ライフサイエンスコーパス: thalamocortical

1 These findings underscore the importance of thalamocortical activation of mPFC gamma-aminobutyric ac

2 ) range consistent with known frequencies of thalamocortical activation.

3 ury that result in the generation of altered thalamocortical activity and a persistent neuropathic pa

4 Consistent with prior reports, MMN-related thalamocortical activity was strongly inhibited by ketam

5 e cortex for L4 aggregation into barrels and thalamocortical afferent (TCA) segregation.

6 receive dense but transient innervation from thalamocortical afferents during the first postnatal wee

7 c cortical topography.SIGNIFICANCE STATEMENT Thalamocortical afferents segregate in primary visual co

8 to repeated brief optogenetic stimulation of thalamocortical afferents.

9 Thalamocortical anatomical connectivity was compared bet

10 st that consciousness depends on large-scale thalamocortical and corticocortical interactions.

11 disruption of the functional connectivity of thalamocortical and corticocortical networks, particular

12 We recently showed that thalamocortical and corticothalamic pathways connecting

13 nd we highlight how divergent and convergent thalamocortical and corticothalamic pathways may complem

14 natomical rules to describe corticocortical, thalamocortical and corticothalamic projections.

15 uggest a competitive interaction between the thalamocortical and hippocampal-cortical networks suppor

16 nisotropy (FA) of auditory and visual system thalamocortical and interhemispheric corticocortical con

17 developmental refinement takes place at both thalamocortical and intracortical circuit levels, but no

18 On the other hand, the tuning shape of both thalamocortical and intracortical excitatory inputs to a

19 Here, we optogenetically isolated the thalamocortical and intracortical excitatory inputs to i

20 its neurites were bifunctional, innervating thalamocortical and local interneurons while also receiv

21 L4 neurons receive both feedforward thalamocortical and recurrent intracortical inputs, but

22 In thalamocortical and thalamic reticular nucleus neurons,

23 that invasion of monoamine, basal forebrain, thalamocortical, and corticocortical axons is mainly res

24 Findings indicate that deficits in thalamocortical, as well as corticocortical, connectivit

25 erentiation of barrel neurons and individual thalamocortical axon (TCA) arbors that synapse with them

26 rons were located in barrel rings encircling thalamocortical axon (TCA) clusters while mGluR5 knock-o

27 lipid-interacting molecule, is important for thalamocortical axon guidance.

28 ccompanied by a broadening of 5-HT-sensitive thalamocortical axon projections.

29 Activation of thalamocortical axon terminals at different frequencies

30 y information reaches the cortex after brief thalamocortical axonal delays, corticothalamic axons can

31 t the maternal gut microbiome promotes fetal thalamocortical axonogenesis, probably through signallin

32 rmalities in fetal brain gene expression and thalamocortical axonogenesis.

33 Thalamocortical axons (TCAs) cross several tissues on th

34 ipients of ascending sensory information via thalamocortical axons (TCAs).

35 tios in recordings of glutamate release from thalamocortical axons and calcium transients in spines o

36 of genes related to axonogenesis, deficient thalamocortical axons and impaired outgrowth of thalamic

37 Using in vivo two-photon calcium imaging of thalamocortical axons in mice, we show that depriving on

38 Therefore, although thalamocortical axons invade appropriate cortical region

39 that the frequency selectivity of individual thalamocortical axons is surprisingly heterogeneous, eve

40 d selective loss of Ctip1 in cortex deprives thalamocortical axons of their receptive "sensory field"

41 tion of polarized dendritic outgrowth toward thalamocortical axons relaying sensory information, (3)

42 metabolites abrogated deficiencies in fetal thalamocortical axons.

43 cal boutons typically form a single synapse, thalamocortical boutons in S1 usually formed multiple sy

44 Unlike M1, where thalamocortical boutons typically form a single synapse,

45 Our findings extend the concept of thalamocortical "brain-state" coding to include affectiv

46 rent subtypes of cortical neurons to unitary thalamocortical bursts are mostly unknown.

47 SOM-mediated, distally directed inhibition, thalamocortical bursts could momentarily enhance the sal

48 This neuron innervated 256 thalamocortical cells spread across functionally distinc

49 e estimation of dynamical characteristics of thalamocortical cells, such as dynamics of ion channels

50 chemas through the interleaved activation of thalamocortical cells.

51 These corticocortical and thalamocortical changes in functional connectivity were

52 These data identify the POm thalamocortical circuit as a site of rapid synaptic plas

53 agal sensory pathways input to a nociceptive thalamocortical circuit capable of regulating jugular se

54 Seminal studies of the thalamocortical circuit in the visual system of the cat

55 f functional information flow in the sensory thalamocortical circuit may play a role in stimulus perc

56 d the instant synchronization in the sensory thalamocortical circuit play a role in stimulus percepti

57 t a fundamental computation performed by the thalamocortical circuit to accentuate salient tactile in

58 to synapses of a single cell-type within the thalamocortical circuit, is sufficient to remodel synchr

59 We will then describe the basal ganglia-thalamocortical circuit, the major locus of PD-related c

60 avior-related computation implemented by the thalamocortical circuit.

61 d auditory-evoked activities in the auditory thalamocortical circuit.

62 munication relayed among corticocortical and thalamocortical circuitry for the ability to learn new v

63 test whether cognitive corticobasal ganglia-thalamocortical circuitry is impaired and whether altern

64 ults demonstrate distinct matrix versus core thalamocortical circuitry underlying the generation of a

65 s is a finding that upends current models of thalamocortical circuitry, and that might as well illumi

66 ts toward the involvement of cortico-striato-thalamocortical circuitry.

67 w sleep affects the activity and function of thalamocortical circuits and current hypotheses regardin

68 amus, which lead to hyperexcitability in the thalamocortical circuits and obsessive-compulsive disord

69 his study will increase our understanding of thalamocortical circuits and will improve computational

70 Several features of thalamocortical circuits are consistent with this sugges

71 Thalamocortical circuits are traditionally thought to un

72 Although the dynamics of the thalamocortical circuits are traditionally thought to un

73 izure resistance, and (2) hyperexcitation of thalamocortical circuits leading to non-convulsive absen

74 Altogether, this suggests that multiple thalamocortical circuits may act synergistically to achi

75 maladaptive changes involving nAChRs within thalamocortical circuits partially underpin the difficul

76 ly sculpt subplate circuits before permanent thalamocortical circuits to layer 4 are present, and dis

77 These association networks (and presumably thalamocortical circuits) are expanded in humans and mig

78 supporting the involvement of basal ganglia-thalamocortical circuits, representing emotional, cognit

79 nt connectivity models for intracortical and thalamocortical circuits.

80 rough modulation of both olivocerebellar and thalamocortical circuits.

81 ubnetworks to the functional organization of thalamocortical circuits.

82 a power both within the thalamus and cortex, thalamocortical coherence and debiased weighted phase la

83 cy power is necessarily related to increased thalamocortical coherence but in support of the theory t

84 tico-cortical communication, while enhancing thalamocortical communication in this frequency band.

85 f consciousness is associated with disrupted thalamocortical communication.

86 the cortex are due to enhanced or disrupted thalamocortical communication.

87 omplex states and various transitions in the thalamocortical computational model of absence epilepsy

88 Thalamocortical conduction times are short, but layer 6

89 FP signature of the single-axon monosynaptic thalamocortical connection as measured by spike-trigger-

90 onnected neurons within thalamus in mouse, a thalamocortical connection in a female rabbit, and an au

91 ation coefficient to describe the pattern of thalamocortical connections among different cortical net

92 sented more uniform distribution patterns of thalamocortical connections in the ipsilateral medial-do

93 uired for several key steps in wiring up the thalamocortical connections to form the cortical somatos

94 nd that the density of existing cortical and thalamocortical connections was altered.

95 cies (8-200 Hz) within the cortex and across thalamocortical connections, during anaesthesia, both fo

96 e intervals, similar to results reported for thalamocortical connections.

97 the relationship between corticocortical and thalamocortical connectivity and atypical visual process

98 To better understand the rules governing thalamocortical connectivity and the origin of cortical

99 ys a role in establishing the specificity of thalamocortical connectivity and the receptive fields (R

100 (A1) of mice exhibits a critical period for thalamocortical connectivity between postnatal days P12

101 naptic inputs and intra-trial variability of thalamocortical connectivity on information transmission

102 he functional significance of this extensive thalamocortical connectivity remains largely unknown.

103 myelination, synaptic transmission, improved thalamocortical connectivity, and functional recovery.

104 n thalamus and cortex, we observed decreased thalamocortical connectivity, contradicting models that

105 Our findings suggest layer-specific thalamocortical correlates of consciousness and inform h

106 Herein, we demonstrate that thalamocortical coupling is a crucial mechanism for gati

107 MENT We demonstrate, for the first time, how thalamocortical coupling is mediating movement execution

108 Thalamocortical coupling was increased in somatomotor re

109 e generalized to map and quantify axons from thalamocortical, deep cerebellar, and cortical projectio

110 onsciousness where movement ceases, coherent thalamocortical delta oscillations (1-5 Hz) develop, dis

111 Intracortical disinhibition, but not thalamocortical disinhibition, accompanied this OD plast

112 d from patients with schizophrenia to relate thalamocortical dynamics to cognitive control performanc

113 Thalamocortical dysconnectivity is present in both chron

114 These results extend current findings on thalamocortical dysfunction and dysrhythmia in chronic p

115 Thalamocortical dysrhythmia is a key pathology of chroni

116 ical oscillatory activity, a self-sustaining thalamocortical dysrhythmia, and the constant perception

117 iated with altered thalamic burst firing and thalamocortical dysrhythmia.

118 associated with altered thalamic firing and thalamocortical dysrhythmia.

119 ed for integrating long-range inhibition and thalamocortical excitation.

120 intracortical input became better tuned than thalamocortical excitation.

121 ese inhibitory inputs intercept L1-targeting thalamocortical excitatory inputs from ATN to coregulate

122 itory input between PV+ neurons and stronger thalamocortical excitatory inputs onto PV+ cells.

123 rtex neurons and corrects the development of thalamocortical excitatory synapses during the CP.

124 f the auditory system of aged monkeys, while thalamocortical FA was lower only in visual system white

125 Developing thalamocortical fibers both in PRG-2 full knockout (KO)

126 lamic inputs from channelrhodopsin-2-labeled thalamocortical fibers, whereas such inputs were less co

127 (LPA), which failed to repel PRG-2-deficient thalamocortical fibers.

128 ogram, as thalamic damage and alterations in thalamocortical functional connectivity (FC) are importa

129 By performing graph-theoretic analyses on thalamocortical functional connectivity data collected f

130 by showing that specific corticocortical and thalamocortical functional connectivity is altered after

131 thalamic and cortical local power as well as thalamocortical functional connectivity, as measured wit

132 uggests these changes result from changes in thalamocortical functional connectivity.

133 primate visual cortex, enhancing feedforward thalamocortical gain while suppressing corticocortical s

134 nstrate the real-time capability to estimate thalamocortical hidden properties with high precision un

135 evaluates a real-time estimation system for thalamocortical hidden properties.

136 t alterations in spike output in response to thalamocortical input and distorted sensory encoding.

137 stages: output of auditory thalamic neurons, thalamocortical input and recurrent excitatory input to

138 bsequently, responses appeared in the future thalamocortical input layer 4, and sound-evoked spike la

139 ruits H(3) heteroreceptor signaling to shift thalamocortical input onto D1(+)-MSNs in the NAc.

140 We also show that thalamocortical input to layer 1 includes collaterals fr

141 es in brain activity evoked by low-frequency thalamocortical input were mediated by GABA and activity

142 These complex thalamocortical input-output transformations significant

143 cy of information transmission from a single thalamocortical input.

144 e, without significantly affecting bottom-up thalamocortical inputs indexed by the early cortical com

145 erneuron network, the synaptic maturation of thalamocortical inputs onto parvalbumin interneurons is

146 g the postsynaptic conductance of the set of thalamocortical inputs to one L4SS cell decreases the en

147 r visual properties, likely caused by direct thalamocortical inputs, and other sensory and motor prop

148 eurons within the same layers receive weaker thalamocortical inputs, yet are strongly innervated by s

149 onse, which could be explained by converging thalamocortical inputs.

150 processed auditory information may modulate thalamocortical inputs.

151 t the importance of both corticocortical and thalamocortical interactions in reward-guided learning i

152 jor source of thalamic inhibition, regulates thalamocortical interactions that are critical for senso

153 trated greater fractional anisotropy in left thalamocortical, limbic, and association fibers, as well

154 t of structures throughout the basal ganglia-thalamocortical loop in the lesioned hemisphere of hemip

155 tructure across a sensory and an associative thalamocortical loop in the mouse.

156 omponent of the limbic cortico-basal ganglia-thalamocortical loop.

157 vity map is needed to understand the role of thalamocortical loops in visually guided behavior.

158 nsic and circuit-level specializations among thalamocortical loops may determine their involvement in

159 h synchronize the cortex through large-scale thalamocortical loops.

160 Here we uncovered a thalamocortical mechanism in which cortical fast-spiking

161 abatement of spike-and-wave discharges in a thalamocortical model using a closed-loop brain stimulat

162 In the thalamocortical model, training a new memory interfered

163 ic stimulation and further highlight a novel thalamocortical modulatory capacity that may explain the

164 that a new classification is needed based on thalamocortical motifs, where structure naturally inform

165 ized the functional organization of both the thalamocortical network and the basal ganglia-thalamus n

166 an analytical pipeline to identify abnormal thalamocortical network dynamics in cLBP patients and va

167 pain intensity are associated with distinct thalamocortical network dynamics.

168 of high beta oscillations throughout the BG-thalamocortical network in the behaving parkinsonian rat

169 To learn how the MD-PFC thalamocortical network is engaged to mediate forms of c

170 on dynamics of synaptic connectivity in the thalamocortical network model implementing spike-timing-

171 her speculate that the intrinsic dynamics of thalamocortical network oscillations are crucial for ear

172 ose that these deficits cooperate to enhance thalamocortical network synchrony and generate pathologi

173 when applied to the brain-wide basal ganglia-thalamocortical network, DCM accurately reproduced the e

174 using biophysically realistic models of the thalamocortical network, we identified the critical intr

175 nal template for the establishment of global thalamocortical networks and cortical architecture.

176 thic pain, but few studies have investigated thalamocortical networks in chronic low back pain (cLBP)

177 ons relevant to seizure physiology including thalamocortical networks may also play a critical role.

178 bnormal low-frequency oscillations (LFOs) in thalamocortical networks of patients in the interictal p

179 nate sources of GABAergic control in nascent thalamocortical networks.

180 s to act as synchrony-dependent "drivers" of thalamocortical neuron firing.

181 ffects of corticothalamic synaptic inputs on thalamocortical neuron membrane potential and allow thes

182 lity in cells throughout the body, including thalamocortical neurons and cardiac pacemaker cells.

183 erminals in contact with distal dendrites of thalamocortical neurons and GABAergic interneurons elici

184 ation level, individual cortico-thalamic and thalamocortical neurons are sparsely recruited to succes

185 ts, thus suggest that recurrently projecting thalamocortical neurons are the principal targets of cor

186 , the numerically dominant synaptic input to thalamocortical neurons comes from the cortex, which pro

187 more, uncaging of MNI glutamate reveals that thalamocortical neurons have postsynaptic voltage-depend

188 We find that thalamocortical neurons have voltage- and synchrony-depe

189 ond order trigemontothalamic and third order thalamocortical neurons in rats.

190 ed how rat dorsal lateral geniculate nucleus thalamocortical neurons integrate excitatory corticothal

191 real-time, mode-switching approach to drive thalamocortical neurons into or out of a phasic firing m

192 Toggling between phasic and tonic firing in thalamocortical neurons launched and aborted absence sei

193 Thalamocortical neurons relay sensory and motor informat

194 Thalamocortical neurons relay sensory and motor informat

195 ion involves interactions between excitatory thalamocortical neurons that carry data to the cortex an

196 s the powerful increase in the inhibition of thalamocortical neurons that originates at least from tw

197 ections to the somatosensory thalamus target thalamocortical neurons that project back to the same co

198 significantly increase the responsiveness of thalamocortical neurons to cortical excitatory input and

199 recordings targeted to retrogradely labeled thalamocortical neurons to dissect these circuits.

200 In hyperpolarized thalamocortical neurons, T-type Ca(2+)channels produce n

201 the mouse, this connection between RGCs and thalamocortical neurons, the retinogeniculate synapse, h

202 ype calcium channel-mediated burst firing of thalamocortical neurons, though the latter is not essent

203 ions of sensory input in mouse somatosensory thalamocortical neurons, we show that membrane excitabil

204 ng of cortical LFPs on spontaneous spikes of thalamocortical neurons.

205 nd temporal input patterns are integrated by thalamocortical neurons.

206 d that connect reciprocally with independent thalamocortical nuclei through dynamically divergent syn

207 graded control of thalamic output, enabling thalamocortical operations to dynamically match ongoing

208 Sleep spindles, a defining thalamocortical oscillation of non-rapid eye movement st

209 nnels remain critical for maintaining normal thalamocortical oscillations and motor control in the ad

210 e seizures result from 3 to 5 Hz generalized thalamocortical oscillations that depend on highly regul

211 us is a major factor in the amplification of thalamocortical oscillations, making it a strong candida

212 us is a major factor in the amplification of thalamocortical oscillations, making it a strong candida

213 amus plays a critical role in the genesis of thalamocortical oscillations, yet the underlying mechani

214 pain pathway that likely underpins increased thalamocortical oscillatory activity, a self-sustaining

215 nder corticothalamic SWO UP and DOWN states, thalamocortical output can exhibit maximum alpha power a

216 ure spread could have occurred via canonical thalamocortical pathway and many cortical structures inv

217 by disruptions thalamic metabolic growth and thalamocortical pathway maturation, particularly in extr

218 ceptor-mediated inhibition in the trigeminal thalamocortical pathway of mice lacking active Met in th

219 Synaptic strengthening within the POm thalamocortical pathway was first observed at thalamic i

220 BAergic transmission in the central auditory thalamocortical pathway, some perceptual and cognitive d

221 can strongly affect visual responses in the thalamocortical pathway.

222 ific alterations in the lateral thalamus and thalamocortical pathways in extremely preterm neonates e

223 c NAA/Cho and microstructural alterations in thalamocortical pathways.

224 or to the formation of retino-geniculate and thalamocortical pathways.

225 We show that thalamocortical phase-amplitude coupling is a manifestat

226 and motor behavior corresponds to changes in thalamocortical phase-amplitude coupling profiles.

227 Thus, a synchronous thalamocortical phasic firing state is required for abse

228 This model suggests that blocking thalamocortical phasic firing would treat absence seizur

229 Thalamocortical posterior nucleus (Po) axons innervating

230 t in vivo characterization of sensory-driven thalamocortical potentials in V1.

231 Several challenges to current views of thalamocortical processing are offered here.

232 ic development by Pax6 deletion results in a thalamocortical projection containing mapping errors.

233 ly outside the cortical region receiving the thalamocortical projection, implying that it indeed prov

234 is, except for the well-known changes in the thalamocortical projection, remains obscure.

235 High-frequency stimulations (25-40 Hz) of thalamocortical projections evoked dramatically differen

236 tions, the auditory cortex receives parallel thalamocortical projections from the medial geniculate n

237 riability and highlight a potential role for thalamocortical projections in this process.

238 Such locally varied thalamocortical projections may be useful in enabling ra

239 In adult mammals, ascending thalamocortical projections target layer 4, and the onse

240 uditory thalamus, an abnormal sensitivity of thalamocortical projections to antipsychotics, and an ab

241 Surprisingly, driving excitatory thalamocortical projections to VLO at low frequencies (5

242 This pattern was unique to thalamocortical projections, with direct stimulations of

243 gnificant cross-rhythm communication between thalamocortical regions, and motor behavior corresponds

244 In contrast, striato- and thalamocortical relationships with socially engaged brai

245 e sole descending cortical synaptic input to thalamocortical relay cells and reticular interneurons a

246 ical relay neurons; however, burst firing in thalamocortical relay neurons remains essential as iKOp/

247 is limited to circuits involving excitatory thalamocortical relay neurons.

248 firing or T-type calcium current (IT) in the thalamocortical relay neurons; however, burst firing in

249 nclear whether anesthesia primarily disrupts thalamocortical relay or intercortical signaling.

250 posterior nucleus, the primary somatosensory thalamocortical relay.

251 ile L6 CT neurons are positioned to regulate thalamocortical response gain and selectivity.

252 the SRTT task, which is linked to hypocretin-thalamocortical responses.

253 equency.SIGNIFICANCE STATEMENT Slow forms of thalamocortical rhythmic activity are thought to be esse

254 rat brain slices containing key parts of the thalamocortical seizure network modulates epileptiform a

255 ortical slow oscillations (SO; 0.5-1 Hz) and thalamocortical spindle activity (12-15 Hz) during sleep

256 r is thought to rely on interactions between thalamocortical spindles and hippocampal ripples.

257 nsory cortex, SRPX2(-/Y) mice show decreased thalamocortical synapse numbers and increased spine prun

258 The thalamocortical synapse of the visual system has been ce

259 relay synapses: even at the relatively weak thalamocortical synapse, each of which contributes minim

260 input to the middle cortical layer and that thalamocortical synapses form a small fraction (M1: 12%;

261 sory areas, which raises the question of how thalamocortical synapses formed in M1 in the mouse compa

262 ent plasticity mediated by NMDA receptors at thalamocortical synapses in acute PFC slices.

263 e of presynaptic 5-HT2A receptors located at thalamocortical synapses in the control of thalamofronta

264 We found that thalamocortical synapses in vivo are unreliable, highly

265 naptic responses to hypocretin, a measure of thalamocortical synapses, compared with its effects on 5

266 t it indeed provides a very local measure of thalamocortical synaptic activation.

267 To determine whether thalamocortical synaptic circuits differ across cortical

268 We investigated somatosensory thalamocortical synaptic communication in mice deficient

269 a third mechanism that, through preferential thalamocortical synaptic connectivity, enhances the tria

270 However, thalamocortical synaptic properties remain poorly unders

271 vo to characterize the dynamic properties of thalamocortical synaptic transmission in monosynapticall

272 ulus amplitude, reflecting externally driven thalamocortical synchronization during stimulus processi

273 esults indicate that bifacial maps along the thalamocortical system do not offer a functional advanta

274 study, we used a computational model of the thalamocortical system to describe the mechanisms behind

275 In the thalamocortical system, gap junctions couple inhibitory

276 nchrony, and rhythmogenesis in the mammalian thalamocortical system, similar to chemical synaptic pla

277 ize the consequences of bifacial maps in the thalamocortical system.

278 ircuit, corticothalamic loop, and cortico-BG-thalamocortical system.

279 alpha could mediate feedback throughout the thalamocortical system.

280 nal properties has lagged behind that of the thalamocortical systems they control.

281 n relationship distinct from that of sensory thalamocortical systems?

282 means that the extent of backpropagation in thalamocortical (TC) and thalamic reticular nucleus (TRN

283 02 caused a reduction in the total number of thalamocortical (TC) axons innervating the somatosensory

284 lamina and averaged on spontaneous spikes of thalamocortical (TC) cells.

285 Here, we investigated the thalamocortical (TC) feedforward inhibitory microcircuit

286 me cortical neurons receive highly selective thalamocortical (TC) input, but others do not.

287 ons in S1 synaptically excited S1-projecting thalamocortical (TC) neurons in subregions of both the v

288 Auditory thalamocortical (TC) projections recently emerged as a n

289 Thalamocortical (TC) relay cells exhibit different tempo

290 ty between retinal ganglion cells (RGCs) and thalamocortical (TC) relay neurons is thought to be esse

291 ights into these mechanisms by investigating thalamocortical (TC) synaptic transmission and the funct

292 ses, and Type I PV-IR synapses from putative thalamocortical terminals comprised the remaining approx

293 enerated optogenetic stimulation of auditory thalamocortical terminals were also attenuated, suggesti

294 In contrast with the thalamocortical theory, it also predicts that reducing t

295 n of these neurons in regulating the gain of thalamocortical transfer of sensory information dependin

296 vealed that mGlu(2) and mGlu(3) NAMs enhance thalamocortical transmission and inhibit long-term depre

297 x is thought to be dependent on the onset of thalamocortical transmission to layer 4 as well as the e

298 , a group of GABAergic neurons that regulate thalamocortical transmission, sleep rhythms, and attenti

299 pmental patterns of signal transformation in thalamocortical versus retinocollicular pathways.

300 In addition to the primary thalamocortical visual relay in the lateral geniculate n