ライフサイエンスコーパス: testicular

1 noncoding RNAs, modulates risk for TGCTs and testicular abnormalities in both parent-of-origin and co

2 fathead minnow had returned to baseline, and testicular abnormalities were absent.

3 ences, laterality of tumors and incidence of testicular abnormalities, are useful for identification

4 In this study, we identified ACPT (testicular acid phosphatase) biallelic mutations causing

5 ct is highly suggestive for the diagnosis of testicular adrenal rest tissues on ultrasonography.

6 magnetic resonance (MR) imaging features of testicular adrenal rest tumors (TART) in patients with c

7 bilateral testicular masses, a diagnosis of testicular adrenal rest tumour was made; biopsy was defe

8 Testicular adrenal rest tumours (TARTs) are benign testi

9 Prompt diagnosis of testicular adrenal rest tumours is essential, as it only

10 patient was discovered to harbour bilateral testicular adrenal rests as well.

11 niche) to direct non-mammary cells including testicular and embryonic stem cells (ESCs) to adopt a ma

12 nscriptome sequencing of precursor, primary (testicular and mediastinal) and chemoresistant metastati

13 zing hormone (LH) and testosterone levels or testicular and semen volume.

14 testis descent, INSL3 has been implicated in testicular and sperm function in adult males via interac

15 (breast, prostate, ovarian, endometrial, and testicular) and to investigate whether dietary fiber int

16 sue and several cancers, including prostate, testicular, and ovarian.

17 As a consequence, the depletion of testicular androgens in patients with prostate cancer re

18 nut supplemented diet significantly improves testicular antioxidant function and semen quality in old

19 id of endogenous germline but possess normal testicular architecture and somatic cell function capabl

20 mbryonic Sertoli cells (SCs) leads to severe testicular atrophy and male sterility owing to rapid dep

21 However, PRL1(-/-)/PRL2(+/-) male mice show testicular atrophy phenotype similar to PRL2(-/-) mice.

22 At post-natal day 200, random appearance of testicular atrophy was noted in exposed offspring, and l

23 display signs of premature aging, including testicular atrophy, reduced LC and Sertoli cell (SC) num

24 ands attributed to androgen effects, such as testicular atrophy, seminiferous tubule diameter reducti

25 fluence this phenotype, the role of PPARD in testicular biology was examined.

26 For prepubertal boys, testicular biopsy cryopreservation is offered in some ce

27 s; the most frequently reported cancers were testicular, breast, and lymphoma.

28 5-C associated with increased pancreatic and testicular but decreased lung cancer and melanoma risk,

29 Rs were highest for multiple myeloma (30.5), testicular cancer (17.0), and kidney cancer (12.5); for

30 ardiovascular disease (CVD) in patients with testicular cancer (TC) given chemotherapy in European st

31 etachronous contralateral (second) germ cell testicular cancer (TC).

32 wo), nasopharyngeal (one), thyroid (one) and testicular cancer (two).

33 The international Testicular Cancer Consortium (TECAC) combined five publi

34 of 5190 men with GCC who entered the Danish Testicular Cancer database between January 1, 1984, and

35 From the Danish Testicular Cancer database, we identified all patients w

36 Clinical data were extracted from the Danish Testicular Cancer database.

37 we show that fine-mapping of pancreatic and testicular cancer GWAS within one of these loci (Region

38 cisplatin-induced ototoxic effects in adult testicular cancer patients.

39 rmation on adverse health outcomes (AHOs) in testicular cancer survivors (TCSs) after four cycles of

40 s are an important complication that affects testicular cancer survivors as a consequence of treatmen

41 carcinoma, men undergoing surveillance after testicular cancer treatment, parents of patients treated

42 inumab and no deaths and one case of cancer (testicular cancer) among 319 patients who received place

43 .6% aged 25-37 years, 57.4% 38-50 years, 88% testicular cancer, 10% lymphoma, matched for body mass i

44 al cancer, 20.2% (18.9-21.5) in survivors of testicular cancer, 26.6% (24.7-28.6) in female survivors

45 cal cancer, 18.9 (16.6-21.1) in survivors of testicular cancer, 55.7 (50.4-61.1) in female survivors

46 long-term survivors of cervical, breast, and testicular cancer, and Hodgkin lymphoma provides an evid

47 survivors of breast cancer, cervical cancer, testicular cancer, and Hodgkin lymphoma.

48 17 years or older, diagnosed with germ cell testicular cancer, and previously treated with cisplatin

49 2 Diabetes, Breast Cancer, Prostate Cancer, Testicular Cancer, Gallstones, Glaucoma, Gout, Atrial Fi

50 30 years from diagnosis of cervical cancer, testicular cancer, Hodgkin lymphoma in women, breast can

51 Children and adolescents with testicular cancer, leukaemia, and Ewing sarcomas are at

52 Male survivors of testicular cancer, lymphoma, and leukaemia aged 25-50 ye

53 resence of cardiovascular disease, diabetes, testicular cancer, or prostate cancer.

54 ug reaction in adult patients with germ cell testicular cancer.

55 from 1.1% for pancreatic cancer to 98.2% for testicular cancer.

56 esophageal, laryngeal, Hodgkin lymphoma, and testicular cancer.

57 er; 487518 due to liver cancer; 13927 due to testicular cancer; and 829396 due to non-Hodgkin lymphom

58 ection, ranging from <1/tumor in thyroid and testicular cancers to >10/tumor in endometrial and color

59 genetic impairment of NER, such as skin and testicular cancers.

60 t left inguinal orchiectomy, which disclosed testicular carcinoma composed of 90% choriocarcinoma, 9%

61 ies to assess interactions of SCs with other testicular cells and to test the ability of anti-ZIKV dr

62 Testicular cells exhibit similar molecular responses to

63 alyzed single-cell transcriptomes of ~10,000 testicular cells from four boys spanning puberty and com

64 PFOS induces Sertoli cell injury using testicular cells isolated from rodent testes, but it rem

65 Testicular cells produce several biologically active pep

66 d from omental fat and lung did not redirect testicular cells to a MEC fate, indicating the necessity

67 studies to explore the interactions of other testicular cells with Sertoli cells and to test novel an

68 can be engrafted from fresh or cryopreserved testicular cells, leading to complete spermatogenesis fr

69 rasite burden, horn length, horn growth, and testicular circumference.

70 r that, magnetic resonance imaging (MRI) and testicular color Doppler ultrasound (CDU) were performed

71 Testicular concentrations of DEHP and PCB153 perturbed s

72 yndromes including Crouzon and Pfeiffer, but testicular defects were not reported.

73 e loss of ClC-2 function lead to retinal and testicular degeneration and leukodystrophy, whereas gain

74 on of ClC-2 in mice to show that retinal and testicular degeneration depend on a loss of ClC-2 in ret

75 Atrophic testes and testicular degeneration were observed in Ppard(-/-) mice

76 to either LCs or SCs were protected against testicular degeneration, demonstrating that age-related

77 lt mice and rats were sufficient to redirect testicular derived cells to produce normal mammary epith

78 are sufficient to direct differentiation of testicular-derived cells and ESCs to form functional mam

79 ing activational roles for ovarian-, but not testicular-, derived hormones in mediating hedonic sensi

80 to heat stress, and therefore, mammals with testicular descent may be at a greater risk in the event

81 This process revealed that testicular development and spermatogenesis, preputial se

82 cific germline ablation but other aspects of testicular development are normal.

83 srupting chemicals during critical phases of testicular development may be related to poorer semen pa

84 is both necessary and sufficient to initiate testicular development, thereby acting as an upstream re

85 d not compensate for low levels during early testicular development.

86 f both SCs and germ cells during prepubertal testicular development.

87 f RSPO1/Rspo1 in XX humans and mice leads to testicular differentiation and female-to-male sex revers

88 In mammals, testicular differentiation is initiated by transcription

89 100 testes of 50 patients with a unilateral testicular disease.

90 her men with similar neurologic features and testicular disease.

91 Among 46,XX individuals with testicular DSD (TDSD) or ovotesticular DSD (OTDSD), test

92 osure on neonatal testes and its relation to testicular dysfunction in adult offspring.

93 ogenic mRNAs, appropriately modeling primary testicular dysfunction observed in aging men.

94 /or to decreased testosterone resulting from testicular dysfunction.

95 findings provide the first evidence for how testicular dysgenesis can result after normal testis dif

96 ral gray matter atrophy), visual impairment, testicular dysgenesis in males and sudden death at infan

97 DBP, a plasticising chemical known to induce testicular dysgenesis in vivo in rats).

98 Focal dysgenesis is a consistent feature of testicular dysgenesis syndrome (TDS) in humans.

99 stosterone, and is used as a model for human testicular dysgenesis syndrome (TDS).

100 Features of focal testicular dysgenesis were present in re-aggregated test

101 found to have a 46,XY karyotype with partial testicular dysgenesis.

102 s to identify features consistent with focal testicular dysgenesis.

103 tivities is carried out leading to sustained testicular endocrine function, with gonadal testosterone

104 t species because it occurs within a complex testicular environment characterized by the intimate ass

105 A testicular examination was normal.

106 Here we used an ex vivo testicular explant model and in vivo exposure to determi

107 ppress testosterone synthesis in human fetal testicular explants to an extent greater than that seen

108 low protein diet modified F1 male offspring testicular expression of central epigenetic regulators.

109 L mice had a molecular phenotype with higher testicular expression of Slc34a2 and Trpv5 than wild-typ

110 s; and, in a significant proportion of mice, testicular failure and atrophy with tubule lithiasis, po

111 ble just two decades ago, azoospermia due to testicular failure, including 47,XXY (Klinefelter syndro

112 Sertoli cells (SCs) regulate testicular fate in the differentiating gonad and are the

113 ther sedentary lifestyle was associated with testicular function (semen quality and reproductive horm

114 e administration altered fetal pituitary and testicular function in ovine male fetuses.

115 Testicular function is often impaired even years after t

116 To investigate the involvement of PLAG1 in testicular function, we determined (i) the spatial distr

117 uld be specifically disruptive of ovarian or testicular function, while leaving extragonadal function

118 heir distinct roles in organ homeostasis and testicular function.

119 gulate vitamin D and mineral homeostasis, on testicular function.

120 6 functions in mouse testis determination or testicular function.

121 tion of PFOS on lipid mediators in affecting testicular functions.

122 that PFOS has potential negative impacts on testicular functions.

123 e absence of detectable changes in the intra-testicular GC transcriptome.

124 not find significant changes in the F0 intra-testicular GC transcriptome.

125 om precursor to primary disease, and primary testicular GCTs (TGCTs) are uniformly wild type for TP53

126 ic study, serum samples of 616 patients with testicular GCTs and 258 male controls were examined for

127 NA profiling found that DMRT1 activates many testicular genes and downregulates ovarian genes and sin

128 ides a rich resource for those investigating testicular germ and somatic cell developmental during th

129 tance: Patients given systemic treatment for testicular germ cell cancer (GCC) are at increased risk

130 ence of teratoma in patients with metastatic testicular germ cell tumor (GCT) is of unknown prognosti

131 rognosticate survival outcomes in metastatic testicular germ cell tumor (MT-GCT), but how the initial

132 Patients with testicular germ cell tumor (TGCT) are at increased risk

133 Genome-wide association (GWA) studies of testicular germ cell tumor (TGCT) have identified 18 sus

134 Unconventional inheritance for testicular germ cell tumor (TGCT) risk both in humans an

135 reported 19 distinct susceptibility loci for testicular germ cell tumor (TGCT).

136 published genome-wide association studies of testicular germ cell tumor (TGCT; 3,558 cases and 13,970

137 and specificity than the classic markers of testicular germ cell tumors (GCTs) and are applicable to

138 Testicular germ cell tumors (TGCT) are the most frequent

139 lity is a risk factor for the development of testicular germ cell tumors (TGCT), but the initiating e

140 ed regulatory networks in two major types of testicular germ cell tumors (TGCT): seminoma (SE) and no

141 Testicular germ cell tumors (TGCTs) are classified into

142 discusses several important developments in testicular germ cell tumors (TGCTs) over the past year.

143 Testicular germ cell tumors (TGCTs) share germline ances

144 ansformed understanding of susceptibility to testicular germ cell tumors (TGCTs), but much of the her

145 ly used anticancer drug for the treatment of testicular germ cell tumors (TGCTs).

146 Testicular germ cell tumour (TGCT) is the most common ca

147 A sizable fraction of testicular germ cell tumour (TGCT) risk is expected to b

148 GWAS) have identified multiple risk loci for testicular germ cell tumour (TGCT), revealing a polygeni

149 ng for >15% of the genetic susceptibility to testicular germ cell tumour (TGCT).

150 Testicular germ cell tumours (TGCTs) are the most common

151 While most testicular germ cell tumours (TGCTs) exhibit exquisite s

152 also summarise the consensus on how to treat testicular germ cell tumours and focus on a few controve

153 Testicular germ cell tumours are at the crossroads of de

154 Testicular germ cell tumours are highly sensitive to rad

155 f the epidemiology, genetics, and biology of testicular germ cell tumours.

156 aternal low-protein diet elevates ROS in the testicular germ cells, altering ATF7 activity and H3K9me

157 sues but was the most abundant CL species in testicular germ cells.

158 Post-pubertal testicular germ-cell tumours (TGCTs) can present with a

159 We demonstrate that a testicular germ-cell-secreted epidermal growth factor-li

160 Testicular global DNA methylation increased, while ovari

161 intrachromosomal inversion involving the pro-testicular growth factor gene FGF9, which is heterochron

162 Gonadotropin Regulated Testicular Helicase (GRTH/DDX25), expressed in the male

163 These alterations of testicular histology and gene expression patterns were s

164 sequences of PLAG1 deficiency by determining testicular histology, daily sperm production and sperm m

165 er 16 types of AYA cancer: breast; cervical; testicular; Hodgkin lymphoma (female); Hodgkin lymphoma

166 ssing cells results in a transient impact on testicular homeostasis, with this population behaving st

167 This phenotype appears to be suppressed by testicular hormones in male Prkca(-/-) mice.

168 difference is at least partly maintained by testicular hormones.

169 gene editing to knockout the HMGB4 gene in a testicular human embryonic carcinoma and examined cellul

170 ive oligosaccharides were obtained by bovine testicular hyaluronidase digestion.

171 in cell culture conditions, using zebrafish testicular hyperplasia cells that accumulate early stage

172 ss and varicocele-related infertility due to testicular hyperthermia, which can result in low sperm f

173 rm trial, patients with IR MGCT (stage II-IV testicular, II-III ovarian, I-II extragonadal, or stage

174 s (TM) play an important role in maintaining testicular immune privilege and display reduced proinfla

175 Our results suggest that TM maintain testicular immune privilege by inhibiting NF-kappaB sign

176 dentify SCs as a therapeutic target to clear testicular infections.

177 e equivalent dose of 20 g/m(2) or greater or testicular irradiation with 20 Gy or greater.

178 reast; cervical; uterine; ovarian; prostate; testicular; kidney; bladder; brain and nervous system; t

179 normal testicular tissues as well as benign testicular lesions (P=0.000).

180 t difference between ADC values of malignant testicular lesions and normal testicular tissues as well

181 From January 2012 to December 2015, 55 focal testicular lesions that were indeterminate on gray-scale

182 Results Of 55 testicular lesions, 43 (78.2%) were benign and 12 (21.8%

183 n differentiating benign and malignant focal testicular lesions.

184 nosis and individualized management of small testicular lesions.

185 Testicular Leydig cells (LCs) are the primary source of

186 axin/insulin superfamily and is expressed in testicular Leydig cells.

187 us system (CNS) lymphoma (PCNSL) and primary testicular lymphoma (PTL) are rare extranodal large B-ce

188 ervous system lymphomas (PCNSLs) and primary testicular lymphomas (PTLs) are extranodal large B-cell

189 Testicular macrophages (TM) play an important role in ma

190 Testicular macrophages (tMphi) are the principal immune

191 with X-linked ichthyosis, corneal opacities, testicular maldescent, cardiac arrhythmia, and higher ra

192 on of gonads, significant down-regulation of testicular markers Amh and Sox9, and remarkable up-regul

193 previously healthy man presented with a left testicular mass, confirmed on ultrasound.

194 .A healthy 27-year-old man discovered a left testicular mass.

195 ular adrenal rest tumours (TARTs) are benign testicular masses that are found in inadequately treated

196 typical sonographic appearance of bilateral testicular masses, a diagnosis of testicular adrenal res

197 that the impacts of persistent pollutants on testicular maturation and function require further inves

198 separate intrinsic LC aging from that of the testicular microenvironment in vivo has made this questi

199 A Young testicular microenvironment protects Leydig cells agains

200 is largely driven by aging of the supporting testicular microenvironment.

201 lusion There is a strong association between testicular microlithiasis and primary testicular neoplas

202 y define the strength of association between testicular microlithiasis and testicular neoplasia in a

203 Testicular microlithiasis was present in 4 of 9 patients

204 Testicular microvessels and blood flow are known to cont

205 Hence HTPCs via control of testicular microvessels may contribute to the regulation

206 23 and Klotho influence gonadal function and testicular mineral ion homeostasis both directly and ind

207 Cul4bled to male infertility, despite normal testicular morphology and comparable numbers of spermato

208 iation between testicular microlithiasis and testicular neoplasia in a large geographically diverse p

209 etween testicular microlithiasis and primary testicular neoplasia in this pediatric population.

210 ive and developmental stages to populate the testicular niche prior to productive spermatogenesis.

211 rs) were calculated for 15,006 patients with testicular nonseminoma reported to the population-based

212 gh prevalence of TP53 mutations not found in testicular nonseminomas.

213 Active surveillance (AS) for testicular nonseminomatous germ cell tumors (NSGCT) is w

214 46,XX karyotype develop testes or ovotestes (testicular or ovotesticular disorder of sex development;

215 gely used as an anti-cancerous agent against testicular, ovarian, small cell lung, colon and breast c

216 tation causing isolated, non-syndromic 46,XX testicular/ovotesticular DSD in humans.

217 ascularity was observed in the heterogeneous testicular parenchyma.

218 Although gross testicular pathology was not seen, the demonstrated brea

219 Our proteomic study using cultured human testicular peritubular cells (HTPCs) i.e. the cells, whi

220 Thus testicular peritubular cells, via PEDF, may prevent vasc

221 ence of modifier genes which exacerbated the testicular phenotype.

222 rmates, which suggests a regulatory role for testicular phosphate and calcium homeostasis.

223 rences in temperature-sensitive expressions, testicular physiology, spermatogenesis, as well as its r

224 al carcinoma and rete testis invasion in the testicular primary identified a group with a relapse ris

225 d an age of 26 years or older at assessment, testicular radiotherapy at any dose, and alkylating agen

226 sk increased with older age, higher doses of testicular radiotherapy, and cyclophosphamide equivalent

227 Older age, testicular radiotherapy, and exposure to alkylating agen

228 ermatogonia that are essential for efficient testicular regeneration after injury.

229 blation of Sox8 and Sox9 prevents ovarian-to-testicular reprogramming observed in XX Rspo1 loss-of-fu

230 We find that DMRT1 blocks testicular retinoic acid (RA) signaling from activating

231 Knowledge of the regulation of testicular retinoic acid synthesis is crucial for unders

232 Gonadotropin-regulated testicular RNA helicase (GRTH/DDX25) is a testis specifi

233 a complex delayed diagnosed example case of testicular rupture clinically mimicing epididymo-orchiti

234 Early diagnosis of testicular rupture may lead to the salvaging of the test

235 Testicular rupture may occur even after moderate sportiv

236 blunt trauma may result in injuries, such as testicular rupture, dislocation, torsion, hematoma, sper

237 time, leptin as a key factor able to affect testicular seminoma behavior, highlighting leptin recept

238 s receptor was significantly higher in human testicular seminoma compared with normal adult testis.

239 arkers, their potential involvement in human testicular seminoma growth and progression remains unexp

240 s into either ovarian pre-granulosa cells or testicular Sertoli cells.

241 velopment of ProSG, their SG descendants and testicular somatic cells during the perinatal period in

242 cases when combining surgical harvesting of testicular sperm and ICSI.

243 Post-testicular sperm maturation, in which sperm centrioles f

244 In testicular sperm, tRNA fragments are scarce but increase

245 Following testicular spermatogenesis, mammalian sperm continue to

246 iarrheic pig from Ohio was isolated in swine testicular (ST) and LLC porcine kidney (LLC-PK) cell cul

247 F3 DEHP males exhibited decreased fertility, testicular steroidogenic capacity, and spermatogenesis t

248 suppress gonadotropins, thereby blocking the testicular T production needed for spermatogenesis, whil

249 Testicular teratocarcinoma cells rarely contain mutation

250 t new therapeutic possibilities of targeting testicular teratocarcinoma.

251 s, whereas male genital development required testicular testosterone plus dihydrotestosterone (DHT) m

252 ravity on Earth disrupts spermatogenesis and testicular testosterone synthesis in rodents, whereas th

253 Cryopreservation of testicular tissue allows storage of early sperm precurso

254 orage aimed at subsequent transplantation of testicular tissue and associated stem cells.

255 loped a protocol to cryopreserve rainbowfish testicular tissue and recover an enriched population of

256 Testicular tissue cryopreservation is an experimental me

257 lts are obtained in noncastrated recipients, testicular tissue grafting may be applied in the clinic.

258 occurs in parallel with the degeneration of testicular tissue in the ovotestis and enhanced ovarian

259 lar DSD (TDSD) or ovotesticular DSD (OTDSD), testicular tissue is present in the gonad.

260 All lesions appeared hypointense compared to testicular tissue on T1W and T2W magnetic resonance imag

261 their female equivalents-granulosa cells-and testicular tissue reorganizes to a more ovarian morpholo

262 Only 12% of the genetic males showed testicular tissue six months after fertilization.

263 Expression of TTBKs is enriched in testicular tissue, but their relevance to reproductive p

264 ion of apoptosis-related genes (P < 0.05) in testicular tissue.

265 s of malignant testicular lesions and normal testicular tissues as well as benign testicular lesions

266 of principle that cryopreserved prepubertal testicular tissues can be autologously grafted under the

267 compared to average risk, ranges from 12 for testicular to 2.5 for ovarian cancer.

268 GWAS heritability vary from 60,000 cases for testicular to over 1,000,000 cases for lung cancer.

269 Extravaginal testicular torsion (ETT), also called prenatal or perina

270 Testicular torsion may concern boys even in the perinata

271 Testicular torsion must be taken into consideration in d

272 A testicular torsion was suspected, so the baby underwent

273 auxiliary method in the diagnosis of partial testicular torsion.

274 ul tool in the early diagnosis of incomplete testicular torsion.

275 ficient (ADC) in the diagnosis of incomplete testicular torsion.

276 ticle affected and 2 patients with bilateral testicular torsion.

277 chitis and radiologically mimicing traumatic testicular torsion.

278 ency surgical treatment, required in case of testicular torsion.

279 ates include hydrocoele, inguinal hernia and testicular torsion; less common is epididymo-orchitis.

280 Studies also suggest that BPA may be a testicular toxicant in animal models, but the data in hu

281 Indeed, testicular transcriptome analysis found that a number of

282 ersity between 1990 and 2016 and had primary testicular tumor specimen from orchiectomy (ORCH) were i

283 GSG does not translate to higher efficacy of testicular tumorigenesis arising from mutant p53 cells,

284 reprogramming in both normal development and testicular tumorigenesis.

285 ata bases were searched for pathology-proven testicular tumors (benign or malignant germ cell or stro

286 test was used to analyze the association of testicular tumors and TM.

287 Benign testicular tumors are frequent incidental findings.

288 ions or microlithiasis and all patients with testicular tumors from pathology database were identifie

289 Testicular tumors, the most common cancer in young men,

290 lurality of suicides is from hematologic and testicular tumors; if > 50, from prostate, lung, and col

291 p53 is a common finding in most cancers but testicular tumours accumulate wild-type p53 (wtp53).

292 accompanied by increased G-CSF signaling and testicular vacuolation associated with decreased fertili

293 Normal testicular vessels coursing through the lesions undistur

294 Doppler ultrasound showed normal testicular vessels passing through the mass which were u

295 th, Tanner stage 5 for pubic hair growth, or testicular volume (TV) >/= 20 mL in either testis.

296 al staging [genitalia (G), pubarche (P), and testicular volume (TV)].

297 d to assess reproductive endocrine function, testicular volume, semen quality, and fertility in adult

298 Treatment with FGF23 increased testicular weight in wild-type mice, while mice with glo

299 lobal loss of either FGF23 or Klotho had low testicular weight, reduced sperm count, and sperm motili

300 ls and to test novel antivirals for clearing testicular ZIKV infection.