ライフサイエンスコーパス: tetracyclines

1 ranslation (e.g. clindamycin, macrolides and tetracyclines).

2 ons, while M errors were often observed with tetracyclines.

3 o overcome problems of resistance to earlier tetracyclines.

4 tively blocked by the oral administration of tetracyclines.

5 along with other eukaryotes, is resistant to tetracyclines.

6 -2 expression, which is distinct from other tetracyclines.

7 tein, TetA, responsible for active efflux of tetracyclines.

8 on of one or more of the non-brain-penetrant tetracyclines.

9 t strains were susceptible to daptomycin and tetracyclines.

10 t(W) gene (22/38, 57.9%) were susceptible to tetracyclines.

11 TF4, rescued the antitumoral response to the tetracyclines.

12 is drugs, carbapenems, fluoroquinolones, and tetracyclines.

13 ed to those who received aminoglycosides and tetracyclines.

14 safety profile similar to that of other oral tetracyclines.

15 operon and replicate only in the presence of tetracyclines.

16 environmentally friendly for the analysis of tetracyclines.

17 rugs, including penicillins, quinolones, and tetracyclines.

18 , alkaloids, prostaglandins, macrolides, and tetracyclines.

19 ally effective 100-200 mg/day dose for these tetracyclines.

20 ugh to the present day examples, such as the tetracyclines.

21 use was linked to higher mortality than for tetracyclines.

22 lly, without accompanying aminoglycosides or tetracyclines.

23 idespread resistance to clinically important tetracyclines.

24 ng/mL for beta-lactams, 0.04-0.98 ng/mL for tetracyclines, 0.08-2.0 ng/mL for quinolones, and 0.1-3.

25 All 6 tetracyclines (2 mg/day) inhibited periodontal breakdown

26 of quinolones (42.0%), sulfonamides (24.0%), tetracyclines (38.0%), and penicillins (38.0%), mainly d

27 Patients were prescribed tetracyclines (49%), aminoglycosides (47%), and fluoroqu

28 ethod covers the analytes from the groups of tetracyclines (6), fluoroquinolones (11), sulphonamides

29 , 85-120% for 13 beta-lactams, 89-115% for 4 tetracyclines, 82-119% for 14 quinolones, 82-115% for 8

30 Tetracyclines, a class of antibiotics that target bacter

31 0.002 [95% CI, 0.001-0.002]; P < .001), and tetracyclines (adjusted beta1 coefficient, 0.0002 [0.000

32 and was significantly more active than other tetracyclines against Burkholderia cepacia, Escherichia

33 uinolones and other compounds (Nor pumps) or tetracyclines alone (Tet38), but the natural substrates

34 nked to drug resistance, primarily targeting tetracyclines, aminoglycosides, and macrolides, lincosam

35 al resistance genes (targeting beta-lactams, tetracyclines, aminoglycosides, macrolides, and glycopep

36 ive pathogens with resistance to macrolides, tetracyclines and fluoroquinolones.

37 The most popular are antibiotics such as tetracyclines and fluoroquinolones.

38 minoglycosides, beta-lactams, sulphonamides, tetracyclines and fosfomycin were identified.

39 minocycline has greater activity than other tetracyclines and glycylcyclines against various MDR pat

40 achomatis, in vitro resistance to first-line tetracyclines and macrolides has never been confirmed de

41 a risk of AMR for 13 TPs, especially TPs of tetracyclines and macrolides.

42 llebrand disease (vWD), and the results with tetracyclines and monoclonal antibody VP-1 offer new str

43 the binding of aminoglycosides, macrolides, tetracyclines and other antibiotics provide opportunitie

44 L in freshwaters and 2.9 ng/g in soils, with tetracyclines and sulfonamides as the predominant compon

45 Tetracyclines and tetracycline analogues are prepared by

46 Mitohormesis induced by non-antimicrobial tetracyclines and the ensuing IFN response may dampen ex

47 th had notably higher rates of resistance to tetracyclines and TMP-SMX, particularly among MRSA isola

48 unties with high rates of resistance to both tetracyclines and TMP-SMX.

49 MRSA isolates were increasingly resistant to tetracyclines and TMP-SMX.

50 emia (aminoglycosides, fluoroquinolones, and tetracyclines) and those with limited efficacy.

51 Aptamers are an attractive way to detect tetracyclines, and all previously reported aptamers for

52 and resistance determinants for quinolones, tetracyclines, and beta-lactamases are shared between aq

53 ses such as new quinolones, aminoglycosides, tetracyclines, and beta-lactams have been designed to ev

54 -lactams, fluoroquinolones, aminoglycosides, tetracyclines, and carbapenems and susceptible only to p

55 nd the repertoire of enzymes that can modify tetracyclines, and facilitate engineered biosynthesis of

56 ms, aminoglycosides, quinolones, macrolides, tetracyclines, and glycopeptides were similar to those a

57 lasses (penicillins, macrolides, quinolones, tetracyclines, and nitrofurans) in Boston, Massachusetts

58 nation, such as colistin, sulbactam, and the tetracyclines, and offer clinical pearls based on our in

59 such as MMP inhibitors, chemically modified tetracyclines, and subantimicrobial formulations of tetr

60 Alternatives such as fluoroquinolones, tetracyclines, and sulfonamides are potentially safer bu

61 resistance to beta-lactams, aminoglycosides, tetracyclines, and sulfonamides were the most abundant.

62 tibiotics, the anticollagenolytic effects of tetracyclines, and the effect of non-steroidal anti-infl

63 s, significant upward trends in clindamycin, tetracyclines, and TMP-SMX resistance were observed.

64 sulfonamides, 3 macrolides, 7 quinolones, 6 tetracyclines, and trimethoprim in chlorine-disinfected

65 other than vancomycin, such as teicoplanin, tetracyclines, and trimethoprim/sulfamethoxazole, have d

66 Aminoglycosides, tetracyclines, and, more recently, fluoroquinolones are

67 levated MICs of aminoglycosides, quinolones, tetracyclines, and/or trimethoprim/sulfamethoxazole.

68 Tetracyclines are a group of important antibiotics with

69 Tetracyclines are a group of natural products sharing a

70 Tetracyclines are antibiotics with pleiotropic cytoprote

71 Tetracyclines are aromatic polyketides biosynthesized by

72 Oral tetracyclines are commonly used for acne and other condi

73 While most tetracyclines are currently used only in animals, their

74 Aminoglycosides, fluoroquinolones, and tetracyclines are effective antimicrobials for treatment

75 Because tetracyclines are fluorescent and their fluorescence int

76 Large numbers of tetracyclines are now possible via these reactions, incl

77 The nonantimicrobial chemically modified tetracyclines are potent inhibitors of MMPs, preventing

78 covered nonantimicrobial chemically modified tetracyclines are potent inhibitors of several classes o

79 Tetracyclines are used in periodontal therapy as antimic

80 ort clinical evaluation of second-generation tetracyclines as affordable, safe therapeutics for lymph

81 sses of antibiotics, the aminoglycosides and tetracyclines as case studies, we review the success and

82 se TetR mutants were identified that require tetracyclines as co-repressors.

83 on more effectively than either of the other tetracyclines at comparable dose levels.

84 mmatory drugs, immunosuppressive agents, and tetracyclines, attenuate the activity of NO and PGE2.

85 or ultrasensitive and selective detection of tetracyclines, based on M-shape structure of aptamer (Ap

86 of CMTs is distinct from that observed with tetracyclines because 1) CMT-3-mediated inhibition of PG

87 cline is distinguished chemically from other tetracyclines because it has a 7-[[methoxy(methyl)amino]

88 extract and accumulate adsorbents bound with tetracyclines before quantitation by HPLC-UV.

89 y can be accomplished with fluoroquinolones, tetracyclines, beta-lactams (including penicillin, amoxi

90 chains, with those conferring resistance to tetracyclines, beta-lactams, aminoglycosides and macroli

91 Macrolides and tetracyclines, both prototypic bacteriostatic protein sy

92 The transport of minocycline and other tetracyclines by isolated human neutrophils was characte

93 Transport of tetracyclines by neutrophils could potentially enhance t

94 at is unclear, systemic fluoroquinolones and tetracyclines can attain higher levels in gingival fluid

95 Fluoroquinolones and tetracyclines can penetrate epithelial cells, but the me

96 factors, and facilitating bacterial killing, tetracyclines can thus have tripartite therapeutic benef

97 among patients who received monotherapy with tetracyclines, chloramphenicol, aminoglycosides, or sulf

98 Tetracyclines, chloramphenicol, and aminoglycosides were

99 rifabutin, while resistance was observed for tetracyclines, ciprofloxacin, and linezolid.

100 Translation inhibitors (such as tetracyclines, clindamycin and macrolides) and gyrase in

101 Chemically modified tetracyclines (CMTs), devoid of antimicrobial activity,

102 In contrast, chemically modified tetracyclines (CMTs), such as CMT-3 and -8 (but not CMT-

103 nsport provide a mechanism by which systemic tetracyclines could be preferentially distributed to gin

104 and Drug Administration-approved drugs, the tetracyclines could be quickly translated to the clinic.

105 te et al. propose in this issue that topical tetracyclines could become safe, efficacious therapy for

106 ocations were associated with penicillins or tetracyclines crossing 50% resistance in the future.

107 idime and piperacillin/tazobactam, alongside tetracyclines demonstrated more variable performance tha

108 First trimester exposure to tetracyclines determined from maternal prescription fill

109 Second-generation tetracyclines directly targeted lymphatic endothelial ce

110 Tetracyclines (doxycycline and minocycline) augmented (o

111 Tetracyclines (doxycycline and minocycline) inhibit indu

112 ic toxic effect which can be counteracted by tetracyclines, drugs able to hinder the formation of lar

113 Of 6340 infants exposed to tetracyclines during the first trimester (3325 male [52.

114 e women, consistent with previous studies on tetracyclines (e.g., doxycycline) in organ culture and a

115 ) for daptomycin and four strains (7.5%) for tetracyclines, each associated with psgA2 mutation and t

116 Among the most potent inhibitors, tetracyclines emerged as a new class of inhibitors.

117 als is implicated in differential potency of tetracyclines, enzyme assays were performed in the prese

118 The cyclohexenone ring A of tetracyclines exhibits unique structural features not ob

119 as a surrogate for the susceptibility other tetracyclines fails to detect minocycline-susceptible is

120 al are effective against mycoplasmas, namely tetracyclines, fluoroquinolones and macrolides.

121 s, other classes of antimicrobials including tetracyclines, fluoroquinolones, and sulfonamides are ef

122 A follow-up of antibiotics (tetracyclines, fluoroquinolones, cephalosporins, penicil

123 ssified into high-efficacy (aminoglycosides, tetracyclines, fluoroquinolones, sulfonamides, and chlor

124 hich could be explained by the common use of tetracyclines for control of sheep abortions in the Unit

125 carbon nanotubes (RACNTs) in the analysis of tetracyclines from milk samples, in a multidimensional l

126 A disadvantage of these systems is that tetracyclines function as transcriptional inducers and h

127 Tetracyclines had no significant effect on the levels of

128 revealed that isolates with elevated MICs of tetracyclines harbored the tetracycline resistance gene

129 The C-8 position of the tetracyclines has been largely underexplored because of

130 The use of tetracyclines has declined because of the appearance of

131 ation of palladium-coupling reactions to the tetracyclines has yielded new tetracycline classes with

132 significance now that minocycline and other tetracyclines have been proposed as therapeutic options

133 Tetracyclines have recently been shown to have "chondrop

134 Various tetracyclines have reduced the severity of osteoarthriti

135 Oral treatments with second-generation tetracyclines improved lymphatic function, while other c

136 was also used to determine sulfonamides and tetracyclines in 16 out of 107 samples, all previously a

137 piece of field kit for on-site monitoring of tetracyclines in a variety of environmental samples, suc

138 recommended antibiotics also increased (eg, tetracyclines in AE-COPD).

139 zed the accumulation of fluoroquinolones and tetracyclines in cultured human gingival fibroblast mono

140 m homeostasis, we caution against the use of tetracyclines in experimental approaches.

141 n clinical and animal sectors and the use of tetracyclines in food production require urgent global a

142 techniques for detection and quantitation of tetracyclines in food products are greatly in demand.

143 has been evaluated for the determination of tetracyclines in infant foods based on meat and vegetabl

144 The method was applied to detect tetracyclines in infant formulas, and the recoveries wer

145 ectic solvent (DES) was developed to extract tetracyclines in infant formulas.

146 pplication of a novel ternary DES to analyze tetracyclines in infant formulas.

147 udies to evaluate the mechanism of action of tetracyclines in RA are indicated.

148 adjunctive usage of the chemically-modified tetracyclines in the treatment of periodontal diseases c

149 ans, penicillins, quinolones, sulfamides and tetracyclines) in Argentinean market fish were investiga

150 mination of 13 antibiotics (sulfonamides and tetracyclines) in catfish.

151 ication of 14 antimicrobials (quinolones and tetracyclines) in fish.

152 We hypothesized that tetracyclines, in addition to their antimicrobial functi

153 Tet(X3) and Tet(X4) inactivate all tetracyclines, including tigecycline and the newly FDA-a

154 rom China, which is capable of degrading all tetracyclines, including tigecycline and the US FDA newl

155 rate in cell and germ-free mouse models that tetracyclines induce a mild adaptive mitochondrial stres

156 We investigate whether tetracyclines inhibit LasB by computational modeling and

157 Tetracyclines inhibit not only bacterial but also mitoch

158 ays with truncated IN mutants indicated that tetracyclines inhibit the IN catalytic core domain.

159 macrophages (RAW 264.7) stimulated with LPS, tetracyclines inhibited NO release and increased PGE2 pr

160 tional (antimicrobial) and non-antimicrobial tetracyclines inhibited periodontal bone resorption indu

161 About 10 years ago we first reported that tetracyclines inhibited the aggregation of prion protein

162 I: 0.82, 0.98; P = 0.01), especially for the tetracyclines (IRR: 0.65; 95% CI: 0.50, 0.85; P = 0.002)

163 indicate that a novel mechanism of action of tetracyclines is to inhibit the expression of NOS.

164 These categories comprised tetracyclines (J01A), amphenicols (J01B), beta-lactam an

165 In contrast to tetracyclines, L-NMMA at low concentrations (< or = 100

166 sis inhibitors (macrolides, aminoglycosides, tetracyclines, lincosamides, and chloramphenicol), DNA s

167 moxicillin < cephalosporins < erythromycin < tetracyclines < azithromycin < metronidazole < amoxicill

168 es, including aminoglycosides, beta-lactams, tetracyclines, macrolides, and fluoroquinolones.

169 widely used antibiotics in acne therapy are tetracyclines, macrolides, and lincosamides.

170 antimicrobials (AMs) including sulfonamides, tetracyclines, macrolides, fluoroquinolones and quinolon

171 rugs in several different classes, including tetracyclines, macrolides, ketolides, lincosamides, and

172 nd Firmicutes phyla and resistance genes for tetracyclines, macrolides, lincosamides, and streptogram

173 enicillins, cephalosporins, aminoglycosides, tetracyclines, macrolides, quinolones, trimethoprim and

174 Tetracyclines, macrolides, streptogramins and lincosamid

175 s corresponding to resistance mechanisms for tetracyclines, macrolides-lincosamides, sulfonamides, am

176 Neuroprotective tetracyclines may be effective in preventing or slowing

177 Our results suggest that tetracyclines may have a dual therapeutic effect in Lyme

178 unique to the United States, and the use of tetracyclines may have facilitated selection of this hig

179 howed consistently very good values over all tetracyclines (milk 80.58 +/- 5.39 %, yoghurt 82.61 +/-

180 ed the potential therapeutic efficacy of two tetracyclines, minocycline and the newer generation tige

181 clinical use, and in contrast to most older tetracyclines, minocycline has high activity against Aci

182 Tetracyclines moderate inflammatory responses of various

183 [52%]), fluoroquinolones (n = 339 [39%]), or tetracyclines (n = 419 [48%]), the fatality rate was 0.7

184 Antibiotics, such as tetracyclines, needed for the treatment of murine typhus

185 servations, the antiamyloidogenic effects of tetracyclines on a variety of amyloidogenic proteins wer

186 r different beta-lactams, ciprofloxacin, and tetracyclines on multiple occasions.

187 umulation, thereby uncoupling the effects of tetracyclines on NO and PGE2 production.

188 cartilage damage, we evaluated the effect of tetracyclines on the expression and function of human OA

189 proteases and determine the effect of pH and tetracyclines on their activity.

190 nd that deactivating microglia in utero with tetracyclines or eliminating microglia from the fetal ce

191 for the selective isolation and clean-up of tetracyclines (oxytetracycline, tetracycline, epi-chloro

192 ally significant resistance to sulfonamides, tetracyclines, penicillins, and ciprofloxacin.

193 tracycline repressor (TetR) and induced with tetracyclines, permitting the construction of conditiona

194 otent initiation inhibitor compared to other tetracyclines, possibly due to drug interactions with th

195 e enzyme coupled with water solubility makes tetracyclines potential candidates for X-ray crystal str

196 Here we find that sub-inhibitory levels of tetracyclines potentiate selection for or against tetrac

197 teriaceae disk diffusion breakpoints for the tetracyclines published in the Clinical and Laboratory S

198 nalysis, the cut-off values of beta-lactams, tetracyclines, quinolones and sulfonamides were determin

199 four families of antibiotics (beta-lactams, tetracyclines, quinolones and sulfonamides) in milk with

200 gene diversity trends were also observed for tetracyclines, quinolones, beta-lactams, and colistin.

201 lasses including sulfonamides, beta-lactams, tetracyclines, quinolones, macrolides, nitrofurans, nitr

202 Systemic fluoroquinolones and tetracyclines reach steady-state levels in gingival crev

203 nas aeruginosa both in vitro and in vivo for tetracyclines reported to date.

204 At subantimicrobial concentrations, tetracyclines sensitized Pseudomonas to neutrophil killi

205 Tetracyclines share a common four-ring naphthacene core

206 ry diseases, these observations suggest that tetracyclines should be evaluated as potential therapeut

207 rsed-phase HPLC-UV method to determinate six tetracyclines simultaneously in various milk products wi

208 Tetracyclines stain calcium phosphate mineral in bone.

209 Aminoglycosides and tetracyclines substantially improve survival of plague,

210 Resistance to lincosamides (clindamycin), tetracyclines, sulfonamides (trimethoprim-sulfamethoxazo

211 the 6-day vermicomposting process, including tetracyclines, sulfonamides, and fluoroquinolones.

212 teen compounds from 6 classes (beta-lactams, tetracyclines, sulfonamides, fluoroquinolones, macrolide

213 were exposed to increasing concentrations of tetracyclines, surface expression of the chimeric recept

214 septicemia model show that many of the novel tetracyclines synthesized have potent antibiotic activit

215 Tetracyclines (TCs) are an important class of antibiotic

216 sensor for the rapid and visual detection of tetracyclines (TCs) in food samples.

217 ation (CIR) EU 2021/808 for quantifying four tetracyclines (TCs) in potatoes and soil.

218 alytical method based on preconcentration of tetracyclines (TCs) in water and milk samples using a ma

219 The excessive use of tetracyclines (TCs), a bacteriostaticantibiotic, in food

220 onsisting of six sulfonamides (SAs) and five tetracyclines (TCs), which commonly are used for veterin

221 pecific for topoisomerase I, and none of the tetracyclines tested induced topoisomerase I-mediated cl

222 potency against purified IN, all substituted tetracyclines tested showed 5-100-fold increased potency

223 macrolides (erm(B)), trimethoprim (dfrG) and tetracyclines (tet(L) and tet(M)) were identified.

224 B4, catA1, floR), sulfonamides (sul1, sul2), tetracyclines (tetA, tetB, tetD), and trimethoprim (dfrA

225 noglycosides, amphenicols, sulfonamides, and tetracyclines) that have perfect nucleotide identity to

226 A new generation of tetracyclines, the glycylcyclines, is being specifically

227 However, all were resistant to tetracyclines, the only antibiotics currently approved i

228 In the absence of tetracyclines, the transfected T cells were shown to exp

229 Importantly, unlike other tetracyclines, the unique C7 extension of sarecycline ex

230 Gingival fibroblasts actively accumulate tetracyclines, thereby enhancing their redistribution fr

231 s appear to accumulate minocycline and other tetracyclines through a mechanism that has not been full

232 udy indicates a novel mechanism of action of tetracyclines to augment the expression of COX-2 and PGE

233 studies have also shown the promise of using tetracyclines to decrease the rate of spontaneous arteri

234 in the distribution of fluoroquinolones and tetracyclines to the gingiva.

235 nolone-induced DNA damage and the ability of tetracyclines to traverse the outer membrane.

236 Similar to most tetracyclines, transient nausea and vomiting and low-mag

237 Semisynthetic tetracyclines used in the adjunctive treatment of inflam

238 rst time a fast, cheap quantification of six tetracyclines via HPLC-UV with a reliable microextractio

239 ent of PGE2 production in RAW 264.7 cells by tetracyclines was accompanied by the accumulation of bot

240 Selectivity of tetracyclines was also examined in an assay specific for

241 se of aminoglycosides, fluoroquinolones, and tetracyclines was independently associated with increase

242 Efficacy of both tetracyclines was reduced by pre-existing tetracycline r

243 ate this collateral damage of macrolides and tetracyclines, we screened for drugs that specifically a

244 terminants for macrolides, beta-lactams, and tetracyclines were 3.4% (95% confidence interval, -4.1%

245 ings, with two exceptions: Longer courses of tetracyclines were associated with reduced tooth loss am

246 Although bisphosphonates and tetracyclines were capable of localizing small amounts o

247 Tetracyclines were effective in preventing infection of

248 Limits of quantitation of examined tetracyclines were from 14.5 to 56.6mug/kg significantly

249 When tetracyclines were introduced in the 1940s, these antibi

250 es, and all previously reported aptamers for tetracyclines were obtained by immobilizing target molec

251 s resistant to macrolides, sulfonamides, and tetracyclines were positively correlated with time in Ho

252 Tetracyclines were the category with the most antibiotic

253 Aminoglycosides and tetracyclines were used more commonly than other classes

254 d antimicrobials, including sulfonamides and tetracyclines, were measured using liquid chromatography

255 travenous aminoglycosides or long courses of tetracyclines where clinically appropriate.

256 nolones, and moderate susceptibility to most tetracyclines, whereas other contemporary isolates had h

257 f bovine urine revealed frequent presence of tetracyclines, which was related with animal's age.

258 ed aptasensor showed high selectivity toward tetracyclines with a limit of detection as low as 266 pM

259 To overcome the interferences of tetracyclines with the host microbiome, we identify tetr