ライフサイエンスコーパス: testis

1 issues), or in only one tissue (for example, testis).

2 r-containing tissues, such as intestines and testis.

3 TEX15 is associated with MILI in testis.

4 germline stem cells (GSCs) in the Drosophila testis.

5 and are frequently targeted by small RNAs in testis.

6 tem cell (GSC) maintenance in the Drosophila testis.

7 hat there is little de novo synthesis in the testis.

8 sticular seminoma compared with normal adult testis.

9 ngle-cell RNA-sequencing of adult Drosophila testis.

10 s of the total amount of ATRA present in the testis.

11 ction of mature piwi-interacting RNAs in the testis.

12 document the expression of p53R172H in mouse testis.

13 pes that support ZIKV infection in the human testis.

14 the principal immune cells of the mammalian testis.

15 in the ovary but remains absent in the fetal testis.

16 ion in the ovary, and wild-type dmrt1 in the testis.

17 tion along the length of Sertoli cell in the testis.

18 ic cyst stem cells (CySCs) in the Drosophila testis.

19 ng a long-term effect on Leydig cells of the testis.

20 two species yet is similarly abundant in the testis.

21 lood-tissue barriers in the eyes, brain, and testis.

22 es with previously known activities in adult testis.

23 the adult Drosophila ovary as well as in the testis.

24 es, whereas MTP-C was prominent in brain and testis.

25 OX9/8 maintain Dmrt1 expression in the adult testis.

26 germline stem cells (GSCs) in the Drosophila testis.

27 driving basal testosterone production in the testis.

28 ce across the seminiferous epithelium in the testis.

29 stem/progenitor cell population in postnatal testis.

30 alog, CTCFL, is normally only present in the testis.

31 d TE repression in germ cells of human fetal testis.

32 volution and is most highly expressed in the testis.

33 es were subjected to mild heat stress of the testis (43 degrees C for 25 min), germ cells with inacti

34 At the apical tip of the Drosophila testis, 8 to 10 germline stem cells (GSCs) surround the

35 cerebellum, heart, kidney, liver, ovary and testis) across developmental time points from early orga

36 dentified human TCRs specific for the cancer testis Ag NY-ESO-1(157-165)-HLA-A2.

37 uman pseudoautosomal regions and from cancer-testis ampliconic gene families (CT-X and GAGE).

38 6), which exhibits expression exclusively in testis and a broad range of human cancers.

39 inary tract anomalies, bilateral undescended testis and absence of anterior abdominal wall muscles.

40 ct endocrine disturbances in the human fetal testis and alteration of the germ cell biology.

41 In testis and brain, Stra6 expression was regulated by vita

42 mester human embryonic and fetal ovaries and testis and confirmed by qPCR and immunohistochemistry (I

43 ed that ZIKV virus can infect and damage the testis and epididymis, and these results has been correl

44 inal wall deficiency, unilateral undescended testis and female neonates with abdominal wall laxity ar

45 in adult tissues revealed expression in the testis and intestine but little or none in the brain and

46 6M mice exhibited differentiation defects in testis and intestine.

47 tumor-exclusive presentation of known cancer/testis and leukemia-associated antigens.

48 However, cellular targets of ZIKV in human testis and mechanisms by which the virus enters seminife

49 ttern and is localized almost exclusively in testis and more specifically in postmeiotic spermatids a

50 e reproductive organs showed atrophy of both testis and ovary.

51 orrelated with the PTEN protein level in the testis and PRL1(+/-)/PRL2(-/-) mice have the highest lev

52 ex that is highly expressed in the ovary and testis and required for mouse fertility.

53 sly identified ubiquitin ligase Huwe1 in the testis and showed that it can ubiquitinate histones.

54 ings will affect target antigen selection in testis and sperm autoimmunity and the immune responses t

55 (PP2B), a calcium regulated phosphatase, in testis and sperm, are also infertile.

56 rculating testosterone is synthesized by the testis and the final step in this canonical pathway is c

57 nesis and oogenesis, which take place in the testis and the ovary, respectively.

58 aintaining the homeostasis of BTB in the rat testis and the phenotypes of Sertoli cell-conditional Cx

59 a single systemic tamoxifen injection on the testis and the wider endocrine system.

60 , but not of perivascular cells in pancreas, testis and thyroid gland, with age in mice and humans.

61 ion induction, caused adverse effects to the testis and to the reproductive endocrine system that per

62 ghly expressed in proliferative tissues like testis and transformed cells, but scarcely in differenti

63 n, esophagus, trachea, tongue, eye, bladder, testis and uterus.

64 r the efficient regenerative capacity of the testis, and also display facultative stem activity in tr

65 lengthening in head and 3' UTR shortening in testis, and characterize new tissue and developmental 3'

66 e preferentially and highly expressed in the testis, and encoding a tetratricopeptide repeat-containi

67 MR are expressed in the brain, heart, ovary, testis, and other nonepithelial tissues, suggesting that

68 small RNA sequencing data from brain, heart, testis, and ovary in both stickleback and zebrafish iden

69 tected in mouse reproductive tissues (ovary, testis, and prostate) and lung and colon tissues from bo

70 he ZZ dmrt1 mutant fish developed ovary-like testis, and the spermatogenesis was disrupted.

71 associated with reduced TL in the liver and testis, and upregulation of telomerase in brain and live

72 ver CD4+ TCRs of optimal affinity for cancer testis antigen (CTA) NY-ESO-1.

73 s exhibiting increased mutation load, cancer-testis antigen expression, and intratumoral heterogeneit

74 and two of the AD subtypes expressed cancer testis antigen genes, whereas three AD subtypes expresse

75 lly relevant peptide derived from the cancer testis antigen melanoma antigen-A4 (MAGE-A4).

76 examined metastasis promoting role of cancer testis antigen SPANXB1 in TNBC and its utility as a ther

77 ssed antigen in melanoma (PRAME) is a cancer-testis antigen that is expressed in many cancers and leu

78 Many MGCA are also expressed as cancer/testis antigens (CTA) in human cancers, but the toleranc

79 Cancer testis antigens (CTAs) are proteins whose expression is

80 AG5 and TSSK6 as putative immunogenic cancer/testis antigens in multiple cancers.

81 ng endogenous retroviruses and latent cancer testis antigens normally silenced by DNA methylation in

82 sed in soma-derived human cancers as "cancer/testis antigens" (CTAs), and piRNA (PIWI-interacting RNA

83 ly targeted differentiation antigens, cancer-testis antigens, and overexpressed antigens and have thu

84 enic alterations, neoantigens, common cancer/testis antigens, and the immune microenvironment, all of

85 s as opposed to hepatitis B virus and cancer-testis antigens.

86 ive new biomarkers, drug targets, and cancer/testis antigens.

87 in development, different cell-types in the testis are able to work together to produce testosterone

88 SRY/SOX9 expression initiated in testis around day 40 pc, followed by initiation of AMH a

89 rdial germ cells (PGCs) that enter the fetal testis around embryonic day (E)10.5.

90 Using the developing mouse testis as a model, we found that spermatogonia and precu

91 t is localized in Sertoli cells at the blood-testis barrier (BTB) and at the apical ectoplasmic speci

92 ed to enhance the transport across the blood-testis barrier (BTB) of contraceptive drugs or to treat

93 stis function by inducing Sertoli cell blood-testis barrier (BTB) remodeling and is also capable of i

94 For instance, remodeling of the blood-testis barrier (BTB) that facilitates the transport of p

95 etween the basement membrane (BM), the blood-testis barrier (BTB), and the apical ectoplasmic special

96 CRB3 also expressed at the blood-testis barrier (BTB), co-localized with F-actin, TJ prot

97 The blood-testis barrier (BTB), formed between adjacent Sertoli ce

98 sing an in vitro model of Sertoli cell blood-testis barrier (BTB), PFOS was found to induce Sertoli c

99 litate nucleoside transport across the blood-testis barrier (BTB).

100 l interface, known as basal ES, at the blood-testis barrier (BTB).

101 on of drugs (e.g., adjudin) across the blood-testis barrier (BTB).

102 cal blood-tissue barriers, such as the blood-testis barrier and the blood-brain barrier.

103 Regulation of the blood-testis barrier by a local axis in the testis: role of la

104 onnexin 43 reboots meiosis and reseals blood-testis barrier following toxicant-mediated aspermatogene

105 igen-presenting cells, and sustain the blood-testis barrier formed by their tight junctions.

106 ENT2 substrates and can circumvent the blood-testis barrier through this transepithelial transport pa

107 assessment, and overexpression of BTB (blood-testis barrier) regulatory genes such as FAK and its pho

108 ed site in the testis protected by the blood-testis barrier, also called the Sertoli cell (SC) barrie

109 the notion that Ct may compromise the blood-testis barrier, impairing spermatogenesis.

110 ent genes and the accumulation of genes with testis-biased expression, many of which are recent dupli

111 ordinated across tissues such that autosomal testis-biased miRNAs tend to be somatically male-biased,

112 ody weight ratio for most of the organs, the testis/body and ovary/body ratio were dramatically decre

113 lncRNAs upregulated in tumors and found that testis, brain, the digestive tract, and blood/spleen wer

114 ose expression is normally restricted to the testis but anomalously activated in human cancer.

115 imum level of testosterone production by the testis but does not control basal testosterone productio

116 ell source for regenerative therapies in the testis but their therapeutic potential in this context i

117 cription is suppressed within the developing testis by the presence of H3K27me3 on these same sites.

118 Using size-based flow cytometry, testis cell suspensions were sorted through "A" (> 9 mum

119 drug, benzalkonium chloride (BC), to deplete testis cell types in vivo.

120 a niche composed of Sertoli cells, and other testis cell types.

121 was ROPN1L, a gene known to be expressed in testis, coincidentally the typical location of DUX4 expr

122 aled a small left-sided palpable mass of the testis, compatible with an inguinal hernia or hydrocele.

123 ly and combined, at 0x, 2x, 10x and 100x dog testis concentrations.

124 e we provide evidence that in the Drosophila testis, connectivity serves as a mechanism that confers

125 WSR1-FLI1 modulates the expression of cancer/testis (CT) antigen genes, whose expression is biased to

126 Cancer/testis (CT) antigens are proteins whose expression is no

127 els have been evaluated as one of the cancer testis (CT) antigens for immunotherapy in melanoma and s

128 Cancer-testis (CT) genes represent the similarity between the p

129 -attenuated Zika vaccine prevents infection, testis damage and transmission to the fetus during pregn

130 vent viral transmission during pregnancy and testis damage in mice, as well as infection of nonhuman

131 em is a postulated signaling system in which testis-derived (upstream) secreted factors enter the mal

132 recipitation of ZFP628 and TAF4b proteins in testis-derived protein extracts supports their endogenou

133 Essential for fetal testis descent, INSL3 has been implicated in testicular

134 asures such as penis and preputial size, and testis descent, were greater in Sgta(-/-).

135 16 on the C57BL/6N background undergo normal testis determination in the fetal period.

136 A model is provided by testis determination in therian mammals.

137 conclude that ADAMTS-16 is not required for testis determination or male fertility in mice.

138 examine whether ADAMTS-16 functions in mouse testis determination or testicular function.

139 We discuss Mod13's influence on the testis determination process and its possible origin in

140 ent (DSD), also implicate this gene in human testis determination.

141 her correlated with silencing of a serial of testis determining genes, including SOX9, SF1, SOX8, AMH

142 Although the testis-determining gene SRY is present in many cases, th

143 SC-SF-1(-/-)) at E14.5, which coincides with testis development post sex determination, using the Amh

144 ows that, in addition to its crucial role in testis development, Sox9, together with Sox8 and coordin

145 Here we show that an alternate testis-differentiating factor exists and that this facto

146 nistic molecular signals ensure ovary versus testis differentiation with canonical Wnt/beta-catenin s

147 esticular dysgenesis can result after normal testis differentiation/development and may be relevant t

148 sion of female sex determinants in the adult testis disrupts tissue morphology.

149 The more severe testis dysgenesis in DBP-MPW animals may result from the

150 -amplified X/Y genes are highly expressed in testis, enriched for meiosis and RNA interference functi

151 showed that both stress-inducible HSPA1 and testis-enriched HSPA2, highly homologous members of the

152 identifies a lumicrine system essential for testis-epididymis-spermatozoa (NELL2-ROS1-OVCH2-ADAM3) s

153 sion in the brain (specifically for HHV-6A), testis, esophagus, and adrenal gland.

154 o disrupt androgen production in human fetal testis explants and to evaluate the importance of mixtur

155 Among these CT antigens, fetal and adult testis expressed 1 (FATE1) is most robustly induced.

156 mplex central element protein 1-3 (SYCE1-3), testis-expressed 12 (TEX12), and six6 opposite strand tr

157 y massive, lineage-specific amplification of testis-expressed gene families, making it the most gene-

158 the transcription start sites of hundreds of testis-expressed genes; evolutionarily conserved across

159 nostaining of intercellular bridge component testis-expressed protein (Tex)14 showed ~59% reduction i

160 ssociated factor (TBP)] and third-trimester [Testis-expressed sequence 15 protein (TEX15)] protein bi

161 H2A.B genes are testis-expressed short histone H2A variants that arose i

162 on recently formed X and Y chromosomes, are testis-expressed, and produce antisense transcripts and

163 The testis expresses the largest number of genes of any mamm

164 ed convergent gene functions associated with testis expression.

165 lated endogenous mRNA/protein complexes from testis extract and identified by mass spectrometry prote

166 phenotypes in humans ranging from a lack of testis formation to male infertility.

167 tructure was visualized in vivo in cells and testis from invertebrate B. mori and vertebrate Chinese

168 s have shown that this NC1 peptide regulates testis function by inducing Sertoli cell blood-testis ba

169 they do not show impaired spermatogenesis or testis function.

170 Among such cancer/testis genes, components of the PIWI-interacting small R

171 , focusing on regulators of adult Drosophila testis germline stem cells (GSCs).

172 internal self-fertilization in a mixed ovary/testis gonad.

173 t sex determination, implies a vital role in testis gonadal differentiation.

174 In summary, the mouse testis has adopted a regenerative strategy to expand ste

175 male fertility, but their role in the adult testis has not been investigated.

176 of thousands of germline-specific genes, the testis has the most diverse and complex transcriptome of

177 mprise >80% of small RNAs in the adult mouse testis, have been proposed to bind and regulate target R

178 Testis histology showed rainbowfish spermatogonia are la

179 o male reproductive development in the fetal testis; however, in vivo exposure during gestation resul

180 ot possible to explain the sterol profile of testis in cAMP responsive element modulator tau (Crem ta

181 and humans have shown that ZIKV targets the testis in males, resulting in persistent infection and o

182 ctor can switch organ fate from the ovary to testis in mammals and represents the first missense muta

183 isruption, making the barrier leaky), in the testis in vivo We report our findings that NC1 domain de

184 tid stage in the seminiferous tubules of the testis in ZFP628-deficient mice that results in male inf

185 lar dysgenesis were present in re-aggregated testis, including ectopic Sertoli cells and intratubular

186 found that synapsin expression in ovary and testis increased during sexual maturation in cells with

187 enged with Zika virus were protected against testis infection, injury, and oligospermia.

188 Also, Sox9/8 warrant testis integrity by controlling the expression of struct

189 The testis is a peculiar tissue in many respects.

190 ic cyst stem cells (CySCs) in the Drosophila testis is actively promoted by PI3K/Tor signaling, as Cy

191 hough its loss determine changes also at the testis level.

192 protein at the basement membrane in the rat testis, likely via proteolytic cleavage of matrix metall

193 novel class of functionally important cancer/testis lncRNAs whose structure and function have undergo

194 y provides a deeper understanding of how the testis maintains its core reproductive function while be

195 postnatal testes, but the mechanism of adult testis maintenance remains mostly unknown.

196 coordinately with Dmrt1, also controls adult testis maintenance.

197 hesis in fetal life has been associated with testis maldescent, malformations of the genitalia at bir

198 Polyorchidism or supernumerary testis means more than two testes.

199 tricts activation by Aly, a component of the testis-meiotic arrest complex, to transcripts for male g

200 ll, Hudry et al. (2019) uncover a Drosophila testis-midgut interaction via cytokine and citrate signa

201 ermination of Sertoli cells that orchestrate testis morphogenesis.

202 blishment of somatic cell populations during testis morphogenesis.

203 t of "model" eRpL22-like polysome-associated testis mRNAs can occur outside the germline within S2 ce

204 ferens and never invades the interior of the testis, neural crest-derived innervation invades the int

205 Nuclear protein of the testis (NUT) midline carcinoma (NMC), is a rare and high

206 igens (MGCA) that are expressed on sperm and testis occur in human infertility and after vasectomy.

207 ated with an elevated risk of an undescended testis (odds ratio [OR] 5.9, 95% confidence interval [CI

208 ably, we obtained an intersex ZW fish with a testis on one side and an ovary on the other side.

209 HCC and preferentially expressed in healthy testis or brain were predicted to function as oncogenes

210 DLBCL (IP-DLBCL) samples originating in the testis or central nervous system.

211 t human tissues, we detect ERbeta protein in testis, ovary, lymphoid cells, granulosa cell tumours, a

212 ulcer, duodenitis, enteritis, or adnexal or testis pathologies.

213 t recruitment of vasculature is critical for testis patterning.

214 in nature to piRNAs [P-element-induced wimpy testis (Piwi)-interacting small RNAs], we investigated w

215 In the fetal mouse testis, PIWI-interacting RNAs (piRNAs) guide PIWI protei

216 In mouse testis, Pontin is essential for the stabilization of axo

217 FA revealed that KDR signaling represses the testis-promoting gene Sox9 in embryonic XX gonads.

218 us tubules, an immune-privileged site in the testis protected by the blood-testis barrier, also calle

219 ranscriptional atlas of the developing human testis provides multiple insights into developmental cha

220 In testis, RA acts directly in Sertoli, Leydig and pre-meio

221 which includes BRD2, BRD3, and BRD4 and the testis-restricted BRDT, are epigenetic reader proteins t

222 Testis-restricted melanoma antigen (MAGE) proteins are f

223 imary spermatocytes and Sertoli cells in the testis, resulting in cell death and destruction of the s

224 ific AD domain proteins, ADAD1 and ADAD2, on testis RNA editing and male germ cell differentiation.

225 Within the testis, RNA editing is catalyzed by ADARB1 and is regula

226 blood-testis barrier by a local axis in the testis: role of laminin alpha2 in the basement membrane.

227 atogenesis by a local functional axis in the testis: role of the basement membrane-derived noncollage

228 specific germ cell subtypes from fixed human testis samples.

229 We visualized the expression patterns in testis sections of the five proteins and found that each

230 ed requirement for SMN expression, wild type testis showed extremely high levels of SMN protein compa

231 However, while testis showed the highest divergence of gene expression

232 age of trajectory changes, and the liver and testis showing the largest.

233 GRTH-KI mice are sterile with reduced testis size, lack sperm with spermatogenic arrest at rou

234 ion pathway to maintain the male identity of testis somatic cells.

235 Conversely, the feminization of the testis somatic stem cell lineage caused by loss of chinm

236 ed testicular RNA helicase (GRTH/DDX25) is a testis specific member of the DEAD-box family of RNA hel

237 This study examined the role of two testis-specific AD domain proteins, ADAD1 and ADAD2, on

238 omolog of a bull Y-amplified gene has become testis-specific and amplified.

239 Testis-specific and dosage-sensitive genes appear to hav

240 roteins, consisting of BRD2, BRD3, BRD4, and testis-specific BRDT members, are epigenetic "readers" a

241 the latter replacement is found in human and testis-specific Cytc.

242 , a murine autosomal retrogene of Rpl10 with testis-specific expression, disturbs ribosome biogenesis

243 2 paralogs have independently specialized to testis-specific expression.

244 h biological processes that are upregulated (testis-specific gene expression) or downregulated (metab

245 pigenetic, allele-specific activation of the testis-specific gene nucleoporin 210 like (NUP210L) in b

246 brain-specific genes evolve slowest, whereas testis-specific genes evolve fastest).

247 dhesion molecule (IgCAM) BT-IgSF (brain- and testis-specific Ig superfamily protein) plays a major ro

248 prises four members-BRD2, BRD3, BRD4 and the testis-specific isoform BRDT-that largely function as tr

249 two distinct isoforms in mammals: a longer, testis-specific isoform that was used for the previous s

250 hat most endogenous X-linked genes, not just testis-specific ones, are transcriptionally suppressed s

251 pulation genetic analyses, we show that most testis-specific paralogs have significantly lower geneti

252 -CATENIN, which may lead to up-regulation of testis-specific pathway.

253 female germ cells, forced expression of the testis-specific PHD finger protein 7 (PHF7) disrupts oog

254 spermatocytes, BRG1 interacts with SCML2, a testis-specific PRC1 factor that is associated with the

255 The gonadoblastoma gene, testis-specific protein Y-encoded (TSPY), on the Y chrom

256 Here we report that TEX15, a testis-specific protein, is required for TE silencing.

257 Here, we demonstrate that the testis-specific protein, MAGE-B2, increases cellular str

258 dings indicate that aberrant expression of a testis-specific transcription factor is sufficient to co

259 and BORIS-only sites are occupied by several testis-specific transcriptional regulators (TSTRs) and a

260 cal ectoplasmic specialization (apical ES; a testis-specific, actin-rich adherens junction at the Ser

261 disrupting ectoplasmic specialization (ES; a testis-specific, actin-rich anchoring junction) function

262 We speculate that the repeated evolution of testis specificity in obscura group Ago2 genes, combined

263 ibution of an F-actin capping protein in the testis, supporting a role for this kinase in cytoskeleto

264 In the mammalian testis, sustained spermatogenesis relies on spermatogoni

265 is, whereas GLI1 was significantly higher in testis than ovaries.

266 In the adult Drosophila testis, the putative transcription factor Chronologicall

267 Specifically, in the testis there is a lack of spermatogenesis, lack of leydi

268 al competition in the cyst stem cells of the testis, there are important tissue-specific differences.

269 s of childhood asthma, and its expression in testis tissue and lung macrophages suggests a potential

270 We explanted testis tissue at postnatal day (P)5.5 and cultured it un

271 dissociation and reconstitution of rat fetal testis tissue during the MPW can be used to model and ma

272 re demonstrate, on examples of rat brain and testis tissue sections, that the combination of MALDI-2

273 Re-aggregation of rat fetal testis tissue xenotransplants during the MPW results in

274 n expression vector was overexpressed in the testis, to better understanding the molecular mechanism

275 toli cells of adult, fertile Sox8(-/-) mice, testis-to-ovary genetic reprogramming occurs and Sertoli

276 This phenotype was mostly replaced by the "testis-to-ovary" or "ovaries" phenotypes during developm

277 t and exacerbation of the C (+/+)/Tia1 (-/-) testis transcriptome.

278 most common causes of ASP are torsion of the testis (TT) or its appendages (TA) and epidymo-orchitis

279 In the adult testis, two different macrophage populations have been i

280 The human testis undergoes dramatic developmental and structural c

281 ated effects on Sertoli cell function in the testis using the rat as an animal model.

282 (i) the spatial distribution of PLAG1 in the testis using X-gal staining; (ii) transcriptomic consequ

283 ection, measures of body size, weaponry, and testis volume may not increase reproductive success via

284 We also collected testis volumes from males.

285 On ultrasound, the left testis was located in the inguinal canal, the right kidn

286 mosome genes are lowly expressed outside the testis, we report many instances of elevated Y-Chromosom

287 However, adult homozygotes have an average testis weight that is around 10% lower than age-matched

288 us adult males exhibit cryptorchidism, lower testis weight, lower sperm count, and subfertility.

289 e to the loss of Sertoli and germ cells, the testis weights of SC-SF-1(-/-) mice at 6-weeks were much

290 The binding partners of CRB3 in the testis were the branched actin polymerization protein Ar

291 In mice, Rfx1-4 are highly expressed in the testis where flagellated sperm are produced, but the fun

292 and ETV5, were significantly higher than in testis, whereas GLI1 was significantly higher in testis

293 role in the evolution of gene expression in testis, which illustrates the tissue-specific nature of

294 ength EB1 cDNA for its overexpression in the testis, which was found to block the NC1-peptide-mediate

295 In summary, overexpression of Cx43 in the testis with aspermatogenesis reboots meiosis and reseals

296 ed hypoechoic lesions around the mediastinum testis with hypervascularity dispersing in ten patients

297 most frequent interstitial neoplasms of the testis with increased incidence in recent years.

298 hoic lesions depicted around the mediastinum testis with no mass effect is highly suggestive for the

299 els of L-2-HG were observed in the brain and testis, with a corresponding increase in histone methyla

300 nonseminoma (NS) is a disease limited to the testis without metastases.