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1 ar DNA duplexes, triplexes and quadruplexes (tetraplexes).
2 mer and lie across the narrow grooves of the tetraplex.
3 ucture was established and was found to be a tetraplex.
4 n unusual K+-dependent intrastrand "cinched" tetraplex.
5 nd at higher ionic strength a double-hairpin tetraplex.
6 C-T)10, probably because it is a two-hairpin tetraplex.
7 metabolism, to destabilize DNA triplexes and tetraplexes.
8 hibited spectra characteristic of parallel G-tetraplexes.
9 orm several intrastrand structures including tetraplexes.
10 as well as two different unusual intrastrand tetraplexes.
11 om the 5'-end of each strand in one cytosine tetraplex and from the 3'-end of each strand in the othe
12 and 1.0 M NaCl, we are also able to identify tetraplex and other similar oligomers formation and to m
14 lmark of previously described intramolecular tetraplexes and contains a number of noncanonical bases
15 erminus, this molecule is capable of forming tetraplexes and other higher order structures in a tempe
16 pands the hydrogen-bonding possibilities for tetraplexes and suggests that the category of sequences
17 p II divalent ions stabilized the parallel G-tetraplexes, and Mg(2+) generally had the weakest stabil
19 ctures with loops, cruciforms, triplexes and tetraplexes) as well as microhomologies are postulated t
21 Our demonstration of the stabilization of tetraplexes by hydrogen bonding between adenines and gua
25 en two chemical structures (i.e., duplex and tetraplex DNA) in the junctions of adjacent origami modu
26 perturb the conformation of nucleic acids in tetraplex, duplex, and single-stranded states was assess
28 ng extends the range of sequences capable of tetraplex formation as well as our appreciation of the c
29 ures, native gel electrophoresis revealed no tetraplex formation at 37 degrees C, the physiologically
33 sitive and specific indicator of intrastrand tetraplex formation that can be used, both to identify s
35 at 0.95 A resolution of a parallel-stranded tetraplex formed by the hexanucleotide d(TG4T) in the pr
36 can be used, both to identify sequences with tetraplex-forming potential and to examine parameters th
37 suggests that the category of sequences with tetraplex-forming potential may be larger than previousl
41 triplex (BePI, coralyne, and berberine) and tetraplex [H(2)TmPyP, 5,10,15, 20-tetrakis[4-(trimethyla
42 Sequences with a propensity to form guanine tetraplexes have been found in chromosomal telomers, imm
44 r polymer (in this case, a four-stranded DNA tetraplex, iDNA) modulates the melting temperature of a
46 ases other than guanine into the stem of the tetraplex, interaction between loop bases and bases in t
49 number of sequences with the ability to form tetraplexes is larger than previously thought, and that
50 ondary structures, in particular intrastrand tetraplexes, is an intrinsic property of some of the mor
52 the number of sequences that can form stable tetraplexes might be much larger than previously thought
54 perturb the CD spectra of a series of other tetraplex nucleic acids, indicating that it does not mod
56 taH of formation per mole of the two-hairpin tetraplex of -116.9 kcal or -29.2 kcal/mol of G-tetrad.
57 ion exhibited by the native MSR molecule for tetraplex over double-stranded or single-stranded nuclei
58 lect the altered internal dimensions of this tetraplex, perhaps resulting from the ability of the C.C
59 at the triple-helical MSR-1 peptide binds to tetraplex poly(I) in a stoichiometric manner and is capa
60 l reference peptide (POG)10 does not bind to tetraplex poly(I), suggesting that binding requires the
63 tions between a triple-helical peptide and a tetraplex polynucleotide are proposed on the basis of th
64 the two enzymes are able to unwind G2 and G4 tetraplexes, prompting speculation that failure to resol
65 that forms a complex mixture of hairpins and tetraplexes, r(CGG)22 forms a single stable hairpin with
66 detecting E. histolytica and E. dispar), our tetraplex real-time PCR assay demonstrated levels of sen
67 Here, we developed a hydrolysis probe-based tetraplex real-time PCR assay that can simultaneously de
69 ization titers of antibodies measured by the TetraPlex RVPNT assay are similar to FRNT/PRNT assay app
70 eporter virus particle neutralization titer (TetraPlex RVPNT) assay for DENV that allows simultaneous
71 nding water patterns are observed within the tetraplex's helical grooves and clustered about the phos
75 ure, led to the complete disruption of the G-tetraplex structure as detected by NMR and confirmed by
77 ce preference arises from the formation of a tetraplex structure held together by a central block of
78 e, the potential for these sequences to form tetraplex structures at lower temperatures may not be re
79 ne, could justify a regulatory mechanism for tetraplex structures in the expression of human insulin.
81 tosine (C)-rich sequences that can fold into tetraplex structures known as i-motif are prevalent in g
82 report here that hairpin and G'2 bimolecular tetraplex structures of the fragile X expanded sequence,
86 ite directions and locked together to form a tetraplex through intercalation of the 5'-most A-A base
87 consistent with conversion of a two-hairpin tetraplex to a single-hairpin duplex with extrahelical r
88 h the normally parallel stranded d(TAGGGTTA) tetraplex to give the first such antiparallel strand ass
89 slipped structures, DNA unwinding elements, tetraplexes, triplexes and sticky DNA) are described.
90 orm unique octaplexes with the neighboring G tetraplexes, whereas the 3'-end uridines are stacked-in