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1 xidative properties, and speculate as to why that is.
2 ence of a known disruptive ASD-risk mutation that is 1) CHD8 (CHD8 group) (n = 15), 2) a gene targete
3 sorption = 72% of sound intensity at 78 kHz) that is 111 times thinner than the longest absorbed wave
4 found to be very different in each of them, that is, 1240, 740, and 56 ns for BTMPA-Im->AlPorF(5)-Ph
5 tion limits in a total experimental duration that is 2 orders of magnitude less than the equivalent s
6 e the most conserved Y RNA contains a domain that is a close tRNA mimic and Ro60 RNPs are often encod
8 ruction of subcellular structures' (TYGRESS) that is a hybrid of cryo-ET and SP-cryo-EM, and is able
9 igellosis, a severe gastrointestinal disease that is a major cause of diarrhea-associated mortality i
11 ogenetically-conserved epithalamic structure that is a powerful modulator of anxiety- and depressive-
13 nsults can lead to a heterogeneous response; that is, a subpopulation acquires a ductular reactive an
15 al poly[3-(6-hydroxy)hexylthiophene] (P3HHT) that is able to transport ions and electrons/holes, as t
17 in these tasks is to choose the first option that is above a threshold that depends on the current po
19 to constitute the cap-binding complex (CBC) that is acquired co-transcriptionally by the precursors
20 ry factor 3 (IRF3) is a transcription factor that is activated by multiple pattern-recognition recept
22 enes, we developed a miRNA regulation system that is activated only when HSPCs are recruited to and d
23 uiring enzyme (IRE1) is one ER stress sensor that is activated to splice the bZIP60 mRNA that produce
28 nefit from bioactive cyclization, a strategy that is amenable to broad application in pharmaceutical
29 metry, we introduce a model-selection method that is applicable for any multimeric complex by investi
30 c infection in immunocompromised individuals that is associated with a high mortality and morbidity.
32 he fatty acid desaturase (FADS) gene cluster that is associated with circulating and tissue concentra
34 first week after liver transplantation (LT) that is associated with graft loss at 3 months after LT.
35 induces a robust neuroinflammatory response that is associated with increased expression of IFN-beta
36 soriasis is a chronic inflammatory condition that is associated with increased prevalence of high-ris
37 (WPE) into grasslands is a global phenomenon that is associated with land degradation via xerificatio
38 Psoriasis is an inflammatory skin disease that is associated with multiple comorbidities and subst
39 ving to another treatment (generally the one that is associated with the subsequent stage) if the app
41 3)Cs NMR signal with a unique chemical shift that is attributed to Cs atoms terminating the surface o
42 lls offer a novel form of CAR-T-cell product that is available for immediate clinical use, thereby br
43 viral genomes in metagenomic assembly graphs that is based on analyzing variations in the coverage de
44 s dynamical viewpoint gives predictive power that is beyond that of the biophysical explanation alone
45 sis revealed that this compound is a prodrug that is bioactivated by the mycobacterial enzyme MymA.
47 e polarity crescent is the unifying landmark that is both necessary and sufficient to orient both nuc
48 cally configure a catalytic CRL architecture that is both robust, to enable rapid ubiquitylation of t
49 a distinct IFN-independent antiviral program that is broadly effective in limiting virus replication
50 n and the hypoxic ventilatory response (HVR) that is called ventilatory acclimatization to hypoxia (V
51 ultifunctional motile microtrap is developed that is capable of autonomously attracting, trapping, an
52 nt a compartmental, logical model of the MEN that is capable of representing spatial aspects of regul
54 role in Birt-Hogg-Dube syndrome, a disorder that is caused by mutations in the RagC and RagD activat
55 n characterized by a specific encephalopathy that is caused by toxic accumulation of lysine degradati
56 Cellular aging is a multifactorial process that is characterized by a decline in homeostatic capaci
60 be the only activating receptor on NK cells that is cleaved by the metalloprotease a disintegrin and
67 tive oxidative C(sp(3))-H methylation method that is compatible with late-stage functionalization of
70 We identified an insertion of eight residues that is conserved across arrestin-2 homologs, but absent
71 The notable features such as the use of air that is considered as a benign oxidant and EtOH as a gre
72 ce bias in major and minor satellite repeats that is consistent with DNMT3A and DNMT3B specificity su
73 widely reported, few show an ideality factor that is constant over more than a decade in current.
74 thcare is a requirement for human well-being that is constrained, in part, by the allocation of healt
75 economically important global insect species that is continuously exposed to environmental RF-EMFs.
76 ing at the Smc3-Scc1 interface in a reaction that is controlled by acetylation and engagement of the
78 llowed by spontaneous extrusion of the ICRS, that is, correlated to an anatomic failure at the site o
79 xhibit highly correlated electrical activity that is critical for proper maturation and circuit refin
81 Here, we review each major class of ncRNA that is currently annotated in the human genome and desc
82 ndopeptidase able to degrade circulating IgG that is currently being tested in transplant patients(8)
84 ists have documented fault valving behavior, that is, cyclic changes in pressure and unsteady fluid m
85 factor for the development of food allergy, that is, D pteronyssinus allergens in breast milk, which
86 ive importance of MEN signaling from the SPB that is delivered into the daughter cell (dSPB) during a
87 rationally simple chromatographic separation that is demonstrated to be applicable to a variety of bl
88 of the EMT master regulator Slug, a process that is dependent on both MEK/ERK signaling and ATF4.
89 ar spinal cord, detailing synaptic diversity that is dependent on developmental stage, anatomical reg
90 d the root microbiota under iron deprivation that is dependent on the secretion of plant-derived coum
91 c mice induces a mucous metaplasia phenotype that is dependent on type 2 innate lymphoid cells (ILC2s
93 y developed trajectory modelling approach(7) that is designed to isolate secular tectonic motions fro
94 tion) is the prostate specific antigen (PSA) that is detected by conventional biochemical assays whic
97 a highly conserved transcriptional repressor that is differentially regulated through mitogen-activat
98 etect venous or partial blood flow occlusion that is difficult to identify using existing modalities
100 l, featuring a broken-symmetry striped phase that is disrupted at both high and low extremes of chemi
101 rential pattern analysis reveals information that is distinct and complimentary to existing methods t
103 s two-stranded filaments with ultrastructure that is distinct from that of cytoskeletal polymers.
105 module-based or classroom ethics instruction that is divorced from the everyday workflow and practice
106 nce alignment strategy for GPU architectures that is domain independent, supporting alignment of sequ
107 Land plants host a vast and diverse virome that is dominated by RNA viruses, with major additional
110 designed a flexible, simple to setup viewer that is easily adaptable to any type of cancer targeted
112 c matter determines the proportion of carbon that is either stored or emitted to the atmosphere as CO
113 counterbalances electrokinetic (EK) motion, that is, electrophoresis (EP) and electro-osmotic flow (
114 onstrates the importance of the adaptability that is enabled by statistical similarity among RHP chai
116 considered in the selection tree, an aspect that is essential for a quantitative method's robustness
118 acrophages demonstrate remarkable plasticity that is essential for host defense and tissue repair.
119 ission from within membrane necks, a process that is essential for many cellular functions, from cell
120 em (MICOS) is a multisubunit protein complex that is essential for the proper architecture of the mit
125 -a, an injury-induced growth factor/cytokine that is expressed by Muller glia following neuronal deat
128 result from the virus using a virus receptor that is expressed predominantly in the lung(2,4); the sa
130 new way of understanding theory of mind-one that is focused on understanding others' minds in relati
131 (E(pc) = -1.58 V and E(pa) = -1.47 V vs SHE) that is followed by an irreversible cathodic peak (E(pc)
132 enerally accepted in the fast-growth regime, that is, for doubling times below 1 h, extension of thes
136 heir fate when soil redox conditions change, that is, from flooding to drainage to reflooding, batch
137 netic analyses across different time scales, that is, from the femtoseconds to the seconds, reveal th
138 e that the miRNA is expressed from an intron that is generated by RNA polymerase II transcribing the
139 h high power conversion efficiencies (PCEs), that is, greater than 20%, normally employ methylammoniu
140 revealed 44,652 high-quality viral genomes (that is, >90% complete), although the vast majority of s
142 ry fail-safe, a duplicate enhancer mechanism that is hard-wired in the machinery of vertebrate retina
143 ly identified groove in the EnvC LytM domain that is here found to be occluded by a "restraining arm"
145 PL and its physiological transporter GBIHBP1 that is highly active and largely resistant to physiolog
146 A1 (SULT4A1) is a cytosolic sulfotransferase that is highly conserved across species and extensively
147 a class-A orphan G-protein-coupled receptor that is highly expressed in the brain and represents a p
149 t increases in tooth extraction, a procedure that is highly used by publicly insured or uninsured pat
150 a complementary divergent synthetic approach that is holistically patterned off of biosynthetic machi
152 gap in our understanding of CM pathogenesis that is impeding development of therapeutics.METHODSUsin
158 rates that resemble the CC domain, a pattern that is in striking contrast to other ancient and simila
159 As a result, only TXNIP(hi)KAP1(lo) cells, that is, in a primed/prolytic state, turn expression of
161 upport a role for EspE and EspF in virulence that is independent of the EsxA and EsxB substrates and
162 ctive substance can facilitate repeated use: That is, individuals experiencing more positive effects
164 We have developed a caged glutamate probe that is inert toward these receptors at concentrations t
165 pushes CMG beyond a '5-ubiquitin threshold' that is inherent to Cdc48, which specifically unfolds ub
167 lper T (Th) cell-dependent lung eosinophilia that is initiated by the rapid response of bronchiolar c
169 regulates the transcription of the MCM6 gene that is involved in DNA replication by directly binding
170 gnaling pathway downstream of MMP activation that is involved in promoting the transient synaptic enl
171 data by assuming an agent behaves rationally-that is, it takes actions that optimize its subjective r
172 protein-9 (BMP-9) is a circulating cytokine that is known to play an essential role in the endotheli
173 ntris were compared with Synodontis eupterus that is known to produce both signal types, and represen
176 is a new, recombinant protein-based vaccine that is licensed to protect against invasive group B men
178 an epithelium-specific cell surface receptor that is low or undetectable in healthy adult epithelium
180 expected to impact photosynthetic capacity, that is, maximum gross primary productivity (GPP(max) ).
182 ine role for BAT to enhance cardiac function that is mediated by regulation of calcium cycling via 12
184 A elicits systemic death of ALT cancer cells that is mitigated by re-expression of ATRX, a protein th
187 in of PC-1 functions as an intrinsic agonist that is necessary and sufficient for channel activation.
188 mechanocomplex with neuropilin-1 and VEGFR2 that is necessary and sufficient for conferring mechanos
190 o switch to a memory consolidation mechanism that is not contingent on sleep may confer an evolutiona
193 Cys 215 in the ATP-binding pocket, a residue that is not present in human CLK1, thereby providing sel
194 TEX15 is predominantly a nuclear protein that is not required for piRNA biogenesis but is essenti
198 down Mitofilin rescues the loss of mitophagy that is observed in the IRGM KD cells, suggesting that I
200 uence the evolutionary trajectory, an aspect that is often overlooked in laboratory directed evolutio
202 c group of cells into an ensemble of tissues that is ordered with reference to three orthogonal axes(
203 is to tailor windows according to a contrast that is orthogonal (strictly parametrically orthogonal)
206 and expressed Hoxb7, a transcription factor that is part of a developmental regulatory system and a
207 as-related GTPase 1 (SAR1) is a small GTPase that is part of COPII and, upon GTP binding, recruits th
209 dentified a heritable component to self-harm that is partially independent from comorbid psychiatric
210 acid (Scia) is a Delta5-olefinic fatty acid that is particularly abundant in edible pine seeds and t
211 tion of the plasma membrane in resting cells that is poised to orchestrate assembly of key signaling
212 , many luciferase-luciferin pairs emit light that is poorly tissue penetrant, hindering efforts to vi
213 nce and revealed a unique sequence signature that is potentially responsible for substrate specificit
214 AST is a ready-to-use microwell array device that is preassembled with custom titers of various antib
215 y into the cocaine-paired chamber, a measure that is predictive of duration in that chamber, stress i
216 e on EsxA, a post-translational modification that is present in mycobacteria but absent in Escherichi
217 ng a characteristic cell behavioral manifold that is preserved under a perturbation to cell speeds, a
218 ose is a common carbohydrate motif in nature that is processed by a variety of glycoside hydrolases f
220 onceptually, slopes that vary by individual, that is, random coefficient models, could be used to acc
221 heterolytic covalent-bond-forming activity (that is, reacting diversely with small molecules at one
222 perties of the material also result in waste that is readily generated, dispersed, and fragmented in
227 to select an assay with high sensitivity and that is regionally used, to ease comparability between o
228 l protrusion formation during cell migration that is regulated by subcellular mitochondrial trafficki
229 e expression and assembly of the LH1 complex that is regulated through interactions with the RC subun
230 a robust and reproducible ketamine biomarker that is related to the mechanisms of antidepressants.
231 and cytochrome c, a proapoptotic peroxidase that is released from mitochondria during sustained oxid
232 teractions in supporting conscious cognition that is relevant to our understanding of clinical disord
233 PSMA(TV50) is a promising PSMA PET biomarker that is reproducible and easily quantified by the propos
234 movements, a pole of Nodal signaling emerges that is required for explant elongation via the planar c
235 role protoporphyrin IX in order to form heme that is required for growth stimulation and survival in
237 unctional insights into an essential protein that is required for organelle-specific trafficking and
238 e a transition from quiescence to activation that is required for regeneration, but it remains unknow
239 f a mutualistic host-microbiota relationship that is required to maintain homeostasis and prevent dis
240 lyses the remarkable ring expansion reaction that is required to produce the distinct carbon scaffold
241 usarium verticillioides is a fungal pathogen that is responsible for maize ear rot and stalk rot dise
242 ting in reduced axonal mitochondrial content that is restored by genetic inhibition of AMPK and autop
243 dent's t-distribution to estimate a manifold that is robust to technical and biological noise found i
244 r an effective approach to leverage HTP data that is routinely generated in agriculture; the methodol
245 ff protection and health surveillance system that is routinely implemented during non-outbreak period
246 approach for characterizing neural responses that is sensitive to invariant relationships that are cr
247 idence of altered neurochemistry in BD youth that is sensitive to medication status and ADHD comorbid
249 ss (mechanical stability) value of ~194 H(V) that is significantly higher compared to the pristine Ge
250 matosensory feedback alone, with an accuracy that is similar to the accuracy of the auditory percepti
251 n of ischemia/reperfusion (I/R) pathobiology that is singular in its origin, cyclicity, complexity, i
252 tau181) is a promising blood-based biomarker that is specific for AD, correlates with cerebral Abeta
253 racterized version of Cdc42p, Cdc42p(E100A), that is specifically defective for fMAPK pathway signali
254 ovides one of the first examples of a factor that is specifically required for the nuclear export of
255 global time series of street-network sprawl-that is, sprawl as measured through the local connectivi
257 nsient pores on a patch of the lipid bilayer that is strengthened by an elastic meshwork representing
258 sitioning adjacent to a polypyrimidine tract that is stronger than that adjacent to the wild-type sit
260 target for obesity-related asthma, a disease that is suboptimally responsive to current therapies.
261 iform magnetic field gradient within a space that is sufficient to accommodate an organ-stage mouse e
262 screen is the cytosolic Malic Enzyme (ME1), that is sufficient to enable survival and proliferation
264 that displays an adhesion molecule phenotype that is suitable for the study of immune cell interactio
266 re, we identify an allele of the GTPase obgE that is synthetically sick in the absence of Mla; provid
268 t is blood flow and not blood oxygen content that is the main driver of tissue oxygenation by RBCs.
269 ular junction (NMJ) is a specialized synapse that is the point of connection between motor neurons an
271 ltural beliefs as manifested in self-beliefs-that is, the confidence gap-commands attention to reduce
272 eems not to extend to the upper vocal tract, that is, the supralaryngeal articulators, which are key
273 to fall at either end of a neural hierarchy that is thought to reflect the brain's response to cogni
274 tion of a number of unactivated alkene-types that is tolerant of electron-rich functionality, giving
278 pproach based on a deep neural network (DNN) that is trained on images of pre-solved acoustic fields.
279 day 21 after inoculation with infective eggs that is transcriptionally characterized by markers of ty
280 ochromatin, a densely packed chromatin state that is transcriptionally silent, is a critical regulato
282 epatitis A virus (HAV) is a common infection that is transmitted through the fecal-oral route, shed i
284 her wild-type (WT) LIN28B or a LIN28B mutant that is unable to inhibit let-7 processing increases the
289 t efficient misannotation detection approach that is useful for large-scale comparative protein funct
290 e-slide histology images contain information that is valuable for clinical and basic science investig
291 e assembly during DNA replication initiation that is vulnerable to inhibition as combination therapy
292 light that selecting for a stable microbiome that is well adapted to a particular host environment is
293 mbolization is a safe and painless procedure that is well tolerated because it avoids rectal trauma a
297 n equilibrium quantity known as the J factor that is widely used to characterize DNA bending mechanic
299 tic recurrence from radiographic recurrence (that is, with radiographic evidence of a new stone, ston
300 can be rapidly transmitted to a human host, that is, within hours of tick attachment, which is disti