ライフサイエンスコーパス: testosterone

1 hormone (ACTH), estradiol, progesterone and testosterone.

2 treatment in adult men with age-related low testosterone.

3 rogesterone derivative allopregnanolone, and testosterone.

4 following administration of estradiol and/or testosterone.

5 uration of hypersensitivity was regulated by testosterone.

6 n marriages with greater conflict had higher testosterone.

7 observation period, grafts grew and produced testosterone.

8 os are protected by high levels of intrinsic testosterone.

9 rnalizes in response to ligand activation by testosterone.

10 gnificantly lower levels of androsterone and testosterone.

11 consecutively administrating and withdrawing testosterone.

12 ury that may be mediated at least in part by testosterone.

13 treatment in adult men with age-related low testosterone.

14 Stenotrophomonas maltophilia, and Comamonas testosterone.

15 e better providers also tended to have lower testosterone.

16 testis are able to work together to produce testosterone.

17 tion includes adult men with age-related low testosterone.

18 atin and artemether, and the steroid hormone testosterone.

19 ne (7.78 vs 3.71 ng/mL, P = .0004) and lower testosterone (0.05 vs 1.34 ng/mL, P = .009) levels in LP

20 mized to placebo gel or 4 different doses of testosterone (1%) gel for 12 weeks.

21 lar patterns were observed for inhibition of testosterone 6beta-hydroxylation by ritonavir and indina

22 ia aged 25-50 years with morning total serum testosterone 7-12 nmol/l were recruited.

23 ng male cancer survivors with borderline low testosterone (7-12 nmol/l).

24 were normal, with a borderline low level of testosterone (7.6 nmol/L; normal range, 8.0-29.0 nmol/L)

25 membrane transport and consumption rates of testosterone, a slightly larger dose of testosterone is

26 We found that testosterone activates the protein JNK in mouse and huma

27 Testosterone activation of GPRC6A has the obligate requi

28 ersus action, analyses further revealed that testosterone administration influenced judgements by inc

29 Counter to predictions, testosterone administration led to increased inaction in

30 This study aimed to determine the effect of testosterone administration on NP levels using a randomi

31 In contrast, ORX decreased risky choice, but testosterone administration was without effect in either

32 escued by transgene-mediated sex reversal or testosterone administration.

33 ior, testosterone and hormones produced from testosterone affect mammalian brain structure.

34 Adjunctive transdermal testosterone, although well tolerated, was not more effe

35 er cognitive functions in older men with low testosterone and age-associated memory impairment (AAMI)

36 As seen with other cetacean species, testosterone and androstenedione could be markers of nea

37 However, the androgens, testosterone and androstenedione were measured in unusua

38 on of the human fetus depends, therefore, on testosterone and androsterone synthesis by both the feta

39 sociation between serum levels of endogenous testosterone and cardiovascular disease, prescription da

40 nce in vHPC-NAc neurons that is dependent on testosterone and causes susceptibility to stress in fema

41 Testosterone and DHEA analyses confirmed that immunocast

42 hat one pathway involves hormone mechanisms (testosterone and DHEA) that contribute to disruption of

43 n of female biology, while androgens such as testosterone and dihydrotestosterone were believed to pr

44 ogens, with potencies equivalent to those of testosterone and dihydrotestosterone.

45 ment for SMAD1/5/8 in hepcidin regulation by testosterone and EGF but not inflammation, and suggest a

46 ross-sectional study of serum levels of free testosterone and estradiol and current asthma in 7,615 a

47 e brain structure and function programmed by testosterone and estradiol exposures in utero.

48 und SHBG with an affinity similar to that of testosterone and estradiol.

49 ibuted to modulation by the gonadal hormones testosterone and estradiol.

50 provide insights into the disease impacts of testosterone and highlight the importance of sex-specifi

51 In addition to influencing behavior, testosterone and hormones produced from testosterone aff

52 tal sex steroid environment of high prenatal testosterone and low prenatal oestrogen inhibits lung de

53 2D:4D, a negative correlate of high prenatal testosterone and low prenatal oestrogen) and the age of

54 C group 6 member A (GPRC6A) is activated by testosterone and modulates prostate cancer progression.

55 Testosterone and prostate-specific antigen (PSA) were me

56 ger and had worse performance status, higher testosterone and prostate-specific antigen, and lower he

57 We investigated the relationship between testosterone and social network dynamics in the wire-tai

58 combining low concentrations of circulating testosterone and specific symptoms associated with impai

59 ing of the ligands midazolam, bromocriptine, testosterone, and ketoconazole to P450 3A4 was consisten

60 ave elevated levels of serum estradiol (E2), testosterone, and LH.

61 olesterol, glomerular filtration rate (GFR), testosterone, androstenedione, and sex hormone binding g

62 is circulating androgens [testosterone, free testosterone, androstenedione, dehydroepiandrosterone su

63 Furthermore, neuronal responses to acute testosterone application onto the amygdala were attenuat

64 in both study arms from baseline to week 8 (testosterone arm: from 26.8 [SD=6.3] to 15.3 [SD=9.6]; p

65 g hormone greater than 9.85 IU/L, and LCD by testosterone as 250 ng/dL or greater and luteinizing hor

66 urrent findings from BaYaka fathers point to testosterone as a psychobiological correlate of cooperat

67 sexual function in men with age-related low testosterone, as costs are considerably lower for the in

68 rly poverty predicted shallower increases of testosterone, but not DHEA, across development, which in

69 Since testosterone can work directly via the androgen receptor

70 d the relationship between the 2D:4D and the testosterone change under an acute exercise among 97 men

71 discussion on the links of the 2D:4D and the testosterone change.

72 cin, lower ACTH, estradiol, progesterone and testosterone compared with non-OC users.

73 ent but no difference in ACC activation with testosterone compared with placebo.

74 associations between serum estradiol or free testosterone concentrations and TFV-DP.

75 Furthermore, when controlling for testosterone, cortisol was associated with increased ing

76 blind placebo-controlled trial of adjunctive testosterone cream in 101 women, ages 21-70, with antide

77 An individual whose serum testosterone decreased by 500 ng/dl had a 26% higher pre

78 During active HCV infection, testosterone deficiency may be masked due to elevated SH

79 dence suggests women's preferences for men's testosterone dependent masculine facial traits are stron

80 We show a testosterone-dependent lower excitability in male versus

81 us female vHPC-NAc neurons and corresponding testosterone-dependent male resilience to reduced sucros

82 ssments of poverty in preschool, measures of testosterone, DHEA, and hippocampal volume across school

83 n a subset of participants demonstrated that testosterone did not result in greater activation of the

84 Testosterone directly stimulated EGFR expression in cult

85 Social networks that were composed of high-testosterone dominant males were less specialized, less

86 Each 1-g increase in testosterone dose was associated with a 4.3% lower NT-pr

87 Replacement of testosterone effectively normalized the tumor burden in

88 The results show that testosterone, estrogen, and hydrocortisone did not alter

89 Groups with high average testosterone exhibit social network properties that are

90 ow different types of factors, such as early testosterone exposure and parental socialization, work t

91 ince then, similar enduring effects of early testosterone exposure have been found in other species,

92 The evidence linking early testosterone exposure to sex-typed play is particularly

93 However, little is known about changes in testosterone following successful HCV treatment.

94 t Middle Eastern PCOS women showed increased testosterone, free androgen index, HDL and CRP (P < 0.01

95 between pre-diagnosis circulating androgens [testosterone, free testosterone, androstenedione, dehydr

96 osomal females passively exposed to prenatal testosterone from male littermates exhibit altered physi

97 reporter system by competitively displacing testosterone from SHBG.

98 many populations may be exposed to prenatal testosterone from their male co-twin.

99 pparent higher selectivity of OATP1B3 toward testosterone glucuronide and androsterone glucuronide ca

100 for the hepatic uptake of major circulating testosterone glucuronides.

101 Lifelong increased free testosterone had beneficial effects on increased bone mi

102 rted that treating pregnant guinea pigs with testosterone had enduring effects on the sex-related beh

103 Low-dose testosterone has been shown to improve depression sympto

104 Androgens like testosterone have been strongly linked to social status,

105 ycerides were higher in the UK cohort whilst testosterone, HDL and CRP were higher in the Middle East

106 iles and correlation of atRA metabolism with testosterone hydroxylation, clearance of atRA in the fet

107 r enzymes able to convert androstenedione to testosterone identifies HSD17B12 as a candidate enzyme c

108 mine whether adjunctive low-dose transdermal testosterone improves depression symptom severity, fatig

109 Both DVT and IPI increased the activity of testosterone in a cell culture androgen reporter system

110 estosterone levels and the prevalence of low testosterone in a cohort of 327 men with chronic HCV inf

111 ught to increase intracellular estradiol and testosterone in bone, thereby inhibiting bone resorption

112 Low testosterone in cancer survivors can be due to orchidect

113 Serum testosterone in female patients significantly increased

114 Here, we find that increasing prenatal testosterone in humans is associated with later reductio

115 le no different change was observed in serum testosterone in male subjects and the sex hormone-bindin

116 s used to treat symptoms associated with low testosterone in males.

117 The results indicate that the role of testosterone in moral judgements is more complex than su

118 Roles for testosterone in Sertoli cell maturation, antimicrobial p

119 ehydroepiandrosterone, which is converted to testosterone in the gonads, followed by further activati

120 steroid analyses revealed a complete lack of testosterone in XY-KO mice and marked accumulation of pr

121 Conversely, testosterone increased EGFR expression and renal injury

122 toli cell (SC) number, decreased circulating testosterone, increased luteinizing hormone/testosterone

123 mple, a genetically determined 1 s.d. higher testosterone increases the risks of type 2 diabetes (odd

124 p70S6 kinase phosphorylation in response to testosterone, indicating that hGPRC6A(ICL3_KGKY) is func

125 therapy if administered with an appropriate testosterone intervention.

126 As observed for estradiol but not testosterone, IPI binding to SHBG was reduced by ~20-fol

127 Testosterone is a key mediator of vertebrate social beha

128 g total serum testosterone, replacement with testosterone is associated with an improvement in body c

129 nt between sexes and that genetically higher testosterone is harmful for metabolic diseases in women

130 In humans and other species, testosterone is often a mediator of life history trade-o

131 s of testosterone, a slightly larger dose of testosterone is recommended.

132 Approximately 95% of circulating testosterone is synthesized by the testis and the final

133 Testosterone is the main male sex hormone and is essenti

134 LCF was defined as serum total testosterone less than 250 ng/dL (or 8.67 nmol/L) and lu

135 pre-exercise testosterone, nor the change in testosterone level after a cycling task.

136 rs7784118 was associated with decreased testosterone level, increased levels of follicle stimula

137 followed for testosterone recovery, the mean testosterone levels 90 days after treatment discontinuat

138 this, we identified genetic determinants of testosterone levels and related sex hormone traits in 42

139 We evaluated testosterone levels and the prevalence of low testostero

140 stosterone production by hCG, although basal testosterone levels are maintained despite the absence o

141 demonstrate that the genetic determinants of testosterone levels are substantially different between

142 study uses national survey data to describe testosterone levels by age in youths aged 6 to 20 years

143 -related or obesity-related decline in serum testosterone levels has increased exponentially even tho

144 stress, seminal plasma vitamin E, and plasma testosterone levels in both groups.

145 31525075

146 osterone levels, which suggests that urinary testosterone levels may not accurately reflect blood lev

147 ection = 150) and in a subset of 85 men with testosterone levels obtained pre-HCV treatment and after

148 hormone (FSH), luteinizing hormone (LH) and testosterone levels or testicular and semen volume.

149 lix achieved rapid, sustained suppression of testosterone levels that was superior to that with leupr

150 pe natriuretic peptide (NT-proBNP) and total testosterone levels were measured at baseline and follow

151 In older men with low testosterone levels without well-established medical con

152 ctioning and quality of life in men with low testosterone levels, although effect sizes were small (l

153 f condition, including baseline cortisol and testosterone levels, body morphology and strength, we te

154 Young male cancer survivors have lower testosterone levels, higher fat mass, and worse quality

155 Sry overexpression, which does not affect testosterone levels, produced an exaggerated male phenot

156 the boys nor a gender-specific difference in testosterone levels, which suggests that urinary testost

157 idity by enabling cyclical recovery of serum testosterone levels.

158 Other features of PCOS (obesity, elevated testosterone, low sex hormone binding globulin) may expl

159 ration to human life history, human fathers' testosterone may be linked to these two behavioral domai

160 Epidemiological studies suggest testosterone may contribute to sex-specific NP differenc

161 Inhibition of NP production by testosterone may partly explain the lower NP levels in m

162 uggested the opposite pattern for endogenous testosterone measured at baseline, in that higher levels

163 ion experienced a profound decrease in serum testosterone (median 540 to 36 ng/dl; p < 0.0001).

164 There is also evidence that lower testosterone men may often engage in greater prosocial b

165 reater prosocial behavior compared to higher testosterone men.

166 In addition, cortisol and testosterone negatively interacted in predicting f(o), a

167 f the steroidogenic enzymes required to make testosterone, nor a nuclear androgen receptor.

168 :4D) were neither predictors of pre-exercise testosterone, nor the change in testosterone level after

169 As the predictor, we analysed the collective testosterone of males within each social network.

170 formed to infer phenome-wide effects of free testosterone on 461 outcomes in 161,268 males from the U

171 We also show adverse effects of higher testosterone on breast and endometrial cancers in women

172 C6A is required for mediating the effects of testosterone on cell proliferation and autophagy.

173 rcentage of patients with castrate levels of testosterone on day 4 was 56.0% with relugolix and 0% wi

174 to the primary end point, castrate levels of testosterone on day 4, and profound castrate levels (<20

175 Although the effects of testosterone on individual behaviour are well establishe

176 udy tested the effect of the steroid hormone testosterone on moral dilemma judgements using a double-

177 ts and mechanistic studies on the effects of testosterone on the cardiovascular system.

178 ples confirmed that f(o)negatively predicted testosterone only among men with lower cortisol levels.

179 ths of stable sex hormone therapy containing testosterone or estradiol (respectively) were enrolled i

180 ments using a double-blind administration of testosterone or placebo.

181 In this analysis, elevated free testosterone (OR for Q4 vs. Q1, 0.59; 95% CI, 0.37-0.91)

182 male genital development required testicular testosterone plus dihydrotestosterone (DHT) made in geni

183 In the past decade, the number of testosterone prescriptions issued for middle-aged or old

184 To determine the role of HSD17B3 in testosterone production and androgenization during male

185 tion of HSD17B3 inhibits hyperstimulation of testosterone production by hCG, although basal testoster

186 rate-limiting-step for the maximum level of testosterone production by the testis but does not contr

187 Testosterone production by the transplants was measured

188 , these findings expand our understanding of testosterone production in males.

189 Suppression of testosterone production in men led to increases in circu

190 a candidate enzyme capable of driving basal testosterone production in the testis.

191 n vitro receptor activity and did not impact testosterone production or expression of genes key to ma

192 testicular endocrine function, with gonadal testosterone production, as well as exocrine function, w

193 ion by the testis but does not control basal testosterone production.

194 Testosterone products are prescribed to males for a vari

195 Endogenous testosterone promotes behaviours intended to enhance soc

196 A single injection of testosterone propionate or estradiol benzoate on the day

197 iron-deficient mice were treated weekly with testosterone propionate or vehicle for 3 weeks.

198 itulated in females by perinatal exposure to testosterone proprionate, 3) perinatal androgen exposure

199 vehicle controls and the luteinising hormone/testosterone ratio returned to Vehicle control levels wh

200 testosterone, increased luteinizing hormone/testosterone ratio, and decreased expression of steroido

201 st, serum sex hormone and adipocyte estrogen/testosterone receptor expression profiles provide prelim

202 Testosterone recovery was evaluated in a subgroup of pat

203 In the subgroup of 184 patients followed for testosterone recovery, the mean testosterone levels 90 d

204 unt in iron-replete mice, but, surprisingly, testosterone reduced red cell count in iron-deficient mi

205 Testosterone regulates dimorphic sexual behaviors in all

206 ces are correlated both with lower levels of testosterone, relative to mice that respond to such trai

207 follow-up NT-proBNP than someone whose serum testosterone remained constant.

208 Men who did not receive testosterone replacement (placebo gel group) after suppr

209 uitary gland or testes has been treated with testosterone replacement for decades without reports of

210 -blind, placebo-controlled, 6-month trial of testosterone replacement in young male cancer survivors

211 The association between the use of testosterone replacement therapy (TRT) and prostate canc

212 ndomized trials and meta-analyses evaluating testosterone replacement therapy and its association wit

213 to make informed decisions when considering testosterone replacement therapy in their patients.

214 es and randomized trials have suggested that testosterone replacement therapy increases the risk of c

215 However, no trials of testosterone replacement therapy published to date were

216 about the potential cardiovascular risks of testosterone replacement therapy.

217 culating NT-proBNP, which were attenuated by testosterone replacement.

218 urvivors with low-normal morning total serum testosterone, replacement with testosterone is associate

219 all samples) that examined the 2D:4D and the testosterone response to a challenging situation (i.e. p

220 ggest that the 2D:4D is also linked with the testosterone response to challenging situations due to o

221 m of portal hypertension and/or to decreased testosterone resulting from testicular dysfunction.

222 and diastolic blood pressures, and increased testosterone results (p < 0.01) compared to Middle Easte

223 However, we found neither a neonatal testosterone rise in the boys nor a gender-specific diff

224 To clarify the role of iron in mediating testosterone's effects on erythropoiesis, we induced iro

225 Iron plays an important role in mediating testosterone's effects on erythropoiesis.

226 ion suggests benefits of long-term increased testosterone should be considered against adverse effect

227 ere, we report that a newly identified rapid testosterone signaling receptor, Transient Receptor Pote

228 ss endogenous GPRC6A(ICL3_KGKY) In addition, testosterone stimulates GPRC6A-dependent cell proliferat

229 Testosterone stimulates iron-dependent erythropoiesis an

230 Indeed, testosterone stimulates time- and dose-dependent activat

231 Testosterone supplementation is commonly used for its ef

232 Testosterone supplementation significantly increased EGF

233 highlighted through single-cell analysis of testosterone-suppressed transfemale testes.

234 ase 3 trial, we assigned patients to receive testosterone suppression plus either open-label enzaluta

235 The primary end point was sustained testosterone suppression to castrate levels (<50 ng per

236 is not known whether adding enzalutamide to testosterone suppression, with or without early docetaxe

237 hormone-sensitive prostate cancer receiving testosterone suppression.

238 tion for prostate cancer despite the initial testosterone surge and delay in therapeutic effect.

239 arth disrupts spermatogenesis and testicular testosterone synthesis in rodents, whereas the male repr

240 Testosterone (T) affects beta-cell function in men and w

241 ly negative results and adverse findings for testosterone (T) and related substances, boldenone and i

242 (LD) photoperiod plus systemically elevated testosterone (T) levels, compared with short-day (SD) co

243 pose stromal cells enabled the metabolism of testosterone (T) to E(2), which induced estrogen respons

244 demonstrated that the combination of chronic testosterone (T) treatment and an obesogenic Western-sty

245 iandrosterone (DHEA), 17beta-estradiol (E2), testosterone (T), and their sulfates in serum and tissue

246 Reduced serum testosterone (T), or hypogonadism, affects millions of m

247 to increase intracellular estradiol (E2) and testosterone (T), which thereby inhibits bone resorption

248 eatment of postmenopausal symptoms, in which testosterone (TES) replacement may play a potential role

249 terize transport kinetics of glucuronides of testosterone (TG), dihydrotestosterone (DHTG), androster

250 e seen as better community sharers had lower testosterone than less generous men.

251 Testosterone therapy for congenital forms of hypogonadis

252 Testosterone therapy had little to no effect on physical

253 Testosterone therapy improved sexual functioning and qua

254 ical conditions known to cause hypogonadism, testosterone therapy may provide small improvements in s

255 k of cardiovascular disease in men receiving testosterone therapy, randomized trials and meta-analyse

256 conditions are not approved indications for testosterone therapy.

257 st, in GPRC6A-deficient cells, the effect of testosterone to activate downstream signaling is abolish

258 in using RNA-sequencing and measured blubber testosterone to compare HOC exposure with cellular and e

259 id metabolism and catalyzes the reduction of testosterone to dihydrotestosterone.

260 s, and anastrazole to suppress conversion of testosterone to estradiol.

261 ce was explained by serial mediation through testosterone to hippocampus to emotion dysregulation.

262 terone treatment in men with age-related low testosterone to improve energy, vitality, physical funct

263 The ability of exogenous or endogenous testosterone to protect embryos was related to its anti-

264 Administration of exogenous testosterone to such nonaggressive mice restores both be

265 oidogenesis enzyme 5alpha-reductase converts testosterone to the more potent androgen 5alpha-dihydrot

266 Participants were randomised 1:1 to receive testosterone (Tostran 2% gel) or placebo for 26 weeks.

267 Testosterone (total and free) and estradiol concentratio

268 findings support the hypothesis of in utero testosterone transfer between twins, which is likely aff

269 To determine if testosterone treatment compared with placebo is associat

270 At 26 weeks, testosterone treatment compared with placebo was associa

271 tematic review on the efficacy and safety of testosterone treatment in adult men with age-related low

272 urrent evidence of the benefits and harms of testosterone treatment in adult men with age-related low

273 Clinicians should discontinue testosterone treatment in men with age-related low testo

274 2: ACP suggests that clinicians not initiate testosterone treatment in men with age-related low testo

275 that clinicians discuss whether to initiate testosterone treatment in men with age-related low testo

276 Testosterone treatment increased red cell count in iron-

277 Testosterone treatment of iron-deficient mice increased

278 ms of hypogonadism must be lifelong, whereas testosterone treatment of late-onset hypogonadism remain

279 o conclusively address risks and benefits of testosterone treatment on these outcomes.

280 Testosterone treatment rates in adult men have increased

281 Conclusion: Testosterone treatment stimulates splenic stress erythro

282 on of ZBTB7A acted in synergy with high-dose testosterone treatment to effectively prevent the recurr

283 han transdermal formulations when initiating testosterone treatment to improve sexual function in men

284 Testosterone treatment was well tolerated.

285 iron-replete mice, and further increased by testosterone treatment, as indicated by the increase in

286 CYP3A-dependent oxidative metabolism of testosterone (TST) and nifedipine (NIF) was assessed by

287 ction are associated with low total and free testosterone (TT and FT) and high sex hormone-binding gl

288 men aged 18 to 50 years, definitions of low testosterone varied, and study entry criteria varied.

289 therosclerosis in CYP17A1 XY KO mice lacking testosterone was associated with altered lipid profiles.

290 Testosterone was directly administered to developing mal

291 Testing whether BaYaka men's testosterone was linked to locally-valued fathering role

292 rogen caused an extension of sensitivity and testosterone was responsible for a decrease in the durat

293 Co-treatment with testosterone was shown to have an anti-apoptotic effect

294 aseline, in that higher levels of endogenous testosterone were associated with lower sensitivity to m

295 in medication use, heart conditions, and low testosterone when compared to non-CTE respondents.

296 the associations of endogenous estradiol and testosterone with carotid plaque composition in elderly

297 terone treatment in men with age-related low testosterone with sexual dysfunction in whom there is no

298 terone treatment in men with age-related low testosterone with sexual dysfunction who want to improve

299 n a reappraisal of the physiological role of testosterone, with emphasis on the critical interpretati

300 e, which bypasses dehydroepiandrosterone and testosterone, with increased activity in congenital adre

301 However, testosterone worsens anemia in iron-deficient mice becau