally, H3f3b null testes also exhibited abnormal germ cell chromatin reorg

65 d the relative male investment in hyoids and testes among howler monkey species in relation to the le

66 A recrudescence of testes and body mass occurred from mid-February, but Dio

67 ne-sheltered spaces, including the placenta, testes and brain.

68 Dominant A. burtoni males possess large testes and bright coloration and perform aggressive and

69 tic variant, FerT, are coexpressed in normal testes and cancerous tumors, but whether they exert rela

70 nscript abundance in the fetal pituitary and testes and circulating steroids, at day 75 gestation, us

71 nol 153 (PCB153), were detected in adult dog testes and commercial dog foods at concentrations report

72 derepresses its target ATP synthase-beta in testes and compromises spermatogenesis and male fertilit

73 ed with apoptotic corpse accumulation in the testes and degeneration of photoreceptors in the eye.

74 ornaments and armaments) and postcopulatory (testes and ejaculates) sexual traits due to the costs as

75 sociated with chromatin domain boundaries in testes and embryonic stem cells.

76 genetic studies of Rdh10 in postnatal mouse testes and found that an RDH10 deficiency in Sertoli cel

77 omeric double-ring TRiC purified from bovine testes and HeLa cells.

78 examine Sertoli and germ cell markers on rat testes and human fetal testis xenografts after exposure

79 ction, likely causing premature aging of the testes and impaired liver metabolic capacity.

80 d to histological alterations of ovaries and testes and increased gonadosomatic index.

81 icantly reduced Sox9 transcripts in cultured testes and increased Sox9 levels in ovaries.

82 than one century ago, the TSE of MRT in the testes and its clinical importance for preventing male f

83 ffects of in utero PFOS exposure on neonatal testes and its relation to testicular dysfunction in adu

84 and androsterone synthesis by both the fetal testes and nongonadal tissues, leading to DHT formation

85 ikely functional, evidenced by expression in testes and ovaries at the RNA and protein level.

86 Upon nhr-1 knockdown, germ cells in the testes and ovaries fail to mature, and remain as undiffe

87 Histological examination of testes and ovaries showed impaired spermatogenesis and o

88 Testes and ovaries undergo sex-specific morphogenetic ch

89 y tissue, PRAME expression is limited to the testes and ovaries, making it a highly attractive cancer

90 and its transcript is detectable only in the testes and ovaries, showing a strong positive signal in

91 e Kdr promoter in the chromatin of embryonic testes and ovaries.

92 KDR are co-expressed in Sertoli cells of the testes and somatic cells of embryonic ovaries.

93 s mice against ZIKV-associated damage to the testes and sperm and prevents viral persistence in the t

94 Atrophic testes and testicular degeneration were observed in Ppar

95 astrocytes was compromised in the absence of testes and testosterone signaling via AR.

96 sistent DNA double-strand breaks in p53R172H testes and the formation of giant spermatogonia (GSG) fo

97 Doppler ultrasonographic (US) images of the testes and the inguinoscrotal region were obtained.

98 strate that basal body formation in the male testes and the production of functional sperm does not r

99 hosphamide therapy had significantly smaller testes and total sperm counts (median: 12.5 mL and 16.3

100 >7,000 transcripts found in the gonads, 243 (testes) and 3,600 (ovaries) occurred pairing-dependently

101 permatozoa generation, lower actin levels in testes, and impaired motility and ultrastructural disorg

102 that GAR22beta is highly expressed in mouse testes, and its absence resulted in reduced spermatozoa

103 manifestations, persistent infection in the testes, and neurologic sequelae.

104 lethality, reduced ZIKV levels in brains and testes, and preserved sperm counts.

105 0.0006, and 0.0074 rad/mCi) for the ovaries, testes, and red marrow, respectively.

106 ms that express this GPCR, such as the lung, testes, and small intestine.

107 varied from 8% in preputial gland to 97% in testes, and the tissue-specificity observed in vivo was

108 , injuries or wounds, neck mass, undescended testes, and vaginal fistula) was created.

109 viremia, and viral loads in spinal cord and testes-and increased mortality.

110 .7 mGy, liver; 2.1 mGy, red marrow; 1.7 mGy, testes; and 1.9 mGy, ovaries.

111 ciated with strong gene expression levels in testes; and overrepresented on the X chromosome.

112 Here we identify the cancer/testes antigen melanoma antigen-A4 (MAGE-A4) as a tumour

113 al use encoding a TCR recognizing the cancer/testes antigen NY-ESO-1, coexpressing the PET/suicide ge

114 The fetal testes are essential for canonical androgen production,

115 About half of the fish showed immature testes around eleven weeks after fertilization.

116 tion of virions with developing sperm within testes as well as with mature sperm within epididymis.

117 roduce divergent gene expression profiles in testes, as measured with RNA sequencing.

118 In fetal testes at embryonic day 17.5, endogenous DNMT3L also enh

119 d the distribution of dose irradiated in the testes at the microscale level is of clinical importance

120 spermatogonia remains similar to normal rat testes, because spermatogonia fail to differentiate into

121 Spermatogenesis occurs in the testes, behind a protective barrier to ensure safeguardi

122 patients with CAIS who chose to retain their testes beyond age 16 years and who were imaged between J

123 Cancers of the lung, head and neck, testes, bladder, and Hodgkin lymphoma had the highest SM

124 was not seen, the demonstrated breach of the testes-blood barrier and targeting of spermatogenic prec

125 gen genes, whose expression is biased to the testes but is also activated in cancer.

126 ituitary and in Leydig and germ cells in the testes, but at very low levels in Sertoli cells.

127 d-type array of premeiotic germ cells in the testes, but in them harmful Stellate genes were derepres

128 using testicular cells isolated from rodent testes, but it remains unknown if PFOS has similar effec

129 Dmrt1 plays a similar role in postnatal testes, but the mechanism of adult testis maintenance re

130 an elevated level in larval males and adult testes, but they are not accessory gland proteins and th

131 e show that CnnT is expressed exclusively in testes by alternative splicing and localizes to giant mi

132 alphaT (Testes)-catenin, a critical factor regulating cell-cell

133 Here we show that alphaT (testes)-catenin, a protein unique to amniotes that is ex

134 mic homeostasis in SC-specific Upf2 knockout testes, characterized by an accumulation of PTC-containi

135 al form (CnnC) and a non-centrosomal form in testes (CnnT).

136 expression increased in hAd-PSC-transplanted testes compared to intact vehicle controls and the lutei

137 a higher level in lung tumor tissue and the testes compared with other nontumor tissues and identifi

138 der Se-compromised conditions, the brain and testes compete for Se utilization, with concomitant effe

139 The testes contribute sperm in addition to a diverse array o

140 We found that both male accessory glands and testes contribute to its formation.

141 In both rat and human fetal testes, DBP exposure induced similar germ cell effects,

142 (-/-) (Sertoli cell specific Nr5a1 knockout) testes demonstrated apoptosis as early as E15.

143 unidirectional replication fork movement in testes-derived chromatin and DNA fibers.

144 eptor Dax1 functions during development as a testes-determining gene.

145 in immune response, muscle differentiation, testes development and DNA damage, although little is kn

146 iency for CRB3 KD in the testis, the CRB3 KD testes displayed defects in spermatid and phagosome tran

147 in the formulation was preferred over salmon testes DNA as it had no effect on PCR amplification and

148 redominantly by testosterone secreted by the testes during the perinatal period.

149 In Drosophila testes, each Germline Stem Cell (GSC) contacts apical hu

150 mice to ZIKV results in severe damage to the testes, epididymis and sperm.

151 Analysis of Mov10l1(-/-) testes established that de novo methylation of the L1 tr

152 Brain regions and testes exhibited significant downregulation of Neanderth

153 an organotypic culture system of human fetal testes explants called FEtal Gonad Assay (FEGA) with tis

154 ction in immune privileged sites such as the testes, eye, and placenta.

155 ctuary sites for viral replication including testes, eyes, and brain.

156 However, spermatocytes from SCARKO testes failed to acquire competence for the meiotic divi

157 sperm and prevents viral persistence in the testes following challenge with a contemporary strain of

158 evealing a competition between the brain and testes for selenium utilization.

159 ex determining SRY, which activates Sox9 for testes formation.

160 Testosterone was not suppressed in testes from fetuses younger than 8 GW, older than 10-12

161 rison to adjacent AR-retaining Leydig cells, testes from littermate controls, and to human testes, in

162 In 14 testes from men aged 39-90 y, we identified 11 distinct

163 at increased levels of IFNbeta were found in testes from mice deficient in MOV10L1, a germ cell-speci

164 In testes from Mtdh exon 3-deficient mice, Rad18 foci were

165 protein Mili was expressed at high levels in testes from Mtdh knock-out mice.

166 ni in-depth we isolated complete ovaries and testes from paired and unpaired schistosomes for compara

167 del that segregates gonadal sex (ovaries and testes) from chromosomal sex (XX and XY), we showed that

168 zation is unique to the ovary because in the testes, gonadotropin receptors are expressed in separate

169 hat ARbeta, but not ARalpha, is required for testes growth and bright coloration, while ARalpha, but

170 ncy in male mice was accompanied by impaired testes growth, a characteristic feature of KS.

171 ease of the hypothalamus, pituitary gland or testes has been treated with testosterone replacement fo

172 While spermatogenesis is completed in the testes, here we demonstrate sperm centriole reduction oc

173 mining endocrine-associated gene expression, testes histology, secondary sexual characteristics, cour

174 s, neck mass, obstetric fistula, undescended testes, hypospadias, hydrocephalus, cleft lip or palate,

175 neck masses, obstetric fistulas, undescended testes, hypospadias, hydrocephalus, cleft lip/palate, an

176 dundant protein species were detected in the testes imaging dataset, 981 in the kidney dataset, and 2

177 of major germ and somatic cell types of the testes in human, macaque, and mice.

178 On the pathological examination, all left testes in the torsion group were recoverable after four

179 direct detection of these steroids in mouse testes, in both basal and maximally stimulated states, a

180 ers reproductive function in oocytes and the testes, in part caused by defects in central neuro-endoc

181 estes from littermate controls, and to human testes, including from patients with complete androgen i

182 sely packed seminiferous tubules in the left testes, indicating reversible damage in the torsion grou

183 ale-specific gene expression in Smad2-mutant testes, indicating that SMAD2 signaling promotes male di

184 represent a 7-fold (brain) and over 10-fold (testes, kidney) improvement on the numbers of proteins p

185 ct proteins in thin tissue sections from rat testes, kidney, and brain.

186 es with sequencing of RNA samples from mouse testes lacking Sox9.

187 distended oviducts or eggs for females, and testes length and sperm activity in males.

188 Diets that optimized testes mass and epididymal sperm counts (indicators of g

189 ve A. insignis invests in relatively greater testes mass and less in pronotal weapon length.

190 Here, we combine the largest vertebrate testes mass dataset ever collected with phylogenetic app

191 We detect explosive radiations of testes mass diversity distributed throughout the vertebr

192 first quantitative evidence for how relative testes mass has changed over time.

193 d evidence for a trade-off when investing in testes mass vs. horn length between the species.

194 ater investment in weapons at the expense of testes mass while the smaller, less-aggressive A. insign

195 Testes mass, an indicator of post-copulatory selection,

196 -resolution X-ray CT scanning data, relative testes mass, and male-male agonistic behaviour between t

197 e heavily in weapon length at the expense of testes mass.

198 e been repeated rapid reductions in relative testes mass.

199 We evaluated fetal testes, maternal and fetal livers, maternal serum clinic

200 ctory receptor function and are expressed in testes more often than expected, consistent with reduced

201 e infertility, as well as abnormal sperm and testes morphology.

202 In adult mouse testes, most piRNAs are derived from long single-strande

203 germ cells are sensitive to heat stress and testes must be maintained outside the body for optimal f

204 chemical manipulations of RA levels in mouse testes now reveal that RA also regulates the two postmei

205 MATERIAL/METHODS: The study included 100 testes of 50 patients with a unilateral testicular disea

206 lly, PAX7+ spermatogonia were present in the testes of a diverse set of mammals.

207 activities are significantly reduced in the testes of ACBP(-/-) mice, concomitant with a significant

208 ression vector pCI-neo was used to transfect testes of adjudin-treated ratsversusempty vector.

209 lower expression of BRD7 was detected in the testes of azoospermia patients exhibiting spermatogenesi

210 ith T-treated PM cells were able to colonize testes of germ cell-depleted mice after transplantation.

211 CL (TPCL), a fully saturated species, in the testes of humans and mice.

212 The testes of Ifnar1(-/-) mice had the highest viral loads,

213 ng the observation of low CHD5 expression in testes of infertile men.

214 target vasa of Drosophila mauritiana in the testes of interspecies hybrids.

215 in spermatogenesis were downregulated in the testes of knock-out mice, as well as Hsd17b3, which enco

216 ues clearance of apoptotic germ cells in the testes of Mertk (-/-) mice it fails to enhance RPE phago

217 nstrated altered expression of piRNAs in the testes of Mtdh knock-out mice as compared with wild type

218 In contrast, testes of patients who had azoospermia with TEX11 mutati

219 more, evaluation of molecular markers in the testes of patients with nonobstructive azoospermia (NOA)

220 s of meiosis to generate round spermatids in testes of rats treated with an acute dose of adjudin tha

221 read overexpression of X-linked genes in the testes of sterile but not fertile F1 males.

222 em cells (SSCs) a selective advantage in the testes of the father, but have a deleterious effect in o

223 ZIKV was present in the testes of two of three males euthanized at 10 or 11 dpi,

224 analyze a novel 57,600 cell dataset from the testes of wild-type mice and mice with gonadal defects d

225 ogaster development, enriched in neurons and testes, often localized within heterochromatic regions,

226 gonadotropic and sex steroid hormones, small testes or ovaries, impaired spermatogenesis, and lack of

227 e individuals with a 46,XX karyotype develop testes or ovotestes (testicular or ovotesticular disorde

228 ation of MRT techniques and a unique ex vivo testes organ culture, we show, for the first time, the M

229 Neonatal testes (P1) were collected for the detection of PFOS, an

230 In developing and adult testes, p53R172H was expressed in gonocytes, type A, Int

231 P-element-induced wimpy testes (Piwi) proteins are known for suppressing retrotr

232 ity to control ZIKV infection in the brains, testes, placentas, and fetuses of mice.

233 Mael129-null mutant testes possess low levels of piRNAs derived from MAEL-as

234 levels, resembling conserved piRNAs in mouse testes [primarily LINE1 (long interspersed nuclear eleme

235 Larger testes produce more sperm and therefore improve reproduc

236 pithelium of the seminiferous tubules of the testes, producing millions of spermatozoa per day in an

237 pression of X-linked genes in the Drosophila testes reflects a balance between chromosome-wide epigen

238 ction have shorter mating seasons and larger testes relative to body size.

239 1(-/-) and noncleavable TFIIAalpha-betanc/nc testes release immature germ cells with impaired transcr

240 opulations are splicing-derived mirtrons and testes-restricted, recently evolved, clustered (TRC) can

241 and expression analysis in the Yhtdc2 mutant testes reveal an upregulation of m(6)A-enriched transcri

242 Aseq analysis of wild-type and SCARKO mutant testes revealed a molecular transcriptomic block in an e

243 alysis of wild-type (WT) and Taf7l(-/Y) (KO) testes revealed that Taf7l ablation impairs the expressi

244 Importantly, histological analysis of testes revealed that Taf7l(-/Y) mice develop postmeiotic

245 ibition of p38 signaling in the Smad2-mutant testes severely impeded XY PGC differentiation and induc

246 Brain and testes showed the highest tissue-specific expression of

247 re likely to have driven changes in relative testes size in opposing directions.

248 eg length, parasite burden, horn length, and testes size, but not for horn growth or our measure of a

249 In foetal testes, SOX9 modulates both transcription and directly o

250 erous tubule epithelia, dilation of the rete testes, sperm agglutinations in the efferent ducts and l

251 centrations were not increased in the liver, testes, spleen, or serum of these mice, and the Cyp26a1

252 The binding of enantiomers with salmon testes (st)-DNA and synthetic polynucleotides are studie

253 HSPBP1 deficiency in testes strongly reduces the expression of the inducible,

254 Immunofluorescence of testes suggested the presence of ZIKV in sperm progenito

255 ngle-male groups have large hyoids and small testes, suggesting high levels of vocally mediated compe

256 Genes that are more highly expressed in testes than in any other tissue are especially reduced i

257 Higher Spiroplasma density in testes than in ovaries was also detected by fluorescent

258 me X and near genes more highly expressed in testes than other tissues (p = 1.2 x 10(-7) to 3.2 x 10(

259 d insects, Spiroplasma density was higher in testes than ovaries, and was significantly higher densit

260 ancy induces focal dysgenetic areas in fetal testes that appear between e19.5-e21.5, manifesting as f

261 2 gene generated by CRISPR-Cas9 editing have testes that are germline ablated but otherwise structura

262 BD18 is a pachytene nuclear protein in mouse testes that occupies a subset of pachytene piRNA-produci

263 zinc-finger protein, primarily expressed in testes, that is required for normal meiotic division and

264 In mouse fetal testes, the majority of germ cell apoptosis coincides wi

265 ough both receptors are expressed within the testes, the potential effect of BAs on testis physiology

266 the presence of SOX9 on chromatin in foetal testes, therefore equating this signature to a genomic b

267 brain, and similar to the role of piRNAs in testes, they may be involved in the silencing of retrotr

268 In wild-type testes, this sex chromosome-wide transcriptional suppres

269 EBOV dissemination into the eyes, brain and testes through vascular structures, similar to observati

270 gement of ectoplasmic specialization (ES) in testes, thus impairing spermiogenesis and spermiation.

271 irradiated germ stem cells in the irradiated testes tissue would be needed for the effective TSE for

272 we subjected Sertoli cells from mouse fetal testes to DNaseI-seq and ChIP-seq for H3K27ac.

273 and stability to transport sperm cells from testes to the eggs.

274 mRNA profiling of Dmrt6 mutant testes together with DMRT6 chromatin immunoprecipitation

275 tion of a BTB-impermeable component into the testes under in vivo conditions.

276 MGB4), a protein preferentially expressed in testes, uniquely blocks excision repair of cisplatin-DNA

277 male and female reproductive organs (penis, testes, uterus, ovaries).

278 as the number of males per group increases, testes volume also increases, indicating higher levels o

279 Both plasma testosterone levels and testes volume were independently inversely correlated wi

280 (ulna length, asymmetry, weight-at-weaning, testes volume, reproductive success and survival).

281 malian sperm development and is expressed in testes, we posed the hypothesis that NlSPATA5 occurs in

282 ced apoptosis in seminiferous tubules of C/C testes, we recorded a drastic increase in cells with DNA

283 ion to finding AgOr transcript expression in testes, we show that the OR coreceptor, AgOrco, is local

284 MECP2 mutations in various tissues including testes were miscarried during midgestation, consistent w

285 On physical examination, both testes were present in the scrotum, with normal dimensio

286 TE) and 15-HETE from arachidonic acid in the testes were significantly elevated and a linear increasi

287 renic acid and docosahexaenoic acid (DHA) in testes were significantly reduced in the PFOS treatment

288 In the majority of hybrid flies, the testes were strongly reduced in size and germline conten

289 After CDU, testes were surgically removed and a pathological examin

290 Fifty normal contralateral testes were used as a control group.

291 Dissociated fetal rat testes were xenotransplanted subcutaneously into recipie

292 ostenone is a boar pheromone produced in the testes, whereas skatole and indole originate from the mi

293 y-stage somatic gonadal cells in E(z) mutant testes, which originate from both overproliferative cyst

294 ts at each recognizable stage from wild-type testes, which were subsequently applied for RNA-seq anal

295 hormone INSL3 during culture of 8-9 GW fetal testes with concomitant reduction in expression of the s

296 Improving drug entry into the testes with drugs that use endogenous transport pathways

297 omatin regions from murine and bovine foetal testes with sequencing of RNA samples from mouse testes

298 ines) resulted in male infertility, atrophic testes with vacuolation, azoospermia, and spermatogenesi

299 ancers of the bladder, kidney, prostate, and testes, with common molecular features spanning differen

300 nal modifications and gene expression in the testes, with the most prominent changes occurring at gen