ライフサイエンスコーパス: tetanus toxin

1 nt were protected from lethal challenge with tetanus toxin.

2 ell binding and intracellular trafficking of tetanus toxin.

3 ct mice from challenge with a lethal dose of tetanus toxin.

4 sary component of the receptor mechanism for tetanus toxin.

5 ffected by pretreatment of synaptosomes with tetanus toxin.

6 he complex was insensitive to proteolysis by tetanus toxin.

7 neurotoxin serotypes A, B, and C, as well as tetanus toxin.

8 carboxyl-terminal 34 amino acid residues of tetanus toxin.

9 f protection against a lethal challenge with tetanus toxin.

10 to define the ganglioside-binding domains of tetanus toxin.

11 by unilateral intrahippocampal injection of tetanus toxin.

12 e remaining BoNT serotypes B-G, anthrax, and tetanus toxin.

13 nd ionotropic glutamate receptor blockers or tetanus toxin.

14 or when synaptic transmission is blocked by tetanus toxin.

15 trafficked similarly but not identically to tetanus toxin.

16 with labeling densities similar to those of tetanus toxin.

17 other neurons, similar to the known route of tetanus toxin.

18 radiolabeled GDNF, BDNF, and CT-1 as well as tetanus toxin.

19 E) complexes as judged by its sensitivity to tetanus toxin.

20 lease, as did treatment of the cultures with tetanus toxin (300 ng/ml) to block endogenous neurotrans

21 relative to mice given the control peptide, tetanus toxin-(830-843).

22 he observation that transgenic expression of tetanus toxin, a blocker of neurotransmitter release via

23 5-HT(2A/2C) receptor agonist, was blocked by tetanus toxin, a substance that prevents vesicular neuro

24 Although tetanus toxin accumulated rapidly (within 8 h) at presyn

25 ptic transmission of select PVT neurons with tetanus toxin activated via retrograde trans-synaptic tr

26 Tetanus toxin acts within the CNS, where there is limite

27 In contrast to control cultures, tetanus toxin added to fumonisin B(1)-treated cultures d

28 Tetanus toxin also inhibits NT-3 release, suggesting tha

29 In addition, CEDE is blocked by tetanus toxin, an inhibitor of regulated exocytosis, and

30 Transient expression of the light chains of tetanus toxin and botulinum toxin A did not disrupt the

31 Mutant tetanus toxin and botulinum toxins, which cleave t-SNARE

32 We have studied the effects of tetanus toxin and botulinus toxin A on neurotransmitter

33 ion or alpha-latrotoxin and was inhibited by tetanus toxin and by phenylarsine oxide, a phosphoinosit

34 with BRD937 or BRD847 were solidly immune to tetanus toxin and salmonella.

35 onella expressing TetC are protected against tetanus toxin and virulent salmonella challenge.

36 universal T helper cell epitope derived from tetanus-toxin and is self-adjuvanted with TLR7/8 ligands

37 strain which expresses fragment C (ToxC) of tetanus toxin, and (ii) soluble tetanus toxoid (TT) with

38 g the pE88 plasmid, which encodes the lethal tetanus toxin, and thus a potential target for drug desi

39 e this, we exposed a domain of the microbial tetanus toxin antigen (TTCF) to disrupted lysosomes that

40 Using the tetanus toxin antigen, we show that the introduction of

41 To determine which amino acids in tetanus toxin are involved in ganglioside binding, homol

42 Tetanus toxin attenuated the response to the second of t

43 We developed a generally applicable tetanus toxin-based method for transgenic mice that perm

44 living motor neurons using a chimera of the tetanus toxin binding fragment (TeNT HC) and a pH-sensit

45 Tetanus toxin binds neuronal tissue prior to internaliza

46 Tetanus toxin binds specifically to motor neurons at the

47 Cleavage of VAMP2 and VAMP3 with tetanus toxin blocked cAMP-stimulated renin release from

48 zes with synaptophysin, is not detectable in tetanus toxin-blocked cultures.

49 Furthermore, B-cell responses to tetanus toxin but not influenza hemagglutinin in the ART

50 is inhibited by the presynaptic injection of tetanus toxin, but not by an inactive mutant.

51 rminal fragment of synaptobrevin released by tetanus toxin, but not its C-terminal membrane-anchored

52 Here, we show that ensilication stabilizes tetanus toxin C fragment (TTCF), a component of the teta

53 terize the fraction of fluorescently labeled tetanus toxin C fragment bound to a ganglioside-populate

54 Protein sequencing of proteolyzed tetanus toxin C fragment co-migrating with that band rev

55 n of both native S. aureus enterotoxin B and tetanus toxin C fragment in spiked dilute serum samples.

56 en, Staphylococcus aureus enterotoxin B, and tetanus toxin C fragment in spiked samples.

57 -specific monoclonal antibody fused with the tetanus toxin C fragment was designed and expressed.

58 When tetanus toxin C fragment was proteolyzed with clostripai

59 licited by an adenovirus vector encoding the tetanus toxin C fragment when administered as a nasal or

60 ng this ligand, we observed radiolabeling of tetanus toxin C fragment which could be specifically inh

61 Furthermore, LTIIa binding was blocked by tetanus toxin C fragment, which binds to gangliosides GD

62 A recombinant protein consisting of a tetanus toxin C fragment-specific monoclonal antibody fu

63 exposed to either cholera toxin B subunit or tetanus toxin C fragment.

64 Intramuscular injections of Tetanus Toxin C-fragment (TTc) labeled with Alexa 790 fl

65 mpetitive immunoassay was also developed for tetanus toxin C-fragment by allowing unlabeled and fluor

66 allowing unlabeled and fluorescently labeled tetanus toxin C-fragment compete to bind to a limited fi

67 owth factor, insulin-like growth factor, and tetanus toxin C-fragment.

68 demonstrate that botulinus toxin type B and tetanus toxin cause a decrease in synaptobrevin II immun

69 ibodies, previously found to protect against tetanus toxin challenge and similar to those observed in

70 Complete protection against in vivo lethal tetanus toxin challenge and the induction of Ag-specific

71 60% of the mice in the BRD937 group survived tetanus toxin challenge if they were preimmunized with B

72 induced protective immune responses against tetanus toxin challenge when applied topically at doses

73 tibodies and were protected against systemic tetanus toxin challenge.

74 Tetanus toxin cleaved platelet vesicle-associated membra

75 rom the cucumber mosaic virus containing the tetanus toxin-derived universal T-cell epitope tt830-843

76 Serotype C and tetanus toxin did not bind effectively to T-84 cells, no

77 and AA were released solely from neurons as tetanus toxin did not cleave astrocytic synaptobrevin-2,

78 Tetanus toxin does block the residual release from perme

79 The vaccines incorporate a domain of tetanus toxin (DOM) fused to a sequence encoding a candi

80 y synthesized with the P30 helper epitope of tetanus toxin, elicited robust LeTx-neutralizing immunit

81 ntigens (beta-galactosidase or fragment C of tetanus toxin) encoded by one plasmid to augment respons

82 Earlier studies implicated a coreceptor for tetanus toxin entry into neurons: a ganglioside binding

83 Tetanus toxin entry into vertebrate motorneurons may inv

84 Unexpectedly, tetanus toxin exposure causes an increase in SNAP-25 imm

85 We find that the axons of individual tetanus toxin expressing reticulospinal neurons have few

86 In stark contrast, myelination along tetanus-toxin-expressing CoPA neuron axons is entirely n

87 bition of vesicle release with cell-specific tetanus toxin expression results in pioneer axon pathfin

88 synaptic output from the SLP316 neurons via tetanus toxin expression shortened the free-running peri

89 anding of the neuronal receptors utilized by tetanus toxin for the initial entry into nerve cells.

90 Sequence regions of tetanus toxin-forming CD4+ cell epitopes in 8 HLA-dispar

91 ntify retrograde transport to spinal cord of tetanus toxin fragment C ((125) I-TTC) following intramu

92 s Typhi and Typhimurium to mucosally deliver tetanus toxin fragment C (Frag C) as a model antigen in

93 HSV) were expressed as C-terminal fusions to tetanus toxin fragment C (TetC) in different Salmonella

94 delivery of a recombinant bacterial vaccine, tetanus toxin fragment C (TTFC) was expressed constituti

95 of recombinant Lactococcus lactis expressing tetanus toxin fragment C (TTFC), which is a known immuno

96 nd spinal cord, we generated a soluble IGF-1:tetanus toxin fragment C fusion protein (IGF-1:TTC) as a

97 In contrast, a similar construct expressing tetanus toxin fragment C under control of the constituti

98 response elicited by CVD 908-htrA expressing tetanus toxin fragment C under the control of the redox-

99 neuronal binding fragment of tetanus toxin (tetanus toxin fragment C, or TTC).

100 ic neuronal binding domain of tetanus toxin (tetanus toxin fragment C, TTC) has been used as a vector

101 llel beta-helix domain of Aap is replaced by tetanus toxin fragment C, we elicit a potent neutralizin

102 on for cholera toxin subunit B and 10 nM for tetanus toxin fragment C.

103 bind plasma proteins, an exogenous protein (tetanus toxin fragment C; TTC), and a viral vector (reco

104 tion stems partly from motor neurone loss, a tetanus toxin fragment-C (TTC) fusion protein was create

105 e have used a pathogen-derived sequence from tetanus toxin (fragment C (FrC)) fused to tumor Ag seque

106 s live vectors for delivery of fragment C of tetanus toxin (FrgC).

107 We conclude that tetanus toxin, GDNF, and BDNF are released from postsyna

108 sis of the dendritic trees revealed that the tetanus toxin group showed a decrease in complexity arou

109 also to be important for the binding of the tetanus toxin H(C) fragment to ganglioside GT1b.

110 e components of the GT1b binding site on the tetanus toxin H(C) fragment.

111 ved X-ray crystallographic structures of the tetanus toxin H(C) fragment.

112 Consistently, tetanus toxin had no effect on secretion from permeabili

113 The carboxyl-terminal region of the tetanus toxin heavy chain (H(C) fragment) binds to di- a

114 mpletely blocking synaptic transmission with tetanus toxin in cerebellar nuclei, which also reversed

115 rgin females can be blocked by expression of tetanus toxin in Or65a, but not Or67d neurons, demonstra

116 chaemia on the subsequent development of the tetanus toxin-induced epilepsy was studied, using contin

117 oxin-GVIA), intact vesicle fusion processes (tetanus toxin inhibits), and transmitter-filled vesicles

118 A small dose of tetanus toxin injected into the rat hippocampus produces

119 ced TNF exocytosis in BMMCs was dependent on tetanus toxin-insensitive vesicle-associated membrane pr

120 We now find that the v-SNARE tetanus toxin-insensitive vesicle-associated membrane pr

121 ver a period of 3-6 weeks after injection of tetanus toxin into the hippocampus.

122 In close correlation, microinjection of tetanus toxin into the presynaptic neuron produced a blo

123 The domains of tetanus toxin involved in ganglioside binding are known

124 s physiological effect is also observed when tetanus toxin is expressed in the GFs.

125 We propose that this domain of tetanus toxin is sufficient for ganglioside binding.

126 ereas Hirudo synaptobrevin is proteolyzed by tetanus toxin, its SNAP-25 isoform is resistant to botul

127 egion- and cell-type-selective expression of tetanus toxin light chain (TeLC) and compared the functi

128 ition of GPe-projecting CeA neurons with the tetanus toxin light chain (TeLC) completely blocks audit

129 BotC astrocytes were targeted to express the tetanus toxin light chain (TeLC).

130 Silencing BPNs with tetanus toxin light chain (TeNT) increases bilateral mas

131 s blocked by both pan-neuronal expression of tetanus toxin light chain (TeTxLC) and by reduction of a

132 We targeted the expression of tetanus toxin light chain (TeTxLC) to single identified

133 or inhibitory (Galpha(i)) Galpha subunit, or tetanus toxin light chain (TNT) in dopamine and serotoni

134 or targeted astrocyte-specific expression of tetanus toxin light chain (to interfere with vesicular r

135 via combinatorial gene expression to deliver tetanus toxin light chain (tox), an inhibitor of vesicul

136 f serotonergic and raphe neurons in mice for tetanus toxin light chain expression, which prevented ve

137 an adenoviral vector to specifically express tetanus toxin light chain in astrocytes) reduced the HVR

138 using Cre-inducible viral expression of the tetanus toxin light chain in male and female PV-Cre mice

139 culum by injecting a viral vector expressing tetanus toxin light chain in male mice.

140 ng neural activity by targeted expression of tetanus toxin light chain or an inwardly rectifying pota

141 By expressing either tetanus toxin light chain or diphtheria toxin in gal4-de

142 ing the activity of the Ib or Is neuron with tetanus toxin light chain resulted in structural changes

143 selectively blocked by the expression of the tetanus toxin light chain subunit (TeNT), the regularity

144 naptically silenced by chronic expression of tetanus toxin light chain tagged with cyan fluorescent p

145 nergic neurons, we inactivated them with the tetanus toxin light chain, a genetically encoded inhibit

146 Conditional expression of tetanus toxin light chain, a molecule that inhibits syna

147 , unc-1(dn) has effects opposite to those of tetanus toxin light chain, separating the roles of ADL e

148 this hypothesis, postsynaptic expression of tetanus toxin light chain, which cleaves synaptobrevin S

149 aptic connectivity observed previously after tetanus toxin light chain-dependent blockade of evoked s

150 exocytosis as strongly as co-transfection of tetanus toxin light chain.

151 le-cell pairs demonstrated directly that the tetanus toxin-mediated block of exocytosis is accompanie

152 Moreover, tetanus toxin-mediated inactivation of Gr66a- or Gr5a-ex

153 Tetanus toxin-mediated inactivation of Gr68a-expressing

154 In the tetanus toxin model of limbic epilepsy, rats have interm

155 dorant stimuli, optogenetics, and transgenic tetanus toxin neurotransmission block show that elevated

156 thesized with two universal Th epitopes from tetanus toxin (p2p30).

157 Tetanus toxin produces spastic paralysis in situ by bloc

158 p53, HER2-ICD, HER2-ECD, and CEA, but not to tetanus toxin, relative to controls and surgically resec

159 The nontoxic fragment C (HC) of tetanus toxin retains the specific nerve cell binding an

160 th presynaptic vesicle fusion by exposure to tetanus toxin reverted functional to silent transmission

161 ross the nanotube, a membrane-bound protein (tetanus toxin) sees the nanotube as a barrier.

162 ced inhibition of early endosome fusion in a tetanus toxin-sensitive manner and removes Hrs from earl

163 rminus or carboxyl terminus of fragment C of tetanus toxin, separated by a 4-amino-acid hinge region.

164 ed by all subjects: one largely overlapped a tetanus toxin sequence region previously identified as a

165 hetic peptides corresponding to the complete tetanus toxin sequence were used to test, in a prolifera

166 Eight weeks after the injection of tetanus toxin, significantly more "dye-coupled' cells we

167 ',N'-tetraacetic acid, or the SNARE blocker, tetanus toxin, suggesting Ca2+- and SNARE-dependent fusi

168 Tetanus toxin suppressed EPSCs but did not influence OT-

169 copies of a PySSP2 sequence, NPNEPS, and two tetanus toxin T helper epitopes in the adjuvant TiterMax

170 Botulinum neurotoxins (BoNTs) and tetanus toxin (TeNT) are the most potent toxins for huma

171 Cleavage of VAMP2 with tetanus toxin (TeNT) did not prevent delivery of TRPC3 t

172 Tetanus toxin (TeNT) elicits spastic paralysis through t

173 n by different neuronal subtypes, we express tetanus toxin (TeNT) in individual reticulospinal or CoP

174 types of bipolar cells in the retina express tetanus toxin (TeNT).

175 man GDNF to the neuronal binding fragment of tetanus toxin (tetanus toxin fragment C, or TTC).

176 The non-toxic neuronal binding domain of tetanus toxin (tetanus toxin fragment C, TTC) has been u

177 pressing an unrelated antigen (fragment C of tetanus toxin [TetC]) was also used for immunization as

178 Tetanus toxin (TeTx) causes sympathetic hyperactivity, a

179 Six rats received injections of tetanus toxin (TeTX) in the ventral hippocampus that res

180 the basis of these analyses, two regions in tetanus toxin that are structurally homologous with the

181 s a non-toxic 47 kDa polypeptide fragment of tetanus toxin that can be used as a subunit vaccine agai

182 Although di- and trisialogangliosides bind tetanus toxin, their role as productive toxin receptors

183 gliosides completely restores the ability of tetanus toxin to bind to the neuronal surface and to blo

184 ion and postsynaptic specialization, we used tetanus toxin to chronically cleave VAMP2 and inhibit SN

185 Expression of tetanus toxin to cleave VAMP2 in VAMP8 knock-out (-/-) a

186 ely, blocking glutamate release by targeting tetanus toxin to individual synapses increases alpha7-nA

187 f the carboxy-terminal 50 kDa HC fragment of tetanus toxin to polysialogangliosides is important for

188 nditional expression of the light chain from tetanus toxin (tox) in raphe neurons expressing serotone

189 red CCMV-VLPs by incorporating the universal tetanus toxin (TT) epitope at the N-terminus.

190 , the motor cortex of rats was injected with tetanus toxin (TT), and gene expression for 67 kDa gluta

191 e separated following rosette formation with tetanus toxin (TT)-coupled immunobeads to study the regu

192 tigated in chronic focal epilepsy induced by tetanus toxin (TT, 20-35 ng) injected in the rat motor c

193 theria toxin (DTx) followed by fragment C of tetanus toxin (TTC).

194 This analysis provides a model for how tetanus toxin utilizes coreceptors for high-affinity bin

195 The gene encoding the C fragment of tetanus toxin was expressed in the aroAD mutant of S. ty

196 On postnatal day 10, tetanus toxin was unilaterally injected into the hippoca

197 of Ca2+ influx, but in a manner sensitive to tetanus toxin, we find that the secretory process is dir

198 or fused to a fragment C (FrC) sequence from tetanus toxin, we induced both anti-Id and anti-FrC anti

199 ins, influenza virus nucleoprotein (NP), and tetanus toxin were examined in adults with mild to moder

200 /C entered cells differently than the HCR of tetanus toxin, which also utilizes dual gangliosides as

201 tion process is the v-SNARE, VAMP-2, because tetanus toxin, which cleaves VAMP-2, inhibited the forma

202 ion of the receptor binding domain (H(C)) of tetanus toxin, which retains the binding and trafficking

203 rface protein 1 and two T-helper epitopes of tetanus toxin (yP2P30Pv20019), formulated in aluminum hy